Article ; Online: Efficacy and Safety of PD-1/PD-L1 Inhibitor Chemotherapy Combined with Lung Cancer Fang No. 1 in Relapsed and Refractory SCLC: A Retrospective Observational Study.
Computational and mathematical methods in medicine
2022 Volume 2022, Page(s) 2848220
Abstract: ... ligand 1 (PD-L1)) inhibitors and Lung Cancer No. 1 efficacy and safety of Lung Cancer Fang No. 1 ... chemotherapy combined with Lung Cancer Fang No. 1 treatment. The differences in immune and tumor marker levels ... statistically significant (: Conclusion: PD-1/PD-L1 inhibitor chemotherapy combined with Lung Cancer Fang No ...
| Abstract | Background: Relapsed and refractory small cell lung cancer (SCLC) accounts for about 15% of all lung cancers. The prognosis of patients is poor. The 5-year survival rate is almost 0. The average survival time of patients who refuse to receive treatment is only 2-4 months. For patients with extensive-stage SCLC, the current first-line treatment regimens are mainly platinum-containing double-drug chemotherapy. Poside combined with cisplatin/carboplatin and irinotecan combined with cisplatin/carboplatin are commonly used clinical regimens for the treatment of patients with extensive-stage SCLC. Although SCLC is very sensitive to radiotherapy and chemotherapy, most patients will develop recurrence and metastasis after initial treatment. Therefore, it is necessary to study clinically effective therapeutic drugs for relapsed and refractory SCLC. Objective: To investigate the relationship between programmed death receptor-1 (programmed death receptor-1 (PD-1)) and programmed death receptor-ligand 1 (programmed death-ligand 1 (PD-L1)) inhibitors and Lung Cancer No. 1 efficacy and safety of Lung Cancer Fang No. 1 in the treatment of relapsed and refractory SCLC. Methods: 80 patients with refractory SCLC were selected and randomly divided into control group and treatment group with 40 cases in each group. Among them, the control group received PD-1/PD-L1 inhibitor chemotherapy, and the treatment group received PD-1/PD-L1 inhibitor chemotherapy combined with Lung Cancer Fang No. 1 treatment. The differences in immune and tumor marker levels, clinical efficacy, and prognostic complications between the two groups before and after treatment were observed and compared. Results: Before treatment, there was no significant difference in clinical improvement between the two groups. After treatment, the clinical symptom scores and body weight changes in the treatment group were significantly improved. The clinical symptom scores in the treatment group were lower than those in the control group, but the body weight changes were higher than those in the control group. The difference was statistically significant ( Conclusion: PD-1/PD-L1 inhibitor chemotherapy combined with Lung Cancer Fang No. 1 has a good and safe effect on SCLC patients. It has a good curative effect in improving the clinical symptoms of patients. It can stabilize the tumor, inhibit the development of lung cancer, improve the body's cellular immune function, adjust the level and expression of tumor markers, improve the body's material metabolism, and restore the balance of yin and yang in the body. |
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| MeSH term(s) | Antigens, Neoplasm ; Biomarkers, Tumor ; Body Weight ; Carboplatin/therapeutic use ; Cisplatin/adverse effects ; Humans ; Immune Checkpoint Inhibitors ; Keratin-19 ; Lung Neoplasms/diagnosis ; Programmed Cell Death 1 Receptor ; Randomized Controlled Trials as Topic ; Receptors, Death Domain ; Small Cell Lung Carcinoma/drug therapy |
| Chemical Substances | Antigens, Neoplasm ; Biomarkers, Tumor ; Immune Checkpoint Inhibitors ; Keratin-19 ; Programmed Cell Death 1 Receptor ; Receptors, Death Domain ; antigen CYFRA21.1 ; Carboplatin (BG3F62OND5) ; Cisplatin (Q20Q21Q62J) |
| Language | English |
| Publishing date | 2022-05-09 |
| Publishing country | United States |
| Document type | Journal Article ; Observational Study ; Retracted Publication |
| ZDB-ID | 2252430-7 |
| ISSN | 1748-6718 ; 1748-670X ; 1027-3662 |
| ISSN (online) | 1748-6718 |
| ISSN | 1748-670X ; 1027-3662 |
| DOI | 10.1155/2022/2848220 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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