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Book ; Online ; Thesis: Frühe Internationalisierung von Human- und Zahnmedizin-Studierenden der Martin-Luther-Universität Halle-Wittenberg und der Columbia University New York City [Kumulative Dissertation]

Gölkel, Camilla Laura [Verfasser] / Kielstein, Heike [Gutachter] / Feller, Stephan Gutachter] / [Hammer, Niels [Gutachter]

2021

Author's details	Camilla Laura Gölkel ; Gutachter: Heike Kielstein, Stephan Feller, Niels Hammer
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Universitäts- und Landesbibliothek Sachsen-Anhalt
Publishing place	Halle (Saale)
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Correction: A mixed methods analysis of the medication review intervention centered around the use of the 'Systematic Tool to Reduce Inappropriate Prescribing' Assistant (STRIPA) in Swiss primary care practices.

Jungo, Katharina Tabea / Deml, Michael J / Schalbetter, Fabian / Moor, Jeanne / Feller, Martin / Lüthold, Renata Vidonscky / Huibers, Corlina Johanna Alida / Sallevelt, Bastiaan Theodoor Gerard Marie / Meulendijk, Michiel C / Spruit, Marco / Schwenkglenks, Matthias / Rodondi, Nicolas / Streit, Sven

BMC health services research

2024 Volume 24, Issue 1, Page(s) 413

Language	English
Publishing date	2024-04-02
Publishing country	England
Document type	Published Erratum
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-024-10896-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Mycorrhizal structures in mycoheterotrophic Thismia spp. (Thismiaceae): functional and evolutionary interpretations

Feller, Benjamin / Dančák, Martin / Hroneš, Michal / Sochor, Michal / Suetsugu, Kenji / Imhof, Stephan

Mycorrhiza. 2022 July, v. 32, no. 3-4

2022

Abstract: Achlorophyllous, mycoheterotrophic plants often have an elaborate mycorrhizal colonization pattern, allowing a sustained benefit from external fungal root penetrations. The present study reveals the root anatomy and mycorrhizal pattern of eight ... ...

Abstract	Achlorophyllous, mycoheterotrophic plants often have an elaborate mycorrhizal colonization pattern, allowing a sustained benefit from external fungal root penetrations. The present study reveals the root anatomy and mycorrhizal pattern of eight mycoheterotrophic Thismia spp. (Thismiaceae), all of which show separate tissue compartments segregating different hyphal shapes of the mycorrhizal colonization, as there are intact straight, coiled and peculiarly knotted hyphae as well as degenerated clumps of hyphal material. Those tissue compartments in Thismia roots potentially comprise exo-, meso- and endoepidermae, and exo-, meso- and endocortices, although not all species develop all these root layers. Differences in details among species according to anatomy (number of root layers, cell sizes and shapes) and colonization pattern (hyphal shapes within cells) are striking and can be discussed as an evolutionary series towards increasing mycorrhizal complexity which roughly parallels the recently established phylogeny of Thismia. We suggest functional explanations for why the distinct elements of the associations can contribute to the mycorrhizal advantage for the plants and, thus, we emphasize the relevance of structural traits for mycorrhizae.
Keywords	fungi ; hyphae ; mycorrhizae ; phylogeny ; root anatomy
Language	English
Dates of publication	2022-07
Size	p. 269-280.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1087945-6
ISSN	1432-1890 ; 0940-6360
ISSN (online)	1432-1890
ISSN	0940-6360
DOI	10.1007/s00572-022-01076-3
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Mycorrhizal structures in mycoheterotrophic Thismia spp. (Thismiaceae): functional and evolutionary interpretations.

Feller, Benjamin / Dančák, Martin / Hroneš, Michal / Sochor, Michal / Suetsugu, Kenji / Imhof, Stephan

