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  1. Article ; Online: Romosozumab and Renal Function.

    Watts, Nelson B

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    2022  Volume 37, Issue 8, Page(s) 1435–1436

    MeSH term(s) Antibodies, Monoclonal/pharmacology ; Bone Density ; Bone Density Conservation Agents ; Female ; Humans ; Kidney/physiology ; Osteoporosis, Postmenopausal
    Chemical Substances Antibodies, Monoclonal ; Bone Density Conservation Agents ; romosozumab (3VHF2ZD92J)
    Language English
    Publishing date 2022-07-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 632783-7
    ISSN 1523-4681 ; 0884-0431
    ISSN (online) 1523-4681
    ISSN 0884-0431
    DOI 10.1002/jbmr.4645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2142: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Letter to the Editor From Watts and Leslie: Comparisons Between Different Antiosteoporosis Medications on Postfracture Mortality: A Population-based Study.

    Watts, Nelson B / Leslie, William D

    The Journal of clinical endocrinology and metabolism

    2023  Volume 108, Issue 12, Page(s) e1759

    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgad317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.134: Show issues Location:
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  3. Article ; Online: Letter to the Editor: "Risk for Infections During Treatment With Denosumab for Osteoporosis: a Systematic Review and Meta-Analysis".

    Watts, Nelson B

    The Journal of clinical endocrinology and metabolism

    2020  Volume 105, Issue 8

    MeSH term(s) Bone Density Conservation Agents/adverse effects ; Denosumab/adverse effects ; Humans ; Osteoporosis/drug therapy
    Chemical Substances Bone Density Conservation Agents ; Denosumab (4EQZ6YO2HI)
    Language English
    Publishing date 2020-05-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgaa295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Updates on Osteoporosis in Men.

    Diab, Dima L / Watts, Nelson B

    Endocrinology and metabolism clinics of North America

    2021  Volume 50, Issue 2, Page(s) 239–249

    Abstract: Osteoporosis is less common in men than women; however, the mortality rate associated with major fragility fractures is higher in men. The diagnosis of osteoporosis is established by measurement of bone mineral density or by the presence of a fragility ... ...

    Abstract Osteoporosis is less common in men than women; however, the mortality rate associated with major fragility fractures is higher in men. The diagnosis of osteoporosis is established by measurement of bone mineral density or by the presence of a fragility fracture, especially spine or hip fracture. However, many men at high risk of fracture will not meet the T-score criteria for osteoporosis, so fracture risk calculation, with a tool such as FRAX, should be performed. Bone-active agents should be prescribed for men at high risk of fracture to decrease fracture risk, and therapy must be individualized.
    MeSH term(s) Bone Density ; Bone and Bones ; Female ; Hip Fractures/complications ; Humans ; Male ; Osteoporosis/diagnosis ; Osteoporosis/etiology ; Osteoporosis/therapy ; Osteoporotic Fractures/epidemiology ; Osteoporotic Fractures/etiology ; Osteoporotic Fractures/prevention & control ; Risk Assessment ; Risk Factors
    Language English
    Publishing date 2021-04-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92116-6
    ISSN 1558-4410 ; 0889-8529
    ISSN (online) 1558-4410
    ISSN 0889-8529
    DOI 10.1016/j.ecl.2021.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 148: Show issues Location:
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  5. Book: Postmenopausal osteoporosis

    Watts, Nelson B.

    an update ; focus on primary care

    (Obstetrical and gynecological survey ; 55,12, Suppl. 3)

    2000  

    Author's details Nelson B. Watts
    Series title Obstetrical and gynecological survey ; 55,12, Suppl. 3
    Obstetrical & gynecological survey
    Collection Obstetrical & gynecological survey
    Language English
    Size S. S49 - S55 : graph. Darst.
    Publisher Lippincott Williams & Wilkins
    Publishing place S.l.
    Publishing country United States
    Document type Book
    HBZ-ID HT012914811
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Um I Zs 218 -55,Suppl.3- verfügbar in Königswinter Königswinter

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  6. Article ; Online: Postmenopausal Osteoporosis: A Clinical Review.

