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  1. Article ; Online: Pituitary surgery in Cushing's disease: first line treatment and role of reoperation.

    Jones, Pamela S / Swearingen, Brooke

    Pituitary

    2022  Volume 25, Issue 5, Page(s) 713–717

    Abstract: Cushing's disease is the most common cause of endogenous hypercortisolemia, and transsphenoidal surgery remains the first line therapy for removal of the ACTH-secreting adenoma. While post-operative remission rates are high in experienced hands, there ... ...

    Abstract Cushing's disease is the most common cause of endogenous hypercortisolemia, and transsphenoidal surgery remains the first line therapy for removal of the ACTH-secreting adenoma. While post-operative remission rates are high in experienced hands, there remains a 2% risk of recurrence per year. Patients with the highest chance for cure are those with small, non-invasive tumors that are visible on pre-operative MRI and identified during surgery and are performed by high-volume pituitary neurosurgeons. Surgery for persistent or recurrent disease is frequently indicated and is most successful in the hands of experienced surgeons and in cases where tumor is visible on MRI.
    MeSH term(s) Humans ; Pituitary ACTH Hypersecretion/surgery ; Pituitary Neoplasms/surgery ; Reoperation ; Adenoma/surgery ; Adrenocorticotropic Hormone ; Treatment Outcome
    Chemical Substances Adrenocorticotropic Hormone (9002-60-2)
    Language English
    Publishing date 2022-07-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1385151-2
    ISSN 1573-7403 ; 1386-341X
    ISSN (online) 1573-7403
    ISSN 1386-341X
    DOI 10.1007/s11102-022-01254-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Wearable Sensors Based on Force-Sensitive Resistors for Touch-Based Collaborative Digital Gaming.

    Dontha, Balaji / Swearingen, Kyoung / Swearingen, Scott / Thrane, Susan E / Kiourti, Asimina

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 1

    Abstract: ... in sensitivity to low forces compared to the most sensitive embroidered FSR reported to date, (b) confirm ...

    Abstract We report new classes of wearable sensors that monitor touch between fully-abled and disabled players in order to empower collaborative digital gaming between the two. Our approach relies on embroidered force-sensitive resistors (FSRs) embedded into armbands, which outperform the state-of-the-art in terms of sensitivity to low applied forces (0 to 5 N). Such low forces are of key significance to this application, given the diverse physical abilities of the players. With a focus on effective gameplay, we further explore the sensor's touch-detection performance, study the effect of the armband fabric selection, and optimize the sensor's placement upon the arm. Our results: (a) demonstrate a 4.4-times improvement in sensitivity to low forces compared to the most sensitive embroidered FSR reported to date, (b) confirm the sensor's ability to empower touch-based collaborative digital gaming for individuals with diverse physical abilities, and (c) provide parametric studies for the future development of diverse sensing solutions and game applications.
    MeSH term(s) Humans ; Textiles ; Touch ; Touch Perception ; Video Games ; Wearable Electronic Devices
    Language English
    Publishing date 2022-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22010342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Diagnosis and Management of Pituitary Disorders

    Swearingen, Brooke / Biller, Beverly M. K.

    2008  

    Author's details edited by Brooke Swearingen, Beverly M. K. Biller
    Keywords Endocrinology ; Neurosurgery ; Oncology
    Language English
    Publisher Humana Press, Totowa, NJ
    Publishing place Totowa, NJ
    Document type Book ; Online
    HBZ-ID TT050387194
    ISBN 978-1-588-29922-2 ; 978-1-597-45264-9 ; 1-588-29922-8 ; 1-597-45264-5
    DOI 10.1007/978-1-59745-264-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book: Cushing's disease

    Swearingen, Brooke / Biller, Beverly M. K.

    (Endocrine updates ; [31] ; Internal medicine)

    2011  

    Author's details Brooke, Swearingen, Beverly M. K. Biller (ed.)
    Series title Endocrine updates ; [31]
    Internal medicine
    Collection
    Language English
    Size XI, 264 S. : Ill., graf. Darst.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT016958221
    ISBN 978-1-4614-0010-3 ; 9781461400110 ; 1-4614-0010-4 ; 1461400112
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2011 A 3393 order for loan Magazin

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  5. Article ; Online: Extended Use of Distal Embolic Protection Devices in Treatment of Distal Embolism During Lower Extremity Arterial Endovascular Interventions.

    Ibrahim, Mudathir / Swearingen, Bruce / Pu, Sirui / Rhee, Robert / Pu, Qinghua

    Innovations (Philadelphia, Pa.)

    2022  Volume 17, Issue 3, Page(s) 231–236

    Abstract: There is no consensus on the best treatment modality for acute distal embolization complications during endovascular interventions for peripheral arterial diseases. We report on 3 patients who underwent mechanical embolectomy using a distal embolic ... ...

