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Article ; Online: Schistosomiasis and hookworm infection in humans: Disease burden, pathobiology and anthelmintic vaccines.

Anisuzzaman / Tsuji, Naotoshi

2020 Volume 75, Page(s) 102051

Abstract: Helminth diseases are the ancient scourges of humans and their damages are 'silent and insidious'. Of the helminth infections, schistosomiasis and hookworm infection have a great impact. This review covers information regarding vaccine candidates against ...

Abstract	Helminth diseases are the ancient scourges of humans and their damages are 'silent and insidious'. Of the helminth infections, schistosomiasis and hookworm infection have a great impact. This review covers information regarding vaccine candidates against schistosomiasis and hookworms that reached at least up to the phase-1 trial and literatures regarding other vaccine candidates have been excluded. For clinical manifestations, all available literatures were included, and for epidemiology and global burden of the diseases (GBD), literatures only within 2000-2019 were included. Literatures were searched surfing various databases including PubMED, Google Scholar, and Science Direct and overall over 150 literatures were identified. Globally ~250 million people are suffering from schistosomiasis, resulting 1430 thousand DALY (disability adjusted life year) per year. On the other hand, about 1.3 billion people are infected with hookworm (HW), and according to WHO, ~878 million school-age children (SAC) are at risk. HW is estimated to cause 65,000 deaths annually, accounts for 845 thousand DALYs as well as to cause 6-35.3% loss in productivity. Despite tremendous efforts, very few anthelmintic vaccine candidates such as Na-GST-1, Na-APR-1 and Na-ASP-2 against HW, and Sm28GST/Sh28GST, Sm-p80, Sm14 and Sm-TSP-1/SmTSP-2 against schistosomiasis reached up to the clinical trials. More efforts are needed to achieve the WHO targets taken against the maladies.
MeSH term(s)	Cost of Illness ; Hookworm Infections/parasitology ; Hookworm Infections/prevention & control ; Humans ; Schistosomiasis/parasitology ; Schistosomiasis/prevention & control ; Vaccines/analysis ; Vaccines/therapeutic use
Chemical Substances	Vaccines
Language	English
Publishing date	2020-01-03
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1363151-2
ISSN	1873-0329 ; 1383-5769
ISSN (online)	1873-0329
ISSN	1383-5769
DOI	10.1016/j.parint.2020.102051
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Article: Schistosomiasis and hookworm infection in humans: Disease burden, pathobiology and anthelmintic vaccines

Anisuzzaman / Tsuji, Naotoshi

Parasitology international. 2020 Apr., v. 75

2020

Abstract: Helminth diseases are the ancient scourges of humans and their damages are ‘silent and insidious’. Of the helminth infections, schistosomiasis and hookworm infection have a great impact. This review covers information regarding vaccine candidates against ...

Abstract	Helminth diseases are the ancient scourges of humans and their damages are ‘silent and insidious’. Of the helminth infections, schistosomiasis and hookworm infection have a great impact. This review covers information regarding vaccine candidates against schistosomiasis and hookworms that reached at least up to the phase-1 trial and literatures regarding other vaccine candidates have been excluded. For clinical manifestations, all available literatures were included, and for epidemiology and global burden of the diseases (GBD), literatures only within 2000–2019 were included. Literatures were searched surfing various databases including PubMED, Google Scholar, and Science Direct and overall over 150 literatures were identified. Globally ~250 million people are suffering from schistosomiasis, resulting 1430 thousand DALY (disability adjusted life year) per year. On the other hand, about 1.3 billion people are infected with hookworm (HW), and according to WHO, ~878 million school-age children (SAC) are at risk. HW is estimated to cause 65,000 deaths annually, accounts for 845 thousand DALYs as well as to cause 6–35.3% loss in productivity. Despite tremendous efforts, very few anthelmintic vaccine candidates such as Na-GST-1, Na-APR-1 and Na-ASP-2 against HW, and Sm28GST/Sh28GST, Sm-p80, Sm14 and Sm-TSP-1/SmTSP-2 against schistosomiasis reached up to the clinical trials. More efforts are needed to achieve the WHO targets taken against the maladies.
Keywords	anthelmintics ; clinical trials ; databases ; disability-adjusted life year ; hookworms ; human diseases ; humans ; risk ; schistosomiasis ; school children ; vaccines
Language	English
Dates of publication	2020-04
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1363151-2
ISSN	1383-5769
ISSN	1383-5769
DOI	10.1016/j.parint.2020.102051
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Article ; Online: Relationship between Eimeria tenella associated-early clinical signs and molecular changes in the intestinal barrier function.

