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  1. Article: Kommentar zu Posteriorer lumbaler Facettengelenkersatz bei Spondylolisthese

    Cabraja, Mario

    Die Wirbelsäule

    2023  Volume 07, Issue 04, Page(s) 212–214

    Language German
    Publishing date 2023-10-24
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2509-825X ; 2509-8241
    ISSN (online) 2509-825X
    ISSN 2509-8241
    DOI 10.1055/a-1993-8749
    Database Thieme publisher's database

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  2. Book ; Online ; Thesis: Die Behandlung degenerativer Wirbelsäulenerkrankungen durch fusionierende und bewegungserhaltende Operationsverfahren

    Čabraja, Mario

    2013  

    Title variant Surgical treatment of degenerative spine diseases
    Author's details vorgelegt von Mario Čabraja
    Language German
    Size Online-Ressource, Ill., graph. Darst.
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ.-Medizin, Habil.--Berlin, 2013
    Database Former special subject collection: coastal and deep sea fishing

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  3. Article ; Online: Comparison of sagittal vertical axis and decompression on the clinical outcome of cervical spondylotic myelopathy.

    Koeppen, Daniel / Stelling, Henrik / Goll, Moritz / Kroppenstedt, Stefan / Cabraja, Mario

    Clinical neurology and neurosurgery

    2022  Volume 213, Page(s) 107125

    Abstract: Objective: Decompression and cervical balance are major goals in the surgical treatment of cervical spondylotic myelopathy (CSM). Cervical balance is assumed to be a key factor for neurological recovery and pain reduction. Surgical reduction of C2-7 ... ...

    Abstract Objective: Decompression and cervical balance are major goals in the surgical treatment of cervical spondylotic myelopathy (CSM). Cervical balance is assumed to be a key factor for neurological recovery and pain reduction. Surgical reduction of C2-7 sagittal vertical axis (SVA) correlates with clinical improvement. However, it remains unclear, how much or even if correction is necessary for clinical improvement as long as surgery results in successful decompression. We aim to evaluate the role of radiological cervical balance parameter on the short-term course of CSM.
    Methods: This is a retrospective study with prospectively collected data of 90 patients. The authors identified 45 patients suffering from CSM that underwent decompressive surgery and instrumentation and showed an increased C2-7 sagittal vertical axis (SVA) after surgery. 45 consecutive patients with a decreased C2-7 SVA were selected as a control group.
    Results: Surgery improved the clinical outcome of both groups significantly. No differences could be seen comparing neck pain and neurological improvement between both groups. An increased C2-7 SVA did not correlate with an inferior clinical outcome. T1-slope correlated with the Cobb-angle.
    Conclusions: Decompression and stabilization appear to be key elements of surgical treatment of CSM. In short terms, clinical improvement does not appear to affect patients negatively who show a larger C2-7 SVA after surgery. Optimal C2-7 SVA and necessity for a specific C2-7 correction is unclear. The term "balance" remains a complex entity without clear definition.
    MeSH term(s) Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/surgery ; Decompression ; Humans ; Lordosis/surgery ; Neck Pain ; Retrospective Studies ; Spinal Cord Diseases/diagnostic imaging ; Spinal Cord Diseases/surgery ; Treatment Outcome
    Language English
    Publishing date 2022-01-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2022.107125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.53: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Book ; Online ; Thesis: Die Behandlung degenerativer Wirbelsäulenerkrankungen durch fusionierende und bewegungserhaltende Operationsverfahren

    Čabraja, Mario [Verfasser]

    2013  

    Author's details Mario Cabraja
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Medizinische Fakultät Charité - Universitätsmedizin Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Article ; Online: The influence of sagittal profile alteration and final lordosis on the clinical outcome of cervical spondylotic myelopathy. A Delta-Omega-analysis.

    Koeppen, Daniel / Piepenbrock, Claudia / Kroppenstedt, Stefan / Čabraja, Mario

    PloS one

    2017  Volume 12, Issue 4, Page(s) e0174527

    Abstract: Purpose: Decompression and maintaining or restoring a cervical lordosis are major goals in the surgical treatment of cervical spondylotic myelopathy (CSM). Numerous studies support the assumption that cervical lordosis is a key factor for neurological ... ...

