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Article ; Online: UniBind: a novel artificial intelligence-based prediction model for SARS-CoV-2 infectivity and variant evolution.

Yan, Qihong / Zhao, Jincun

Signal transduction and targeted therapy

2023 Volume 8, Issue 1, Page(s) 464

MeSH term(s)	Humans ; Artificial Intelligence ; COVID-19 ; SARS-CoV-2/genetics
Language	English
Publishing date	2023-12-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2886872-9
ISSN	2059-3635 ; 2095-9907
ISSN (online)	2059-3635
ISSN	2095-9907
DOI	10.1038/s41392-023-01691-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Relationship between Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and the Risk of COVID-19: A Meta-Analysis.

Luoyi, Hu / Yan, Pan / Qihong, Fan

Journal of the renin-angiotensin-aldosterone system : JRAAS

2023 Volume 2023, Page(s) 3431612

Abstract: Introduction: Research shows the correlation between angiotensin-converting enzyme (ACE) deletion and insertion (D/I) polymorphism and COVID-19 risk; yet, conclusive evidence is still lacking. Thus, a meta-analysis of relevant articles was performed to ... ...

Abstract	Introduction: Research shows the correlation between angiotensin-converting enzyme (ACE) deletion and insertion (D/I) polymorphism and COVID-19 risk; yet, conclusive evidence is still lacking. Thus, a meta-analysis of relevant articles was performed to more accurately estimate the relationship of ACE I/D polymorphism with the risk of COVID-19. Results: The meta-analysis eventually contained 8 studies, including 1362 COVID-19 cases and 4312 controls. Based on the data, the ACE I/D polymorphism did not show an association with COVID-19 risk (D vs. I: OR = 1.25, 95% CI = 0.96-1.64; DD vs. II: OR = 1.89, 95% CI = 0.95-3.74; DI vs. II: OR = 1.75, 95% CI = 0.92-3.31; dominant model: OR = 1.88, 95% CI = 0.99-3.53; and recessive model: OR = 1.24, 95% CI = 0.81-1.90). Further, subgroup analyses stratified based on case proved that the ACE D allele demonstrated an association with increasing risk of COVID-19 severity (D vs. I: OR = 1.64, 95% CI = 1.01-2.66; DD vs. II: OR = 4.62, 95% CI = 2.57-8.30; DI vs. II: OR = 3.07, 95% CI = 1.75-5.38; dominant model: OR = 3.74, 95% CI = 2.15-6.50; and recessive model: OR = 1.28, 95% CI = 0.46-3.51). Conclusions: The ACE D allele was clearly related to an enhanced risk of COVID-19 severity. Hence, it is imperative to take into account the influence of genetic factors during the development of future vaccines.
MeSH term(s)	Humans ; COVID-19/genetics ; Genetic Predisposition to Disease ; INDEL Mutation/genetics ; Peptidyl-Dipeptidase A/genetics ; Polymorphism, Genetic ; Risk Factors
Chemical Substances	Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE protein, human (EC 3.4.15.1)
Language	English
Publishing date	2023-11-28
Publishing country	England
Document type	Meta-Analysis ; Journal Article
ZDB-ID	2086948-4
ISSN	1752-8976 ; 1470-3203
ISSN (online)	1752-8976
ISSN	1470-3203
DOI	10.1155/2023/3431612
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5668: Show issues

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Article ; Online: A nomogram for predicting immunoglobulin-resistant Kawasaki disease in children.

Pan, Yan / Fan, Qihong

The Journal of international medical research

2023 Volume 51, Issue 2, Page(s) 3000605221139704

Abstract: Objective: This case-control study focused on the establishment and internal validation of a risk nomogram for intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) using the Kawasaki Disease Database.: Methods: The Kawasaki Disease ... ...