Mycorrhiza

2022 Volume 32, Issue 3-4, Page(s) 269–280

Abstract	Achlorophyllous, mycoheterotrophic plants often have an elaborate mycorrhizal colonization pattern, allowing a sustained benefit from external fungal root penetrations. The present study reveals the root anatomy and mycorrhizal pattern of eight mycoheterotrophic Thismia spp. (Thismiaceae), all of which show separate tissue compartments segregating different hyphal shapes of the mycorrhizal colonization, as there are intact straight, coiled and peculiarly knotted hyphae as well as degenerated clumps of hyphal material. Those tissue compartments in Thismia roots potentially comprise exo-, meso- and endoepidermae, and exo-, meso- and endocortices, although not all species develop all these root layers. Differences in details among species according to anatomy (number of root layers, cell sizes and shapes) and colonization pattern (hyphal shapes within cells) are striking and can be discussed as an evolutionary series towards increasing mycorrhizal complexity which roughly parallels the recently established phylogeny of Thismia. We suggest functional explanations for why the distinct elements of the associations can contribute to the mycorrhizal advantage for the plants and, thus, we emphasize the relevance of structural traits for mycorrhizae.
MeSH term(s)	Biological Evolution ; Hyphae ; Mycorrhizae ; Plant Roots/microbiology ; Seeds ; Symbiosis
Language	English
Publishing date	2022-04-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1087945-6
ISSN	1432-1890 ; 0940-6360
ISSN (online)	1432-1890
ISSN	0940-6360
DOI	10.1007/s00572-022-01076-3
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Article ; Online: Thyroid Hormone Therapy for Subclinical Hypothyroidism-Reply.

Feller, Martin / Rodondi, Nicolas / Dekkers, Olaf M

JAMA

2019 Volume 321, Issue 8, Page(s) 804–805

MeSH term(s)	Humans ; Hypothyroidism ; Thyroid Hormones
Chemical Substances	Thyroid Hormones
Language	English
Publishing date	2019-02-26
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2018.20006
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Article ; Online: Trends of incidence, mortality and survival for chronic lymphocytic leukaemia / small lymphocytic lymphoma in Switzerland between 1997 and 2016: a population-based study.

Andres, Martin / Feller, Anita / Arndt, Volker / The Nicer Working Group

Swiss medical weekly

2021 Volume 151, Page(s) w20463

Abstract: Background: During the last 20 years, treatment for chronic lymphocytic leukaemia (CLL) / small lymphocytic lymphoma (SLL) has advanced, with improved clinical outcomes in randomised controlled trials. Currently, no data have been published from ... ...

Abstract	Background: During the last 20 years, treatment for chronic lymphocytic leukaemia (CLL) / small lymphocytic lymphoma (SLL) has advanced, with improved clinical outcomes in randomised controlled trials. Currently, no data have been published from Switzerland to assess effectiveness of recent healthcare advances in CLL/SLL on a population-based level. We aimed to estimate trends in incidence, mortality and survival for patients with CLL/SLL in Switzerland. Methods: We retrospectively studied registry data from the National Agency for Cancer Registration (NACR) database in Switzerland from 1997 to 2016. We investigated incidence, mortality and survival in consecutive 5-year periods. Age-specific rates were calculated for three age groups (<65 years, 65–74 years and ≥75 years). Results: We obtained 6301 cases with CLL/SLL. Median age at diagnosis was 72 years. From 7.0 per 100,000 person-years in 1997–2002, age-adjusted incidence rates peaked at 7.8 per 100,000 person-years in the second time period, 2002–2006, and declined afterwards to 6.4 per 100,000 person-years in 2012–2016. Mortality declined from 2.4 per 100,000 person-years in 1997–2002 to 2.0 per 100,000 in 2012–2016. Five- and 10-year age-standardised relative survival increased from 77.9% and 55.6%, respectively, in 1997–2001 to 83.6% (p = 0.009) and 64.2% (p = 0.005), respectively, in 2012–2016. Improvement in age-specific relative survival was only significant in the middle age group (65–74 years). Incidence and mortality were significantly higher in males. Females had better relative survival. Conclusion: We found no clear down- or upward trend in age-adjusted incidence rates. Age-standardised survival improved over time, mainly in the two younger age-groups, but this improvement was statistically significant in those aged 65–74 years only. Males have higher incidence rates, higher mortality and shorter survival than females. Reporting delay and underreporting are major limitations in the interpretation of registry data from patients diagnosed with CLL/SLL.
MeSH term(s)	Aged ; Aged, 80 and over ; Female ; Humans ; Incidence ; Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology ; Male ; Middle Aged ; Registries ; Retrospective Studies ; Switzerland/epidemiology
Language	English
Publishing date	2021-03-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2036179-8
ISSN	1424-3997 ; 1424-7860
ISSN (online)	1424-3997
ISSN	1424-7860
DOI	10.4414/smw.2021.20463
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Article: Statin therapy in multimorbid older patients with polypharmacy- a cross-sectional analysis of the Swiss OPERAM trial population.