Pham, Hung Hoang Son / Matsubayashi, Makoto / Tsuji, Naotoshi / Hatabu, Toshimitsu

Veterinary immunology and immunopathology

2021 Volume 240, Page(s) 110321

Abstract: The major clinical signs of coccidiosis in chickens due to Eimeria parasite are diarrhea and bloody feces. Previous studies showed that the impairment of the intestinal epithelial barrier and the elevation of the intestinal permeability are causes of ... ...

Abstract	The major clinical signs of coccidiosis in chickens due to Eimeria parasite are diarrhea and bloody feces. Previous studies showed that the impairment of the intestinal epithelial barrier and the elevation of the intestinal permeability are causes of clinical signs associated with coccidia challenges. Nevertheless, the information about molecular changes of the epithelial barrier at the early stage of the infection with a specific Eimeria species has not been mentioned. Hence, this study aims to elucidate the temporal relationships between epithelial barrier conditions and clinical signs in chickens infected with Eimeria tenella over the time from the earliest stages of infection. White Leghorn chickens were inoculated with 1 × 10
MeSH term(s)	Animals ; Cadherins ; Chickens ; Coccidiosis/veterinary ; Diarrhea/veterinary ; Eimeria tenella ; Fluorescein-5-isothiocyanate ; Intestines/parasitology ; Intestines/physiopathology
Chemical Substances	Cadherins ; Fluorescein-5-isothiocyanate (I223NX31W9)
Language	English
Publishing date	2021-08-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	754160-0
ISSN	1873-2534 ; 0165-2427
ISSN (online)	1873-2534
ISSN	0165-2427
DOI	10.1016/j.vetimm.2021.110321
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Article ; Online: A possible circulation of a dominant Dibothriocephalus nihonkaiensis haplotype in Japan revealed by molecular analysis of clinical tapeworm samples.

Ladzekpo, Danielle / Kwofie, Kofi Dadzie / Kawada, Hayato / Mikami, Fusako / Tsuji, Naotoshi / Iwanaga, Shiroh / Dadzie, Samuel Kweku / Hatta, Takeshi / Ishino, Tomoko

Parasitology international

2023 Volume 96, Page(s) 102771

Abstract: Human diphyllobothriasis, caused by Dibothriocephalus nihonkaiensis, is prevalent globally, especially in regions where raw fish is consumed. Recent molecular diagnostic techniques have made species identification of tapeworm parasites and the ... ...

Abstract	Human diphyllobothriasis, caused by Dibothriocephalus nihonkaiensis, is prevalent globally, especially in regions where raw fish is consumed. Recent molecular diagnostic techniques have made species identification of tapeworm parasites and the determination of genetic variations among parasite populations possible. However, only a few studies done over a decade ago, have reported on the genetic variation among D. nihonkaiensis in Japan. The present study employed PCR-based mitochondrial DNA analysis to specifically detect D. nihonkaiensis from archived clinical samples, and to determine any genetic variation that may exist among the Japanese broad tapeworms from patients of Kanagawa Prefecture, Japan. Target genes were amplified from DNA extracted from the ethanol- or formaldehyde-fixed samples by PCR. Further sequencing and comparative phylogenetic analyses based on mitochondrial COI and ND1 sequences were also performed. In our results, all PCR-amplified and sequenced samples were identified as D. nihonkaiensis. Analysis of COI sequences revealed two haplotype lineages. However, clustering of almost all COI (and ND1) sample sequences into one of the two haplotype clades, together with reference sequences from different countries worldwide, revealed a common haplotype among D. nihonkaiensis samples in our study. Our results suggest a possible presence of a dominant D. nihonkaiensis haplotype, with a global distribution circulating in Japan. Results from this study have the potential to improve the management of clinical cases and establish robust control measures to reduce the burden of human diphyllobothriasis in Japan.
MeSH term(s)	Animals ; Humans ; Haplotypes ; Phylogeny ; Japan ; Diphyllobothrium/genetics ; Cestoda/genetics ; Cestode Infections/veterinary ; Diphyllobothriasis/diagnosis ; Diphyllobothriasis/parasitology ; Genetic Variation
Language	English
Publishing date	2023-06-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1363151-2
ISSN	1873-0329 ; 1383-5769
ISSN (online)	1873-0329
ISSN	1383-5769
DOI	10.1016/j.parint.2023.102771
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Article ; Online: Food- and vector-borne parasitic zoonoses: Global burden and impacts.

