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  1. Article ; Online: Review of global epidemiology data for Alopecia Areata highlights gaps and a call for action.

    Sibbald, Cathryn / Castelo-Soccio, Leslie

    The British journal of dermatology

    2024  

    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljae088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A review of hair removal modalities in pediatric patients: Ethical and clinical considerations.

    Sanfilippo, Eric / Castelo-Soccio, Leslie / Kirkorian, Anna Yasmine

    Pediatric dermatology

    2024  

    Abstract: Unwanted hair is a common concern among patients presenting to pediatric dermatology clinics, and parents and patients alike inquire about the safety of methods employed for elective removal. Various methods of hair removal exist with different levels of ...

    Abstract Unwanted hair is a common concern among patients presenting to pediatric dermatology clinics, and parents and patients alike inquire about the safety of methods employed for elective removal. Various methods of hair removal exist with different levels of invasiveness and permanence, from simple mechanical depilation to light-based therapies. All methods of hair removal appear to be safe and generally well tolerated in children, and there are no age restrictions to any modality. In this review, we aim to address the available literature on the safety and efficacy of hair removal modalities in pediatric patients and propose guidance on how to manage requests for at-home and in-office therapies within an ethical framework.
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605539-4
    ISSN 1525-1470 ; 0736-8046
    ISSN (online) 1525-1470
    ISSN 0736-8046
    DOI 10.1111/pde.15564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Alopecia Areata: A Review of the Genetic Variants and Immunodeficiency Disorders Associated with Alopecia Areata.

    Englander, Hanna / Paiewonsky, Briana / Castelo-Soccio, Leslie

    Skin appendage disorders

    2023  Volume 9, Issue 5, Page(s) 325–332

    Abstract: Alopecia areata (AA) is an autoimmune form of non-scarring hair loss that occurs on a spectrum from patchy loss of hair on the scalp, to complete hair loss. Histology features can vary, but increased abundance of telogen hair and miniaturized hair ... ...

    Abstract Alopecia areata (AA) is an autoimmune form of non-scarring hair loss that occurs on a spectrum from patchy loss of hair on the scalp, to complete hair loss. Histology features can vary, but increased abundance of telogen hair and miniaturized hair follicles are classic hallmarks [Clin Cosmet Investig Dermatol. 2015;8:397-403]. Additionally, lymphocytic infiltration of the hair bulb is a commonly observed histology feature of AA which underscores how the disease is an autoimmune-mediated one that results from immune-mediated attack of the hair follicle. In a healthy individual, the hair follicle is one of the body's immune-privileged sites, but the breakdown of this immune privilege is thought to be an important driver in AA disease development. Diagnosis of AA is usually based on phenotypic manifestations in conjunction with biopsies which can help conclude whether the hair loss is autoimmune based. However, varied manifestation of disease both clinically and histologically makes diagnosis criteria more ambiguous and early identification of disease harder to achieve. A better understanding of genes that are associated with increased AA risk may help elucidate potential gene targets for future therapeutics.
    Language English
    Publishing date 2023-07-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2806972-9
    ISSN 2296-9160 ; 2296-9195
    ISSN (online) 2296-9160
    ISSN 2296-9195
    DOI 10.1159/000530432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Stripping Away Barriers to Find Relevant Skin Biomarkers for Pediatric Atopic Dermatitis.

    Castelo-Soccio, Leslie

    JAMA dermatology

    2019  Volume 155, Issue 12, Page(s) 1342–1343

    MeSH term(s) Biomarkers ; Causality ; Child ; Dermatitis, Atopic/diagnosis ; Eczema ; Humans ; Skin
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-10-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2019.2792
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Disorders in Children.

    George, Elisabeth A / Nwankwo, Christy / Castelo-Soccio, Leslie / Oboite, Michelle

    Dermatologic clinics

    2023  Volume 41, Issue 3, Page(s) 491–507

    Abstract: Pediatric dermatoses can present at birth or develop over time. When managing dermatology conditions in children, caregiver involvement is important. Patients may have lesions that need to be monitored or need assistance with therapeutic administration. ... ...

