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Article: A disease of too much iron.

Felitti, V J

1999 Volume 5, Issue 1, Page(s) 4–5

MeSH term(s)	Female ; Ferritins/blood ; Hemochromatosis/complications ; Hemochromatosis/diagnosis ; Hemochromatosis/genetics ; Humans ; Male ; Transferrin/analysis
Chemical Substances	Transferrin ; Ferritins (9007-73-2)
Language	English
Publishing date	1999-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1494083-8
ISSN	1081-5880
ISSN	1081-5880
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Article ; Online: REPRINT OF: Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults: The Adverse Childhood Experiences (ACE) Study.

Felitti, Vincent J / Anda, Robert F / Nordenberg, Dale / Williamson, David F / Spitz, Alison M / Edwards, Valerie / Koss, Mary P / Marks, James S

American journal of preventive medicine

2019 Volume 56, Issue 6, Page(s) 774–786

Abstract: Background: The relationship of health risk behavior and disease in adulthood to the breadth of exposure to childhood emotional, physical, or sexual abuse, and household dysfunction during childhood has not previously been described.: Methods: A ... ...

Abstract	Background: The relationship of health risk behavior and disease in adulthood to the breadth of exposure to childhood emotional, physical, or sexual abuse, and household dysfunction during childhood has not previously been described. Methods: A questionnaire about adverse childhood experiences was mailed to 13,494 adults who had completed a standardized medical evaluation at a large HMO; 9,508 (70.5%) responded. Seven categories of adverse childhood experiences were studied: psychological, physical, or sexual abuse; violence against mother; or living with household members who were substance abusers, mentally ill or suicidal, or ever imprisoned. The number of categories of these adverse childhood experiences was then compared to measures of adult risk behavior, health status, and disease. Logistic regression was used to adjust for effects of demographic factors on the association between the cumulative number of categories of childhood exposures (range: 0-7) and risk factors for the leading causes of death in adult life. Results: More than half of respondents reported at least one, and one-fourth reported ≥2 categories of childhood exposures. We found a graded relationship between the number of categories of childhood exposure and each of the adult health risk behaviors and diseases that were studied (P < .001). Persons who had experienced four or more categories of childhood exposure, compared to those who had experienced none, had 4- to 12-fold increased health risks for alcoholism, drug abuse, depression, and suicide attempt; a 2- to 4-fold increase in smoking, poor self-rated health, ≥50 sexual intercourse partners, and sexually transmitted disease; and a 1.4- to 1.6-fold increase in physical inactivity and severe obesity. The number of categories of adverse childhood exposures showed a graded relationship to the presence of adult diseases including ischemic heart disease, cancer, chronic lung disease, skeletal fractures, and liver disease. The seven categories of adverse childhood experiences were strongly interrelated and persons with multiple categories of childhood exposure were likely to have multiple health risk factors later in life. Conclusions: We found a strong graded relationship between the breadth of exposure to abuse or household dysfunction during childhood and multiple risk factors for several of the leading causes of death in adults.
Language	English
Publishing date	2019-06-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	632646-8
ISSN	1873-2607 ; 0749-3797
ISSN (online)	1873-2607
ISSN	0749-3797
DOI	10.1016/j.amepre.2019.04.001
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Article: Ursprünge des Suchtverhaltens - Evidenzen aus einer Studie zu belastenden Kindheitserfahrungen

Felitti, V. J.

Praxis der Kinderpsychologie und Kinderpsychiatrie

2003 Volume 52, Issue 8, Page(s) 547

Language	German
Document type	Article
ZDB-ID	123711-1
ISSN	0032-7034 ; 0017-4947
Database	Current Contents Medicine

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Article: Belastungen in der Kindheit und Gesundheit im Erwachsenenalter: die Verwandlung von Gold in Blei

Felitti, V. J.

Zeitschrift für psychosomatische Medizin und Psychtherapie

2002 Volume 48, Issue 4, Page(s) 359

Language	German
Document type	Article
ZDB-ID	462944-6
Database	Current Contents Medicine

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Article: Childhood sexual abuse, depression, and family dysfunction in adult obese patients: a case control study.