Anisuzzaman / Hossain, Md Shahadat / Hatta, Takeshi / Labony, Sharmin Shahid / Kwofie, Kofi Dadzie / Kawada, Hayato / Tsuji, Naotoshi / Alim, Md Abdul

Advances in parasitology

2023 Volume 120, Page(s) 87–136

Abstract: Around 25% of the global population suffer from one or more parasitic infections, of which food- and vector-borne parasitic zoonotic diseases are a major concern. Additionally, zoonoses and communicable diseases, common to man and animals, are drawing ... ...

Abstract	Around 25% of the global population suffer from one or more parasitic infections, of which food- and vector-borne parasitic zoonotic diseases are a major concern. Additionally, zoonoses and communicable diseases, common to man and animals, are drawing increased attention worldwide. Significant changes in climatic conditions, cropping pattern, demography, food habits, increasing international travel, marketing and trade, deforestation, and urbanization play vital roles in the emergence and re-emergence of parasitic zoonoses. Although it is likely to be underestimated, the collective burden of food- and vector-borne parasitic diseases accounts for ∼60 million disability-adjusted life years (DALYs). Out of 20 neglected tropical diseases (NTDs) listed by the World Health Organization (WHO) and the Centres for Disease Control and Prevention (CDC), 13 diseases are of parasitic origin. There are about 200 zoonotic diseases of which the WHO listed eight as neglected zoonotic diseases (NZDs) in the year 2013. Out of these eight NZDs, four diseases, namely cysticercosis, hydatidosis, leishmaniasis, and trypanosomiasis, are caused by parasites. In this review, we discuss the global burden and impacts of food- and vector-borne zoonotic parasitic diseases.
MeSH term(s)	Animals ; Parasites ; Zoonoses/prevention & control ; Parasitic Diseases/epidemiology ; Cysticercosis ; Echinococcosis/epidemiology ; Neglected Diseases/epidemiology ; Neglected Diseases/prevention & control ; Global Health
Language	English
Publishing date	2023-03-13
Publishing country	England
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	165-x
ISSN	2163-6079 ; 0065-308X
ISSN (online)	2163-6079
ISSN	0065-308X
DOI	10.1016/bs.apar.2023.02.001
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Article ; Online: Reduction of macrophages by carrageenan decreases oocyst output and modifies local immune reaction in chick cecum with Eimeria tenella.

Ho, Dung Thi / Pham, Hung Hoang Son / Aota, Wataru / Matsubayashi, Makoto / Tsuji, Naotoshi / Hatabu, Toshimitsu

Research in veterinary science

2021 Volume 139, Page(s) 59–66

Abstract: This study aimed to evaluate the disease severity and local immune responses in macrophage-depleted chicks with Eimeria tenella. Macrophages were reduced by intraperitoneal injection of a carrageenan solution at 12, 13, and 16 days old, whereas the ... ...

Abstract	This study aimed to evaluate the disease severity and local immune responses in macrophage-depleted chicks with Eimeria tenella. Macrophages were reduced by intraperitoneal injection of a carrageenan solution at 12, 13, and 16 days old, whereas the control group received intraperitoneal phosphate-buffered saline. Both chick groups were orally inoculated with E. tenella sporulated oocysts at 14 days old. Feces were collected daily, which were then quantified for oocysts. The chicks were sacrificed on day 5, and the ceca were collected for histopathological observation. The gene expression levels were measured using real-time quantitative reverse transcription-polymerase chain reaction. Macrophage-depleted chicks have been observed to shed a significantly reduced number of fecal oocysts compared to the infected control group. The parasite burden score in cecum specimens of macrophage-depleted chicks was significantly lower than those of infected control on day 5 after infection. Furthermore, macrophage reduction yielded significantly lower cecum histopathological scores and CD4 expression than those of the infected control group. The expression of interleukin (IL)-18, IL-22, interferon-γ, and inducible nitric oxide synthase was also noted to be significantly upregulated in both infected control and macrophage-depleted chicks compared to uninfected chicks. IL-4, IL-13, IL-17, and perforin expressions were also higher with macrophage depletion than in both control groups. These results suggest that macrophages serve as an invasive gate or a transporting vehicle to the site of first merogony. Furthermore, mononuclear phagocytes may play an important role in local immune responses, thus contributing to parasite development during early E. tenella infection.
MeSH term(s)	Animals ; Carrageenan ; Cecum ; Chickens ; Coccidiosis/veterinary ; Eimeria tenella ; Macrophages ; Oocysts ; Poultry Diseases/parasitology
Chemical Substances	Carrageenan (9000-07-1)
Language	English
Publishing date	2021-07-06
Publishing country	England
Document type	Journal Article
ZDB-ID	840961-4
ISSN	1532-2661 ; 0034-5288
ISSN (online)	1532-2661
ISSN	0034-5288
DOI	10.1016/j.rvsc.2021.07.003
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Article: Mammalian and Avian Larval Schistosomatids in Bangladesh: Molecular Characterization, Epidemiology, Molluscan Vectors, and Occurrence of Human Cercarial Dermatitis.