    Abstract Purpose: Decompression and maintaining or restoring a cervical lordosis are major goals in the surgical treatment of cervical spondylotic myelopathy (CSM). Numerous studies support the assumption that cervical lordosis is a key factor for neurological recovery and pain reduction. However, even kyphotic patients can be asymptomatic. The balance of the spine is subject of an increasing number of publications. The main purpose of the study was to evaluate the validity of lordotic alignment on the course of CSM and to set this parameter in context with well-validated tools, namely the modified Japanese Orthopaedic Association scoring system (mJOAS) and the visual analogue scale (VAS), to predict and measure the clinical outcome after surgery.
    Methods: This is a retrospective study with prospectively collected data of a heterogeneous cohort. The authors analyzed the records of 102 patients suffering from CSM that underwent decompressive surgery and instrumentation. Clinical outcome was assessed by using the mJOAS, VAS and Odom's criteria. The radiological analysis involved comparison of pre- and postoperative radiographs. The patients were divided into subgroups to be able to compare the influence of various amounts of correction (3 Delta-groups: <0°, 1-7° and ≥8°) and final lordosis (4 Omega-groups: 0-7°, 8-14°, 15-21°, ≥22°).
    Results: 219 levels were fused in 102 patients. Surgery improved the clinical outcome of all groups significantly. A lordotic profile was achieved in all analyzed groups. Patients that showed small lordosis after surgery (<8°) did not have an inferior clinical outcome compared to patients with larger cervical lordosis (>14°). The comparison of Odom's criteria showed that preoperatively kyphotic patients benefitted more from surgery than lordotic patients (p = 0.029), but no differences could be seen comparing neck pain and neurological improvement. The improvement of pain and neurological impairment measured by VAS and mJOAS supports the statistical impact and validity of the data despite comparatively small numbers of patients. The lack of postoperative kyphosis is a major limitation of the study to encompass the impact of sagittal alignment on clinical outcome.
    Conclusions: Decompression and stabilization appear to be key elements of surgical treatment of CSM. While the achievement of cervical lordosis remains a major goal of surgery, clinical improvement is not hindered in patients who show small lordosis. However, kyphosis should be eliminated in symptomatic patients. The terms "balance" and "physiologic lordosis" remain complex entities without clear definition. To check the results of our study controlled randomized trials to validate and determine the exact role of cervical balance on the course of CSM would be helpful.
    MeSH term(s) Humans ; Lordosis/diagnostic imaging ; Lordosis/pathology ; Retrospective Studies ; Spinal Cord Diseases/diagnostic imaging ; Spinal Cord Diseases/pathology ; Spondylosis/diagnostic imaging ; Spondylosis/pathology ; Treatment Outcome
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0174527
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The influence of sagittal profile alteration and final lordosis on the clinical outcome of cervical spondylotic myelopathy. A Delta-Omega-analysis.

    Daniel Koeppen / Claudia Piepenbrock / Stefan Kroppenstedt / Mario Čabraja

    PLoS ONE, Vol 12, Iss 4, p e

    2017  Volume 0174527

    Abstract: Decompression and maintaining or restoring a cervical lordosis are major goals in the surgical treatment of cervical spondylotic myelopathy (CSM). Numerous studies support the assumption that cervical lordosis is a key factor for neurological recovery ... ...

    Abstract Decompression and maintaining or restoring a cervical lordosis are major goals in the surgical treatment of cervical spondylotic myelopathy (CSM). Numerous studies support the assumption that cervical lordosis is a key factor for neurological recovery and pain reduction. However, even kyphotic patients can be asymptomatic. The balance of the spine is subject of an increasing number of publications. The main purpose of the study was to evaluate the validity of lordotic alignment on the course of CSM and to set this parameter in context with well-validated tools, namely the modified Japanese Orthopaedic Association scoring system (mJOAS) and the visual analogue scale (VAS), to predict and measure the clinical outcome after surgery.This is a retrospective study with prospectively collected data of a heterogeneous cohort. The authors analyzed the records of 102 patients suffering from CSM that underwent decompressive surgery and instrumentation. Clinical outcome was assessed by using the mJOAS, VAS and Odom's criteria. The radiological analysis involved comparison of pre- and postoperative radiographs. The patients were divided into subgroups to be able to compare the influence of various amounts of correction (3 Delta-groups: <0°, 1-7° and ≥8°) and final lordosis (4 Omega-groups: 0-7°, 8-14°, 15-21°, ≥22°).219 levels were fused in 102 patients. Surgery improved the clinical outcome of all groups significantly. A lordotic profile was achieved in all analyzed groups. Patients that showed small lordosis after surgery (<8°) did not have an inferior clinical outcome compared to patients with larger cervical lordosis (>14°). The comparison of Odom's criteria showed that preoperatively kyphotic patients benefitted more from surgery than lordotic patients (p = 0.029), but no differences could be seen comparing neck pain and neurological improvement. The improvement of pain and neurological impairment measured by VAS and mJOAS supports the statistical impact and validity of the data despite comparatively small ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 616 ; 610
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Book ; Online ; Thesis: Stereologie Calretinin-immunopositiver Neurone des Ganglion vestibulare (Scarpae) in cerebellären und vestibulären Mäusemutanten