Adam, Luise / Baretella, Oliver / Feller, Martin / Blum, Manuel Raphael / Papazoglou, Dimitrios David / Boland, Benoit / Aujesky, Drahomir / Baggio, Stéphanie / Rodondi, Nicolas

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1236547

Abstract: Background: Statin therapy in multimorbid older individuals with polypharmacy is controversial, particularly in primary prevention of cardiovascular disease. Thereby, physicians must weigh potential benefits against potential side effects, drug-drug ... ...

Abstract	Background: Statin therapy in multimorbid older individuals with polypharmacy is controversial, particularly in primary prevention of cardiovascular disease. Thereby, physicians must weigh potential benefits against potential side effects, drug-drug interactions, and limited life expectancy. Aim: To assess the prevalence and determinants of potentially inappropriate statin therapy in multimorbid older patients. Methods: We conducted a cross-sectional analysis of patients aged ≥70 years with multimorbidity and polypharmacy in the Swiss study center of OPERAM, a cluster-randomized trial on pharmacotherapy optimization to reduce drug-related hospital admissions. We assessed potential underuse (no statin but formal indication) and potential overuse (statin but no formal indication, including predicted >60% one-year mortality based on the Walter Score) based on current guidelines for patients in secondary and primary cardiovascular prevention. We assessed the association of potential statin overuse and underuse with six patient characteristics (age, gender, number of diagnoses, number of medications, mental impairment, being housebound) in LASSO-selection analyses. Results: Of 715 multimorbid older adults (79.7 ± 6.5 years, 39.9% women), 337 (47%) were on statin. Statin therapy was appropriate in 474 (66.3%), underused in 130 (18.2%), and overused in 111 (15.5%) patients. In participants in secondary cardiovascular prevention ( Conclusion: A third of hospitalized multimorbid older patients with polypharmacy potentially (either) overused or underused statin therapy. Among patients in secondary cardiovascular prevention, women were at risk for potential statin underuse. Housebound patients and those taking ≥10 medications were at risk for potential overuse of a statin. Physicians should carefully evaluate the indication for statin prescription in multimorbid older patients with polypharmacy.
Language	English
Publishing date	2023-09-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1236547
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Article ; Online: Achilles tendon ultrasonography in the clinical screening of familial hypercholesterolaemia - a cross-sectional analysis.

De Montmollin, Maria / Bétrisey, Sylvain / Feller, Martin / Moutzouri, Elisavet / Blum, Manuel R / Amsler, Jennifer / Papazoglou, Dimitrios D / Möller, Burkhard / Rodondi, Nicolas

Swiss medical weekly

2023 Volume 153, Page(s) 40127

Abstract: Background and aims: People with familial hypercholesterolaemia are 13 times more likely to develop cardiovascular disease than the general population. However, familial hypercholesterolaemia remains largely underdiagnosed. Tendon xanthoma is a specific ...

Abstract	Background and aims: People with familial hypercholesterolaemia are 13 times more likely to develop cardiovascular disease than the general population. However, familial hypercholesterolaemia remains largely underdiagnosed. Tendon xanthoma is a specific clinical feature of familial hypercholesterolaemia and its presence alone implies a probable diagnosis of familial hypercholesterolaemia according to the Dutch Lipid Clinic Network Score (DLCNS). The aim of the study was to determine whether ultrasound detects more Achilles tendon xanthomas (ATX) than clinical examination. Methods: We recruited 100 consecutive patients with LDL-C ≥4 mmol/l. Achilles tendons were evaluated through clinical examination by trained physicians and sonographic examination by another physician blind to the results of clinical examination. Blind second readings of ultrasound images were performed by an expert in musculoskeletal ultrasound. We compared the proportion of patients with ATX detected by either clinical examination or ultrasound and the proportion of patients with a probable/definite familial hypercholesterolaemia diagnosis on the DLCNS before and after ultrasound. Results: Mean (SD) age was 47 (12) years; mean highest LDL-C was 6.57 mmol/l (2.2). ATX were detected in 23% of patients by clinical examination and in 60% by ultrasound. In consequence, 43% had a probable/definite diagnosis of familial hypercholesterolaemia on the DLCNS using clinical examination compared with 72% when ultrasound was used. Conclusion: Compared to clinical examination, ultrasound examination of the Achilles tendon substantially improves the detection of ATX and may help to better identify patients with familial hypercholesterolaemia who are at high risk for premature cardiovascular disease.
MeSH term(s)	Humans ; Middle Aged ; Achilles Tendon/diagnostic imaging ; Cholesterol, LDL ; Cross-Sectional Studies ; Cardiovascular Diseases ; Hyperlipoproteinemia Type II/diagnostic imaging ; Ultrasonography
Chemical Substances	Cholesterol, LDL
Language	English
Publishing date	2023-11-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2036179-8
ISSN	1424-3997 ; 1424-7860
ISSN (online)	1424-3997
ISSN	1424-7860
DOI	10.57187/smw.2023.40127
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Article ; Online: A mixed methods analysis of the medication review intervention centered around the use of the 'Systematic Tool to Reduce Inappropriate Prescribing' Assistant (STRIPA) in Swiss primary care practices.

