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  1. Article: A controlled trial of ondansetron in the pruritus of cholestasis.

    O'Donohue, J W / Pereira, S P / Ashdown, A C / Haigh, C G / Wilkinson, J R / Williams, R

    Alimentary pharmacology & therapeutics

    2005  Volume 21, Issue 8, Page(s) 1041–1045

    Abstract: Background: In patients with pruritus of cholestasis, response to conventional drug treatment may be unsatisfactory. Activation of 5-hydroxytryptamine receptors on dermal sensory nerve-endings plays a role in the perception of pruritus. The 5- ... ...

    Abstract Background: In patients with pruritus of cholestasis, response to conventional drug treatment may be unsatisfactory. Activation of 5-hydroxytryptamine receptors on dermal sensory nerve-endings plays a role in the perception of pruritus. The 5-hydroxytryptamine(3) receptor antagonist, ondansetron, has been used in the treatment of pruritus of cholestasis, but there are few controlled data.
    Aim: To determine whether ondansetron is effective in treating the pruritus of cholestasis.
    Methods: A total of 19 patients with resistant pruritus were randomized, double blind, to receive either ondansetron 8 mg or placebo as a single intravenous bolus, followed by oral ondansetron 8 mg or placebo twice daily for 5 days. Patients' perception of pruritus was recorded hourly using a visual analogue scale, and scratching activity measured by means of a piezo-electric crystal attached to the fingernail.
    Results: Mean pruritus score using visual analogue scale and scratching activity were reduced on the first treatment day compared with baseline in both the ondansetron and placebo groups (P < 0.05), but there were no significant differences in mean pruritus perception or scratching activity between the two groups.
    Conclusion: Ondansetron was of no benefit in this group of pruritic patients during short-term treatment.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Antipruritics/adverse effects ; Antipruritics/therapeutic use ; Cholestasis/complications ; Female ; Humans ; Liver Cirrhosis, Biliary/complications ; Male ; Middle Aged ; Ondansetron/adverse effects ; Ondansetron/therapeutic use ; Pruritus/drug therapy ; Pruritus/etiology ; Treatment Outcome
    Chemical Substances Antipruritics ; Ondansetron (4AF302ESOS)
    Language English
    Publishing date 2005-04-15
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/j.1365-2036.2005.02430.x
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  2. Article ; Online: Infectious viral shedding of SARS-CoV-2 Delta following vaccination: A longitudinal cohort study.

    Garcia-Knight, Miguel / Anglin, Khamal / Tassetto, Michel / Lu, Scott / Zhang, Amethyst / Goldberg, Sarah A / Catching, Adam / Davidson, Michelle C / Shak, Joshua R / Romero, Mariela / Pineda-Ramirez, Jesus / Diaz-Sanchez, Ruth / Rugart, Paulina / Donohue, Kevin / Massachi, Jonathan / Sans, Hannah M / Djomaleu, Manuella / Mathur, Sujata / Servellita, Venice /
    McIlwain, David / Gaudiliere, Brice / Chen, Jessica / Martinez, Enrique O / Tavs, Jacqueline M / Bronstone, Grace / Weiss, Jacob / Watson, John T / Briggs-Hagen, Melissa / Abedi, Glen R / Rutherford, George W / Deeks, Steven G / Chiu, Charles / Saydah, Sharon / Peluso, Michael J / Midgley, Claire M / Martin, Jeffrey N / Andino, Raul / Kelly, J Daniel

    PLoS pathogens

    2022  Volume 18, Issue 9, Page(s) e1010802

    Abstract: The impact of vaccination on SARS-CoV-2 infectiousness is not well understood. We compared longitudinal viral shedding dynamics in unvaccinated and fully vaccinated adults. SARS-CoV-2-infected adults were enrolled within 5 days of symptom onset and nasal ...