Abstract	Objective: This case-control study focused on the establishment and internal validation of a risk nomogram for intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) using the Kawasaki Disease Database. Methods: The Kawasaki Disease Database is the first public database for KD researchers. A prediction nomogram for IVIG-resistant KD was constructed using multivariable logistic regression. Then, the C-index was used to assess the discriminating ability of the proposed prediction model, a calibration plot was drawn to evaluate its calibration, and a decision curve analysis was adopted to assess its clinical usefulness. Bootstrapping validation was performed for interval validation. Results: The median ages of IVIG-resistant and -sensitive KD groups were 3.3 and 2.9 years, respectively. Predicting factors incorporated into the nomogram were coronary artery lesions, C-reactive protein, percentage of neutrophils, platelets, aspartate aminotransferase, and alanine transaminase. Our constructed nomogram exhibited favorable discriminating ability (C-index: 0.742; 95% confidence interval: 0.673-0.812) and excellent calibration. Moreover, interval validation achieved a high C-index of 0.722. Conclusions: The as-constructed new IVIG-resistant KD nomogram that incorporated C-reactive protein, coronary artery lesions, platelets, percentage of neutrophils, alanine transaminase, and aspartate aminotransferase may be adopted for predicting the risk of IVIG-resistant KD.
MeSH term(s)	Child ; Humans ; Infant ; Immunoglobulins, Intravenous/therapeutic use ; C-Reactive Protein/analysis ; Nomograms ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Mucocutaneous Lymph Node Syndrome/drug therapy ; Case-Control Studies ; Alanine Transaminase ; Retrospective Studies ; Aspartate Aminotransferases
Chemical Substances	Immunoglobulins, Intravenous ; C-Reactive Protein (9007-41-4) ; Alanine Transaminase (EC 2.6.1.2) ; Aspartate Aminotransferases (EC 2.6.1.1)
Language	English
Publishing date	2023-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605221139704
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Zs.A 925: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Clostridium Symbiosum Sepsis Diagnosed Using Next-Generation Sequencing in a 2 Year Old Child: A Case Report.

Pan, Yan / Fan, Qihong

Fetal and pediatric pathology

2022 Volume 42, Issue 3, Page(s) 518–521

Abstract: ... ...

Abstract	Background
MeSH term(s)	Male ; Infant, Newborn ; Infant ; Humans ; Child, Preschool ; Clostridium symbiosum ; Anti-Bacterial Agents/therapeutic use ; Sepsis/diagnosis ; Sepsis/genetics ; Sepsis/drug therapy ; Meropenem/therapeutic use ; Sulbactam/therapeutic use ; High-Throughput Nucleotide Sequencing
Chemical Substances	Anti-Bacterial Agents ; Meropenem (FV9J3JU8B1) ; Sulbactam (S4TF6I2330)
Language	English
Publishing date	2022-12-21
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2165508-X
ISSN	1551-3823 ; 1551-3815 ; 1522-7952
ISSN (online)	1551-3823
ISSN	1551-3815 ; 1522-7952
DOI	10.1080/15513815.2022.2158696
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Zs.A 2043: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Visualizing Low-Abundance Proteins and Post-Translational Modifications in Living Drosophila Embryos via Fluorescent Antibody Injection.

Zheng, Qihong / Xiang, Xiaoxiang / Yan, Yan / Yu, Huapeng H

Journal of visualized experiments : JoVE

2024 , Issue 203

Abstract: Visualization of proteins in living cells using GFP (Green Fluorescent Protein) and other fluorescent tags has greatly improved understanding of protein localization, dynamics, and function. Compared to immunofluorescence, live imaging more accurately ... ...