    Abstract There is no consensus on the best treatment modality for acute distal embolization complications during endovascular interventions for peripheral arterial diseases. We report on 3 patients who underwent mechanical embolectomy using a distal embolic protection device (EPD). All patients showed angiographic evidence of distal embolism, which occurred during lower extremity limb salvage endovascular procedures. After embolectomy, all had complete recanalization of the involved vessel on completion angiogram, and none had any device-related complications or adverse outcomes from the embolization. This initial experience suggests that EPD can be used for both the prevention and treatment of intraoperative distal embolization during endovascular intervention of lower extremity arterial disease.
    MeSH term(s) Embolic Protection Devices ; Embolism/etiology ; Embolism/prevention & control ; Embolism/surgery ; Endovascular Procedures ; Humans ; Lower Extremity/blood supply ; Peripheral Arterial Disease/surgery ; Stents/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2022-05-13
    Publishing country United States
    Document type Journal Article
    ISSN 1559-0879
    ISSN (online) 1559-0879
    DOI 10.1177/15569845221096126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Intraoperative MRI for Pituitary Adenomas.

    Jones, Pamela S / Swearingen, Brooke

    Neurosurgery clinics of North America

    2019  Volume 30, Issue 4, Page(s) 413–420

    Abstract: Since the 1990s, MRI scanners have been incorporated into the operating room environment. Studies of the use of intraoperative MRI (iMRI) for pituitary adenomas have shown that images are highly sensitive and specific for residual tumor detection, ... ...

    Abstract Since the 1990s, MRI scanners have been incorporated into the operating room environment. Studies of the use of intraoperative MRI (iMRI) for pituitary adenomas have shown that images are highly sensitive and specific for residual tumor detection, especially at higher Tesla magnet strengths. Given this accuracy, iMRI also increases the rates of achieving gross total resection (GTR). Owing to the slow-growing nature of pituitary adenomas, comparison of long-term control rates with and without use of iMRI remains to be studied, but the increased rates of GTR with this technology are promising for improved long-term outcomes.
    MeSH term(s) Adenoma/diagnostic imaging ; Adenoma/surgery ; Humans ; Magnetic Resonance Imaging ; Monitoring, Intraoperative/methods ; Neoplasm, Residual ; Pituitary Neoplasms/diagnostic imaging ; Pituitary Neoplasms/surgery ; Treatment Outcome
    Language English
    Publishing date 2019-07-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196855-2
    ISSN 1558-1349 ; 1042-3680
    ISSN (online) 1558-1349
    ISSN 1042-3680
    DOI 10.1016/j.nec.2019.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Prolactin per Unit Tumor Volume Ratio Accurately Distinguishes Prolactinomas From Secondary Hyperprolactinemia due to Stalk Effect.

    Faje, Alexander / Jones, Pamela / Swearingen, Brooke / Tritos, Nicholas A

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2022  Volume 28, Issue 6, Page(s) 572–577

    Abstract: Objective: The prolactin levels alone are insufficient to distinguish between some cases of prolactinomas and stalk effect. We aimed to formally characterize the relationship between serum prolactin and prolactinoma volume, determine a cutoff for ... ...

    Abstract Objective: The prolactin levels alone are insufficient to distinguish between some cases of prolactinomas and stalk effect. We aimed to formally characterize the relationship between serum prolactin and prolactinoma volume, determine a cutoff for prolactin/mm
    Methods: We used the Research Patient Data Registry and transsphenoidal surgery database in our institution to retrospectively identify adult patients with clinically nonfunctioning (NF) tumors (primary analysis, n = 279; validation cohort, n = 10) and prolactinomas (primary analysis, n = 94; validation cohort, n = 18). Solid tumor volumes were measured by Visage 7 software, and cystic foci within tumors were excluded.
    Results: Prolactin levels were significantly correlated with prolactinoma volume (r
    Conclusion: The prolactin/volume ratio correctly distinguished all prolactinomas from stalk effect in this study, including a validation cohort specifically chosen for potential ambiguity. To our knowledge, this study is the first formal volumetric analysis of prolactin secretion in pituitary adenomas, and our results suggest that the measurement of prolactin/mm
    MeSH term(s) Adult ; Humans ; Hyperprolactinemia/diagnosis ; Pituitary Neoplasms/complications ; Prolactin ; Prolactinoma/complications ; Retrospective Studies ; Tumor Burden
    Chemical Substances Prolactin (9002-62-4)
    Language English
    Publishing date 2022-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.1016/j.eprac.2022.03.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Distinct Functional Connectivity Patterns for Intermittent Vs Constant Neuropathic Pain Phenotypes in Persistent Spinal Pain Syndrome Type 2 Patients.

    Pahapill, Peter A / Arocho-Quinones, Elsa V / Chen, Guangyu / Swearingen, Brad / Tomas, Carissa W / Koch, Kevin M / Nencka, Andrew Scott

    Journal of pain research

    2024  Volume 17, Page(s) 1453–1460

    Abstract: Background: Chronic low back pain (cLBP) has been associated with alterations in brain functional connectivity (FC) but based upon heterogeneous populations and single network analyses. Our goal is to study a more homogeneous cLBP population and focus ... ...