    Abstract The impact of vaccination on SARS-CoV-2 infectiousness is not well understood. We compared longitudinal viral shedding dynamics in unvaccinated and fully vaccinated adults. SARS-CoV-2-infected adults were enrolled within 5 days of symptom onset and nasal specimens were self-collected daily for two weeks and intermittently for an additional two weeks. SARS-CoV-2 RNA load and infectious virus were analyzed relative to symptom onset stratified by vaccination status. We tested 1080 nasal specimens from 52 unvaccinated adults enrolled in the pre-Delta period and 32 fully vaccinated adults with predominantly Delta infections. While we observed no differences by vaccination status in maximum RNA levels, maximum infectious titers and the median duration of viral RNA shedding, the rate of decay from the maximum RNA load was faster among vaccinated; maximum infectious titers and maximum RNA levels were highly correlated. Furthermore, amongst participants with infectious virus, median duration of infectious virus detection was reduced from 7.5 days (IQR: 6.0-9.0) in unvaccinated participants to 6 days (IQR: 5.0-8.0) in those vaccinated (P = 0.02). Accordingly, the odds of shedding infectious virus from days 6 to 12 post-onset were lower among vaccinated participants than unvaccinated participants (OR 0.42 95% CI 0.19-0.89). These results indicate that vaccination had reduced the probability of shedding infectious virus after 5 days from symptom onset.
    MeSH term(s) Adult ; COVID-19/prevention & control ; Humans ; Longitudinal Studies ; RNA, Viral/genetics ; SARS-CoV-2 ; Vaccination ; Virus Shedding
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2022-09-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1010802
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  3. Article: Histological evaluation of the dopaminergic regulation of proopiomelanocortin gene expression in the intermediate lobe of the rat pituitary, involving in situ hybridization and [3H]thymidine uptake measurement.

    Chronwall, B M / Millington, W R / Griffin, W S / Unnerstall, J R / O'Donohue, T L

    Endocrinology

    1987  Volume 120, Issue 3, Page(s) 1201–1211

    Abstract: The melanotroph, a polyhedral secretory cell with an ovoid smooth nucleus, is the primary cell type of the intermediate lobe (IL) of the rat pituitary. The melanotrophs are not uniform, but differ in the tinctorial properties of their cytoplasm; some ... ...

    Abstract The melanotroph, a polyhedral secretory cell with an ovoid smooth nucleus, is the primary cell type of the intermediate lobe (IL) of the rat pituitary. The melanotrophs are not uniform, but differ in the tinctorial properties of their cytoplasm; some cells appear distinctly darker, others lighter, and cells staining in intermediate shades are also found. In addition, in situ hybridization using proopiomelanocortin (POMC) probes shows an uneven distribution of POMC mRNA among melanotrophs, indicating that different cells maintain different levels of biosynthetic activity. Dopaminergic drugs known to alter the secretion of POMC-related peptides from the IL produced parallel changes in histological staining properties and the amount of POMC mRNA per cell, as determined by in situ hybridization. Acute bromocriptine treatment (6 h) produced a dramatic reduction in grain counts over melanotroph cytoplasm (to 10% of the control levels). A similar reduction persisted after chronic treatment. Six hours after a single haloperidol injection, the grain counts were 180% of control levels. After chronic haloperidol treatment, they were further elevated to 300% of control levels. Chronic bromocriptine and haloperidol treatment also changed the thickness of the IL. Bromocriptine reduced and haloperidol treatment increased the number of cell layers in the IL by changing the rate of cell proliferation. Thus, haloperidol treatment significantly increased and bromocriptine treatment significantly decreased the number of melanotrophs labeled by [3H]thymidine. The mitotic index followed the same trend. These results suggest that dopamine regulation of the IL acts by two different mechanisms: POMC gene expression and cellular proliferation. The change in POMC gene expression is the cell's first rapid response. The influence on the cell cycle appears after subchronic and chronic treatment.
    MeSH term(s) Animals ; Autoradiography ; Biological Transport ; Bromocriptine/pharmacology ; Cell Division ; Genes ; Haloperidol/pharmacology ; Male ; Nucleic Acid Hybridization ; Pituitary Gland/cytology ; Pituitary Gland/drug effects ; Pituitary Gland/metabolism ; Pro-Opiomelanocortin/genetics ; Rats ; Rats, Inbred Strains ; Thymidine/metabolism ; Transcription, Genetic ; Tritium
    Chemical Substances Tritium (10028-17-8) ; Bromocriptine (3A64E3G5ZO) ; Pro-Opiomelanocortin (66796-54-1) ; Haloperidol (J6292F8L3D) ; Thymidine (VC2W18DGKR)
    Language English
    Publishing date 1987-03
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endo-120-3-1201
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  4. Article ; Online: High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers.