Abstract	Visualization of proteins in living cells using GFP (Green Fluorescent Protein) and other fluorescent tags has greatly improved understanding of protein localization, dynamics, and function. Compared to immunofluorescence, live imaging more accurately reflects protein localization without potential artifacts arising from tissue fixation. Importantly, live imaging enables quantitative and temporal characterization of protein levels and localization, crucial for understanding dynamic biological processes such as cell movement or division. However, a major limitation of fluorescent tagging approaches is the need for sufficiently high protein expression levels to achieve successful visualization. Consequently, many endogenously tagged fluorescent proteins with relatively low expression levels cannot be detected. On the other hand, ectopic expression using viral promoters can sometimes lead to protein mislocalization or functional alterations in physiological contexts. To address these limitations, an approach is presented that utilizes highly sensitive antibody-mediated protein detection in living embryos, essentially performing immunofluorescence without the need for tissue fixation. As proof of principle, endogenously GFP-tagged Notch receptor that is barely detectable in living embryos can be successfully visualized after antibody injection. Furthermore, this approach was adapted to visualize post-translational modifications (PTMs) in living embryos, allowing the detection of temporal changes in tyrosine phosphorylation patterns during early embryogenesis and revealing a novel subpopulation of phosphotyrosine (p-Tyr) underneath apical membranes. This approach can be modified to accommodate other protein-specific, tag-specific, or PTM-specific antibodies and should be compatible with other injection-amenable model organisms or cell lines. This protocol opens new possibilities for live imaging of low-abundance proteins or PTMs that were previously challenging to detect using traditional fluorescent tagging methods.
MeSH term(s)	Animals ; Drosophila/metabolism ; Protein Processing, Post-Translational ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Cell Membrane/metabolism ; Coloring Agents/metabolism ; Fluorescent Antibody Technique
Chemical Substances	Green Fluorescent Proteins (147336-22-9) ; Coloring Agents
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/66080
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Genome-wide transcriptome profiling reveals molecular response pathways of

Yang, Qihong / Mao, Zhenchuan / Hao, Yali / Zheng, Shijie / Zhao, Jianlong / Li, Yan / Yang, Yuhong / Xie, Bingyan / Ling, Jian / Li, Yanlin

Frontiers in microbiology

2024 Volume 15, Page(s) 1342584

Abstract: Trichoderma ... ...

Abstract	Trichoderma harzianum
Language	English
Publishing date	2024-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2024.1342584
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Article ; Online: The Role of Procalcitonin for Predicting Kawasaki Disease.

Pan, Yan / Fan, Qihong

Fetal and pediatric pathology

2022 Volume 41, Issue 6, Page(s) 1015–1022

Abstract: Some studies have estimated the diagnostic value of procalcitonin (PCT) for Kawasaki disease (KD), but the results are not always consistent. The aim of this study was to ascertain the diagnostic value of PCT for KD.: Relevant and eligible articles ... ...

Abstract	Some studies have estimated the diagnostic value of procalcitonin (PCT) for Kawasaki disease (KD), but the results are not always consistent. The aim of this study was to ascertain the diagnostic value of PCT for KD. Relevant and eligible articles assessing the diagnostic significance of PCT in KD were systematically searched from PubMed as well as the CNKI databases (last update: October 31, 2020), followed by bivariate models to evaluate the overall diagnostic significance of PCT in KD. This systematic review and meta-analysis included four articles. The overall diagnostic specificity and sensitivity were 0.78 (95% CI: 0.74-0.82) and 0.73 (95% CI: 0.69-0.76), respectively. The area under the summary receiver operating characteristic (sROC) curve (AUC) was 0.82. The negative likelihood ratio (NLR) and positive likelihood ratio (PLR) values for PCT were 0.34 and 3.23, respectively. By analyzing the accessible articles, we showed PCT is not a particularly useful test for KD diagnosis.
MeSH term(s)	Humans ; Procalcitonin ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Biomarkers ; ROC Curve ; Sensitivity and Specificity
Chemical Substances	Procalcitonin ; Biomarkers
Language	English
Publishing date	2022-02-11
Publishing country	England
Document type	Systematic Review ; Meta-Analysis ; Journal Article
ZDB-ID	2165508-X
ISSN	1551-3823 ; 1551-3815 ; 1522-7952
ISSN (online)	1551-3823
ISSN	1551-3815 ; 1522-7952
DOI	10.1080/15513815.2022.2036881
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2043: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Relationship between Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and the Risk of COVID-19

Hu Luoyi / Pan Yan / Fan Qihong

Journal of the Renin-Angiotensin-Aldosterone System, Vol

A Meta-Analysis

2023 Volume 2023

Abstract: Introduction. Research shows the correlation between angiotensin-converting enzyme (ACE) deletion and insertion (D/I) polymorphism and COVID-19 risk; yet, conclusive evidence is still lacking. Thus, a meta-analysis of relevant articles was performed to ... ...