    Čabraja, Mario

    2004  

    Author's details vorgelegt von Mario Čabraja
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Freie Univ., Diss--Berlin, 2004
    Note Dateiformat: zip, Dateien im PDF-Format
    Database Former special subject collection: coastal and deep sea fishing

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  8. Book ; Online ; Thesis: Stereologie Calretinin-immunopositiver Neurone des Ganglion vestibulare (Scarpae) in cerebellären und vestibulären Mäusemutanten

    Čabraja, Mario [Verfasser]

    2004  

    Author's details vorgelegt von Mario Čabraja
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  9. Article: Empty polyetheretherketone (PEEK) cages in anterior cervical diskectomy and fusion (ACDF) show slow radiographic fusion that reduces clinical improvement: results from the prospective multicenter "PIERCE-PEEK" study.

    Suess, Olaf / Schomaker, Martin / Cabraja, Mario / Danne, Marco / Kombos, Theodoros / Hanna, Michael

    Patient safety in surgery

    2017  Volume 11, Page(s) 12

    Abstract: Background: Anterior cervical diskectomy and fusion (ACDF) is a well-established surgical treatment for radiculopathy and myelopathy. Previous studies showed that empty PEEK cages have lower radiographic fusion rates, but the clinical relevance remains ... ...

    Abstract Background: Anterior cervical diskectomy and fusion (ACDF) is a well-established surgical treatment for radiculopathy and myelopathy. Previous studies showed that empty PEEK cages have lower radiographic fusion rates, but the clinical relevance remains unclear. This paper's aim is to provide high-quality evidence on the outcomes of ACDF with empty PEEK cages and on the relevance of radiographic fusion for clinical outcomes.
    Methods: This large prospective multicenter clinical trial performed single-level ACDF with empty PEEK cages on patients with cervical radiculopathy or myelopathy. The main clinical outcomes were VAS (0-10) for pain and NDI (0-100) for functioning. Radiographic fusion was evaluated by two investigators for three different aspects.
    Results: The median (range) improvement of the VAS pain score was: 3 (1-6) at 6 months, 3 (2-8) at 12 months, and 4 (2-8) at 18 months. The median (range) improvement of the NDI score was: 12 (2-34) at 6 months, 18 (4-46) at 12 months, and 22 (2-44) at 18 months. Complete radiographic fusion was reached by 126 patients (43%) at 6 months, 214 patients (73%) at 12 months, and 241 patients (83%) at 18 months. Radiographic fusion was a highly significant (
    Conclusion: This study provides strong evidence that ACDF is effective treatment, but the overall rate of radiographic fusion with empty PEEK cages is slow and insufficient. Lack of complete radiographic fusion leads to less improvement of pain and disability. We recommend against using empty uncoated pure PEEK cages in ACDF.
    Trial registration: ISRCTN42774128. Retrospectively registered 14 April 2009.
    Language English
    Publishing date 2017-04-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2409244-7
    ISSN 1754-9493
    ISSN 1754-9493
    DOI 10.1186/s13037-017-0128-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Conference proceedings: Characterization of anulus fibrosus tissue and cells from mild and severe degenerated lumbar intervertebral discs

    Stich, Stefan / Jagielski, Michal / Cabraja, Mario / Reimann, Kolja / Endres, Michaela / Ertel, Wolfgang / Sittinger, Michael

    2019  , Page(s) AB59–1045

    Event/congress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2019); Berlin; ; Berufsverband der Fachärzte für Orthopädie; 2019
    Keywords Medizin, Gesundheit ; anulus fibrosus ; gene expression analysis ; genome-wide microarrays ; cell stimulation
    Publishing date 2019-10-22
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/19dkou555
    Database German Medical Science

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