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  1. Article: Assessing the association between dipeptidyl peptidase-4 inhibitors use and celiac disease through drug adverse event reporting.

    Li, Dandan / Silvester, Jocelyn Anne / Crowley, Matthew J / Yang, Jeff Y / Alexopoulos, Anastasia-Stefania / Xu, Yang / Zhan, Siyan / Wang, Tiansheng

    Therapeutic advances in chronic disease

    2020  Volume 11, Page(s) 2040622320904301

    Language English
    Publishing date 2020-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2554816-5
    ISSN 2040-6231 ; 2040-6223
    ISSN (online) 2040-6231
    ISSN 2040-6223
    DOI 10.1177/2040622320904301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Coeliac disease and a gluten-free diet.

    Silvester, Jocelyn Anne / Rashid, Mohsin

    BMJ (Clinical research ed.)

    2009  Volume 338, Page(s) b380

    MeSH term(s) Adult ; Celiac Disease/diagnosis ; Celiac Disease/diet therapy ; Celiac Disease/psychology ; Child ; Diet, Gluten-Free ; Female ; Humans
    Language English
    Publishing date 2009-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.b380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.10: Show issues Location:
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  3. Article ; Online: Long-term management of patients with celiac disease: current practices of gastroenterologists in Canada.

    Silvester, Jocelyn Anne / Rashid, Mohsin

    Canadian journal of gastroenterology = Journal canadien de gastroenterologie

    2010  Volume 24, Issue 8, Page(s) 499–509

    Abstract: Background: Long-term follow-up of patients with celiac disease is important for monitoring their clinical status, dietary compliance and complications.: Aim: To examine the current practices of Canadian gastroenterologists providing long-term care ... ...

    Abstract Background: Long-term follow-up of patients with celiac disease is important for monitoring their clinical status, dietary compliance and complications.
    Aim: To examine the current practices of Canadian gastroenterologists providing long-term care to patients with celiac disease.
    Methods: All gastroenterologists in Canada (n=585) were surveyed regarding their practice demographics, familiarity with celiac disease practice guidelines, and follow-up clinical examination and investigations.
    Results: Of the 585 surveys mailed to gastroenterologists, 567 were expected to be returned. A total of 242 completed surveys (43%) were received. Of these, 237 (184 adult, 51 pediatric and two mixed) had an active practice that included patients with celiac disease. Long-term follow-up care was provided routinely by 76% of respondents. Follow-up consisted of annual clinic visits (67%), dietary review (77%), reinforcement of the need for adherence to a gluten-free diet (90%) and recommending membership in an advocacy group (65%). Physical examination was performed by 78%; most ordered laboratory tests including serology (65%).Adult gastroenterologists performed routine follow-up intestinal biopsy more often than their pediatric counterparts (46% versus 10%), but performed serology less frequently (48% versus 86%). Pediatric patients were more likely to be followed by a multidisciplinary team. All pediatric gastroenterologists were familiar with at least one celiac disease practice guideline, whereas 15% of adult gastroenterologists were not familiar with any practice guideline. The majority of gastroenterologists who did not routinely provide follow-up expected care to be provided by the patient's primary physician (86%).
    Conclusions: Most gastroenterologists in Canada who responded to the survey provided long-term follow-up care to patients with celiac disease. The diverse practices reported underscore the need to develop consensus-based guidelines for long-term care of these patients.
    MeSH term(s) Adult ; Canada ; Celiac Disease/diet therapy ; Celiac Disease/pathology ; Celiac Disease/therapy ; Child ; Continuity of Patient Care ; Diet, Gluten-Free ; Disease Management ; Female ; Humans ; Intestines/pathology ; Male ; Practice Guidelines as Topic ; Practice Patterns, Physicians'
    Language English
    Publishing date 2010-08-10
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639439-5
    ISSN 1916-7237 ; 0835-7900
    ISSN (online) 1916-7237
    ISSN 0835-7900
    DOI 10.1155/2010/140289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2360: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Prospective longitudinal study: use of faecal gluten immunogenic peptides to monitor children diagnosed with coeliac disease during transition to a gluten-free diet.

    Comino, Isabel / Segura, Verónica / Ortigosa, Luis / Espín, Beatríz / Castillejo, Gemma / Garrote, José Antonio / Sierra, Carlos / Millán, Antonio / Ribes-Koninckx, Carmen / Román, Enriqueta / Rodríguez-Herrera, Alfonso / Díaz, Jacobo / Silvester, Jocelyn Anne / Cebolla, Ángel / Sousa, Carolina

    Alimentary pharmacology & therapeutics

    2019  Volume 49, Issue 12, Page(s) 1484–1492

    Abstract: Background: Treatment for coeliac disease is a lifelong strict gluten-free diet. Although guidelines recommend regular follow-up with dietary interviews and coeliac serology, these methods may be inaccurate.: Aim: To evaluate the usefulness of faecal ...

