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  1. Article ; Online: The real-world clinical decisions of physicians in the management of Takayasu arteritis and giant cell arteritis in Japan: A cross-sectional web-questionnaire survey.

    Abe, Yoshiyuki / Fujii, Takao / Miyawaki, Yoshia / Sugihara, Takahiko / Uchida, Haruhito A / Maejima, Yasuhiro / Watanabe, Yoshiko / Hashimoto, Takuya / Miyamae, Takako / Nakaoka, Yoshikazu / Harigai, Masayoshi / Tamura, Naoto

    Modern rheumatology

    2024  

    Abstract: ... Takayasu arteritis (TAK) and giant cell arteritis (GCA) after the publication of the Japanese Circulation Society ...

    Abstract Objectives: To access the real-world clinical management of physicians who treat Takayasu arteritis (TAK) and giant cell arteritis (GCA) after the publication of the Japanese Circulation Society (JCS) 2017 Guidelines for the Management of Vasculitis Syndrome.
    Methods: This descriptive, cross-sectional study utilized self-administered electronic questionnaires, which were answered in February 2022 by physicians treating TAK or GCA and registered with Macromill Inc.
    Results: The 329 survey respondents comprised 110 cardiologists, 110 rheumatologists, 34 cardiovascular surgeons, 24 surgeons, 35 internal medicine physicians, 13 nephrologists, and 7 pediatricians. The 2017 JCS Guidelines were the most commonly referenced information source for resolving clinical questions, accessed by 70% of respondents. Ophthalmoscopy was performed in only 50% of patients with TAK, and in 70% for GCA. The median percentages of patients who underwent 18F-fluorodeoxyglucose-positron emission tomography/computed tomography for TAK and GCA patients were 23% and 20% at diagnosis, respectively, and 10% each at follow-up within 12 months. Tocilizumab was the most frequently used medication in combination with glucocorticoids for both TAK and GCA, especially in remission induction therapy for relapsed patients.
    Conclusions: The majority of physician treating TAK and GCA referred to the 2017 JCS guidelines. This report clarified the current clinical practice for large vessel vasculitis in Japan, providing information for the next revision of the guidelines.
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2078157-X
    ISSN 1439-7609 ; 1439-7595
    ISSN (online) 1439-7609
    ISSN 1439-7595
    DOI 10.1093/mr/roae034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Organ Damage and Quality of Life in Takayasu Arteritis - Evidence From a National Registry Analysis.

    Yoshifuji, Hajime / Nakaoka, Yoshikazu / Uchida, Haruhito A / Sugihara, Takahiko / Watanabe, Yoshiko / Funakoshi, Sohei / Isobe, Mitsuaki / Harigai, Masayoshi

    Circulation journal : official journal of the Japanese Circulation Society

    2023  Volume 88, Issue 3, Page(s) 285–294

    Abstract: Background: Takayasu arteritis, affecting primarily young women, damages large arteries and organs ... ischemic heart disease, may improve the quality of life of patients with Takayasu arteritis, especially women. ...

    Abstract Background: Takayasu arteritis, affecting primarily young women, damages large arteries and organs. We examined the impact of disease duration and sex on organ damage and quality of life using Japan's Intractable Disease Registry.Methods and Results: After refining data, 2,013 of 2,795 patients were included in the study. Longer disease duration was related to a lower prevalence of disease activity symptoms, a higher prevalence of organ damage, and a higher proportion of patients requiring nursing care. Compared with men, women tended to have an earlier onset age, exhibiting longer disease duration. A higher proportion of women had aortic regurgitation and required nursing care. The proportion of female patients in employment was lower than that of the general female population, whereas no difference was observed between male patients and the general male population. Logistic regression analysis revealed that age at surveillance, brain ischemia, visual impairment/loss, and ischemic heart disease were significant factors associated with high nursing care needs (Level ≥2, with daily activity limitations).
    Conclusions: Early diagnosis and effective treatment, particularly to prevent brain ischemia, visual impairment, and ischemic heart disease, may improve the quality of life of patients with Takayasu arteritis, especially women.
    MeSH term(s) Humans ; Male ; Female ; Takayasu Arteritis/epidemiology ; Takayasu Arteritis/complications ; Quality of Life ; Brain Ischemia/complications ; Vision Disorders/complications ; Myocardial Ischemia ; Registries
    Language English
    Publishing date 2023-12-19
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-23-0656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Establishing clinical remission criteria and the framework of a treat-to-target algorithm for Takayasu arteritis: Results of a Delphi exercise carried out by an expert panel of the Japan Research Committee of the Ministry of Health, Labour and Welfare for intractable vasculitis.

