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Article: Does Surgical Day of the Week Affect Hospital Course and Outcomes for Patients Undergoing Adult Spinal Deformity Surgery?

Graham, Benjamin C / Lucasti, Christopher / Scott, Maxwell M / Baker, Seth C / Vallee, Emily K / Patel, Dil V / Hamill, Christopher L

Global spine journal

2024 , Page(s) 21925682241226821

Abstract: Study design: Retrospective Cohort Analysis.: Objectives: Extended hospital length of stay (LOS) poses a significant cost burden to patients undergoing adult spinal deformity (ASD) surgery. The purpose of this study is to investigate the relationship ...

Abstract	Study design: Retrospective Cohort Analysis. Objectives: Extended hospital length of stay (LOS) poses a significant cost burden to patients undergoing adult spinal deformity (ASD) surgery. The purpose of this study is to investigate the relationship between late-week surgery and LOS in patients undergoing ASD surgery. Methods: 256 patients who underwent ASD surgery between January 2018 and December 2021 by a single fellowship-trained orthopedic spine surgeon comprised the patient sample. Demographics, intraoperative, and perioperative data were collected for the 256 patients who underwent ASD surgery. Patients were divided into two groups based on surgical day of the week: (1) Early-week (Monday/Tuesday) n = 126 and (2) Late-week (Thursday/Friday) n = 130. Descriptive statistics, T-tests, and linear and logistic regression models were used to analyze the data. Results: Surgical details and sociodemographic characteristics did not differ between the groups. When controlling for TLIF/DLIF status and PSO status there was no difference in mean length of stay between the groups. The late-week group was associated with a greater risk of 30-day readmission, but there was no difference in complications, infections, or intraoperative complications. Conclusions: We found no difference in mean length of stay between surgeries performed early in the week vs late in the week. Although late-week surgeries had higher 30-day readmission risk, all other outcomes, including complication rates, showed no significant differences. When adequate weekend post-operative care is available, we do not advise restricting ASD surgeries to specific weekdays.
Language	English
Publishing date	2024-01-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2648287-3
ISSN	2192-5690 ; 2192-5682
ISSN (online)	2192-5690
ISSN	2192-5682
DOI	10.1177/21925682241226821
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Article ; Online: Measuring Instructional Interactions During Reading Instruction for Students Receiving Intervention in Middle School.

Baker, Scott K / Kennedy, Patrick C / Richards, Dean / Nelson, Nancy J / Fien, Hank / Doabler, Christian T

Journal of learning disabilities

2023 , Page(s) 222194231211948

Abstract: More than two-thirds of middle school students do not read proficiently. Research has shown that targeted interventions using explicit instruction methods can improve reading outcomes for struggling readers. A central feature of explicit instruction is ... ...

Abstract	More than two-thirds of middle school students do not read proficiently. Research has shown that targeted interventions using explicit instruction methods can improve reading outcomes for struggling readers. A central feature of explicit instruction is the systematic implementation of instructional interactions, but it is not clear what specific instructional interaction practices lead to stronger outcomes for middle school readers. This study used a regression discontinuity design to compare the frequency and impact of instructional interactions experienced by eighth-grade students who received a targeted reading intervention (
Language	English
Publishing date	2023-11-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	217619-1
ISSN	1538-4780 ; 0022-2194
ISSN (online)	1538-4780
ISSN	0022-2194
DOI	10.1177/00222194231211948
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Article: Differences in Financial Conflicts of Interest Among Participants in a National Spine Conference.

Lucasti, Christopher / Vallee, Emily K / Scott, Maxwell M / Baker, Seth C / Das, Ashtah A / Patel, Dil V

Global spine journal

2023 , Page(s) 21925682231168578

Abstract: Study: Retrospective Study.: Objective: At the North American Spine Society (NASS) conference, participants may influence spine surgery practices and patient care through their contributions. Therefore, their financial conflicts of interest are of ... ...