    Watts, Nelson B

    Journal of women's health (2002)

    2018  Volume 27, Issue 9, Page(s) 1093–1096

    Abstract: In postmenopausal women, osteoporotic fractures are more common than stroke, myocardial infarction, and breast cancer combined, and fractures can be costly and result in disability or death. Because there are no signs or symptoms of osteoporosis other ... ...

    Abstract In postmenopausal women, osteoporotic fractures are more common than stroke, myocardial infarction, and breast cancer combined, and fractures can be costly and result in disability or death. Because there are no signs or symptoms of osteoporosis other than fracture, risk assessment is necessary to identify those at higher risk for clinical events. For women, a clinical fracture risk assessment (FRAX) is appropriate at menopause. Bone mineral density (BMD) measurement is recommended for women at age 65, and earlier for those who have risk factors. Adequate calcium, vitamin D, and weight-bearing exercise are important for bone health at all ages, and those at high risk for fracture based on BMD or FRAX should be offered medical therapy to reduce fracture risk after an appropriate medical evaluation. Bisphosphonates can accumulate in bone, so after a period of treatment, lower risk patients may be offered a period off drug therapy. However, the effects of denosumab are not sustained when treatment is discontinued, so there is no "drug holiday" with denosumab. Anabolic therapy can be offered to those with higher risk for fracture. Although rare safety concerns regarding atypical femoral fracture and osteonecrosis of the jaw have received prominent attention, for patients who are appropriately treated according to National Osteoporosis Foundation guidelines, the benefit of hip fracture risk reduction far outweighs the risk of these uncommon side effects. Accurate information for patients and shared decision-making are important for acceptance and persistent with appropriate treatment.
    MeSH term(s) Aged ; Aged, 80 and over ; Bone Density/drug effects ; Bone Density Conservation Agents/adverse effects ; Bone Density Conservation Agents/therapeutic use ; Denosumab/therapeutic use ; Diphosphonates/therapeutic use ; Female ; Humans ; Osteoporosis, Postmenopausal/drug therapy ; Osteoporotic Fractures/physiopathology ; Osteoporotic Fractures/prevention & control ; Risk Assessment ; Risk Factors
    Chemical Substances Bone Density Conservation Agents ; Diphosphonates ; Denosumab (4EQZ6YO2HI)
    Language English
    Publishing date 2018-03-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1139774-3
    ISSN 1931-843X ; 1059-7115 ; 1540-9996
    ISSN (online) 1931-843X
    ISSN 1059-7115 ; 1540-9996
    DOI 10.1089/jwh.2017.6706
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3584: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book: Osteoporosis

    Watts, Nelson B.

    (Endocrinology and metabolism clinics of North America ; 27,2)

    1998  

    Author's details Nelson B. Watts, guest ed
    Series title Endocrinology and metabolism clinics of North America ; 27,2
    Collection
    Language English
    Size XII S., S. 255 - 502 S. : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT008741097
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 148 -27,2- verfügbar in Königswinter Königswinter

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  8. Article: American Association of Clinical Endocrinologists/American College of Endocrinology Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis-2020 Update.

    Watts, Nelson B / Camacho, Pauline M / Lewiecki, E Michael / Petak, Steven M

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2021  Volume 27, Issue 4, Page(s) 379–380

    MeSH term(s) Endocrinologists ; Endocrinology ; Female ; Humans ; Osteoporosis, Postmenopausal/diagnosis ; Osteoporosis, Postmenopausal/therapy ; Societies, Medical ; United States
    Language English
    Publishing date 2021-02-09
    Publishing country United States
    Document type Letter
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.1016/j.eprac.2021.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5034: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 508: Show issues

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  9. Article ; Online: Long-term risks of bisphosphonate therapy.

    Watts, Nelson B

    Arquivos brasileiros de endocrinologia e metabologia

    2014  Volume 58, Issue 5, Page(s) 523–529

    Abstract: The objective this study was to summarize long-term risks associated with bisphosphonate therapy. Search of relevant medical publications for data from clinical trials, trial extensions, observational studies and post-marketing reports. Trial extensions ... ...

