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Article ; Online: The relationship between β-amylase and the degradation of starch temporarily stored in rice leaf blades.

Sugimura, Yu / Fukayama, Hiroshi / Michiyama, Hiroyasu / Hirano, Tatsuya

Bioscience, biotechnology, and biochemistry

2023 Volume 87, Issue 7, Page(s) 736–741

Abstract: Starch is stored temporarily in the leaves during the day but degraded during the night. In this study, we investigated the relationship between diurnal changes in starch content in rice leaf blades and the mRNA levels of β-amylase genes. In addition to ... ...

Abstract	Starch is stored temporarily in the leaves during the day but degraded during the night. In this study, we investigated the relationship between diurnal changes in starch content in rice leaf blades and the mRNA levels of β-amylase genes. In addition to the known plastid-type β-amylases OsBAM2 and OsBAM3, OsBAM4, and OsBAM5 were also identified as plastid targeted proteins. In the leaf blades, starch contents, which reached its maximum at the end of day, showed two periods of marked decrease: from 18:00 to 21:00 and from 24:00 to 6:00. The expression of OsBAM2, OsBAM3, OsBAM4, and OsBAM5 was maintained at a low level from 18:00 to 21:00 but increased strongly after midnight. Furthermore, β-amylase activity gradually increased after 21:00, reaching a maximum during the early morning. These results suggest that in rice leaf blades, β-amylase plays an important role in starch degradation by being highly active from midnight to dawn.
MeSH term(s)	Starch/metabolism ; beta-Amylase/genetics ; Oryza/genetics ; Oryza/metabolism ; Plant Leaves/genetics ; Plant Leaves/metabolism ; Carbohydrate Metabolism
Chemical Substances	Starch (9005-25-8) ; beta-Amylase (EC 3.2.1.2)
Language	English
Publishing date	2023-05-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1106450-x
ISSN	1347-6947 ; 0916-8451
ISSN (online)	1347-6947
ISSN	0916-8451
DOI	10.1093/bbb/zbad052
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Zs.A 4647: Show issues

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Article ; Online: Characterization of proteinous coagulant in Moringa tree seeds for water purification: Stepwise laboratory exercise for high-school students.

Oyama, Hiroshi / Nabeshima, Yuka / Morimoto, Koichi / Sugimura, Yukio

Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

2023 Volume 51, Issue 5, Page(s) 588–599

Abstract: Coagulation is an important process in the context of water purification; and the seed protein of the moringa tree (Moringa oleifera) is a remarkably effective coagulant. The laboratory course described here is designed to provide high-school students ... ...

Abstract	Coagulation is an important process in the context of water purification; and the seed protein of the moringa tree (Moringa oleifera) is a remarkably effective coagulant. The laboratory course described here is designed to provide high-school students with a stepwise, hands-on experience in investigating the protein-rich coagulant found in Moringa seeds. First, the seed powder was applied to model polluted water containing fine clay, food dyes, copper sulfate, and bacteria. This treatment changed the polluted water into clear water via coagulation; all students were convinced that the coagulation-inducing agent was a thermostable cationic protein. Finally, basic biochemical techniques (e.g., chromatographic separation and electrophoresis) were used to show that the target coagulant is a dimeric protein composed of 6.5 and 4.5 kDa subunits. Overall, this made it possible for the students to gain a deeper understanding (more comprehensive than the information taught in formal classes) of protein structure and its real-world implications. This stepwise exercise can be applied to research-based learning programs in high school, as it is an effective learning tool.
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2039717-3
ISSN	1539-3429 ; 1470-8175
ISSN (online)	1539-3429
ISSN	1470-8175
DOI	10.1002/bmb.21763
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Article: Robot-assisted radical nephroureterectomy for right renal pelvic tumor post sacrocolpopexy with mesh: A case report.

Sugimura, Koki / Kira, Satoru / Shimura, Hiroshi / Mochizuki, Takanori / Sawada, Norifumi / Mitsui, Takahiko

International journal of surgery case reports

2024 Volume 117, Page(s) 109523

Abstract: Introduction: Robot-assisted nephroureterectomy for upper tract urothelial carcinoma has been increasingly performed as a minimally invasive procedure recently. However, there are concerns regarding its adoption in highly complex cases with dense ... ...