Labony, Sharmin Shahid / Hossain, Md Shahadat / Hatta, Takeshi / Dey, Anita Rani / Mohanta, Uday Kumar / Islam, Ausraful / Shahiduzzaman, Md / Hasan, Muhammad Mehedi / Alim, Md Abdul / Tsuji, Naotoshi / Anisuzzaman

Pathogens (Basel, Switzerland)

2022 Volume 11, Issue 10

Abstract: Schistosomiasis is a neglected tropical disease (NTD) caused by blood flukes ( ...

Abstract	Schistosomiasis is a neglected tropical disease (NTD) caused by blood flukes (
Language	English
Publishing date	2022-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens11101213
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Article ; Online: A possible circulation of a dominant Dibothriocephalus nihonkaiensis haplotype in Japan revealed by molecular analysis of clinical tapeworm samples

Ladzekpo, Danielle / Kwofie, Kofi Dadzie / Kawada, Hayato / Mikami, Fusako / Tsuji, Naotoshi / Iwanaga, Shiroh / Dadzie, Samuel Kweku / Hatta, Takeshi / Ishino, Tomoko

Parasitology International. 2023 Oct., v. 96 p.102771-

2023

Abstract	Human diphyllobothriasis, caused by Dibothriocephalus nihonkaiensis, is prevalent globally, especially in regions where raw fish is consumed. Recent molecular diagnostic techniques have made species identification of tapeworm parasites and the determination of genetic variations among parasite populations possible. However, only a few studies done over a decade ago, have reported on the genetic variation among D. nihonkaiensis in Japan. The present study employed PCR-based mitochondrial DNA analysis to specifically detect D. nihonkaiensis from archived clinical samples, and to determine any genetic variation that may exist among the Japanese broad tapeworms from patients of Kanagawa Prefecture, Japan. Target genes were amplified from DNA extracted from the ethanol- or formaldehyde-fixed samples by PCR. Further sequencing and comparative phylogenetic analyses based on mitochondrial COI and ND1 sequences were also performed. In our results, all PCR-amplified and sequenced samples were identified as D. nihonkaiensis. Analysis of COI sequences revealed two haplotype lineages. However, clustering of almost all COI (and ND1) sample sequences into one of the two haplotype clades, together with reference sequences from different countries worldwide, revealed a common haplotype among D. nihonkaiensis samples in our study. Our results suggest a possible presence of a dominant D. nihonkaiensis haplotype, with a global distribution circulating in Japan. Results from this study have the potential to improve the management of clinical cases and establish robust control measures to reduce the burden of human diphyllobothriasis in Japan.
Keywords	Japan ; diphyllobothriasis ; genetic variation ; geographical distribution ; haplotypes ; humans ; mitochondria ; mitochondrial DNA ; parasitology ; phylogeny ; polymerase chain reaction ; raw fish ; species identification ; tapeworms ; Tapeworm ; Dibothriocephalus nihonkaiensis ; Mitochondrial cytochrome c oxidase subunit I (COI) ; NADH dehydrogenase subunit 1 (ND1)
Language	English
Dates of publication	2023-10
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	1363151-2
ISSN	1383-5769
ISSN	1383-5769
DOI	10.1016/j.parint.2023.102771
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Article: Relationship between Eimeria tenella associated-early clinical signs and molecular changes in the intestinal barrier function