    Abstract The objective this study was to summarize long-term risks associated with bisphosphonate therapy. Search of relevant medical publications for data from clinical trials, trial extensions, observational studies and post-marketing reports. Trial extensions and modifications did not reveal significant long-term safety issues. Observational data suggest at least as many benefits as risks. Post-marketing reports of musculoskeletal pain, osteonecrosis of the jaw and atypical femur fractures have been widely circulated in the lay press. Most focus on long-terms risks has been on osteonecrosis of the jaw and atypical femur fractures which occur in patients who have not received bisphosphonate therapy but may be more frequent (though still uncommon) in patients who have been on treatment for 5 years or longer. Lower-risk patients may be able to stop treatment after 3-5 years for a "drug holiday," which mitigates these long-term risks; for higher risk patients, therapy through 6-10 years appears to be advisable and offers more benefits than risks.
    MeSH term(s) Atrial Fibrillation/chemically induced ; Bisphosphonate-Associated Osteonecrosis of the Jaw/etiology ; Bone Density Conservation Agents/adverse effects ; Bone Density Conservation Agents/therapeutic use ; Carcinoma/chemically induced ; Clinical Trials as Topic ; Diphosphonates/adverse effects ; Diphosphonates/therapeutic use ; Esophageal Neoplasms/chemically induced ; Femoral Fractures/chemically induced ; Humans ; Long-Term Care ; Musculoskeletal Pain/chemically induced ; Osteonecrosis/chemically induced ; Osteoporosis/drug therapy ; Protective Factors ; Risk Assessment ; Risk Factors
    Chemical Substances Bone Density Conservation Agents ; Diphosphonates
    Language English
    Publishing date 2014-08-25
    Publishing country Brazil
    Document type Journal Article ; Review
    ZDB-ID 603919-4
    ISSN 1677-9487 ; 0004-2730
    ISSN (online) 1677-9487
    ISSN 0004-2730
    DOI 10.1590/0004-2730000003308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 264: Show issues Location:
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  10. Article ; Online: Insights from the Global Longitudinal Study of Osteoporosis in Women (GLOW).

    Watts, Nelson B

    Nature reviews. Endocrinology

    2014  Volume 10, Issue 7, Page(s) 412–422

    Abstract: GLOW is an observational, longitudinal, practice-based cohort study of osteoporosis in 60,393 women aged ≥55 years in 10 countries on three continents. In this Review, we present insights from the first 3 years of the study. Despite cost analyses being ... ...

    Abstract GLOW is an observational, longitudinal, practice-based cohort study of osteoporosis in 60,393 women aged ≥55 years in 10 countries on three continents. In this Review, we present insights from the first 3 years of the study. Despite cost analyses being frequently based on spine and hip fractures, we found that nonvertebral, nonhip fractures were around five times more common and doubled the use of health-care resources compared with hip and spine fractures combined. Fractures not at the four so-called major sites in FRAX(®) (upper arm, forearm, hip and clinical vertebral fractures) account for >40% of all fractures. The risk of fracture is increased by various comorbidities, such as Parkinson disease, multiple sclerosis and lung and heart disease. Obesity, although thought to be protective against all fractures, substantially increased the risk of fractures in the ankle or lower leg. Simple assessment by age plus fracture history has good predictive value for all fractures, but risk profiles differ for first and subsequent fractures. Fractures diminish quality of life as much or more than diabetes mellitus, arthritis and lung disease, yet women substantially underestimate their own fracture risk. Treatment rates in patients at high risk of fracture are below those recommended but might be too frequent in women at low risk. Comorbidities and the limits of current therapeutic regimens jeopardize the efficacy of drugs; new regimens should be explored for severe cases.
    MeSH term(s) Accidental Falls/statistics & numerical data ; Aged ; Aged, 80 and over ; Comorbidity ; Female ; Hip Fractures/epidemiology ; Hospitalization/trends ; Humans ; Longitudinal Studies ; Middle Aged ; Obesity/complications ; Osteoporosis/complications ; Osteoporosis/economics ; Osteoporosis, Postmenopausal/drug therapy ; Osteoporotic Fractures/epidemiology ; Prevalence ; Quality of Life ; Risk ; Risk Factors ; Spinal Fractures/epidemiology
    Language English
    Publishing date 2014-04-22
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/nrendo.2014.55
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 93: Show issues

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