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Article: Soft sediment deformation structures in the Lixian lacustrine sediments, eastern Tibetan Plateau and implications for postglacial seismic activity

Jiang, Hanchao / Ning Zhong / Yanhao Li / Hongyan Xu / Huili Yang / Xiaoping Peng

Sedimentary geology. 2016 Oct., v. 344

2016

Abstract: ... of M>7 in the study area, most SSD structures in the Lixian lacustrine sequence indicate seismic events ...

Abstract	The eastern margin of the Tibetan Plateau is characterized by frequent earthquakes, which are closely associated with tectonic activity. To assess tectonic activity during the Late Pleistocene, we studied a well-exposed, 23-m-thick lacustrine sequence on the eastern margin of the plateau and found a variety of soft-sediment deformation (SSD) structures. Distributed in 24 stratigraphic levels, they comprise clastic dykes, ball-and-pillow structures, flame structures, clastic gravels, micro-faults, and slump folds. Most of the SSD structures indicate deformation mechanisms related to liquefaction and/or fluidization processes, most probably triggered by paleoseismic events. Given at least 4 historical earthquakes of M>7 in the study area, most SSD structures in the Lixian lacustrine sequence indicate seismic events with M>6 while simple flame structures point to some lower-magnitude earthquakes. OSL dating indicates that the sequence accumulated between 15.8 and 6.0ka, giving a mean recurrence interval of 480years for the 24 events, and demonstrating that lacustrine sediments in eastern Tibet have the potential to record a continuous seismic history on the centennial scale.
Keywords	deformation ; earthquakes ; geophysics ; lacustrine sediments ; liquefaction ; plateaus ; tectonics ; China
Language	English
Dates of publication	2016-10
Size	p. 123-134.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	216739-6
ISSN	0037-0738
ISSN	0037-0738
DOI	10.1016/j.sedgeo.2016.06.011
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Comprehensive analysis of ACKR family members in breast cancer using prognostic values.

Yang, Lixian / Zhang, Shiyu / Pu, Pengpeng

Oncology letters

2023 Volume 26, Issue 4, Page(s) 425

Abstract: Breast cancer (BC) is by far the most prevalent malignancy found in the female population. Atypical chemokine receptors (ACKRs) are a subclass of G-protein-coupled receptors, which are characterized by disrupted ligand binding and a breakdown of ... ...

Abstract	Breast cancer (BC) is by far the most prevalent malignancy found in the female population. Atypical chemokine receptors (ACKRs) are a subclass of G-protein-coupled receptors, which are characterized by disrupted ligand binding and a breakdown of signaling following ligand binding. The evolution and function of multiple ACKRs in BC have yet to be fully elucidated, although certain findings on this family have been reported in several studies in
Language	English
Publishing date	2023-08-14
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2023.14011
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Article ; Online: Association of ADP‑ribosylation factor family genes with prognosis and immune infiltration of breast cancer.

Yang, Lixian / Zhang, Shiyu / Zheng, Lei / Kong, Fanting / Pu, Pengpeng / Li, Xiaowei / Jia, Lining

Oncology letters

2024 Volume 27, Issue 6, Page(s) 280

Abstract: Breast cancer (BC) is the most common type of cancer found in women. ADP-ribosylation factors (ARFs) are a group of small proteins that bind to GTP and are involved in controlling different cellular functions. The function and evolution of multiple ARFs ... ...

Abstract	Breast cancer (BC) is the most common type of cancer found in women. ADP-ribosylation factors (ARFs) are a group of small proteins that bind to GTP and are involved in controlling different cellular functions. The function and evolution of multiple ARFs in BC have remained to be fully elucidated, despite existing studies on this protein family in
Language	English
Publishing date	2024-04-23
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2024.14413
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Article ; Online: Analysis of risk factors affecting poor wound healing after primary cleft palate surgery.