Abstract	Study: Retrospective Study. Objective: At the North American Spine Society (NASS) conference, participants may influence spine surgery practices and patient care through their contributions. Therefore, their financial conflicts of interest are of notable interest. This study aims to compare the demographics and payments made to participating surgeons. Methods: A list of 151 spine surgeons was created based on those who participated in the 2022 NASS conference. Demographic information was obtained from public physician profiles. General payments, research payments, associated research funding, and ownership interest were collected for each physician. Descriptive statistics and two-tailed t-tests were used. Results: In 2021, 151 spine surgeon participants received industry payments, totaling USD 48 294 115. The top 10% of orthopedic surgeons receiving payments accounted for 58.7% of total orthopedic general value, while the top 10% of neurosurgeons accounted for 70.1%. There was no significant difference between these groups' general payment amounts. Surgeons with 21-30 years of experience received the most general funding. There was no difference in funding between surgeons in academic or private settings. For all surgeons, royalties accounted for the largest percentage of the general value exchanged, while food/beverage accounted for the largest percentage of transactions. Conclusions: Our study found that only years of experience had a positive association with general payments, and most monetary value belonged to a small handful of surgeons. These participants receiving significant money may promote techniques requiring products of companies providing their compensation. Future conferences may require disclosure policy changes so attendees understand the degree of funding participants receive.
Language	English
Publishing date	2023-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2648287-3
ISSN	2192-5690 ; 2192-5682
ISSN (online)	2192-5690
ISSN	2192-5682
DOI	10.1177/21925682231168578
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Article ; Online: Reversal learning in those with early psychosis features contingency-dependent changes in loss response and learning.

Baker, Andrea / Suetani, Shuichi / Cosgrove, Peter / Siskind, Dan / Murray, Graham K / Scott, James G / Kesby, James P

Cognitive neuropsychiatry

2023 Volume 28, Issue 5, Page(s) 342–360

Abstract: Introduction: People with psychotic disorders commonly feature broad decision-making impairments that impact their functional outcomes. Specific associative/reinforcement learning problems have been demonstrated in persistent psychosis. But these ... ...

Abstract	Introduction: People with psychotic disorders commonly feature broad decision-making impairments that impact their functional outcomes. Specific associative/reinforcement learning problems have been demonstrated in persistent psychosis. But these phenotypes may differ in early psychosis, suggesting that aspects of cognition decline over time. Methods: The present proof-of-concept study examined goal-directed action and reversal learning in controls and those with early psychosis. Results: Equivalent performance was observed between groups during outcome-specific devaluation, and reversal learning at an 80:20 contingency (reward probability for high:low targets). But when the low target reward probability was increased (80:40) those with early psychosis altered their response to loss, whereas controls did not. Computational modelling confirmed that in early psychosis there was a change in punishment learning that increased the chance of staying with the same stimulus after a loss, multiple trials into the future. In early psychosis, the magnitude of this response was greatest in those with higher IQ and lower clinical severity scores. Conclusions: We show preliminary evidence that those with early psychosis present with a phenotype that includes altered responding to loss and hyper-adaptability in response to outcome changes. This may reflect a compensatory response to overcome the milieu of corticostriatal changes associated with psychotic disorders.
MeSH term(s)	Humans ; Reversal Learning/physiology ; Psychotic Disorders ; Reinforcement, Psychology ; Reward ; Motivation
Language	English
Publishing date	2023-11-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1324282-9
ISSN	1464-0619 ; 1354-6805
ISSN (online)	1464-0619
ISSN	1354-6805
DOI	10.1080/13546805.2023.2259019
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Article: Using epigenetic clocks to investigate changes in the age structure of critically endangered Māui dolphins.

Hernandez, Keith M / O'Neill, Kaimyn B / Bors, Eleanor K / Steel, Debbie / Zoller, Joseph A / Constantine, Rochelle / Horvath, Steve / Baker, C Scott

Ecology and evolution

2023 Volume 13, Issue 10, Page(s) e10562

Abstract: The age of an individual is an essential demographic parameter but is difficult to estimate without long-term monitoring or invasive sampling. Epigenetic approaches are increasingly used to age organisms, including nonmodel organisms such as cetaceans. ... ...