    Ohri, Rachana / Bhakta, Sunil / Fourie-O'Donohue, Aimee / Dela Cruz-Chuh, Josefa / Tsai, Siao Ping / Cook, Ryan / Wei, Binqing / Ng, Carl / Wong, Athena W / Bos, Aaron B / Farahi, Farzam / Bhakta, Jiten / Pillow, Thomas H / Raab, Helga / Vandlen, Richard / Polakis, Paul / Liu, Yichin / Erickson, Hans / Junutula, Jagath R /
    Kozak, Katherine R

    Bioconjugate chemistry

    2018  Volume 29, Issue 2, Page(s) 473–485

    Abstract: THIOMAB antibody technology utilizes cysteine residues engineered onto an antibody to allow for site-specific conjugation. The technology has enabled the exploration of different attachment sites on the antibody in combination with small molecules, ... ...

    Abstract THIOMAB antibody technology utilizes cysteine residues engineered onto an antibody to allow for site-specific conjugation. The technology has enabled the exploration of different attachment sites on the antibody in combination with small molecules, peptides, or proteins to yield antibody conjugates with unique properties. As reported previously ( Shen , B. Q. , et al. ( 2012 ) Nat. Biotechnol. 30 , 184 - 189

    Pillow , T. H. , et al. ( 2017 ) Chem. Sci. 8 , 366 - 370 ), the specific location of the site of conjugation on an antibody can impact the stability of the linkage to the engineered cysteine for both thio-succinimide and disulfide bonds. High stability of the linkage is usually desired to maximize the delivery of the cargo to the intended target. In the current study, cysteines were individually substituted into every position of the anti-HER2 antibody (trastuzumab), and the stabilities of drug conjugations at those sites were evaluated. We screened a total of 648 THIOMAB antibody-drug conjugates, each generated from a trastuzamab prepared by sequentially mutating non-cysteine amino acids in the light and heavy chains to cysteine. Each THIOMAB antibody variant was conjugated to either maleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl-monomethyl auristatin E (MC-vc-PAB-MMAE) or pyridyl disulfide monomethyl auristatin E (PDS-MMAE) using a high-throughput, on-bead conjugation and purification method. Greater than 50% of the THIOMAB antibody variants were successfully conjugated to both MMAE derivatives with a drug to antibody ratio (DAR) of >0.5 and <50% aggregation. The relative in vitro plasma stabilities for approximately 750 conjugates were assessed using enzyme-linked immunosorbent assays, and stable sites were confirmed with affinity-capture LC/MS-based detection methods. Highly stable conjugation sites for the two types of MMAE derivatives were identified on both the heavy and light chains. Although the stabilities of maleimide conjugates were shown to be greater than those of the disulfide conjugates, many sites were identified that were stable for both. Furthermore, in vitro stabilities of selected stable sites translated across different cytotoxic payloads and different target antibodies as well as to in vivo stability.
    MeSH term(s) Animals ; Antineoplastic Agents, Immunological/blood ; Antineoplastic Agents, Immunological/chemistry ; Cysteine/blood ; Cysteine/chemistry ; Cysteine/genetics ; Disulfides/blood ; Disulfides/chemistry ; Drug Stability ; High-Throughput Screening Assays ; Humans ; Immunoconjugates/blood ; Immunoconjugates/chemistry ; Maleimides/blood ; Maleimides/chemistry ; Models, Molecular ; Mutagenesis, Site-Directed ; Oligopeptides/blood ; Oligopeptides/chemistry ; Protein Aggregates ; Protein Stability ; Rats ; Trastuzumab/blood ; Trastuzumab/chemistry ; Trastuzumab/genetics
    Chemical Substances Antineoplastic Agents, Immunological ; Disulfides ; Immunoconjugates ; Maleimides ; Oligopeptides ; Protein Aggregates ; maleimide (2519R1UGP8) ; Cysteine (K848JZ4886) ; Trastuzumab (P188ANX8CK) ; monomethyl auristatin E (V7I58RC5EJ)
    Language English
    Publishing date 2018-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1024041-x
    ISSN 1520-4812 ; 1043-1802
    ISSN (online) 1520-4812
    ISSN 1043-1802
    DOI 10.1021/acs.bioconjchem.7b00791
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    Zs.A 3400: Show issues Location:
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  5. Article: Presence and distribution of immunoreactive and bioactive FMRFamide-like peptides in the nervous system of the horseshoe crab, Limulus polyphemus.