Felitti, V J

Southern medical journal

1993 Volume 86, Issue 7, Page(s) 732–736

Abstract: One hundred significantly overweight patients sequentially applying to a very low calorie diet (VLCD) program were interviewed to learn how the onset of obesity correlated with other life events. By comparison with a control group of 100 always-slender ... ...

Abstract	One hundred significantly overweight patients sequentially applying to a very low calorie diet (VLCD) program were interviewed to learn how the onset of obesity correlated with other life events. By comparison with a control group of 100 always-slender adults, the obese applicants were found to be different at a highly significant level in the prevalence of childhood sexual abuse, nonsexual childhood abuse, early parental loss, parental alcoholism, chronic depression, and marital family dysfunction in their own adult lives. The obese patients commonly reported using obesity as a sexually protective device; many reported overeating to cope with emotional distress. Inquiry into depression, past sexual abuse, and past or present dysfunctional family life should be added to the current medical evaluation of all obese patients. The resultant findings are likely to be relevant to their treatment, whether for obesity or for other medical conditions.
MeSH term(s)	Adult ; Alcoholism ; Bereavement ; Case-Control Studies ; Chi-Square Distribution ; Child ; Child Abuse/psychology ; Child Abuse, Sexual/complications ; Child Abuse, Sexual/psychology ; Depression/complications ; Family Characteristics ; Family Health ; Female ; Humans ; Hyperphagia/etiology ; Hyperphagia/psychology ; Male ; Marriage ; Obesity/etiology ; Obesity/psychology ; Suicide
Language	English
Publishing date	1993-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	185329-6
ISSN	1541-8243 ; 0038-4348
ISSN (online)	1541-8243
ISSN	0038-4348
DOI	10.1097/00007611-199307000-00002
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Article: Transcriptome analysis of seed development in apomictic Paspalum notatum

Felitti, S.A / Acuña, C.A / Ortiz, J.P.A / Quarin, C.L

Annals of applied biology. 2015 July, v. 167, no. 1

2015

Abstract: The seed developmental process involves various tissues with several ploidy levels and different genetic origins. Therefore, its characterisation at the transcriptome level is certainly a challenge. The hypothesis of endosperm balance number (EBN) ... ...

Abstract	The seed developmental process involves various tissues with several ploidy levels and different genetic origins. Therefore, its characterisation at the transcriptome level is certainly a challenge. The hypothesis of endosperm balance number (EBN) postulates that each species has an effective number that is important for normal endosperm and seed development to occur. Understanding endosperm formation in apomictic plants is crucial for the perspective of transferring apomixis to sexual species of agronomic interest. Since sexual tetraploid Paspalum plants fit the EBN premise, the EBN insensitivity observed in apomictic plants might be a requirement for the spread of pseudogamous apomixis. Crosses using several cytotypes of Paspalum notatum were made in order to induce the development of seeds with different maternal/paternal genomic ratios in the endosperm. A transcriptome characterisation of ovaries 3 h after pollination was performed using cDNA‐AFLP methodology. Forty‐six of the 100 differentially expressed transcript‐derived fragments (DETDFs) were specifically found in crosses in which apomictic plants were used as the female parent and presented a predicted m : p ratio in the endosperm that was different to the 2:1 requirement of the EBN. Moreover, 12 of the DETDFs presented identity with proteins that were differentially expressed in response to changes in the levels of extracellular ATP (eATP) in Arabidopsis cell suspension cultures. eATP is an important molecular switch in plants that tightly controls organellar energy metabolism and activates gene expression controlling specific growth and developmental programmes. The results suggest that eATP‐mediated signalling could be involved in the regulation of endosperm development.
Keywords	Arabidopsis ; Paspalum notatum ; adenosine triphosphate ; apomixis ; crossing ; cytotypes ; endosperm ; energy metabolism ; females ; gene expression ; gene expression regulation ; plant ovary ; pollination ; proteins ; seed development ; seeds ; tetraploidy ; tissues ; transcriptome ; transcriptomics
Language	English
Dates of publication	2015-07
Size	p. 36-54.
Publishing place	Blackwell Publishing Ltd
Document type	Article
ZDB-ID	283072-3
ISSN	0003-4746 ; 0951-4309
ISSN	0003-4746 ; 0951-4309
DOI	10.1111/aab.12206
Database	NAL-Catalogue (AGRICOLA)

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Article: Long-term medical consequences of incest, rape, and molestation.