Abstract	The age of an individual is an essential demographic parameter but is difficult to estimate without long-term monitoring or invasive sampling. Epigenetic approaches are increasingly used to age organisms, including nonmodel organisms such as cetaceans. Māui dolphins (
Language	English
Publishing date	2023-09-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.10562
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Article ; Online: Population structure of pygmy (Kogia breviceps) and dwarf (Kogia sima) sperm whales in the Southern Hemisphere may reflect foraging ecology and dispersal patterns.

Plön, Stephanie / Best, Peter B / Duignan, Pádraig / Lavery, Shane D / Bernard, Ric T F / Van Waerebeek, Koen / Baker, C Scott

Advances in marine biology

2023 Volume 96, Page(s) 85–114

Abstract: Little is known about the biology of pygmy (Kogia breviceps) and dwarf (K. sima) sperm whales ... base pair consensus region of the mitochondrial cytochrome b gene was sequenced for 96 K. breviceps (53 ... tissue and 43 teeth or bone samples) and 29 K. sima (3 tissue and 26 teeth or bone samples), and 26 and ...

Abstract	Little is known about the biology of pygmy (Kogia breviceps) and dwarf (K. sima) sperm whales as these animals are difficult to observe in the wild. However, both species strand frequently along the South African, Australian and New Zealand coastlines, providing samples for these otherwise inaccessible species. The use of DNA samples from tissue and DNA extracted from historical material, such as teeth and bone, allowed a first analysis of the population structure of both species in the Southern Hemisphere. A 279 base pair consensus region of the mitochondrial cytochrome b gene was sequenced for 96 K. breviceps (53 tissue and 43 teeth or bone samples) and 29 K. sima (3 tissue and 26 teeth or bone samples), and 26 and 12 unique haplotypes were identified, respectively. K. breviceps showed a higher nucleotide diversity of 0.82% compared to 0.40% in K. sima. Significant genetic differentiation was detected in the Southern Hemisphere between K. breviceps from South Africa and New Zealand (Ф
MeSH term(s)	Humans ; Animals ; Sperm Whale ; Phylogeny ; Australia ; Whales ; DNA ; Nucleotides
Chemical Substances	DNA (9007-49-2) ; Nucleotides
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Journal Article
ISSN	2162-5875
ISSN (online)	2162-5875
DOI	10.1016/bs.amb.2023.09.001
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Article ; Online: Intensive longitudinal assessment of mobility, social activity and loneliness in individuals with severe mental illness during COVID-19.

Valeri, Linda / Rahimi-Eichi, Habiballah / Liebenthal, Einat / Rauch, Scott L / Schutt, Russell K / Öngür, Dost / Dixon, Lisa B / Onnela, Jukka-Pekka / Baker, Justin T

Schizophrenia (Heidelberg, Germany)

2023 Volume 9, Issue 1, Page(s) 62

Language	English
Publishing date	2023-09-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	3133210-9
ISSN	2754-6993 ; 2754-6993
ISSN (online)	2754-6993
ISSN	2754-6993
DOI	10.1038/s41537-023-00383-8
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Article: Modular Chemical Construction of IgG-like Mono- and Bispecific Synthetic Antibodies (SynAbs).

Thoreau, Fabien / Szijj, Peter A / Greene, Michelle K / Rochet, Léa N C / Thanasi, Ioanna A / Blayney, Jaine K / Maruani, Antoine / Baker, James R / Scott, Christopher J / Chudasama, Vijay

ACS central science

2023 Volume 9, Issue 3, Page(s) 476–487

Abstract: In recent years there has been rising interest in the field of protein-protein conjugation, especially related to bispecific antibodies (bsAbs) and their therapeutic applications. These constructs contain two paratopes capable of binding two distinct ... ...

Abstract	In recent years there has been rising interest in the field of protein-protein conjugation, especially related to bispecific antibodies (bsAbs) and their therapeutic applications. These constructs contain two paratopes capable of binding two distinct epitopes on target molecules and are thus able to perform complex biological functions (mechanisms of action) not available to monospecific mAbs. Traditionally these bsAbs have been constructed through protein engineering, but recently chemical methods for their construction have started to (re)emerge. While these have been shown to offer increased modularity, speed, and for some methods even the inherent capacity for further functionalization (e.g., with small molecule cargo), most of these approaches lacked the ability to include a fragment crystallizable (Fc) modality. The Fc component of IgG antibodies offers effector function and increased half-life. Here we report a first-in-class disulfide rebridging and click-chemistry-based method for the generation of Fc-containing, IgG-like mono- and bispecific antibodies. These are in the Fc
Language	English
Publishing date	2023-02-21
Publishing country	United States
Document type	Journal Article
ISSN	2374-7943
ISSN	2374-7943
DOI	10.1021/acscentsci.2c01437
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Article ; Online: Magmatic connectivity among six Galápagos volcanoes revealed by satellite geodesy.