Wu, Min / Yin, Heng / Chen, Lixian / Shi, Bing / Li, Yang

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology

2024 Volume 41, Issue 6, Page(s) 719–724

Abstract: Objectives: To study the risk factors of poor wound healing after primary cleft palate surgery.: Methods: In this study, 980 cases of congenital cleft palate treated by Sommerlad-Furlow in the Department of Cleft Lip and Palate Surgery of Sichuan ... ...

Abstract	Objectives: To study the risk factors of poor wound healing after primary cleft palate surgery. Methods: In this study, 980 cases of congenital cleft palate treated by Sommerlad-Furlow in the Department of Cleft Lip and Palate Surgery of Sichuan University from 2017 to 2021 were continuously analyzed. Indicators included patient's age, gender, body weight, cleft palate type, width of the widest fistula, cleft palate index (width of the widest fistula/width at the posterior edge of the maxillary tubercle plane), preoperative white blood cell count, preoperative hemoglobin level, preoperative antibiotic use, doctor's seniority, use of relaxation incision, operation time, postoperative upper respiratory tract infection, and postoperative wound healing. The postoperative wound healing was divided into normal healing, delayed healing, and palatal fistula. Both delayed healing and palatal fistula were classified as poor healing. The factors that may affect the healing outcome of the palatal wound after primary cleft palate repair were analyzed using SPSS 26.0 software. Results: A total of 825 patients (84.2%) had normal healing, 112 patients (11.4%) had delayed hea-ling, and 43 patients (4.4%) had palatal fistula. Doctor's seniority, width of the widest fissure, cleft palate index, and operation time influenced the wound healing effect after cleft palate surgery ( Conclusions: Doctor's seniority, width of the widest fissure, cleft palate index, and operation time are related to the effect of healing effect after cleft palate surgery.
MeSH term(s)	Humans ; Infant ; Cleft Palate/surgery ; Cleft Palate/complications ; Cleft Lip/surgery ; Postoperative Complications/etiology ; Retrospective Studies ; Fistula ; Wound Healing ; Risk Factors
Language	Chinese
Publishing date	2024-04-10
Publishing country	China
Document type	Journal Article
ZDB-ID	1202342-5
ISSN	2618-0456 ; 1000-1182
ISSN (online)	2618-0456
ISSN	1000-1182
DOI	10.7518/hxkq.2023.2023117
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Article ; Online: Application of Different Ventilation Modes Combined with AutoFlow Technology in Thoracic Surgery.

Lixian, Wang / Yanfang, Yang / Chengzong, Cui / Ning, Jiang / Yufeng, Guo

publication RETRACTED

Journal of healthcare engineering

2022 Volume 2022, Page(s) 2507149

Abstract: To investigate the effect of AutoFlow on airway pressure and hemodynamics in mechanical ventilation constant volume-control ventilation mode, 100 patients receiving mechanical ventilation were randomly divided into observation group (SIMV-PSV-PEEP + ... ...

Abstract	To investigate the effect of AutoFlow on airway pressure and hemodynamics in mechanical ventilation constant volume-control ventilation mode, 100 patients receiving mechanical ventilation were randomly divided into observation group (SIMV-PSV-PEEP + AutoFlow) and control group (SIMV-PSV-PEEP). The results showed that the peak airway pressure and average airway pressure decreased with different flow rate settings and automatic flow conversion (
MeSH term(s)	Hemodynamics ; Humans ; Respiration, Artificial/methods ; Technology ; Thoracic Surgery ; Tidal Volume
Language	English
Publishing date	2022-03-28
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Retracted Publication
ZDB-ID	2545054-2
ISSN	2040-2309 ; 2040-2295
ISSN (online)	2040-2309
ISSN	2040-2295
DOI	10.1155/2022/2507149
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Article ; Online: Comparison of efficacy and safety of PD-1/PD-L1 combination therapy in first-line treatment of advanced NSCLC: an updated systematic review and network meta-analysis.

Yang, Yanqing / Chen, Wei / Dong, Lixian / Duan, Lian / Gao, Pengfei

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

2024

Abstract: Background: The use of immune checkpoint inhibitors has led to an increase in randomized controlled trials exploring various first-line combination treatment regimens. With the introduction of new PD-1/PD-L1 inhibitors, there are now more clinical ... ...