Abstract	Introduction: Robot-assisted nephroureterectomy for upper tract urothelial carcinoma has been increasingly performed as a minimally invasive procedure recently. However, there are concerns regarding its adoption in highly complex cases with dense adhesions. Presentation of case: An 86-year-old woman presented to our hospital with gross hematuria one year after having undergone robot-assisted sacrocolpopexy using a mesh for pelvic organ prolapse. Cystoscopy revealed hematuria from the right ureteral orifice. Computed tomography suggested right hydronephrosis; retrograde pyelography showed a defect in the right renal pelvis with class V urine cytology of the urine from the right kidney. Based on these findings, a right renal pelvic tumor was diagnosed, and robot-assisted nephroureterectomy was performed. The patient was discharged on postoperative day 7 without complications. Discussion: To the best of our knowledge, this is the first case report in which robot-assisted radical nephroureterectomy was performed after robot-assisted sacrocolpopexy with a mesh. Dense tissue adhesions are encountered not only between the bladder and the anterior vaginal wall but also around the right ureter in the pelvis. In this case, dense adhesions were confirmed around the right ureter in the pelvis. Conclusion: Robot-assisted nephroureterectomy may be considered an option for minimally invasive surgery in cases with a history of pelvic organ prolapse surgery using mesh.
Language	English
Publishing date	2024-03-15
Publishing country	Netherlands
Document type	Case Reports
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2024.109523
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Article ; Online: Prognostic impact of nodal status and lymphovascular invasion in patients undergoing neoadjuvant chemotherapy for esophageal squamous cell carcinoma.

Miyata, Hiroshi / Sugimura, Keijirou / Kanemura, Takashi / Takeoka, Tomohira / Sugase, Takahito / Yasui, Masayoshi / Nishimura, Junichi / Wada, Hiroshi / Akita, Hiroshi / Yamamoto, Masaaki / Hara, Hisashi / Shinno, Naoki / Omori, Takeshi / Yano, Masahiko

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

2024

Abstract: Nodal status is well known to be the most important prognostic factor for esophageal cancer patients, even if they are treated with neoadjuvant therapy. To establish an optimal postoperative adjuvant strategy for patients, we aimed to more accurately ... ...

Abstract	Nodal status is well known to be the most important prognostic factor for esophageal cancer patients, even if they are treated with neoadjuvant therapy. To establish an optimal postoperative adjuvant strategy for patients, we aimed to more accurately predict the prognosis of patients and systemic recurrence by using clinicopathological factors, including nodal status, in patients with esophageal cancer who received neoadjuvant chemotherapy. The clinicopathological factors associated with survival and systemic recurrence were investigated in 488 patients with esophageal squamous cell carcinoma who received neoadjuvant chemotherapy. Overall survival differed according to tumor depth, nodal status, tumor regression, and lymphovascular (LV) invasion. In the multivariate analysis, nodal status and LV invasion were identified as independent prognostic factors (P < 0.0001, P = 0.0008). Nodal status was also identified as an independent factor associated with systemic recurrence, although LV invasion was a borderline factor (P = 0.066). In each pN stage, patients with LV invasion showed significantly worse overall survival than those without LV invasion (pN0: P = 0.036, pN1: P = 0.0044, pN2: P = 0.0194, pN3: P = 0.0054). Patients with LV invasion were also more likely to have systemic, and any recurrence than those without LV invasion in each pN stage. Pathological nodal status and LV invasion were the most important predictors of survival and systemic recurrence in patients with esophageal cancer who underwent neoadjuvant chemotherapy followed by surgery. This finding could provide useful information about selecting candidates for adjuvant therapy among these patients. Our analysis showed that LV invasion was an independent prognostic factor in patients with esophageal cancer who underwent neoadjuvant chemotherapy and that combining LV invasion with pathological nodal status makes it possible to stratify the prognosis in those patients.
Language	English
Publishing date	2024-05-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	639470-x
ISSN	1442-2050 ; 1120-8694
ISSN (online)	1442-2050
ISSN	1120-8694
DOI	10.1093/dote/doae038
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Zs.A 2378: Show issues

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Article ; Online: Correction to: Intravenous ferric derisomaltose versus saccharated ferric oxide for iron deficiency anemia associated with menorrhagia: a randomized, open-label, active-controlled, noninferiority study.

Kawabata, Hiroshi / Tamura, Takeshi / Tamai, Soichiro / Fujibayashi, Akiko / Sugimura, Motoi

International journal of hematology

2022 Volume 116, Issue 6, Page(s) 976–977

Language	English
Publishing date	2022-11-08
Publishing country	Japan
Document type	Published Erratum
ZDB-ID	1076875-0
ISSN	1865-3774 ; 0917-1258 ; 0925-5710
ISSN (online)	1865-3774
ISSN	0917-1258 ; 0925-5710
DOI	10.1007/s12185-022-03485-8
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Article ; Online: Effect of rechallenge nivolumab in a hemodialysis patient with multiple metastases from a rapidly progressed T1a renal clear cell carcinoma: An autopsy case.