Reddin, Eoin / Ebmeier, Susanna K / Rivalta, Eleonora / Bagnardi, Marco / Baker, Scott / Bell, Andrew F / Mothes, Patricia / Aguaiza, Santiago

Nature communications

2023 Volume 14, Issue 1, Page(s) 6614

Abstract: Shallow magmatic reservoirs that produce measurable volcanic surface deformation are often considered as discrete independent systems. However, petrological analyses of erupted products suggest that these may be the shallowest expression of extensive, ... ...

Abstract	Shallow magmatic reservoirs that produce measurable volcanic surface deformation are often considered as discrete independent systems. However, petrological analyses of erupted products suggest that these may be the shallowest expression of extensive, heterogeneous magmatic systems that we show may be interconnected. We analyse time series of satellite-radar-measured displacements at Western Galápagos volcanoes from 2017 to 2022 and revisit historical displacements. We demonstrate that these volcanoes consistently experience correlated displacements during periods of heightened magma supply to the shallow crust. We rule out changes in static stress, shallow hydraulic connections, and data processing and analysis artefacts. We propose that episodic surges of magma into interconnected magmatic systems affect neighbouring volcanoes, simultaneously causing correlations in volcanic uplift and subsidence. While expected to occur globally, such processes are uniquely observable at the dense cluster of Western Galápagos volcanoes, thanks to the high rate of surface displacements and the wealth of geodetic measurements.
Language	English
Publishing date	2023-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-42157-x
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Article ; Online: Long-term complications in adolescent and young adult leukemia survivors.

Baker, K Scott / Syrjala, Karen L

Hematology. American Society of Hematology. Education Program

2018 Volume 2018, Issue 1, Page(s) 146–153

Abstract: Adolescents and young adults (AYAs) with cancer, defined by the National Cancer Institute as having been diagnosed between the ages of 15 and 39 years old, have not benefited from the same improvements in quality of outcomes and survival that have been ... ...

Abstract	Adolescents and young adults (AYAs) with cancer, defined by the National Cancer Institute as having been diagnosed between the ages of 15 and 39 years old, have not benefited from the same improvements in quality of outcomes and survival that have been seen for individuals diagnosed in childhood or as older adults. Although is leukemia composed of a diverse group of diagnoses, leukemia AYA survivors share unique vulnerabilities with other AYA diagnostic groups. They will spend the majority of their lives as survivors, with clear evidence of adverse medical conditions, health care requirements, and social and psychological needs that differ not only from their peers but also, from the needs of other cancer survivor populations. Furthermore, they share a developmental stage of life in which careers, finances, and family concerns are uniquely impacted by the cancer diagnosis and treatment. Leukemia in AYAs typically presents with higher-risk biologic features, and treatment requires multiagent chemotherapy, including alkylating agents, anthracyclines, high-dose steroids, frequently intrathecal chemotherapy, and sometimes, cranial radiation. Thus, AYAs have significant risks for long-term complications, subsequent malignancies, and accelerated development of usual age-related comorbid conditions, such as cardiovascular disease and dyslipidemias. AYAs require specialized health care monitoring, surveillance for late effects, and periodic evaluation of psychosocial, health behavior, and life goal outcomes.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Cancer Survivors/psychology ; Female ; Humans ; Leukemia/pathology ; Leukemia/psychology ; Leukemia/therapy ; Male ; Young Adult
Language	English
Publishing date	2018-11-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2084287-9
ISSN	1520-4383 ; 1520-4391
ISSN (online)	1520-4383
ISSN	1520-4391
DOI	10.1182/asheducation-2018.1.146
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