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  1. Article ; Online: Colorectal cancer.

    Paty, Philip B / Garcia-Aguilar, Julio

    Journal of surgical oncology

    2022  Volume 126, Issue 5, Page(s) 881–887

    Abstract: Although surgery is the established standard and mainstay for treatment of colorectal cancer, advances in technology and clinical trials over the past 50 years have dramatically expanded and improved the detection, staging, treatment, and understanding ... ...

    Abstract Although surgery is the established standard and mainstay for treatment of colorectal cancer, advances in technology and clinical trials over the past 50 years have dramatically expanded and improved the detection, staging, treatment, and understanding of this disease. This review highlights contributions by surgeons, oncologists, gastroenterologists, engineers, and scientists to increase postsurgical recurrence-free survival, reduce the time and toxicity of treatment, and improve the quality of life for patients over the past half-century.
    MeSH term(s) Colorectal Neoplasms/drug therapy ; Humans ; Quality of Life
    Language English
    Publishing date 2022-05-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 82063-5
    ISSN 1096-9098 ; 0022-4790
    ISSN (online) 1096-9098
    ISSN 0022-4790
    DOI 10.1002/jso.27079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 706: Show issues Location:
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  2. Article ; Online: Watch and Wait in Rectal Cancer or More Wait and See?

    Smith, J Joshua / Paty, Philip B / Garcia-Aguilar, Julio

    JAMA surgery

    2020  Volume 155, Issue 7, Page(s) 657–658

    MeSH term(s) Humans ; Rectal Neoplasms/therapy ; Watchful Waiting
    Language English
    Publishing date 2020-04-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2020.0226
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  3. Article: Enhancing Chemotherapy Response Prediction via Matched Colorectal Tumor-Organoid Gene Expression Analysis and Network-Based Biomarker Selection.

    Zhang, Wei / Wu, Chao / Huang, Hanchen / Bleu, Paulina / Zambare, Wini / Alvarez, Janet / Wang, Lily / Paty, Philip B / Romesser, Paul B / Smith, J Joshua / Chen, X Steven

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: This study presents an innovative methodology for predicting chemotherapy responses in colorectal cancer patients by integrating gene expression data from matched colorectal tumor and organoid samples. Employing Consensus Weighted Gene Co-expression ... ...

    Abstract This study presents an innovative methodology for predicting chemotherapy responses in colorectal cancer patients by integrating gene expression data from matched colorectal tumor and organoid samples. Employing Consensus Weighted Gene Co-expression Network Analysis (WGCNA) across multiple datasets, we identified key gene modules and hub genes linked to patient response to chemotherapy, focusing on 5-fluorouracil (5-FU). This integrative approach marks a significant advancement in precision medicine, enhancing the specificity and accuracy of chemotherapy regimen selection based on individual tumor profiles. Our predictive model, validated by independent datasets demonstrated improved accuracy over traditional methods. This strategy shows promise in overcoming typical challenges in high-dimensional genomic data analysis for cancer biomarker research.
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.24.24301749
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  4. Article ; Online: Looking Forward, Not Backward, on Watch and Wait for Rectal Cancer-In Reply.

    Smith, J Joshua / Garcia-Aguilar, Julio / Paty, Philip B

    JAMA oncology

    2019  Volume 5, Issue 8, Page(s) 1231

    Language English
    Publishing date 2019-06-26
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2019.1887
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reducing the Morbidity of Rectal Cancer Treatment.

    Paty, Philip B / Cercek, Andrea / Crane, Christopher H

    JAMA oncology

    2019  Volume 5, Issue 7, Page(s) 940–941

    MeSH term(s) Feasibility Studies ; Humans ; Magnetic Resonance Imaging ; Morbidity ; Prognosis ; Rectal Neoplasms
    Language English
    Publishing date 2019-04-11
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2019.0181
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  6. Article: Discovery of Oncogenic Mediator Genes in Rectal Cancer Chemotherapy Response using Gene Expression Data from Matched Tumor and Patient-Derived Organoid.

    Huang, Hanchen / Wu, Chao / Colaprico, Antonio / Bleu, Paulina / Zambare, Wini / Alvarez, Janet / Kim, Min Jung / Bercz, Aron / Wang, Lily / Paty, Philip B / Romesser, Paul B / Smith, J Joshua / Chen, X Steven

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: Rectal cancer (RC) presents significant treatment challenges, particularly in the context of chemotherapy resistance. Addressing this, our study pioneers the use of matched RC tumor tissue and patient-derived organoid (PDO) models coupled with the ... ...