    Watson, W H / Groome, J R / Chronwall, B M / Bishop, J / O'Donohue, T L

    Peptides

    1984  Volume 5, Issue 3, Page(s) 585–592

    Abstract: FMRFamide immunoreactivity was detected in all regions of the Limulus nervous system, including the brain (6.5 +/- 0.6 pg FMRFamide/mg), cardiac ganglion (2.06 +/- 0.67 pg FMRFamide/mg), and ventral nerve cord (5.8 +/- 0.7 pg FMRFamide/mg). The ... ...

    Abstract FMRFamide immunoreactivity was detected in all regions of the Limulus nervous system, including the brain (6.5 +/- 0.6 pg FMRFamide/mg), cardiac ganglion (2.06 +/- 0.67 pg FMRFamide/mg), and ventral nerve cord (5.8 +/- 0.7 pg FMRFamide/mg). The distribution of immunoreactive FMRFamide (irFMRFamide) was mapped by immunofluorescence and the distribution corresponded to regional RIA data. A good proportion of the CNS and cardiac ganglion neuropile contained irFMRFamide, and fluorescent cell bodies were observed in several areas. High performance liquid chromatography (HPLC) was employed to separate and characterize the FMRFamide-like peptides from extracts of Limulus brains. HPLC fractions were analyzed using coincidental radioimmunoassay and bioassay (the radula protractor muscle of Busycon contrarium). There appear to be at least three FMRFamide-like peptides in the Limulus brain, including one similar to clam FMRFamide. FMRFamide acts on Limulus heart in a biphasic manner at relatively high concentrations (10(-5)M), but has no effect on the activity of the isolated ventral nerve cord. These data suggest that in Limulus FMRFamide-like peptides are acting as neurotransmitters, or neuromodulators.
    MeSH term(s) Animals ; Biological Assay ; Chromatography, High Pressure Liquid/methods ; FMRFamide ; Horseshoe Crabs/analysis ; Nervous System/analysis ; Oligopeptides/analysis ; Oligopeptides/pharmacology ; Radioimmunoassay/methods ; Tissue Distribution
    Chemical Substances Oligopeptides ; FMRFamide (64190-70-1)
    Language English
    Publishing date 1984-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/0196-9781(84)90089-5
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  6. Article: Acute adult respiratory distress syndrome associated with gonococcal septicemia.

    Markham, J D / Vilseck, J R / O'Donohue, W J

    Chest

    1976  Volume 70, Issue 5, Page(s) 667–670

    Abstract: A case of gonococcal septicemia with monoarticular arthritis and adult respiratory distress syndrome is presented. Prompt treatment of the infection and early treatment for the adult respiratory distress syndrome prior to the full development of the ... ...

    Abstract A case of gonococcal septicemia with monoarticular arthritis and adult respiratory distress syndrome is presented. Prompt treatment of the infection and early treatment for the adult respiratory distress syndrome prior to the full development of the syndrome appeared to ameliorate the course of illness to the extent that intubation and mechanical ventilation were not required. The patient was successfully traeted in a community hospital with a relatively short course of therapy and full recovery.
    MeSH term(s) Acute Disease ; Adult ; Anti-Bacterial Agents/therapeutic use ; Arthritis, Infectious/complications ; Blood Gas Analysis ; Female ; Gonorrhea/complications ; Humans ; Intermittent Positive-Pressure Breathing ; Knee Joint ; Neisseria gonorrhoeae/isolation & purification ; Oxygen/therapeutic use ; Radiography, Thoracic ; Respiratory Distress Syndrome, Adult/complications ; Respiratory Distress Syndrome, Adult/therapy ; Sepsis/complications
    Chemical Substances Anti-Bacterial Agents ; Oxygen (S88TT14065)
    Language English
    Publishing date 1976-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1378/chest.70.5.667
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  7. Article ; Online: Infectious viral shedding of SARS-CoV-2 Delta following vaccination: a longitudinal cohort study