Felitti, V J

Southern medical journal

1991 Volume 84, Issue 3, Page(s) 328–331

Abstract: One hundred thirty-one patients who gave a history of childhood sexual abuse were seen in a general medical practice decades after the event and were compared with a control group. The subject patients were found to be distinct for chronic depression, ... ...

Abstract	One hundred thirty-one patients who gave a history of childhood sexual abuse were seen in a general medical practice decades after the event and were compared with a control group. The subject patients were found to be distinct for chronic depression, morbid obesity, marital instability, high utilization of medical care, and certain psychosomatic symptoms, particularly chronic gastrointestinal distress and recurrent headaches. It is clear that these remote events can underlie difficult chronic medical problems. Questions about childhood sexual abuse must become part of the practitioner's review of systems in these difficult cases, if not routinely.
MeSH term(s)	Child ; Child Abuse, Sexual/complications ; Child Abuse, Sexual/psychology ; Chronic Disease ; Depression/etiology ; Female ; Follow-Up Studies ; Gastrointestinal Diseases/etiology ; Headache/etiology ; Humans ; Incest/psychology ; Male ; Marriage ; Morbidity ; Obesity, Morbid/etiology ; Psychophysiologic Disorders/etiology ; Rape/psychology ; Recurrence
Language	English
Publishing date	1991-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	185329-6
ISSN	1541-8243 ; 0038-4348
ISSN (online)	1541-8243
ISSN	0038-4348
DOI	10.1097/00007611-199103000-00008
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Article ; Online: Adverse childhood experiences and frequent headaches in adults.

Anda, Robert / Tietjen, Gretchen / Schulman, Elliott / Felitti, Vincent / Croft, Janet

Headache

2010 Volume 50, Issue 9, Page(s) 1473–1481

Abstract: Background: A variety of studies have linked childhood maltreatment to headaches, including migraines, and to headache severity. This study assesses the relationship of adverse childhood experiences (ACEs) to frequent headaches during adulthood.: ... ...

Abstract	Background: A variety of studies have linked childhood maltreatment to headaches, including migraines, and to headache severity. This study assesses the relationship of adverse childhood experiences (ACEs) to frequent headaches during adulthood. Methods: We used data from the Adverse Childhood Experiences (ACE) study, which included 17,337 adult members of the Kaiser Health Plan in San Diego, CA who were undergoing a comprehensive preventive medical evaluation. The study assessed 8 ACEs including abuse (emotional, physical, sexual), witnessing domestic violence, growing up with mentally ill, substance abusing, or criminal household members, and parental separation or divorce. Our measure of headaches came from the medical review of systems using the question: "Are you troubled by frequent headaches?" We used the number of ACEs (ACE score) as a measure of cumulative childhood stress and hypothesized a "dose-response" relationship of the ACE score to the prevalence and risk of frequent headaches. Results: Each of the ACEs was associated with an increased prevalence and risk of frequent headaches. As the ACE score increased the prevalence and risk of frequent headaches increased in a "dose-response" fashion. The risk of frequent headaches increased more than 2-fold (odds ratio 2.1, 95% confidence interval 1.8-2.4) in persons with an ACE score ≥5, compared to persons with and ACE score of 0. The dose-response relationship of the ACE score to frequent headaches was seen for both men and women. Conclusions: The number of ACEs showed a graded relationship to frequent headaches in adults. Future studies should examine general populations with headache, and carefully classify them. A better understanding of the link between ACEs and migraine may lead to new knowledge regarding pathophysiology and enhanced additional therapies for headache patients.
MeSH term(s)	Adult ; Child ; Child Abuse/classification ; Child Abuse/mortality ; Child Abuse/psychology ; Comorbidity ; Female ; Headache Disorders, Secondary/classification ; Headache Disorders, Secondary/epidemiology ; Headache Disorders, Secondary/psychology ; Humans ; Male ; Neuropsychological Tests/standards ; Prevalence ; Time
Language	English
Publishing date	2010-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	410130-3
ISSN	1526-4610 ; 0017-8748
ISSN (online)	1526-4610
ISSN	0017-8748
DOI	10.1111/j.1526-4610.2010.01756.x
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Article: Ursprünge des Suchtverhaltens

Felitti, Vincent J.