Hanawa, Kazushi / Sawada, Norifumi / Yokota, Yuka / Aikawa, Junki / Otake, Yuko / Sugimura, Koki / Shimura, Hiroshi / Mochizuki, Takanori / Kira, Satoru / Mitsui, Takahiko

IJU case reports

2024 Volume 7, Issue 3, Page(s) 202–205

Abstract: Introduction: Distant metastasis of T1a renal cell carcinoma is rare and whether metastasis is more probable in patients undergoing hemodialysis remains unclear. We report the autopsy case of a patient undergoing hemodialysis with multiple metastases ... ...

Abstract	Introduction: Distant metastasis of T1a renal cell carcinoma is rare and whether metastasis is more probable in patients undergoing hemodialysis remains unclear. We report the autopsy case of a patient undergoing hemodialysis with multiple metastases that rapidly progressed from T1a renal cell carcinoma treated with multimodal therapy including nivolumab. Case presentation: A 70-year-old male who underwent hemodialysis was diagnosed with clear cell carcinoma (pT1a, G2) after nephrectomy. Six months post-surgery, bone and lung metastases appeared and treated with radiotherapy and pazopanib, respectively. Nivolumab was administered as second- and fourth-line treatments for lung metastases. The patient died approximately 60 months after initial diagnosis; however, nivolumab controlled disease progression for 24 months. An autopsy revealed the lung's occupation with clear cell carcinoma tumor tissue. Conclusion: Nivolumab has potential to control lung metastasis progression. Additionally, rechallenge is possible in patients with renal cell carcinoma undergoing hemodialysis.
Language	English
Publishing date	2024-02-14
Publishing country	Australia
Document type	Case Reports
ISSN	2577-171X
ISSN (online)	2577-171X
DOI	10.1002/iju5.12699
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Article ; Online: Association between intrapleural urokinase monotherapy and treatment failure in patients with pleural infection: a retrospective cohort study.

Taniguchi, Jumpei / Matsui, Hiroki / Nagai, Tatsuya / Otsuki, Ayumu / Ito, Hiroyuki / Sugimura, Hiroshi / Nakashima, Kei

BMC pulmonary medicine

2023 Volume 23, Issue 1, Page(s) 273

Abstract: Background: Pleural infection, an infection of the pleural space, is frequently treated with antibiotics and thoracic tube drainage. In case of insufficient drainage, an intrapleural fibrinolytic agent is considered before surgical intervention. However, ...

Abstract	Background: Pleural infection, an infection of the pleural space, is frequently treated with antibiotics and thoracic tube drainage. In case of insufficient drainage, an intrapleural fibrinolytic agent is considered before surgical intervention. However, the effectiveness of fibrinolytic monotherapy is still controversial. Therefore, we aimed to examine the association between urokinase monotherapy and treatment failure in patients with pleural infection. Methods: In this retrospective observational study, patients with pleural infection underwent chest tube insertion were divided into two groups including patients treated with or without intrapleural instillation of urokinase. The propensity score overlap weighting was used to balance the baseline characteristics between the groups. Treatment failure was defined by the composite primary outcome of in-hospital death and referral for surgery. Results: Among the 94 patients, 67 and 27 patients were in the urokinase and non-urokinase groups, respectively. Urokinase monotherapy improved the composite outcome between the groups (19.4% vs. 48.1%, p = 0.01). After adjusting using propensity score overlap weighting, urokinase monotherapy improved the composite outcome compared to the non-urokinase group (19.0% vs. 59.5%, p = 0.003). Conclusions: Urokinase monotherapy can be an important nonsurgical treatment option for patients with pleural infection. Trial registration: The participants were retrospectively registered.
MeSH term(s)	Humans ; Urokinase-Type Plasminogen Activator/therapeutic use ; Empyema, Pleural/therapy ; Pleural Effusion/drug therapy ; Hospital Mortality ; Retrospective Studies ; Pleural Diseases/drug therapy ; Treatment Failure
Chemical Substances	Urokinase-Type Plasminogen Activator (EC 3.4.21.73)
Language	English
Publishing date	2023-07-21
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-023-02559-5
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Article ; Online: Intravenous ferric derisomaltose versus saccharated ferric oxide for iron deficiency anemia associated with menorrhagia: a randomized, open-label, active-controlled, noninferiority study.

Kawabata, Hiroshi / Tamura, Takeshi / Tamai, Soichiro / Fujibayashi, Akiko / Sugimura, Motoi

International journal of hematology

2022 Volume 116, Issue 5, Page(s) 647–658

Abstract: A multicenter, randomized, open-label, phase III study was conducted to compare the efficacy and safety of intravenous ferric derisomaltose (FDI) versus saccharated ferric oxide (SFO) in Japanese patients with iron deficiency anemia associated with ... ...