    Sugihara, Takahiko / Nakaoka, Yoshikazu / Uchida, Haruhito A / Yoshifuji, Hajime / Maejima, Yasuhiro / Watanabe, Yoshiko / Amiya, Eisuke / Tanemoto, Kazuo / Miyata, Tetsuro / Umezawa, Natsuka / Manabe, Yusuke / Ishizaki, Jun / Shirai, Tsuyoshi / Nagafuchi, Hiroko / Hasegawa, Hitoshi / Miyamae, Takako / Niiro, Hiroaki / Ito, Shuichi / Ishii, Tomonori /
    Isobe, Mitsuaki / Harigai, Masayoshi

    Modern rheumatology

    2021  Volume 32, Issue 5, Page(s) 930–937

    Abstract: ... T2T) algorithm for Takayasu arteritis (TAK).: Methods: A study group of the large-vessel vasculitis ...

    Abstract Objectives: To develop a proposal for remission criteria and a framework for a treat-to-target (T2T) algorithm for Takayasu arteritis (TAK).
    Methods: A study group of the large-vessel vasculitis group of the Japanese Research Committee of the Ministry of Health, Labour and Welfare for Intractable Vasculitis consists of 10 rheumatologists, 5 cardiologists, 1 nephrologist, 1 vascular surgeon, 1 cardiac surgeon, and 2 paediatric rheumatologists. A Delphi survey of remission criteria items was circulated among the study group over four reiterations. To develop the T2T algorithm, the study group conducted four face-to-face meetings and two rounds of Delphi together with three patients.
    Results: Initial literature review resulted in a list of 117 candidate items for remission criteria, of which 56 items with a mean score of ≥4 (0-5) were extracted including disease activity domains and treatment/comorbidity domains. The study group provided six overarching principles for the T2T algorithm, two recommendations on treatment goals, five on evaluation of disease activity and imaging findings including positron emission tomography-computed tomography, and two on treatment intensification.
    Conclusions: We developed a T2T algorithm and proposals for standardised remission criteria by means of a Delphi exercise. These will guide future evaluation of different TAK treatment regimens.
    MeSH term(s) Algorithms ; Child ; Giant Cell Arteritis ; Humans ; Japan ; Takayasu Arteritis/diagnostic imaging ; Takayasu Arteritis/therapy
    Language English
    Publishing date 2021-11-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2078157-X
    ISSN 1439-7609 ; 1439-7595
    ISSN (online) 1439-7609
    ISSN 1439-7595
    DOI 10.1093/mr/roab081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Angioplasty with autologous pericardium for bilateral coronary ostial stenosis in Takayasu disease.

    Kawase, Isamu / Ozaki, Shigeyuki / Yamashita, Hiromasa / Uchida, Shin / Nozawa, Yukinari / Matsuyama, Takayoshi / Takatoh, Mikio / Hagiwara, So

    The Annals of thoracic surgery

    2012  Volume 93, Issue 2, Page(s) 645–647

    Abstract: ... We encountered bilateral ostial stenosis with Takayasu disease. This report describes successful patch ... to Takayasu disease. ...

    Abstract Coronary ostial stenosis is usually treated by conventional coronary artery bypass graft surgery. Although patch angioplasty is a widely accepted alternative surgical treatment, it has been reported sporadically. We encountered bilateral ostial stenosis with Takayasu disease. This report describes successful patch angioplasty using glutaraldehyde-treated autologous pericardium of bilateral coronary ostial stenosis owing to Takayasu disease.
    MeSH term(s) Angioplasty/methods ; Bioprosthesis ; Coronary Angiography ; Coronary Stenosis/etiology ; Coronary Stenosis/surgery ; Female ; Glutaral ; Humans ; Pericardium/transplantation ; Takayasu Arteritis/surgery ; Tomography, X-Ray Computed ; Transplantation, Autologous ; Young Adult
    Chemical Substances Glutaral (T3C89M417N)
    Language English
    Publishing date 2012-02
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2011.07.070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Takayasu arteritis evaluated by multi-slice computed tomography in an old man.