Abstract	Introduction. Research shows the correlation between angiotensin-converting enzyme (ACE) deletion and insertion (D/I) polymorphism and COVID-19 risk; yet, conclusive evidence is still lacking. Thus, a meta-analysis of relevant articles was performed to more accurately estimate the relationship of ACE I/D polymorphism with the risk of COVID-19. Material and Methods. Relevant literature from the PubMed database was systematically reviewed, and odds ratios (ORs) and associated 95% confidence intervals (CIs) were measured. Additionally, the metapackage from Stata version 15.0 was used for statistical analysis. Results. The meta-analysis eventually contained 8 studies, including 1362 COVID-19 cases and 4312 controls. Based on the data, the ACE I/D polymorphism did not show an association with COVID-19 risk (D vs. I: OR=1.25, 95% CI=0.96–1.64; DD vs. II: OR=1.89, 95% CI=0.95–3.74; DI vs. II: OR=1.75, 95% CI=0.92–3.31; dominant model: OR=1.88, 95% CI=0.99–3.53; and recessive model: OR=1.24, 95% CI=0.81–1.90). Further, subgroup analyses stratified based on case proved that the ACE D allele demonstrated an association with increasing risk of COVID-19 severity (D vs. I: OR=1.64, 95% CI=1.01–2.66; DD vs. II: OR=4.62, 95% CI=2.57–8.30; DI vs. II: OR=3.07, 95% CI=1.75–5.38; dominant model: OR=3.74, 95% CI=2.15–6.50; and recessive model: OR=1.28, 95% CI=0.46–3.51). Conclusions. The ACE D allele was clearly related to an enhanced risk of COVID-19 severity. Hence, it is imperative to take into account the influence of genetic factors during the development of future vaccines.
Keywords	Medicine (General) ; R5-920
Subject code	332
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Hindawi - SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Salt Tolerance in

Mo, Qiong / Liu, Yang / Wei, Haohui / Jiang, Liyuan / Wu, En / Lin, Ling / Yang, Qihong / Yu, Xiaoying / Yan, Lihong / Li, Yanlin

Biology

2024 Volume 13, Issue 2

Abstract: Adversity stress is the main environmental factor limiting plant growth and development, including salt and other stress factors. This study delves into the adaptability and salt tolerance mechanisms ... ...

Abstract	Adversity stress is the main environmental factor limiting plant growth and development, including salt and other stress factors. This study delves into the adaptability and salt tolerance mechanisms of
Language	English
Publishing date	2024-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology13020075
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Treatment of immunoglobulin-resistant kawasaki disease: a Bayesian network meta-analysis of different regimens.

Pan, Yan / Fan, Qihong / Hu, Luoyi

Frontiers in pediatrics

2023 Volume 11, Page(s) 1149519

Abstract: Background: This study aimed to gather evidence from clinical trials on the efficacy and safety of the available treatments for intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) in children.: Methods: This work adopted the Newcastle- ... ...

Abstract	Background: This study aimed to gather evidence from clinical trials on the efficacy and safety of the available treatments for intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) in children. Methods: This work adopted the Newcastle-Ottawa scale to analyse the quality of the enrolled articles. A network meta-analysis was performed using clinical trials that compared drugs used to treat IVIG-resistant KD. Aggregate Data Drug Information System software v.1.16.5 was employed to analyse whether infliximab, second IVIG infusions, and intravenous pulse methylprednisolone (IVMP) were safe and effective. Results: Ten studies, involving 704 patients with IVIG-resistant KD, were identified and analysed. Overall, infliximab exhibited remarkable antipyretic activity compared with the second IVIG infusions (2.46, 1.00-6.94). According to the drug rank, infliximab was the best option against IVIG-resistant KD. Regarding adverse effects, the infliximab group was more prone to hepatomegaly. A second IVIG infusion was more likely to result in haemolytic anaemia. IVMP treatment was more susceptible to bradycardia, hyperglycaemia, hypertension, and hypothermia. In addition, infliximab, IVMP, and the second IVIG infusions showed no significant differences in the risk of developing a coronary artery aneurysm (CAA). Conclusion: Infliximab was the best option against IVIG-resistant KD, and IVMP, infliximab, and second IVIG infusions have not significant differences of prevent CAA in patients with IVIG-resistant KD. Systematic review registration: Identifier: https://osf.io/3894y.
Language	English
Publishing date	2023-07-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1149519
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