Abstract	A multicenter, randomized, open-label, phase III study was conducted to compare the efficacy and safety of intravenous ferric derisomaltose (FDI) versus saccharated ferric oxide (SFO) in Japanese patients with iron deficiency anemia associated with menorrhagia. FDI can be administered as a single dose up to 1000 mg, whereas SFO has a maximum single dose of 120 mg. The primary endpoint, which was the maximum change in hemoglobin concentration from baseline, was noninferior for the FDI group compared with the SFO group. The incidence of treatment-emergent adverse events was lower in the FDI group (66.2%) than in the SFO group (90.8%). Notably, the incidence of serum phosphorus level < 2.0 mg/dL was significantly lower in the FDI group (8.4%) than in the SFO group (83.2%), and severe hypophosphatemia (≤ 1.0 mg/dL) occurred in 6.7% of SFO‑treated patients compared with none in the FDI group. The percentage of patients who achieved the cumulative total iron dose during the 8-week treatment period was higher in the FDI group (92.8%) than in the SFO group (43.2%). The study met its primary endpoint, and also demonstrated the tolerability of a high dose of FDI per infusion, with a lower incidence of hypophosphatemia.
MeSH term(s)	Female ; Humans ; Anemia, Iron-Deficiency/drug therapy ; Anemia, Iron-Deficiency/etiology ; Ferric Compounds/therapeutic use ; Ferric Oxide, Saccharated/adverse effects ; Hemoglobins/analysis ; Hypophosphatemia/chemically induced ; Iron ; Iron Deficiencies ; Menorrhagia/complications ; Menorrhagia/drug therapy ; Phosphorus/blood
Chemical Substances	Ferric Compounds ; ferric derisomaltose (AHU547PI9H) ; Ferric Oxide, Saccharated (FZ7NYF5N8L) ; Hemoglobins ; Iron (E1UOL152H7) ; Phosphorus (27YLU75U4W)
Language	English
Publishing date	2022-07-06
Publishing country	Japan
Document type	Clinical Trial, Phase III ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	1076875-0
ISSN	1865-3774 ; 0917-1258 ; 0925-5710
ISSN (online)	1865-3774
ISSN	0917-1258 ; 0925-5710
DOI	10.1007/s12185-022-03401-0
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Article ; Online: ASO Author Reflections: Clinical Impact of Conversion Surgery After Induction Therapy for Esophageal Cancer with Synchronous Distant Metastasis: A Multi-institutional, Retrospective Study.

Sugimura, Keijiro / Tanaka, Koji / Sugase, Takahito / Momose, Kota / Kanemura, Takashi / Yamashita, Kotaro / Makino, Tomoki / Shiraishi, Osamu / Motoori, Masaaki / Yamasaki, Makoto / Miyata, Hiroshi / Fujitani, Kazumasa / Yasuda, Takushi / Yano, Masahiko / Eguchi, Hidetoshi / Doki, Yuichiro

Annals of surgical oncology

2024 Volume 31, Issue 5, Page(s) 3475–3476

MeSH term(s)	Humans ; Retrospective Studies ; Induction Chemotherapy ; Esophageal Neoplasms/surgery ; Esophagectomy
Language	English
Publishing date	2024-02-24
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-024-15007-3
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Article ; Online: Cholesterol as a Subsidiary Component of Sorbitan Surfactant-Based Aggregates: A Study of Formation, Hydrophobicity, and Estimation of Localization of Embedded Molecules.

Hayashi, Keita / Ota, Hikaru / Sugimura, Haruna / Shimanouchi, Toshinori / Iwasaki, Tomoyuki / Fujita, Sakiko / Nakamura, Hidemi / Umakoshi, Hiroshi

The journal of physical chemistry. B

2023 Volume 127, Issue 10, Page(s) 2214–2223

Abstract: Aggregates of amphiphilic molecules can be used as drug carriers, for which the properties can be modified by mixing with other molecules such as cholesterol. It is important to understand the effects of such additives on the properties because they ... ...

Abstract	Aggregates of amphiphilic molecules can be used as drug carriers, for which the properties can be modified by mixing with other molecules such as cholesterol. It is important to understand the effects of such additives on the properties because they directly define the material functions. In this work, we investigated the effect of cholesterol on the formation and hydrophobicity of aggregates of sorbitan surfactants. As cholesterol changed its formation from micelles to vesicles, an increase in hydrophobicity was seen, particularly in the middle regions compared with the shallow and deep regions. We show that this gradual hydrophobicity is related to the localization of the embedded molecules. 4-Hydroxy-TEMPO and 4-carboxy-TEMPO were preferentially localized in the shallow region of the aggregates, whereas 4-PhCO
Language	English
Publishing date	2023-03-07
Publishing country	United States
Document type	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.2c08153
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