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  1. Article: Therapeutic Effect and Mechanism of Si-Miao-Yong-An-Tang on Thromboangiitis Obliterans Based on the Urine Metabolomics Approach.

    Li, Hui-Yu / Sun, Hui / Zhang, Ai-Hua / He, Lu-Wen / Qiu, Shi / Xue, Jun-Ru / Wu, Fangfang / Wang, Xi-Jun

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 827733

    Abstract: Si-Miao-Yong-An-Tang (SMYAT) is a classic prescription for the treatment ...

    Abstract Si-Miao-Yong-An-Tang (SMYAT) is a classic prescription for the treatment of thromboangiitis obliterans (TAO). However, the effect and mechanism are still unclear. This experiment aims to evaluate the therapeutic effect and mechanism of SMYAT on sodium laurate solution induced thromboangiitis obliterans model rats using urine metabolomics. The therapeutic effect of SMYAT was evaluated by histopathology, hemorheology and other indexes. The urine metabolomic method, principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were used for clustering group and discriminant analysis to screen urine differential metabolic biomarkers, and explore new insight into pathophysiological mechanisms of SMYAT in the treatment of TAO. SMYAT has significant antithrombotic and anti-inflammatory effects, according to the results of urine metabolomic analysis, and regulate the metabolic profile of TAO rats, and its return profile is close to the state of control group. Through metabolomics technology, a total of 35 urine biomarkers of TAO model were characterized. Among them, SMYAT treatment can regulate 22 core biomarkers, such as normetanephrine and 4-pyridoxic acid. It is found that the therapeutic effect of SMYAT is closely related to the tyrosine metabolism, vitamin B6 metabolism and cysteine and methionine metabolism. It preliminarily explored the therapeutic mechanism of SMYAT, and provided a scientific basis for the application of SMYAT.
    Language English
    Publishing date 2022-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.827733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Jiu-Wei-Yong-An Formula suppresses JAK1/STAT3 and MAPK signaling alleviates atopic dermatitis-like skin lesions.

    Qinwufeng, Gu / Jiacheng, Lin / Xiaoling, Lu / Tingru, Chen / Yunyang, Wu / Yanlong, Yang

    Journal of ethnopharmacology

    2022  Volume 295, Page(s) 115428

    Abstract: Ethnopharmacological relevance: Jiu-Wei-Yong-An (JWYA) formula is a traditional Chinese medicine ...

    Abstract Ethnopharmacological relevance: Jiu-Wei-Yong-An (JWYA) formula is a traditional Chinese medicine (TCM) prescription used to treat atopic dermatitis (AD) in the clinic. JWYA is considered to have anti-inflammatory and antipruritic properties. However, the mechanism of JWYA remains unclear.
    Aim of the study: This study aimed to investigate the effect of JWYA on an experimental mouse AD model.
    Materials and methods: Mice were sensitized with 2,4-dinitrochlorobenzene (DNCB) and intragastrically administered with JWYA for 14 days. The therapeutic effect was assessed using a grade four dermatitis score, skin moisture, thickness measurements, and a mouse behavior tests. H&E and toluidine blue staining were used to observe epidermal inflammatory thickening and mast cells in mouse skin lesions. Serum IgE levels and skin TNF-α and IL-4 levels were determined using ELISAs. The TNF-α, IL-1β, IL-4, IL-13, IL-31, IL-33, and IFN-γ mRNA expression levels in skin lesions were detected using qPCR. Network pharmacology analysis based on serum active components was performed to elucidate the mechanism, and the results were verified by Western blotting. Finally, we tested the binding affinity between the active ingredients of JWYA and JAK1 via molecular docking.
    Results: JWYA improved the skin lesions of AD mice, relieved itching and reduced skin thickening. Additionally, JWYA decreased the serum IgE level and the levels of TNF-α, IL-1β, IL-4, IL-13, IL-31, IL-33, and IFN-γ in skin. Moreover, JWYA inhibited the activation of JAK1/STAT3 and MAPK (p38, ERK, and JNK) signaling. Molecular docking showed that kaempferol, luteolin, and forsythin have high affinity for JAK1.
    Conclusions: JWYA alleviates AD-like skin lesions and inhibited inflammation and skin itch. The effect of JWYA is attributed to blocking the JAK1/STAT3 and MAPK signaling pathways. We suggest that JWYA may be an alternative therapy for the treatment of AD.
    MeSH term(s) Animals ; Cytokines/metabolism ; Dermatitis, Atopic/chemically induced ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/metabolism ; Dinitrochlorobenzene ; Immunoglobulin E ; Interleukin-13/metabolism ; Interleukin-33/metabolism ; Interleukin-4/metabolism ; MAP Kinase Signaling System ; Mice ; Mice, Inbred BALB C ; Molecular Docking Simulation ; Plant Extracts/pharmacology ; Skin/pathology ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Cytokines ; Dinitrochlorobenzene ; Interleukin-13 ; Interleukin-33 ; Plant Extracts ; Tumor Necrosis Factor-alpha ; Interleukin-4 (207137-56-2) ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2022-05-31
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.115428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Jiu-Wei-Yong-An Formula suppresses JAK1/STAT3 and MAPK signaling alleviates atopic dermatitis-like skin lesions