    Garcia-Knight, Miguel A / Anglin, Khamal / Tassetto, Michel / Lu, Scott / Zhang, Amethyst / Goldberg, Sarah A / Catching, Adam / Davidson, Michelle C / Shak, Joshua R / Romero, Mariela / Pineda-Ramirez, Jesus / Diaz-Sanchez, Ruth / Rugart, Paulina / Donohue, Kevin / Massachi, Jonathan / Sans, Hannah M / Djomaleu, Manuella / Mathur, Sujata / Servellita, Venice /
    McIlwain, David / Gaudiliere, Brice / Chen, Jessica / Martinez, Enrique O / Tavs, Jacqueline M / Bronstone, Grace / Weiss, Jacob / Watson, John T / Briggs-Hagen, Melissa / Abedi, Glen R / Rutherford, George W / Deeks, Steven G / Chiu, Charles / Saydah, Sharon / Peluso, Michael J / Midgley, Claire M / Martin, Jeffrey N / Andino, Raul / Kelly, J Daniel

    medRxiv

    Abstract: The impact of vaccination on SARS-CoV-2 infectiousness is not well understood. We compared longitudinal viral shedding dynamics in unvaccinated and fully vaccinated adults. SARS-CoV-2-infected adults were enrolled within 5 days of symptom onset and nasal ...

    Abstract The impact of vaccination on SARS-CoV-2 infectiousness is not well understood. We compared longitudinal viral shedding dynamics in unvaccinated and fully vaccinated adults. SARS-CoV-2-infected adults were enrolled within 5 days of symptom onset and nasal specimens were self-collected daily for two weeks and intermittently for an additional two weeks. SARS-CoV-2 RNA load and infectious virus were analyzed relative to symptom onset stratified by vaccination status. We tested 1080 nasal specimens from 52 unvaccinated adults enrolled in the pre-Delta period and 32 fully vaccinated adults with predominantly Delta infections. While we observed no differences by vaccination status in maximum RNA levels, maximum infectious titers and the median duration of viral RNA shedding, the rate of decay from the maximum RNA load was faster among vaccinated; maximum infectious titers and maximum RNA levels were highly correlated. Furthermore, amongst participants with infectious virus, median duration of infectious virus detection was reduced from 7.5 days (IQR: 6.0-9.0) in unvaccinated participants to 6 days (IQR: 5.0-8.0) in those vaccinated (P=0.02). Accordingly, the odds of shedding infectious virus from days 6 to 12 post-onset were lower among vaccinated participants than unvaccinated participants (OR 0.42 95% CI 0.19-0.89). These results indicate that vaccination had reduced the probability of shedding infectious virus after 5 days from symptom onset.
    Keywords covid19
    Language English
    Publishing date 2022-05-19
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.05.15.22275051
    Database COVID19

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  8. Article: Mechanical ventilation beyond the intensive care unit. Report of a consensus conference of the American College of Chest Physicians.

    Make, B J / Hill, N S / Goldberg, A I / Bach, J R / Criner, G J / Dunne, P E / Gilmartin, M E / Heffner, J E / Kacmarek, R / Keens, T G / McInturff, S / O'Donohue, W J / Oppenheimer, E A / Robert, D

    Chest

    1998  Volume 113, Issue 5 Suppl, Page(s) 289S–344S

    MeSH term(s) Adolescent ; Adult ; Advance Directives ; Bone Diseases/complications ; Cardiovascular Diseases/complications ; Child ; Chronic Disease ; Equipment Design ; Health Care Costs ; Health Facilities/standards ; Humans ; Infant ; Intensive Care Units/standards ; Neuromuscular Diseases/complications ; Outcome Assessment (Health Care) ; Patient Care Team/organization & administration ; Patient Discharge ; Respiration, Artificial/classification ; Respiration, Artificial/economics ; Respiration, Artificial/instrumentation ; Respiration, Artificial/standards ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy ; Respiratory Tract Diseases/complications ; Social Support ; United States
    Language English
    Publishing date 1998-05
    Publishing country United States
    Document type Consensus Development Conference ; Journal Article ; Review
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1378/chest.113.5_supplement.289s
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  9. Article ; Online: Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design.