    Abstract Background: Chronic low back pain (cLBP) has been associated with alterations in brain functional connectivity (FC) but based upon heterogeneous populations and single network analyses. Our goal is to study a more homogeneous cLBP population and focus on multiple cross-network (CN) connectivity analysis. We hypothesize that within this population: 1) altered CN FC, involving emotion and reward/aversion functions are related to their pain levels and 2) altered relationships are dependent upon pain phenotype (constant neuropathic vs intermittent pain).
    Methods: In this case series, resting state fcMRI scans were obtained over a study duration of 60 months from 23 patients (13 constant neuropathic and 10 intermittent pain) with Persistent Spinal Pain Syndrome (PSPS Type 2) being considered for spinal cord stimulation (SCS) therapy at a single academic center. Images were acquired using a Discovery MR750 GE scanner. During the resting state acquisitions, they were asked to close their eyes and relax. The CN analysis was performed on 7 brain networks and compared to age-matched controls. Linear regression was used to test the correlation between CN connectivity and pain scores.
    Results: CN FC involving emotion networks (STM: striatum network index) was significantly lower than controls in all patients, regardless of pain phenotype (P < 0.003). Pain levels were positively correlated with emotional FC for intermittent pain but negatively correlated for constant pain.
    Conclusion: This is the first report of 1) altered CN FC involving emotion/reward brain circuitry in 2) a homogeneous population of cLBP patients with 3) two different pain phenotypes (constant vs intermittent) in PSPS Type 2 patients being considered for SCS. FC patterns were altered in cLBP patients as compared to controls and were characteristic for each pain phenotype. These data support fcMRI as a potential and objective tool in assessing pain levels in cLBP patients with different pain phenotypes.
    Language English
    Publishing date 2024-04-12
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2495284-9
    ISSN 1178-7090
    ISSN 1178-7090
    DOI 10.2147/JPR.S426640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Update on pituitary surgery.

    Swearingen, Brooke

    The Journal of clinical endocrinology and metabolism

    2012  Volume 97, Issue 4, Page(s) 1073–1081

    Abstract: Transsphenoidal surgery has an important role in the management of pituitary tumors and remains the primary treatment for most adenomas, with the exception of prolactinomas. This update will review the recent neurosurgical literature; modifications to ... ...

    Abstract Transsphenoidal surgery has an important role in the management of pituitary tumors and remains the primary treatment for most adenomas, with the exception of prolactinomas. This update will review the recent neurosurgical literature; modifications to the traditional microscopic approach, including the potential utility of endoscopy and intraoperative magnetic resonance imaging, are discussed. The value of experienced surgical judgment and expertise remains clear, over and above the possible advantages of current technology. Preliminary data on the relative cost-effectiveness of surgery vs. medical treatment suggest that surgical approaches compare favorably. It will be important to incorporate future technological advances in surgical technique with new medical therapies in a combined multidisciplinary approach for improved treatment algorithms.
    MeSH term(s) Cost-Benefit Analysis ; Endoscopy ; Health Care Costs ; Humans ; Intraoperative Period ; Magnetic Resonance Imaging ; Microsurgery ; Pituitary Diseases/drug therapy ; Pituitary Diseases/economics ; Pituitary Diseases/pathology ; Pituitary Diseases/surgery ; Pituitary Gland/drug effects ; Pituitary Gland/pathology ; Pituitary Gland/surgery ; Pituitary Neoplasms/drug therapy ; Pituitary Neoplasms/economics ; Pituitary Neoplasms/pathology ; Pituitary Neoplasms/surgery
    Language English
    Publishing date 2012-04
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/jc.2011-3237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Maternal reminiscing during middle childhood: Associations with maternal personality and child temperament from the Growing Up in New Zealand cohort study.

    Swearingen, Isabelle / Reese, Elaine / Garnett, Madeline / Peterson, Elizabeth / Salmon, Karen / Atatoa Carr, Polly / Morton, Susan M B / Bird, Amy

    Developmental psychology

    2023  Volume 59, Issue 12, Page(s) 2248–2264

    Abstract: The way that mothers talk about the past (reminisce) with young children is linked to key memory, language, and socioemotional outcomes. The present research explored the role of a range of child, maternal, socioeconomic, and cultural factors that ... ...

    Abstract The way that mothers talk about the past (reminisce) with young children is linked to key memory, language, and socioemotional outcomes. The present research explored the role of a range of child, maternal, socioeconomic, and cultural factors that predict maternal reminiscing style, with a particular focus on maternal personality and child temperament. A total of 1,404 mother-child dyads from the prebirth longitudinal cohort study
    MeSH term(s) Child ; Female ; Humans ; Child, Preschool ; Mother-Child Relations/psychology ; Temperament ; Cohort Studies ; Longitudinal Studies ; New Zealand ; Memory, Episodic ; Mothers/psychology ; Personality
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2066223-3
    ISSN 1939-0599 ; 0012-1649
    ISSN (online) 1939-0599
    ISSN 0012-1649
    DOI 10.1037/dev0001596
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