    Qinwufeng, Gu / Jiacheng, Lin / Xiaoling, Lu / Tingru, Chen / Yunyang, Wu / Yanlong, Yang

    Journal of ethnopharmacology. 2022 Sept. 15, v. 295

    2022  

    Abstract: Jiu-Wei-Yong-An (JWYA) formula is a traditional Chinese medicine (TCM) prescription used to treat ...

    Abstract Jiu-Wei-Yong-An (JWYA) formula is a traditional Chinese medicine (TCM) prescription used to treat atopic dermatitis (AD) in the clinic. JWYA is considered to have anti-inflammatory and antipruritic properties. However, the mechanism of JWYA remains unclear. Aim of the study: This study aimed to investigate the effect of JWYA on an experimental mouse AD model. Mice were sensitized with 2,4-dinitrochlorobenzene (DNCB) and intragastrically administered with JWYA for 14 days. The therapeutic effect was assessed using a grade four dermatitis score, skin moisture, thickness measurements, and a mouse behavior tests. H&E and toluidine blue staining were used to observe epidermal inflammatory thickening and mast cells in mouse skin lesions. Serum IgE levels and skin TNF-α and IL-4 levels were determined using ELISAs. The TNF-α, IL-1β, IL-4, IL-13, IL-31, IL-33, and IFN-γ mRNA expression levels in skin lesions were detected using qPCR. Network pharmacology analysis based on serum active components was performed to elucidate the mechanism, and the results were verified by Western blotting. Finally, we tested the binding affinity between the active ingredients of JWYA and JAK1 via molecular docking. JWYA improved the skin lesions of AD mice, relieved itching and reduced skin thickening. Additionally, JWYA decreased the serum IgE level and the levels of TNF-α, IL-1β, IL-4, IL-13, IL-31, IL-33, and IFN-γ in skin. Moreover, JWYA inhibited the activation of JAK1/STAT3 and MAPK (p38, ERK, and JNK) signaling. Molecular docking showed that kaempferol, luteolin, and forsythin have high affinity for JAK1. JWYA alleviates AD-like skin lesions and inhibited inflammation and skin itch. The effect of JWYA is attributed to blocking the JAK1/STAT3 and MAPK signaling pathways. We suggest that JWYA may be an alternative therapy for the treatment of AD.
    Keywords Oriental traditional medicine ; atopic dermatitis ; blood serum ; gene expression ; inflammation ; interleukin-13 ; interleukin-4 ; kaempferol ; luteolin ; mice ; models ; pharmacology ; therapeutics ; toluidine blue
    Language English
    Dates of publication 2022-0915
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.115428
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 90/710: Show issues

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  4. Article ; Online: Comparative Pharmacokinetics of Seven Major Compounds in Normal and Atherosclerosis Mice after Oral Administration of Simiao Yong’an Decoction

    Ke-han Sun / Man-fang Yang / Xin-rui Xu / Yang Li / Zhao Gao / Qing-yue Zhang / Hui Li / Shu-qi Wang / Li-xia Lou / Ai-ming Wu / Qiu-shuo Jin / Sheng-xian Wu / Bo Nie

    Evidence-Based Complementary and Alternative Medicine, Vol

    2022  Volume 2022

    Abstract: Simiao Yong’an decoction (SMYAD), a classic traditional Chinese medicine formula, has been used ...