    Horwitz, Leora I / Thaweethai, Tanayott / Brosnahan, Shari B / Cicek, Mine S / Fitzgerald, Megan L / Goldman, Jason D / Hess, Rachel / Hodder, S L / Jacoby, Vanessa L / Jordan, Michael R / Krishnan, Jerry A / Laiyemo, Adeyinka O / Metz, Torri D / Nichols, Lauren / Patzer, Rachel E / Sekar, Anisha / Singer, Nora G / Stiles, Lauren E / Taylor, Barbara S /
    Ahmed, Shifa / Algren, Heather A / Anglin, Khamal / Aponte-Soto, Lisa / Ashktorab, Hassan / Bassett, Ingrid V / Bedi, Brahmchetna / Bhadelia, Nahid / Bime, Christian / Bind, Marie-Abele C / Black, Lora J / Blomkalns, Andra L / Brim, Hassan / Castro, Mario / Chan, James / Charney, Alexander W / Chen, Benjamin K / Chen, Li Qing / Chen, Peter / Chestek, David / Chibnik, Lori B / Chow, Dominic C / Chu, Helen Y / Clifton, Rebecca G / Collins, Shelby / Costantine, Maged M / Cribbs, Sushma K / Deeks, Steven G / Dickinson, John D / Donohue, Sarah E / Durstenfeld, Matthew S / Emery, Ivette F / Erlandson, Kristine M / Facelli, Julio C / Farah-Abraham, Rachael / Finn, Aloke V / Fischer, Melinda S / Flaherman, Valerie J / Fleurimont, Judes / Fonseca, Vivian / Gallagher, Emily J / Gander, Jennifer C / Gennaro, Maria Laura / Gibson, Kelly S / Go, Minjoung / Goodman, Steven N / Granger, Joey P / Greenway, Frank L / Hafner, John W / Han, Jenny E / Harkins, Michelle S / Hauser, Kristine S P / Heath, James R / Hernandez, Carla R / Ho, On / Hoffman, Matthew K / Hoover, Susan E / Horowitz, Carol R / Hsu, Harvey / Hsue, Priscilla Y / Hughes, Brenna L / Jagannathan, Prasanna / James, Judith A / John, Janice / Jolley, Sarah / Judd, S E / Juskowich, Joy J / Kanjilal, Diane G / Karlson, Elizabeth W / Katz, Stuart D / Kelly, J Daniel / Kelly, Sara W / Kim, Arthur Y / Kirwan, John P / Knox, Kenneth S / Kumar, Andre / Lamendola-Essel, Michelle F / Lanca, Margaret / Lee-Lannotti, Joyce K / Lefebvre, R Craig / Levy, Bruce D / Lin, Janet Y / Logarbo, Brian P / Logue, Jennifer K / Longo, Michele T / Luciano, Carlos A / Lutrick, Karen / Malakooti, Shahdi K / Mallett, Gail / Maranga, Gabrielle / Marathe, Jai G / Marconi, Vincent C / Marshall, Gailen D / Martin, Christopher F / Martin, Jeffrey N / May, Heidi T / McComsey, Grace A / McDonald, Dylan / Mendez-Figueroa, Hector / Miele, Lucio / Mittleman, Murray A / Mohandas, Sindhu / Mouchati, Christian / Mullington, Janet M / Nadkarni, Girish N / Nahin, Erica R / Neuman, Robert B / Newman, Lisa T / Nguyen, Amber / Nikolich, Janko Z / Ofotokun, Igho / Ogbogu, Princess U / Palatnik, Anna / Palomares, Kristy T S / Parimon, Tanyalak / Parry, Samuel / Parthasarathy, Sairam / Patterson, Thomas F / Pearman, Ann / Peluso, Michael J / Pemu, Priscilla / Pettker, Christian M / Plunkett, Beth A / Pogreba-Brown, Kristen / Poppas, Athena / Porterfield, J Zachary / Quigley, John G / Quinn, Davin K / Raissy, Hengameh / Rebello, Candida J / Reddy, Uma M / Reece, Rebecca / Reeder, Harrison T / Rischard, Franz P / Rosas, Johana M / Rosen, Clifford J / Rouphael, Nadine G / Rouse, Dwight J / Ruff, Adam M / Saint Jean, Christina / Sandoval, Grecio J / Santana, Jorge L / Schlater, Shannon M / Sciurba, Frank C / Selvaggi, Caitlin / Seshadri, Sudha / Sesso, Howard D / Shah, Dimpy P / Shemesh, Eyal / Sherif, Zaki A / Shinnick, Daniel J / Simhan, Hyagriv N / Singh, Upinder / Sowles, Amber / Subbian, Vignesh / Sun, Jun / Suthar, Mehul S / Teunis, Larissa J / Thorp, John M / Ticotsky, Amberly / Tita, Alan T N / Tragus, Robin / Tuttle, Katherine R / Urdaneta, Alfredo E / Utz, P J / VanWagoner, Timothy M / Vasey, Andrew / Vernon, Suzanne D / Vidal, Crystal / Walker, Tiffany / Ward, Honorine D / Warren, David E / Weeks, Ryan M / Weiner, Steven J / Weyer, Jordan C / Wheeler, Jennifer L / Whiteheart, Sidney W / Wiley, Zanthia / Williams, Natasha J / Wisnivesky, Juan P / Wood, John C / Yee, Lynn M / Young, Natalie M / Zisis, Sokratis N / Foulkes, Andrea S

    PloS one

    2023  Volume 18, Issue 6, Page(s) e0286297

    Abstract: Importance: SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, prevalence, ... ...