Abstract	Background: The use of immune checkpoint inhibitors has led to an increase in randomized controlled trials exploring various first-line combination treatment regimens. With the introduction of new PD-1/PD-L1 inhibitors, there are now more clinical options available. For the first time, the AK105 monoclonal antibody Penpulimab, developed in China, was included. The AK105-302 Phase III trial studied the efficacy and safety of Penpulimab combined with chemotherapy in patients with advanced or metastatic squamous NSCLC. To determine the optimal treatment options, we conducted an updated network meta-analysis to compare the effectiveness and safety of these regimens. Methods: The system retrieves data from Chinese and English electronic databases, Clinical Trials, and the gov Clinical Trial Registration website up to September 6, 2023. The study indirectly compared the efficacy and safety of PD-1/PD-L1 combination regimens, including overall survival (OS), progression-free survival (PFS), objective response rate (ORR), all-grade adverse events, and above-grade III adverse events. Subgroup analyses were conducted based on programmed death ligand 1 (PD-L1) level, histological type, ECOG score, sex, and smoking history. Results: Nineteen RCTS were included, with a total of ten thousand eight hundred patients. Penpulimab plus chemotherapy (Pen + CT) provided the best OS (HR = 0.55, 95% CI 0.38-0.81) for PD-L1 patients with non-selective advanced NSCLC. Except Nivolumab plus Ipilimumab (Niv + Ipi), other PD-1/PD-L1 combination therapies significantly extended PFS compared with CT, and Nivolumab plus Bevacizumab combined with chemotherapy (Niv + Bev + CT) (HR = 0.43, 95% CI 0.26-0.74) provided the best PFS benefit and was comparable to Pen + CT (HR = 1.0) for PFS prolongation. For ORR, except Niv + Ipi, all the other regimens significantly improved ORR compared with CT. In terms of safety, except Tor + CT, the incidence of any-grade AEs or grade ≥ 3 adverse events may be higher than those of chemotherapy. The subgroup analysis revealed that for patients with PD-L1 levels below 1%, treatment with Tor + CT resulted in the best progression-free survival (HR = 0.47, 95% CI 0.25-0.86). For patients with PD-L1 levels of 1% or higher, Sintilimab plus chemotherapy (Sin + CT) (HR = 0.56, 95% CI 0.31-0.99) and Camrelizumab plus chemotherapy (Cam + CT) (HR = 0.43, 95% CI 0.28-0.64) were associated with the best overall survival and progression-free survival, respectively. For patients with SqNSCLC, combined immunotherapy may provide greater survival benefits. For patients with Non-sqNSCLC, Niv + Bev + CT and Tor + CT were associated with optimal PFS and OS, respectively. Cam + CT provided the best PFS in male patients with a history of smoking and an ECOG score of 0. In both female and non-smoking patient subgroups, Pem + CT was associated with the best PFS and OS benefits. Conclusion: For patients with advanced non-selective PD-L1 NSCLC, two effective regimens are Pen + CT and Niv + Bev + CT, which rank first in OS and PFS among all patients. Cam + CT and Tor + CT have advantages for OS in patients with SqNSCLC and Non-sqNSCLC, respectively. Niv + Ipi + CT provided the best OS benefit for patients with an ECOG score of 0, while Pem + CT may be the most effective treatment for patients with an ECOG score of 1. Pem + CT has a better effect on female patients and non-smokers. Sin + CT was found to be the most effective treatment for male patients and the smoking subgroup, while Cam + CT was found to be the most effective for PFS. In addition, Tor + CT was associated with the best PFS for patients with negative PD-L1 expression. Pem + CT was found to significantly improve both PFS and OS compared to CT alone. For patients with positive PD-L1 expression, Sin + CT and Cam + CT were found to be optimal for OS and PFS, respectively. It is important to note that, with the exception of Tor + CT, the toxicity of the other combinations was higher than that of CT alone.
Language	English
Publishing date	2024-04-16
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2397359-6
ISSN	1699-3055 ; 1699-048X
ISSN (online)	1699-3055
ISSN	1699-048X
DOI	10.1007/s12094-024-03442-3
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Article ; Online: Bioinformatic analysis reveals an association between Metadherin with breast cancer prognosis and tumor immune infiltration.