    Abstract Simiao Yong’an decoction (SMYAD), a classic traditional Chinese medicine formula, has been used to treat atherosclerosis (AS) in clinical in China, but its therapeutic mechanism and pharmacodynamic material basis are not clear. In this study, the AS model was caused by a high-fat diet and perivascular carotid collar placement (PCCP), and SMYAD was orally administered to the model and normal mice. A rapid, sensitive, selective, and reliable method using ultrahigh-performance liquid chromatography (UHPLC) system combined with a Q Exactive HF-X mass spectrometer (UHPLC-Q Exactive HF-X MS) was established and validated for the simultaneous determination of seven compounds, including harpagide, chlorogenic acid, swertiamarin, sweroside, angoroside C, liquiritin, and isoliquiritigenin in the plasma of normal and AS mice. The specificity, linearity, precision, accuracy, recovery, and stability of the method were all within the acceptable criteria. The results showed that some pharmacokinetic behaviors of harpagide, chlorogenic acid, and isoliquiritigenin were significantly different among the two groups of mice. The specific parameter changes were harpagide (AUC0–t and AUC0–∞ were 11075.09 ± 2132.38 and 16221.95 ± 5622.42 ng·mL−1·h, respectively; CLz/F was 2.45 ± 0.87 L/h/mg), chlorogenic acid (t1/2 was 21.59 ± 9.16 h; AUC0–∞ was 2637.51 ± 322.54 ng·mL−1·h; CLz/F was 13.49 ± 1.81 L/h/mg) and isoliquiritigenin (AUC0–t and AUC0–∞ were 502.25 ± 165.65 and 653.68 ± 251.34 ng·mL−1·h, respectively; CLz/F was 62.16 ± 23.35 L/h/mg) were altered under the pathological status of AS. These differences might be partly ascribed to the changes in gastrointestinal microbiota, nonspecific drug transporters, and cytochrome P450 activity under the AS state, providing research ideas and experimental basis for pharmacological effects and pharmacodynamic material basis.
    Keywords Other systems of medicine ; RZ201-999
    Subject code 540
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Si-Miao-Yong-An decoction ameliorates cardiac function through restoring the equilibrium of SOD and NOX2 in heart failure mice.

    Ren, Yinglu / Chen, Xiangyang / Li, Peng / Zhang, Huimin / Su, Congping / Zeng, Zifan / Wu, Yan / Xie, Xuan / Wang, Qing / Han, Jing / Guo, Shuzhen / Liu, Bin / Wang, Wei

    Pharmacological research

    2019  Volume 146, Page(s) 104318

    Abstract: Si-Miao-Yong-An decoction (SMYAD), a Chinese herbal formula, has been used in treating ischemic ...

    Abstract Si-Miao-Yong-An decoction (SMYAD), a Chinese herbal formula, has been used in treating ischemic cardiovascular diseases. However, the cardioprotective mechanism of SMYAD treating heart failure (HF) remains unclear. Herein we investigated the effect of SMYAD on isoprenaline (ISO)-induced HF in C57BL/6 mice. Cardiac function and pathological changes in myocardial tissue were evaluated as well as A-type natriuretic peptide (ANP) and brain natriuretic peptide (BNP) expression. The underlying mechanism of SMYAD was deciphered using UHPLC MS/MS coupled with bioinformatics and was verified. SMYAD treatment significantly ameliorated cardiac function, reduced collagen deposition and cardiomyocyte apoptosis, reversed cardiac hypertrophy and down-regulated the expression levels of ANP and BNP mRNA compared with those in HF mice. Decipherment analyses based on 138 ingredients prompted that anti-oxidation was the key mechanism of SMYAD treating HF. In vitro and in vivo, SMYAD showed antioxidant activity, significantly up-regulated superoxide dismutase (SOD)-1 and SOD-2 mRNA expression levels and reduced NADP/NADPH ratio. Moreover, the increased expression levels of NADPH oxidase 2 (NOX2), p47
    MeSH term(s) Animals ; Drugs, Chinese Herbal/pharmacology ; Heart/drug effects ; Heart Failure/drug therapy ; Heart Failure/metabolism ; Isoproterenol/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Myocardium/metabolism ; NADPH Oxidase 2/metabolism ; Natriuretic Peptide, Brain ; Oxidative Stress/drug effects ; Superoxide Dismutase/metabolism
    Chemical Substances Drugs, Chinese Herbal ; Natriuretic Peptide, Brain (114471-18-0) ; Superoxide Dismutase (EC 1.15.1.1) ; Cybb protein, mouse (EC 1.6.3.-) ; NADPH Oxidase 2 (EC 1.6.3.-) ; Isoproterenol (L628TT009W)
    Language English
    Publishing date 2019-06-20
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2019.104318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 721: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book: Zhongguo yao yong zhen jun