    Abstract Rectal cancer (RC) presents significant treatment challenges, particularly in the context of chemotherapy resistance. Addressing this, our study pioneers the use of matched RC tumor tissue and patient-derived organoid (PDO) models coupled with the innovative computational tool, Moonlight, to explore the gene expression landscape of RC tumors and their response to chemotherapy. We analyzed 18 tissue samples and 32 matched PDOs, ensuring a high-fidelity representation of the tumor bioloy. Our comprehensive integration strategy involved differential expression analyses (DEAs) and gene regulatory network (GRN) analyses, facilitating the identification of 5,199 genes governing at least one regulon. By using the biological processes (BPs) collected from Moonlight closely related to cancer, we pinpointed 2,118 regulator-regulon groups with potential roles in oncogenic processes. Further, through integration of Moonlight and DEA results identified 334 regulator-regulon groups significantly enriched in both tissue and PDO samples, classifying them as oncogenic mediators (OMs). Among these, four genes (NCKAP1L, LAX1, RAD51AP1, and NAT2) demonstrated an association with drug responsiveness and recurrence-free survival (RFS), offering new insights into the molecular mechanisms of chemotherapy response in RC. Our integrated approach not only underscores the translational fidelity of PDOs, but also harnesses the analytical prowess of Moonlight, setting a new benchmark for targeted therapy research in rectal cancer.
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.29.24301906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Oncologic Outcomes of Salvage Abdominoperineal Resection for Anal Squamous Cell Carcinoma Initially Managed with Chemoradiation.

    Rosen, Roni / Quezada-Diaz, Felipe F / Gönen, Mithat / Karagkounis, Georgios / Widmar, Maria / Wei, Iris H / Smith, J Joshua / Nash, Garrett M / Weiser, Martin R / Paty, Philip B / Cercek, Andrea / Romesser, Paul B / Sanchez-Vega, Francisco / Adileh, Mohammad / Roth O'Brien, Diana / Hajj, Carla / Williams, Vonetta M / Shcherba, Marina / Gu, Ping /
    Crane, Christopher / Saltz, Leonard B / Garcia Aguilar, Julio / Pappou, Emmanouil

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082156
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  8. Article: Rectal Cancer after Prostate Radiation: A Complex and Controversial Disease.

    Omer, Dana M / Thompson, Hannah M / Verheij, Floris S / Yuval, Jonathan B / Rosen, Roni / Beets, Nathalie R A / Luthra, Anisha / Romesser, Paul B / Paty, Philip B / Garcia-Aguilar, Julio / Sanchez-Vega, Francisco

    Cancers

    2023  Volume 15, Issue 8

    Abstract: A small proportion of rectal adenocarcinomas develop in patients many years after the treatment of a previous cancer using pelvic radiation, and the incidence of these rectal cancers depends on the length of follow-up from the end of radiotherapy. The ... ...

    Abstract A small proportion of rectal adenocarcinomas develop in patients many years after the treatment of a previous cancer using pelvic radiation, and the incidence of these rectal cancers depends on the length of follow-up from the end of radiotherapy. The risk of radiation-associated rectal cancer (RARC) is higher in patients treated with prostate external beam radiotherapy than it is in patients treated with brachytherapy. The molecular features of RARC have not been fully investigated, and survival is lower compared to non-irradiated rectal cancer patients. Ultimately, it is unclear whether the worse outcomes are related to differences in patient characteristics, treatment-related factors, or tumor biology. Radiation is widely used in the management of rectal adenocarcinoma; however, pelvic re-irradiation of RARC is challenging and carries a higher risk of treatment complications. Although RARC can develop in patients treated for a variety of malignancies, it is most common in patients treated for prostate cancer. This study will review the incidence, molecular characteristics, clinical course, and treatment outcomes of rectal adenocarcinoma in patients previously treated with radiation for prostate cancer. For clarity, we will distinguish between rectal cancer not associated with prostate cancer (RCNAPC), rectal cancer in non-irradiated prostate cancer patients (RCNRPC), and rectal cancer in irradiated prostate cancer patients (RCRPC). RARC represents a unique but understudied subset of rectal cancer, and thus requires a more comprehensive investigation in order to improve its treatment and prognosis.
    Language English
    Publishing date 2023-04-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15082214
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  9. Article ; Online: Tumour deposits are independently associated with recurrence in colon cancer.

    Hakki, Lynn / Khan, Asama / Do, Eric / Gonen, Mithat / Firat, Canan / Vakiani, Efsevia / Shia, Jinru / Widmar, Maria / Wei, Iris H / Smith, J Joshua / Pappou, Emmanouil P / Nash, Garrett M / Paty, Philip B / Garcia-Aguilar, Julio / Weiser, Martin R

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2024  Volume 26, Issue 3, Page(s) 459–465

    Abstract: Aim: Tumour deposits are focal aggregates of cancer cells in pericolic fat and mesentery, distinct from vessels, nerves and lymphatics. Their presence upstages lymph node negative patients but is ignored in lymph node positive patients. We investigated ... ...

