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  1. Book ; Thesis: Aurora B-Kinase-Inhibitor und Therapie mit elektrischen Feldern als neues adjuvantes Therapiekonzept in der Behandlung maligner Glioblastomrezidive

    Lachmann, Doris / Krex, Dietmar / Schaich, Markus

    2020  

    Institution Klinik und Poliklinik für Neurochirurgie
    Author's details von Doris Lachmann aus Annaberg-Buchholz ; Klinik und Poliklinik für Neurochirurgie [Dresden]
    Language German
    Size III, 97 Blätter, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2021
    HBZ-ID HT021129866
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 E 1337 order for loan Magazin

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  2. Article: Digitaler OP eröffnet neue Perspektiven in der Pflege

    Krex, Dietmar / Köbsch, Daniel

    Gesundheitsökonomie & Qualitätsmanagement

    2022  Volume 27, Issue 01, Page(s) 19–20

    Abstract: Die Digitalisierung verändert Prozesse und Abläufe, aber auch bestehende hierarchische Strukturen im OP. Dies birgt insbesondere für die OP-Pflege das Potenzial, sich neue Tätigkeitsfelder zu erschließen. Gleichzeitig müssen durch die veränderten ... ...

    Abstract Die Digitalisierung verändert Prozesse und Abläufe, aber auch bestehende hierarchische Strukturen im OP. Dies birgt insbesondere für die OP-Pflege das Potenzial, sich neue Tätigkeitsfelder zu erschließen. Gleichzeitig müssen durch die veränderten Modalitäten im digitalen OP neue organisatorische Strukturen etabliert werden.:
    Language German
    Publishing date 2022-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1376570-x
    ISSN 1439-4049 ; 1432-2625
    ISSN (online) 1439-4049
    ISSN 1432-2625
    DOI 10.1055/a-1708-9385
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4746: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Book ; Thesis: Daten zum perioperativen immunologischen Status bei Patienten mit Meningiomen und Glioblastomen

    Krex, Dietmar

    1992  

    Author's details vorgelegt von Dietmar Krex
    Language German
    Size 131 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Marburg, Univ., Diss., 1993
    HBZ-ID HT005021811
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    93 D 3535 order for loan Magazin

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  4. Article: Digitale Transformation: Digitaler OP eröffnet neue Perspektiven in der Pflege

    Krex, Dietmar / Köbsch, Daniel

    kma - Klinik Management aktuell

    2021  Volume 26, Issue 07/08, Page(s) 58–60

    Abstract: Die Digitalisierung verändert Prozesse und Abläufe, aber auch bestehende hierarchische Strukturen im OP. Dies birgt insbesondere für die OP-Pflege das Potenzial, sich neue Tätigkeitsfelder zu erschließen. Gleichzeitig müssen durch die veränderten ... ...

    Abstract Die Digitalisierung verändert Prozesse und Abläufe, aber auch bestehende hierarchische Strukturen im OP. Dies birgt insbesondere für die OP-Pflege das Potenzial, sich neue Tätigkeitsfelder zu erschließen. Gleichzeitig müssen durch die veränderten Modalitäten im digitalen OP neue organisatorische Strukturen etabliert werden.
    Language German
    Publishing date 2021-07-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2106067-8
    ISSN 2197-621X ; 1439-3514
    ISSN (online) 2197-621X
    ISSN 1439-3514
    DOI 10.1055/s-0041-1732895
    Database Thieme publisher's database

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  5. Conference proceedings: The effect of a novel Aurora-A kinase inhibitor in combination with tumour treating fields and temozolomide on glioblastoma cells

    Novikova, Kseniia / Michen, Susanne / Robel, Katja / Temme, Achim / Krex, Dietmar

    2022  , Page(s) V144

    Title translation Die Wirkung eines neuartigen Aurora-A-Kinase-Inhibitors in Kombination mit Tumortherapiefeldern und Temozolomid auf Glioblastomzellen
    Event/congress 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie; Köln; Deutsche Gesellschaft für Neurochirurgie; 2022
    Keywords Medizin, Gesundheit
    Publishing date 2022-05-25
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/22dgnc142
    Database German Medical Science

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  6. Conference proceedings: Surgery of malignant melanoma brain metastasis in the light of checkpoint-and BRAF/MEK inhibitor therapy

    Harlaß, Sophia / Hennig, Silke / Schackert, Gabriele / Meier, Friedegund / Krex, Dietmar

    2022  , Page(s) V168

    Title translation Der Stellenwert der Chirurgie bei Patienten mit Melanom-Hirnmetastasen nach Einführung der Checkpoint- und BRAF/MEK Inhibitor Therapie
    Event/congress 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie; Köln; Deutsche Gesellschaft für Neurochirurgie; 2022
    Keywords Medizin, Gesundheit
    Publishing date 2022-05-25
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/22dgnc164
    Database German Medical Science

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  7. Book ; Online ; Thesis: Aurora B-Kinase-Inhibitor und Therapie mit elektrischen Feldern als neues adjuvantes Therapiekonzept in der Behandlung maligner Glioblastomrezidive

    Lachmann, Doris [Verfasser] / Krex, Dietmar Gutachter] / [Schaich, Markus [Gutachter]