    Wu, Xingliang

    2013  

    Title variant Medicinal fungi of China
    Author's details Wu Xingliang [and 10 others] zhu = Medicinal fungi of China / Wu Xingliang [and 10 others]
    MeSH term(s) Agaricales
    Keywords China
    Language Chinese ; Latin
    Size v, 923 pages :, color illustrations ;, 30 cm
    Edition Di 1 ban.
    Document type Book
    Note Nomenclature also in Latin.
    ISBN 9787030387332 ; 7030387333
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Book: Shi yong kou qiang zheng ji lin chuang ji shu tu pu

    Wu, Guangzeng

    Pragmatic orthodontic clinical technology of illustration

    2015  

    Title variant Pragmatic orthodontic clinical technology of illustration
    Author's details Wu Guangzeng zhu bian
    MeSH term(s) Orthodontics/methods
    Language Chinese
    Size 10, 355 pages :, illustrations
    Edition Di 1 ban.
    Document type Book
    ISBN 9787538189087 ; 7538189084
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Book: Si ni tang xian dai yan jiu yu ying yong

    Wu, Weikang

    (Zhong yao ming fang xian dai yan jiu yu ying yong cong shu)

    2011  

    Title variant Si ni tang
    Author's details zhu bian Wu Weikang ; fu zhu bian Jia Yuhua, Yan Can, Fang Xiangming ; bian wei Wang Jian ... [et al.]
    Series title Zhong yao ming fang xian dai yan jiu yu ying yong cong shu
    MeSH term(s) Materia Medica/therapeutic use ; Formularies as Topic ; Medicine, Chinese Traditional
    Keywords China
    Language Chinese
    Size 11, 371 p. :, ill. ;, 27 cm.
    Edition Di 1 ban.
    Publisher Ren min wei sheng chu ban she
    Publishing place Beijing Shi
    Document type Book
    ISBN 9787117141208 ; 7117141204
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Book: Cheng qi tang lei fang xian dai yan jiu yu ying yong

    Wu, Xianzhong

    (Zhong yao ming fang xian dai yan jiu yu ying yong cong shu)

    2011  

    Author's details zhu bian Wu Xianzhong ; fu zhu bian Tian Zaishan
    Series title Zhong yao ming fang xian dai yan jiu yu ying yong cong shu
    MeSH term(s) Drugs, Chinese Herbal/therapeutic use ; Formularies as Topic
    Keywords China
    Language Chinese
    Size 12, 404 p. :, ill. ;, 27 cm.
    Edition Di 1 ban.
    Publisher Ren min wei sheng chu ban she
    Publishing place Beijing Shi
    Document type Book
    ISBN 9787117140577 ; 7117140577
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Book: Shi yong Ying Han ji kong yi xue ci dian

    Wu, Wenzhi

    A practical English-Chinese dictionary for disease control and prevention

    2011  

    Title variant Practical English-Chinese dictionary for disease control and prevention
    Author's details Wu Wenzhi, Wang Zhongchan, Jiang Zhikuan zhu bian
    MeSH term(s) Communicable Disease Control ; Preventive Medicine
    Language Chinese ; English
    Size iv, 724 p. ;, 24 cm.
    Edition Di 1 ban.
    Publisher Suzhou da xue chu ban she
    Publishing place Suzhou Shi
    Document type Book
    ISBN 9787811377057 ; 7811377055
    Database Catalogue of the US National Library of Medicine (NLM)

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