Yang, Lixian / Yang, Liu / Kong, Fanting / Zhang, Shiyu / Pu, Pengpeng / Li, Xiaowei / Song, Zhenchuan

Scientific reports

2024 Volume 14, Issue 1, Page(s) 1949

Abstract: Breast cancer metastasis and invasion are both promoted by the oncoprotein Metadherin (MTDH). However, the the role of Metadherin in breast cancer progression and its role in the immune microenvironment. Are not clear. A bioinformatic analysis was ... ...

Abstract	Breast cancer metastasis and invasion are both promoted by the oncoprotein Metadherin (MTDH). However, the the role of Metadherin in breast cancer progression and its role in the immune microenvironment. Are not clear. A bioinformatic analysis was performed to demonstrate the prognostic value of Metadherin in BC. In the present study, we found that Metadherin is overexpressed in BC and is significantly correlated with individual cancer stage, age, subclasses, menopause and nodal metastasis status. Metadherin overexpression was associated with a significant decrease in OS and DSS. Cox multivariate analysis indicated that Metadherin was an independent negative prognostic indicator for OS and DSS. Moreover, Metadherin hypomethylation status was associated with poor prognosis. A negative correlation was also noted between Metadherin overexpression and the number of plasmacytoid dendritic cells, cluster of differentiation 8
MeSH term(s)	Female ; Humans ; Computational Biology ; Membrane Proteins/genetics ; Neoplasms, Second Primary ; Prognosis ; RNA, Messenger ; RNA-Binding Proteins/genetics ; Tumor Microenvironment ; Breast Neoplasms/genetics ; Breast Neoplasms/immunology ; Breast Neoplasms/pathology
Chemical Substances	Membrane Proteins ; MTDH protein, human ; RNA, Messenger ; RNA-Binding Proteins
Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52403-x
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Article ; Online: A Nonbactericidal Anionic Antimicrobial Peptide Provides Prophylactic and Therapeutic Efficacies against Bacterial Infections in Mice by Immunomodulatory-Antithrombotic Duality.

He, Yanmei / Ruan, Shimei / Liang, Guozhu / Hao, Jing / Zhou, Xiaoyan / Li, Zhuorui / Mu, Lixian / Wu, Jing / Yang, Hailong

Journal of medicinal chemistry

2024

Abstract: Although bactericidal cationic antimicrobial peptides (AMPs) have been well characterized, less information is available about the antibacterial properties and mechanisms of action of nonbactericidal AMPs, especially nonbactericidal anionic AMPs. Herein, ...

Abstract	Although bactericidal cationic antimicrobial peptides (AMPs) have been well characterized, less information is available about the antibacterial properties and mechanisms of action of nonbactericidal AMPs, especially nonbactericidal anionic AMPs. Herein, a novel anionic antimicrobial peptide (Gy-CATH) with a net charge of -4 was identified from the skin of the frog
Language	English
Publishing date	2024-04-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.4c00342
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Article ; Online: Metabolomics and transcriptomics of embryonic livers reveal hypoxia adaptation of Tibetan chickens.

Xue, Mingming / Yu, Runjie / Yang, Lixian / Xie, Fuyin / Fang, Meiying / Tang, Qiguo

BMC genomics

2024 Volume 25, Issue 1, Page(s) 131

Abstract: Background: Exploring the hypoxia adaptation mechanism of Tibetan chicken is of great significance for revealing the survival law of Tibetan chicken and plateau animal husbandry production. To investigate the hypoxia adaptation of Tibetan chickens (TBCs) ...