    2021  

    Author's details Doris Lachmann ; Gutachter: Dietmar Krex, Markus Schaich
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Technische Universität Dresden
    Publishing place Dresden
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  8. Conference proceedings: Genomic characterisation of IDH-Wildtype Glioblastoma in different age groups

    Richter, Sven / Stasik, Sebastian / Schackert, Gabriele / Thiede, Christian / Krex, Dietmar / Juratli, Tareq

    2022  , Page(s) V223

    Title translation Genomische Charakterisierung der IDH-Wildtyp Glioblastome in verschiedenen Altersgruppen
    Event/congress 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie; Köln; Deutsche Gesellschaft für Neurochirurgie; 2022
    Keywords Medizin, Gesundheit
    Publishing date 2022-05-25
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/22dgnc216
    Database German Medical Science

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  9. Conference proceedings: The correlation of microscopic intraoperative aspects, histological and radiological diagnostics in surgery of brain metastases

    Dybowski, Lena / Engellandt, Kay / Meinhardt, Matthias / Krex, Dietmar

    2020  , Page(s) P166

    Title translation Korrelation von radiologischen, histologischen und mikroskopisch intraoperativen Befunden bei der Resektion von Hirnmetastasen
    Event/congress 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie; sine loco [digital]; Deutsche Gesellschaft für Neurochirurgie; 2020
    Keywords Medizin, Gesundheit
    Publishing date 2020-06-26
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/20dgnc449
    Database German Medical Science

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  10. Article ; Online: Improved prognostic stratification of patients with isocitrate dehydrogenase-mutant astrocytoma.

    Weller, Michael / Felsberg, Jörg / Hentschel, Bettina / Gramatzki, Dorothee / Kubon, Nadezhda / Wolter, Marietta / Reusche, Matthias / Roth, Patrick / Krex, Dietmar / Herrlinger, Ulrich / Westphal, Manfred / Tonn, Joerg C / Regli, Luca / Maurage, Claude-Alain / von Deimling, Andreas / Pietsch, Torsten / Le Rhun, Emilie / Reifenberger, Guido

    Acta neuropathologica

    2024  Volume 147, Issue 1, Page(s) 11

    Abstract: Prognostic factors and standards of care for astrocytoma, isocitrate dehydrogenase (IDH)-mutant, CNS WHO grade 4, remain poorly defined. Here we sought to explore disease characteristics, prognostic markers, and outcome in patients with this newly ... ...

    Abstract Prognostic factors and standards of care for astrocytoma, isocitrate dehydrogenase (IDH)-mutant, CNS WHO grade 4, remain poorly defined. Here we sought to explore disease characteristics, prognostic markers, and outcome in patients with this newly defined tumor type. We determined molecular biomarkers and assembled clinical and outcome data in patients with IDH-mutant astrocytomas confirmed by central pathology review. Patients were identified in the German Glioma Network cohort study; additional cohorts of patients with CNS WHO grade 4 tumors were identified retrospectively at two sites. In total, 258 patients with IDH-mutant astrocytomas (114 CNS WHO grade 2, 73 CNS WHO grade 3, 71 CNS WHO grade 4) were studied. The median age at diagnosis was similar for all grades. Karnofsky performance status at diagnosis inversely correlated with CNS WHO grade (p < 0.001). Despite more intensive treatment upfront with higher grade, CNS WHO grade was strongly prognostic: median overall survival was not reached for grade 2 (median follow-up 10.4 years), 8.1 years (95% CI 5.4-10.8) for grade 3, and 4.7 years (95% CI 3.4-6.0) for grade 4. Among patients with CNS WHO grade 4 astrocytoma, median overall survival was 5.5 years (95% CI 4.3-6.7) without (n = 58) versus 1.8 years (95% CI 0-4.1) with (n = 12) homozygous CDKN2A deletion. Lower levels of global DNA methylation as detected by LINE-1 methylation analysis were strongly associated with CNS WHO grade 4 (p < 0.001) and poor outcome. MGMT promoter methylation status was not prognostic for overall survival. Histomolecular stratification based on CNS WHO grade, LINE-1 methylation level, and CDKN2A status revealed four subgroups of patients with significantly different outcomes. In conclusion, CNS WHO grade, global DNA methylation status, and CDKN2A homozygous deletion are prognostic in patients with IDH-mutant astrocytoma. Combination of these parameters allows for improved prediction of outcome. These data aid in designing upcoming trials using IDH inhibitors.
    MeSH term(s) Humans ; Astrocytoma/genetics ; Astrocytoma/therapy ; Cohort Studies ; Homozygote ; Isocitrate Dehydrogenase/genetics ; Prognosis ; Retrospective Studies ; Sequence Deletion
    Chemical Substances Isocitrate Dehydrogenase (EC 1.1.1.41) ; IDH1 protein, human (EC 1.1.1.42.)
    Language English
    Publishing date 2024-01-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1079-0
    ISSN 1432-0533 ; 0001-6322
    ISSN (online) 1432-0533
    ISSN 0001-6322
    DOI 10.1007/s00401-023-02662-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui II Zs.188: Show issues Location:
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