    Abstract Pediatric dermatoses can present at birth or develop over time. When managing dermatology conditions in children, caregiver involvement is important. Patients may have lesions that need to be monitored or need assistance with therapeutic administration. The following section provides a subset of pediatric dermatoses and notable points for presentation in skin of color patients. Providers need to be able to recognize dermatology conditions in patients of varying skin tones and provide therapies that address the condition and any associated pigmentary alterations.
    MeSH term(s) Infant, Newborn ; Humans ; Child ; Hyperpigmentation ; Skin/pathology ; Skin Pigmentation
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 82798-8
    ISSN 1558-0520 ; 0733-8635
    ISSN (online) 1558-0520
    ISSN 0733-8635
    DOI 10.1016/j.det.2023.02.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Modern Interventions for Pediatric Atopic Dermatitis: An Updated Pharmacologic Approach.

    Kondratuk, Katherine / Netravali, Ilka Arun / Castelo-Soccio, Leslie

    Dermatology and therapy

    2022  Volume 13, Issue 2, Page(s) 367–389

    Abstract: Pediatric atopic dermatitis (AD) has historically challenged dermatologists given the variable response of patients to treatment and limited available therapeutic options, often with significant potential side effects. Over the last decade, targeted ... ...

    Abstract Pediatric atopic dermatitis (AD) has historically challenged dermatologists given the variable response of patients to treatment and limited available therapeutic options, often with significant potential side effects. Over the last decade, targeted treatments including dupilumab and Janus kinase (JAK) inhibitors have emerged as significant treatment advances. An updated therapeutic approach for incorporating these new practice-changing medications can help clinicians manage these challenging patients. In this review, we discuss emerging topical and systemic (oral and injectable) treatments in pediatric AD, including topical PDE4 inhibitors and tapinarof, oral JAK inhibitors, and injected biologics including IL-4Rα inhibitor dupilumab, IL-13 inhibitor tralokinumab, IL-13Rα inhibitor lebrikizumab, IL-31Rα inhibitor nemolizumab, and IL-5Rα inhibitor benralizumab. We also review experimental agents in early clinical trials, such as targeted microbiome transplant lotions/antimicrobials, which may gain relevance in AD treatment. Finally, we propose a therapeutic approach for pediatric AD that incorporates newer therapies including dupilumab and JAK inhibitors, recognizing that these agents may not be universally available or approved. Further trials that include pediatric patients, especially head-to-head studies among therapeutic classes, are needed to clarify the role of emerging treatments.
    Language English
    Publishing date 2022-12-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2680284-3
    ISSN 2190-9172 ; 2193-8210
    ISSN (online) 2190-9172
    ISSN 2193-8210
    DOI 10.1007/s13555-022-00868-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Trichotillomania in Children and the Different Approaches between Dermatological and Behavioral Health Professionals at an Urban Tertiary Care Center.

    Rangu, Sneha / Castelo-Soccio, Leslie

    Skin appendage disorders

    2020  Volume 7, Issue 1, Page(s) 1–7

    Abstract: Background: Trichotillomania (TTM) is a complex disease with varying clinical characteristics, and psychosocial impairment is noted in many TTM patients. Despite its prevalence in childhood, there is limited research on pediatric TTM.: Objective: To ... ...