    Abstract Aim: Tumour deposits are focal aggregates of cancer cells in pericolic fat and mesentery, distinct from vessels, nerves and lymphatics. Their presence upstages lymph node negative patients but is ignored in lymph node positive patients. We investigated the clinicopathological factors associated with tumour deposits and their impact on recurrence in lymph node positive and negative patients.
    Method: Clinicopathological variables were collected from the medical records of patients with Stage I-III colon cancer who underwent resection in 2017-2019. Pathology was reviewed by a gastrointestinal pathologist. Patients with rectal cancer, metastasis, and concurrent malignancy were excluded.
    Results: Tumour deposits were noted in 69 (9%) of 770 patients. They were associated with the presence of lymph node metastasis, advanced T category, poorly differentiated tumours, microsatellite stable subtype and lymphovascular and perineural invasion (p < 0.05). The presence of tumour deposits (hazard ratio 2.48, 95% CI 1.49-4.10) and of lymph node metastasis (hazard ratio 3.04, 95% CI 1.72-5.37) were independently associated with decreased time to recurrence. There was a weak correlation (0.27) between the number of tumour deposits and the number of positive lymph nodes.
    Conclusion: Tumour deposits are associated with more advanced disease and high-risk pathological features. The presence of tumour deposits and lymph node metastasis were found to be independent risk factors for decreased time to recurrence. A patient with both lymph node metastasis and tumour deposits is more than twice as likely to have recurrence compared with a patient with only lymph node metastasis. Tumour deposits independently predict recurrence and should not be ignored in lymph node positive patients.
    MeSH term(s) Humans ; Lymphatic Metastasis/pathology ; Extranodal Extension/pathology ; Prognosis ; Retrospective Studies ; Colonic Neoplasms/surgery ; Colonic Neoplasms/pathology ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Neoplasm Staging
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.16873
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    Zs.A 5799: Show issues Location:
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  10. Article ; Online: Identification of a Subset of Stage I Colorectal Cancer Patients With High Recurrence Risk.

    Lee, Lik Hang / Davis, Lindy / Ylagan, Lourdes / Omilian, Angela R / Attwood, Kristopher / Firat, Canan / Shia, Jinru / Paty, Philip B / Cance, William G

    Journal of the National Cancer Institute

    2022  Volume 114, Issue 5, Page(s) 732–739

    Abstract: Background: A challenge in early-stage colorectal cancer (CRC) is identifying biomarkers that predict an increased risk for recurrence. A potential clinically adaptable biomarker is focal adhesion kinase (FAK), a tyrosine kinase that promotes invasion ... ...

    Abstract Background: A challenge in early-stage colorectal cancer (CRC) is identifying biomarkers that predict an increased risk for recurrence. A potential clinically adaptable biomarker is focal adhesion kinase (FAK), a tyrosine kinase that promotes invasion and metastasis.
    Methods: An initial, single-institution, 298-patient cohort with all stages of CRC and long-term follow-up was assessed for FAK with tissue microarrays using immunohistochemistry. FAK expression was scored and dichotomized into high and low. Subsequently, a validation cohort of 517 early-stage CRCs from a separate institution was evaluated. All statistical tests were 2-sided.
    Results: FAK overexpression did not correlate with any known histologic feature and was an early event in CRC, increasing from normal colon to stage I, and stage I to II, but not different at higher stages. High FAK was associated with decreased 10-year recurrence-free survival (RFS) among stage I patients (70.2% for high FAK vs 94.1% for low, P = .02), but not among higher stages in the initial cohort. The same finding was seen in the validation cohort (73.1% for high FAK vs 93.1% for low, P = .004). Multivariable survival analysis for stage I patients showed only two statistically significant factors predicting RFS: FAK (hazard ratio = 5.27, 95% confidence interval = 1.81 to 15.33, P = .002) and perineural invasion (hazard ratio = 7.38, 95% confidence interval = 1.01 to 53.96, P = .049). FAK was the only statistically significant factor in multivariable analysis across RFS, overall, and disease-specific survivals.
    Conclusions: High FAK expression identified a subset of stage I CRC patients with high incidence of recurrence and reduced survival, suggesting that FAK has important prognostic value. These patients would immediately benefit from more rigorous surveillance protocols for recurrent disease.
    MeSH term(s) Colorectal Neoplasms/pathology ; Humans ; Immunohistochemistry ; Neoplasm Staging ; Prognosis ; Proportional Hazards Models
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djac023
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