BMC health services research

2024 Volume 24, Issue 1, Page(s) 350

Abstract: Background: Electronic clinical decision support systems (eCDSS), such as the 'Systematic Tool to Reduce Inappropriate Prescribing' Assistant (STRIPA), have become promising tools for assisting general practitioners (GPs) with conducting medication ... ...

Abstract	Background: Electronic clinical decision support systems (eCDSS), such as the 'Systematic Tool to Reduce Inappropriate Prescribing' Assistant (STRIPA), have become promising tools for assisting general practitioners (GPs) with conducting medication reviews in older adults. Little is known about how GPs perceive eCDSS-assisted recommendations for pharmacotherapy optimization. The aim of this study was to explore the implementation of a medication review intervention centered around STRIPA in the 'Optimising PharmacoTherapy In the multimorbid elderly in primary CAre' (OPTICA) trial. Methods: We used an explanatory mixed methods design combining quantitative and qualitative data. First, quantitative data about the acceptance and implementation of eCDSS-generated recommendations from GPs (n = 21) and their patients (n = 160) in the OPTICA intervention group were collected. Then, semi-structured qualitative interviews were conducted with GPs from the OPTICA intervention group (n = 8), and interview data were analyzed through thematic analysis. Results: In quantitative findings, GPs reported averages of 13 min spent per patient preparing the eCDSS, 10 min performing medication reviews, and 5 min discussing prescribing recommendations with patients. On average, out of the mean generated 3.7 recommendations (SD=1.8). One recommendation to stop or start a medication was reported to be implemented per patient in the intervention group (SD=1.2). Overall, GPs found the STRIPA useful and acceptable. They particularly appreciated its ability to generate recommendations based on large amounts of patient information. During qualitative interviews, GPs reported the main reasons for limited implementation of STRIPA were related to problems with data sourcing (e.g., incomplete data imports), preparation of the eCDSS (e.g., time expenditure for updating and adapting information), its functionality (e.g., technical problems downloading PDF recommendation reports), and appropriateness of recommendations. Conclusions: Qualitative findings help explain the relatively low implementation of recommendations demonstrated by quantitative findings, but also show GPs' overall acceptance of STRIPA. Our results provide crucial insights for adapting STRIPA to make it more suitable for regular use in future primary care settings (e.g., necessity to improve data imports). Trial registration: Clinicaltrials.gov NCT03724539, date of first registration: 29/10/2018.
MeSH term(s)	Humans ; Aged ; Inappropriate Prescribing/prevention & control ; Medication Review ; Switzerland ; Polypharmacy ; General Practitioners ; Primary Health Care/methods
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-024-10773-y
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Article ; Online: Minimalistic peptidic scaffolds harbouring an artificial carbene-containing amino acid modulate reductase activity.

Lenzen, Karst / Planchestainer, Matteo / Feller, Isabelle / Padrosa, David Roura / Paradisi, Francesca / Albrecht, Martin

Chemical communications (Cambridge, England)

2021 Volume 57, Issue 72, Page(s) 9068–9071

Abstract: Inspired by the boom of new artificial metalloenzymes, we developed an Fmoc-protected histidinium salt (Hum) as N-heterocyclic carbene precursor. Hum was ... ...

Abstract	Inspired by the boom of new artificial metalloenzymes, we developed an Fmoc-protected histidinium salt (Hum) as N-heterocyclic carbene precursor. Hum was placed
MeSH term(s)	Amino Acids/chemistry ; Amino Acids/metabolism ; Methane/analogs & derivatives ; Methane/chemistry ; Methane/metabolism ; Molecular Structure ; Oxidoreductases/chemistry ; Oxidoreductases/metabolism ; Peptides/chemistry ; Peptides/metabolism
Chemical Substances	Amino Acids ; Peptides ; carbene (2465-56-7) ; Oxidoreductases (EC 1.-) ; Methane (OP0UW79H66)
Language	English
Publishing date	2021-09-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d1cc03158a
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