    Abstract Importance: SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are ill-defined. The objectives of the Researching COVID to Enhance Recovery (RECOVER) Multi-site Observational Study of PASC in Adults (RECOVER-Adult) are to: (1) characterize PASC prevalence; (2) characterize the symptoms, organ dysfunction, natural history, and distinct phenotypes of PASC; (3) identify demographic, social and clinical risk factors for PASC onset and recovery; and (4) define the biological mechanisms underlying PASC pathogenesis.
    Methods: RECOVER-Adult is a combined prospective/retrospective cohort currently planned to enroll 14,880 adults aged ≥18 years. Eligible participants either must meet WHO criteria for suspected, probable, or confirmed infection; or must have evidence of no prior infection. Recruitment occurs at 86 sites in 33 U.S. states, Washington, DC and Puerto Rico, via facility- and community-based outreach. Participants complete quarterly questionnaires about symptoms, social determinants, vaccination status, and interim SARS-CoV-2 infections. In addition, participants contribute biospecimens and undergo physical and laboratory examinations at approximately 0, 90 and 180 days from infection or negative test date, and yearly thereafter. Some participants undergo additional testing based on specific criteria or random sampling. Patient representatives provide input on all study processes. The primary study outcome is onset of PASC, measured by signs and symptoms. A paradigm for identifying PASC cases will be defined and updated using supervised and unsupervised learning approaches with cross-validation. Logistic regression and proportional hazards regression will be conducted to investigate associations between risk factors, onset, and resolution of PASC symptoms.
    Discussion: RECOVER-Adult is the first national, prospective, longitudinal cohort of PASC among US adults. Results of this study are intended to inform public health, spur clinical trials, and expand treatment options.
    Registration: NCT05172024.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Observational Studies as Topic ; Post-Acute COVID-19 Syndrome ; Prospective Studies ; Retrospective Studies ; SARS-CoV-2 ; Adolescent ; Adult ; Multicenter Studies as Topic
    Language English
    Publishing date 2023-06-23
    Publishing country United States
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0286297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: 2018 American Society of Consultant Pharmacists Annual Meeting & Exhibition.