Praxis der Kinderpsychologie und Kinderpsychiatrie

Evidenzen aus einer Studie zu belastenden Kindheitserfahrungen

2003 Volume 52, Issue 8, Page(s) 547–559

Abstract: Es wird von einer Untersuchung mit mehr als 17.000 Erwachsenen der amerikanischen Mittelschicht berichtet, die an einer umfassenden biopsychosozialen medizinischen Evaluation teilgenommen haben. Es zeigte sich, dass drei verbreitete Suchtkategorien ... ...

Title translation	The origins of addiction: Evidence from the Adverse Childhood Experiences Study
Abstract	Es wird von einer Untersuchung mit mehr als 17.000 Erwachsenen der amerikanischen Mittelschicht berichtet, die an einer umfassenden biopsychosozialen medizinischen Evaluation teilgenommen haben. Es zeigte sich, dass drei verbreitete Suchtkategorien verhältnismäßig eng mit spezifischen belastenden Erfahrungen in der Kindheit verbunden sind. Das lässt in Verbindung mit darauf bezogenen Informationen den Schluss zu, dass Ursachen einer Sucht hauptsächlich in Kindheitserfahrungen und nicht in Eigenschaften des Suchtmittels zu suchen sind. Implikationen für die medizinische Praxis und die Behandlungsprogramme werden aufgezeigt.
Keywords	Addiction ; At Risk Populations ; Early Experience ; Etiology ; Frühkindliche Erfahrungen ; Risikofaktoren ; Risikogruppen ; Risk Factors ; Sucht ; Ätiologie
Language	German
Document type	Article
ZDB-ID	123711-1
ISSN	0032-7034
ISSN	0032-7034
Database	PSYNDEX

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Article: New developments in hereditary hemochromatosis.

Felitti, V J / Beutler, E

The American journal of the medical sciences

1999 Volume 318, Issue 4, Page(s) 257–268

Abstract: The iron content of the body is normally tightly controlled by regulation of iron absorption. In hereditary hemochromatosis, mutation of an HLA class 1 gene, designated HFE, results in excessive iron absorption. Over many years, accumulating iron ... ...

Abstract	The iron content of the body is normally tightly controlled by regulation of iron absorption. In hereditary hemochromatosis, mutation of an HLA class 1 gene, designated HFE, results in excessive iron absorption. Over many years, accumulating iron produces tissue damage, most notably cirrhosis, cardiomyopathy, diabetes, and arthropathies. Hereditary hemochromatosis is the most common hereditary disease of Northern Europeans with a prevalence of approximately 5 per 1000. The most sensitive screening test for hemochromatosis is saturation of the transferrin with iron; a fasting value greater than 50% is strongly suggestive of the disease. Confirmation of increased iron storage can be achieved most readily by serial phlebotomy. We do not regard liver biopsy to be indicated, except in unusual circumstances. Early diagnosis and treatment by phlebotomy before tissue damage has occurred is essential, because life span seems to be normal in treated patients but markedly shortened in those who are not. Therefore, genetic counseling with evaluation of first-degree relatives is mandatory.
MeSH term(s)	Genetic Counseling ; Hemochromatosis/diagnosis ; Hemochromatosis/genetics ; Hemochromatosis/metabolism ; Hemochromatosis/physiopathology ; Hemochromatosis/therapy ; Humans ; Prognosis
Language	English
Publishing date	1999-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	82078-7
ISSN	1538-2990 ; 0002-9629
ISSN (online)	1538-2990
ISSN	0002-9629
DOI	10.1097/00000441-199910000-00005
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