Pham, Hung Hoang Son / Matsubayashi, Makoto / Tsuji, Naotoshi / Hatabu, Toshimitsu

Veterinary immunology and immunopathology. 2021 Oct., v. 240

2021

Abstract	The major clinical signs of coccidiosis in chickens due to Eimeria parasite are diarrhea and bloody feces. Previous studies showed that the impairment of the intestinal epithelial barrier and the elevation of the intestinal permeability are causes of clinical signs associated with coccidia challenges. Nevertheless, the information about molecular changes of the epithelial barrier at the early stage of the infection with a specific Eimeria species has not been mentioned. Hence, this study aims to elucidate the temporal relationships between epithelial barrier conditions and clinical signs in chickens infected with Eimeria tenella over the time from the earliest stages of infection.White Leghorn chickens were inoculated with 1 × 10⁴ oocysts of E. tenella. Thereafter the chickens were monitored for their daily clinical signs through observation, and between 5 dpi to 10 dpi, feces were collected for oocysts counting. Chickens were then administrated with fluorescein isothiocyanate-dextran (FITC-d) for gastrointestinal permeability test and tissues were collected each day for histopathological observation and total RNA extraction. Finally, the mRNA expression levels of the tight and adherens junction genes and cytokine genes were evaluated using the quantitative real-time polymerase chain reaction (qRT-PCR).In this study, clinical signs such as diarrhea and bloody feces were observed concurrently from 3 to 8 dpi. Histopathology changes such as severe inflammation, hemorrhage, and epithelial desquamation were identified in the cecum specimens. The FITC-d level in the E. tenella-infected group was significantly higher than in the control group. In the infected group, the expression of claudin-2 gene was also upregulated, whereas the expressions of claudin-3 and E-cadherin genes were decreased as compared to the control group. These results implied that clinical signs of avian coccidiosis were associated with the intestinal barrier disruption via changes in expression levels of claudins and E-cadherin at the intestine.
Keywords	Eimeria tenella ; cadherins ; cecum ; coccidiosis ; cytokines ; diarrhea ; epithelium ; feces ; fluorescein ; gene expression ; genes ; hemorrhage ; histopathology ; immunopathology ; inflammation ; oocysts ; parasites ; permeability ; quantitative polymerase chain reaction
Language	English
Dates of publication	2021-10
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	754160-0
ISSN	1873-2534 ; 0165-2427
ISSN (online)	1873-2534
ISSN	0165-2427
DOI	10.1016/j.vetimm.2021.110321
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Article ; Online: Mitochondria as a Potential Target for the Development of Prophylactic and Therapeutic Drugs against Schistosoma mansoni Infection.

Talaam, Keith Kiplangat / Inaoka, Daniel Ken / Hatta, Takeshi / Tsubokawa, Daigo / Tsuji, Naotoshi / Wada, Minoru / Saimoto, Hiroyuki / Kita, Kiyoshi / Hamano, Shinjiro

Antimicrobial agents and chemotherapy

2021 Volume 65, Issue 10, Page(s) e0041821

Abstract: The emergence of parasites resistant to praziquantel, the only therapeutic agent, and its ineffectiveness as a prophylactic agent (inactive against the migratory/juvenile Schistosoma mansoni), make the development of new antischistosomal drugs urgent. ... ...

Abstract	The emergence of parasites resistant to praziquantel, the only therapeutic agent, and its ineffectiveness as a prophylactic agent (inactive against the migratory/juvenile Schistosoma mansoni), make the development of new antischistosomal drugs urgent. The parasite's mitochondrion is an attractive target for drug development, because this organelle is essential for survival throughout the parasite's life cycle. We investigated the effects of 116 compounds against Schistosoma mansoni cercaria motility that have been reported to affect mitochondrion-related processes in other organisms. Next, eight compounds plus two controls (mefloquine and praziquantel) were selected and assayed against the motility of schistosomula (
MeSH term(s)	Animals ; Mice ; Mitochondria ; Pharmaceutical Preparations ; Schistosoma mansoni ; Schistosomiasis mansoni/drug therapy ; Schistosomiasis mansoni/prevention & control ; Schistosomicides/therapeutic use
Chemical Substances	Pharmaceutical Preparations ; Schistosomicides
Language	English
Publishing date	2021-08-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.00418-21
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