    Bridgeman, Mary / Prete, Donna / Rolston, Nicole / Abazia, Daniel / Sturgill, Marc / Finn, Laura / Summers, Deborah / Marvanova, Marketa / Henkel, Paul / Thompson, Jayson / Dewey, Mark / Friesner, Daniel / Alessi, Carolyn / Cuellar, Lourdes / Yamagishi, Lisa / O'Neil, Christine / Erickson, Olivia / Mazzei, Kelly / Kamal, Khalid /
    Early, Nicole / Bainter, Brian / Hanson, Laura / Schmitz, Emily / Loomis, Amanda / Norberto, Marissa / Hume, Anne / Meyer, Marsha / Batra, Romilla / Likar, Denise / Enguidanos, Susan / Liu, Catherine / Kotansky, Brian / Fisher, Ann / Ruby, Christine M / Pruskowski, Jennifer / Karim, Siti Nurhana Abdul / Yong, Belinda Soon Wei / Slattum, Patricia / Crouse, Ericka / Delafuente, Jeffrey / Donohoe, Krista / Ogbonna, Kelechi / Peron, Emily / Powers, Kacie / Price, Elvin / Zimmerman, Kristin / Rahim, Sarah / Gendron, Tracey / Cho, Clarissa / Elliott, Lindsay / Minter, Candace / Morin, Mary / Marshall, Leisa / Stevens, Gregg / Cordaro, Charles / Hill, Matthew / Nagy, Kayla / Kroustos, Kelly Reilly / Sobota, Kristen Finley / Mahan, Rebecca / Bailey, Trista / Ioannou, Kara / Mansour, Diana / Thompson, Tristan / Chatellier, Kristel / Schwenk, Amanda / Ruby, Christine / Chen, Tsuhua Susan / Li, Shilun / James, Marian / Spilios, Maria / Leschak, Andrea / Levine, Alexander / Forgette, Stephanie / Oluigbo, Nneka / Szollosi, Doreen / Avalime, Dzifa / Weaver, Salome Bwayo / Maneno, Mary / Ettienne, Earl / Yi, Julia Yunkyung / Hart, Laura / Gray, Shelly / Ozalas, Stephanie / Miller, Kayla / Dave, Rohini / Bork, Jacqueline / Emmelhainz, Janetta / Adams, Kaylee / Postolski, Joshua / Willoughby, Matthew / Feldman, Elizabeth / Braham, Kelly / Miller, Christopher / Barbagallo, Deena / Seabury, Robert / Noviasky, John / Dabhi, Jayvir / Bartlett, Donna / Le, Tham / Simoni-Wastila, Linda / Kuzucan, Aida / Park, Siyeon / Choi, Michelle / Khokhar, Bilal / Brody, Peter / Hejna, Mary / Mason, Jessica / Graham, Miranda / Micceri, Jessica / Lypska, Roksolana / Quinn, Bryan / Wilson, Henry / Wahler, Robert / Aloyo, Marissa / Tomm, Vanessa / Hill, Angela / Obringer, Alan / Butterfoss, Kirsten / Blak, Julia / Balcer, Rebecca / Boza, Jenna / Foster, Amanda / Shafique, Ehtesham / Kleven, Casondra / Wigle, Patricia / Brown, Bethanne / Meyer, Kristin / Mobley-Bukstein, Wendy / Singh, Hemlata / Perez, Emelia / Mira, Alaa-Eldin / Kuehner, William / Czechowski, Lou / Cook, Heather / Brandt, Nicole / Parson, Janee / Fornaro, Rachyl / Claeys, Kimberly / Zarowitz, Barbara / Mansour, Daniel / McFadden, Chelsea / Simpkins, Sierra / Ojowa, Folarin / Klutts, Abigail / Holmes, Sarah / Smith, Everett / Cornman, Jr Reba / Doran, Kelly / Resnick, Barbara / Umeozulu, Chinasa / Williams, Anne / Hennawi, George / Thomas, Danielle / Gerber, Dawn Knudsen / Sharma, Kriti / Cooke, Catherine / Howard, Amy / Chater, Rebecca / Vogler, Abbie / Kennett-Hayes, Kaitlyn / Elliott, Laura / Engelbert, John / Hargrave, Emily / Bambico, Chynna / Patel, Kripali / Warriner, Cynthia / Desai, Nihar R / Rowan, Christopher G / Alvarez, Paula / Fogli, Jeanene / Toto, Robert D / Reed, Pamala / Owens, Mary Kay / Greden, John F / Rothschild, Anthony J / Zandy, Shannon / Thase, Michael / Dunlop, Boadie W / DeBattista, Charles / Conway, Charles R / Forester, Brent P / Mondimore, Francis M / Shelton, Richard C / Li, James / Gilbert, Alexa / Burns, Lindsey / Jablonski, Michael / Dechairo, Bryan / Parikh, Sagar / Donohue, James / Feldman, Gregory / Sethi, Sanjay / Barnes, Chris / Pendyala, Srikanth / Bourdet, David / Ferguson, Gary / Crater, Glenn / Mayo, Martha / Gross, Coleman / Miyawa, John / Ono, Reyn / Woods, Steven / Garza, Dahlia / Panov, Natalie / Moran, Edmund / Sabesan, Vijay / Wertman, James / Ngim, Kenley

    The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists

    2018  Volume 33, Issue 10, Page(s) 572–608

    Abstract: Poster abstracts are evaluated based on the following criteria: significance of the problem to healthy aging or medication management; innovativeness of ideas, methods, and/or approach; methodological rigor of methods and approach; presentation of ... ...

    Abstract Poster abstracts are evaluated based on the following criteria: significance of the problem to healthy aging or medication management; innovativeness of ideas, methods, and/or approach; methodological rigor of methods and approach; presentation of finding; implications identified for future research, practice, and/or policy; and clarity of writing. Submissions are not evaluated through the peer-reviewed process used by
    Language English
    Publishing date 2018-10-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1107921-6
    ISSN 2331-0936 ; 0888-5109
    ISSN (online) 2331-0936
    ISSN 0888-5109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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