    Abstract Background: Trichotillomania (TTM) is a complex disease with varying clinical characteristics, and psychosocial impairment is noted in many TTM patients. Despite its prevalence in childhood, there is limited research on pediatric TTM.
    Objective: To analyze the clinical and epidemiologic features of TTM in children evaluated by dermatologists and behavioral health specialists.
    Method: We performed a retrospective chart review of 137 pediatric patients seen at the Children's Hospital of Philadelphia with initial presentation of TTM at age 17 or younger. Patients were treated by dermatology or behavioral health.
    Results: The majority of the patients were females, with an average diagnosis age around 8 years. Over half had a psychiatric comorbidity, and over a quarter had a skin disorder. Skin disorders were more commonly present in those evaluated by dermatology, and psychiatric comorbidities were more commonly present in those evaluated by behavioral health. The most common form of treatment was behavioral therapy, with medications prescribed more often by dermatologists.
    Conclusions: TTM patients choose to present to behavioral health or dermatology; however, there are distinctive differences between the two cohorts. With behavioral and pharmacologic treatment options, a relationship between dermatologists and behavioral health specialists is necessary for multifactorial management of TTM.
    Language English
    Publishing date 2020-10-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2806972-9
    ISSN 2296-9160 ; 2296-9195
    ISSN (online) 2296-9160
    ISSN 2296-9195
    DOI 10.1159/000510524
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  8. Article ; Online: Alopecia areata flare patterns in children and young adults while on systemic tofacitinib.

    McKenzie, Paige L / Castelo-Soccio, Leslie

    Journal of the American Academy of Dermatology

    2021  Volume 86, Issue 3, Page(s) 683–685

    MeSH term(s) Alopecia ; Alopecia Areata/chemically induced ; Alopecia Areata/drug therapy ; Child ; Humans ; Piperidines/adverse effects ; Pyrimidines/adverse effects ; Pyrroles/adverse effects ; Young Adult
    Chemical Substances Piperidines ; Pyrimidines ; Pyrroles ; tofacitinib (87LA6FU830)
    Language English
    Publishing date 2021-03-02
    Publishing country United States
    Document type Letter
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2021.02.071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Dupilumab therapy for alopecia areata in pediatric patients with concomitant atopic dermatitis.

    McKenzie, Paige L / Castelo-Soccio, Leslie

    Journal of the American Academy of Dermatology

    2021  Volume 84, Issue 6, Page(s) 1691–1694

    MeSH term(s) Adolescent ; Alopecia Areata/complications ; Alopecia Areata/drug therapy ; Alopecia Areata/immunology ; Antibodies, Monoclonal, Humanized/administration & dosage ; Child ; Dermatitis, Atopic/complications ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/immunology ; Female ; Follow-Up Studies ; Humans ; Injections, Subcutaneous ; Male ; Treatment Outcome ; Young Adult
    Chemical Substances Antibodies, Monoclonal, Humanized ; dupilumab (420K487FSG)
    Language English
    Publishing date 2021-01-20
    Publishing country United States
    Document type Letter
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2021.01.046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Severe recalcitrant hidradenitis suppurativa in a 2-year-old boy with partial trisomy 13.

    Keyes, Emily / Larijani, Mary / Castelo-Soccio, Leslie / Treat, James R

    Pediatric dermatology

    2022  Volume 39, Issue 3, Page(s) 491–493

    Abstract: We report the case of a 2-year-old boy with mosaic trisomy 13 and immunodeficiency who developed severe hidradenitis suppurativa beginning at the age of 18 months. Unresponsive to standard therapies, he exhibited a partial response to immunoglobulin ... ...

    Abstract We report the case of a 2-year-old boy with mosaic trisomy 13 and immunodeficiency who developed severe hidradenitis suppurativa beginning at the age of 18 months. Unresponsive to standard therapies, he exhibited a partial response to immunoglobulin replacement therapy.
    MeSH term(s) Child, Preschool ; Chromosomes, Human, Pair 13 ; Hidradenitis Suppurativa/complications ; Hidradenitis Suppurativa/diagnosis ; Hidradenitis Suppurativa/genetics ; Hidradenitis Suppurativa/therapy ; Humans ; Immunoglobulins/administration & dosage ; Immunologic Deficiency Syndromes/genetics ; Immunologic Deficiency Syndromes/therapy ; Male ; Trisomy ; Trisomy 13 Syndrome/complications ; Trisomy 13 Syndrome/diagnosis
    Chemical Substances Immunoglobulins
    Language English
    Publishing date 2022-03-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 605539-4
    ISSN 1525-1470 ; 0736-8046
    ISSN (online) 1525-1470
    ISSN 0736-8046
    DOI 10.1111/pde.14949
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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