Abstract	Background: Exploring the hypoxia adaptation mechanism of Tibetan chicken is of great significance for revealing the survival law of Tibetan chicken and plateau animal husbandry production. To investigate the hypoxia adaptation of Tibetan chickens (TBCs), an integrative metabolomic-transcriptomic analysis of the liver on day 18 of embryonic development was performed. Dwarf laying chickens (DLCs), a lowland breed, were used as a control. Results: A total of 1,908 metabolites were identified in both TBCs and DLCs. Energy metabolism and amino acid metabolism related differentially regulated metabolites (DRMs) were significantly enriched under hypoxia. Important metabolic pathways including the TCA cycle and arginine and proline metabolism were screened; PCK1, SUCLA2, and CPS1 were found to be altered under hypoxic conditions. In addition, integrated analysis suggested potential differences in mitochondrial function, which may play a crucial role in the study of chicken oxygen adaptation. Conclusions: These results suggest that hypoxia changed the gene expression and metabolic patterns of embryonic liver of TBCs compared to DLCs. Our study provides a basis for uncovering the molecular regulation mechanisms of hypoxia adaptation in TBCs with the potential application of hypoxia adaptation research for other animals living on the Qinghai-Tibet plateau, and may even contribute to the study of diseases caused by hypoxia.
MeSH term(s)	Animals ; Chickens/genetics ; Tibet ; Hypoxia/genetics ; Hypoxia/veterinary ; Gene Expression Profiling ; Liver ; Adaptation, Physiological/genetics ; Altitude
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2041499-7
ISSN	1471-2164 ; 1471-2164
ISSN (online)	1471-2164
ISSN	1471-2164
DOI	10.1186/s12864-024-10030-w
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Article ; Online: An amphibian-derived cathelicidin accelerates cutaneous wound healing through its main regulatory effect on phagocytes.

Zhou, Xiaoyan / Shen, Huan / Wu, Shuxin / Mu, Lixian / Yang, Hailong / Wu, Jing

International immunopharmacology

2024 Volume 129, Page(s) 111595

Abstract: Cathelicidins are an important family of antimicrobial peptides (AMPs) involved in the innate immunity in vertebrates. The mammalian cathelicidins have been well characterized, but the relationship between structure and function in amphibian ... ...

Abstract	Cathelicidins are an important family of antimicrobial peptides (AMPs) involved in the innate immunity in vertebrates. The mammalian cathelicidins have been well characterized, but the relationship between structure and function in amphibian cathelicidins is still not well understood. In this study, a novel 29-residue cathelicidin antimicrobial peptide (BugaCATH) was identified from the skin of Bufo gargarizans. Unlike other AMPs, BugaCATH does not display any direct antimicrobial effects in vitro. However, it effectively promotes full-thickness wound repair in mice. Following injury, BugaCATH initiates and expedites the inflammatory stage by recruiting neutrophils and macrophages to the wound site. BugaCATH not only regulates neutrophil phagocytic activity but also stimulates the generation of cytokines (TNF-α, IL-6, and IL-1β) and chemokines (CXCL1, CXCL2, CCL2, and CCL3) in macrophages and in mice. Furthermore, it promotes macrophage M2 polarization that facilitates the conversion from a pro-inflammatory macrophage-dominated wound environment to an anti-inflammatory one during the mid to late stages, which is crucial for reducing inflammation and effective wound repair. The MAPK (ERK, JNK, and p38) and NF-κB-NLRP3 signaling pathways are involved in the activity. Moreover, BugaCATH directly enhances the migration of keratinocytes and vascular endothelial cells without affecting their proliferation. Notably, BugaCATH significantly improves the proliferation of keratinocytes and endothelial cells in the presence of macrophages. The current study revealed that in addition to proliferation of keratinocytes and endothelial cells, BugaCATH possesses the ability to modulate inflammatory processes during skin injury through its regulatory effect on phagocytes. The combination of these capabilities makes BugaCATH a potent candidate for skin wound therapy.
MeSH term(s)	Mice ; Animals ; Cathelicidins ; Antimicrobial Cationic Peptides ; Endothelial Cells ; Wound Healing ; Macrophages ; Anura ; Mammals
Chemical Substances	Cathelicidins ; Antimicrobial Cationic Peptides
Language	English
Publishing date	2024-01-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2024.111595
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