    Abstract Background: Treatment for coeliac disease is a lifelong strict gluten-free diet. Although guidelines recommend regular follow-up with dietary interviews and coeliac serology, these methods may be inaccurate.
    Aim: To evaluate the usefulness of faecal gluten immunogenic peptides to support the diagnosis and to determine the adherence to the gluten-free diet in coeliac children.
    Methods: Multicentre prospective observational study including 64 coeliac children. Faecal gluten peptides, and tissue transglutaminase and deamidated gliadin peptide antibodies were analyzed at diagnosis, and 6, 12 and 24 months thereafter. Gluten consumption was estimated from gluten peptide levels.
    Results: Most children (97%) had detectable gluten peptides at diagnosis. On a gluten-free diet, the rate of gluten peptides increased from 13% at 6 months to 25% at 24 months. Mean estimated gluten exposure dropped from 5543 mg/d at diagnosis to 144 mg/d at 6 months, then increased to 606 mg/d by 24 months. In contrast, deamidated gliadin peptide antibodies normalised and only 20% had elevated tissue transglutaminase antibody by 24 months. The elevation of tissue transglutaminase antibody was more prolonged in patients with detectable gluten peptides (P < 0.05). Nevertheless, absolute levels of tissue transglutaminase antibody had low sensitivity to identify patients with detectable gluten peptides (P > 0.1). Dietitian assessment was only moderately correlated with gluten peptide detection (κ = 0.5).
    Conclusions: Faecal gluten peptides testing may guide treatment of coeliac disease prior to diagnosis and during the assessment diet adherence. Further studies could determine if early identification of gluten exposure reduces the need for expensive/invasive investigations for non-responsive coeliac disease. ClinicalTrials.gov Number: NCT02711397.
    MeSH term(s) Adolescent ; Antibodies/blood ; Celiac Disease/diet therapy ; Celiac Disease/metabolism ; Child ; Child, Preschool ; Diet, Gluten-Free ; Feces/chemistry ; Female ; Glutens/chemistry ; Humans ; Infant ; Male ; Peptides/analysis ; Peptides/immunology ; Transglutaminases/immunology
    Chemical Substances Antibodies ; Peptides ; Glutens (8002-80-0) ; Transglutaminases (EC 2.3.2.13)
    Language English
    Publishing date 2019-05-10
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.15277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2206: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Clinical classification and long-term outcomes of seronegative coeliac disease: a 20-year multicentre follow-up study.

    Schiepatti, Annalisa / Rej, Anupam / Maimaris, Stiliano / Cross, Simon S / Porta, Petra / Aziz, Imran / Key, Tim / Goodwin, John / Therrien, Amelie / Yoosuf, Shakira / Leffler, Daniel A / Silvester, Jocelyn A / Klersy, Catherine / Biagi, Federico / Sanders, David S

    Alimentary pharmacology & therapeutics

    2021  Volume 54, Issue 10, Page(s) 1278–1289

    Abstract: Background: Seronegative coeliac disease is poorly defined.: Aims: To study clinical phenotypes and long-term outcomes of seronegative coeliac disease in a multicentre cohort over 20 years.: Methods: Seronegative coeliac disease was diagnosed in ... ...

    Abstract Background: Seronegative coeliac disease is poorly defined.
    Aims: To study clinical phenotypes and long-term outcomes of seronegative coeliac disease in a multicentre cohort over 20 years.
    Methods: Seronegative coeliac disease was diagnosed in HLA-DQ2/DQ8-positive patients with villous atrophy (VA), negative IgA endomysial (EmA), tissue transglutaminase (tTG) and deamidated-gliadin antibodies (DGP), clinical and histological response to a gluten-free diet (GFD), and no alternative causes for VA. In patients with IgA deficiency, coeliac disease was diagnosed through VA, positive IgG EmA/tTG/DGP and clinical/histological response to a GFD (coeliac disease+IgAd). Patients with seropositive coeliac disease served as controls.
    Results: Of 227 patients previously diagnosed with seronegative coeliac disease, true seronegative coeliac disease was confirmed in 84, coeliac disease+IgAd in 48, and excluded in 55. Lack of follow-up duodenal biopsy precluded diagnosing seronegative coeliac disease in 40 patients. 2084 patients with seropositive coeliac disease served as controls. True seronegative coeliac disease had more severe symptoms at diagnosis and a higher risk of complications (HR 10.87, 95% CI 6.11-19.33, P < 0.001) and mortality (HR 2.18, 95% CI 1.12-4.26, P < 0.01) than seropositive coeliac disease. There were no differences between true seronegative coeliac disease and coeliac disease+IgAd. On multivariate analysis, age at diagnosis, lack of clinical response to a GFD, true seronegative coeliac disease, coeliac disease+IgAd, and classical presentation predicted complications. Age at diagnosis, complications and absence of clinical response to a GFD predicted mortality.
    Conclusions: Seronegative coeliac disease has a more aggressive disease phenotype than seropositive coeliac disease. These data argue against over-reliance on serology for the diagnosis of coeliac disease and support a strict clinical and histologic follow-up in seronegative coeliac disease.
    MeSH term(s) Autoantibodies ; Biopsy ; Celiac Disease/diagnosis ; Diet, Gluten-Free ; Follow-Up Studies ; Gliadin ; Humans ; Immunoglobulin A ; Transglutaminases
    Chemical Substances Autoantibodies ; Immunoglobulin A ; Gliadin (9007-90-3) ; Transglutaminases (EC 2.3.2.13)
    Language English
    Publishing date 2021-09-08
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.16599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2206: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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