    Fujita, Tetsuo / Ohtsuka, Masashi / Uchida, Eiji / Yamaguchi, Hiroyuki / Nakajima, Toru / Akazawa, Hiroshi / Takano, Hiroyuki / Nakaya, Haruaki / Komuro, Issei

    International journal of cardiology

    2008  Volume 125, Issue 2, Page(s) 286–287

    Abstract: In the case of patients with Takayasu arteritis (TA), they consult a doctor for the first time ... tool to detect unexpected lesion in Takayasu arteritis in a non-invasive manner. ...

    Abstract In the case of patients with Takayasu arteritis (TA), they consult a doctor for the first time when they have a slight fever, shoulder pain, chest pain, back pain, or headache, or when they are pointed out to have high CRP or anemia by chance in medical check-up. In TA, they are usually young women. In our case, the very old patient had bilateral massive pleural effusion and aortic aneurysm with a 64-slice computed tomography (CT). TA commonly affects primarily large elastic arteries such as the aorta and its main branches. Steroid was very effective for suppression of inflammatory symptom being dose-dependent. His pleural effusion had been decreasing without reducing the size of aortic aneurysm. Multi-slice CT was a very useful tool to detect unexpected lesion in Takayasu arteritis in a non-invasive manner.
    MeSH term(s) Aged, 80 and over ; Humans ; Male ; Takayasu Arteritis/diagnosis ; Takayasu Arteritis/diagnostic imaging ; Tomography, Spiral Computed/methods
    Language English
    Publishing date 2008-04-10
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2007.05.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: NCC regulation by WNK signal cascade.

    Uchida, Shinichi / Mori, Takayasu / Susa, Koichiro / Sohara, Eisei

    Frontiers in physiology

    2023  Volume 13, Page(s) 1081261

    Abstract: With-no-lysine (K) (WNK) kinases have been identified as the causal genes for pseudohypoaldosteronism type II (PHAII), a rare hereditary hypertension condition characterized by hyperkalemia, hyperchloremic metabolic acidosis, and thiazide- ... ...

    Abstract With-no-lysine (K) (WNK) kinases have been identified as the causal genes for pseudohypoaldosteronism type II (PHAII), a rare hereditary hypertension condition characterized by hyperkalemia, hyperchloremic metabolic acidosis, and thiazide-hypersensitivity. We thought that clarifying the link between WNK and NaCl cotransporter (NCC) would bring us new mechanism(s) of NCC regulation. For the first time, we were able to produce a knock-in mouse model of PHAII and anti-phosphorylated NCC antibodies against the putative NCC phosphorylation sites and discover that constitutive activation of NCC and increased phosphorylation of NCC are the primary pathogenesis of the disease
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.1081261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Case of hereditary kidney disease presenting thin basement membrane with a single heterozygous variant of Intersectin 2.

    Kondo, Madoka / Mori, Takayasu / Oshita, Tadashi / Ohashi, Atsuki / Sohara, Eisei / Uchida, Shinichi / Maeda, Yoshitaka

    Journal of rural medicine : JRM

    2023  Volume 18, Issue 2, Page(s) 143–148

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2023-04-05
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2768933-5
    ISSN 1880-4888 ; 1880-487X
    ISSN (online) 1880-4888
    ISSN 1880-487X
    DOI 10.2185/jrm.2022-048
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  8. Article ; Online: Global cognition and executive functions of older adults with type 1 diabetes mellitus without dementia.

    Nagasawa, Kaoru / Matsumura, Kimio / Uchida, Takayasu / Suzuki, Yuya / Nishimura, Akihiro / Okubo, Minoru / Igeta, Yukifusa / Kobayashi, Tetsuro / Sakurai, Takashi / Mori, Yasumichi

    Journal of diabetes investigation

    2024  

    Abstract: Aims/introduction: This study aimed to characterize the global cognition and executive functions of older adults with type 1 diabetes mellitus in comparison with type 2 diabetes mellitus.: Materials and methods: This study included 37 patients with ... ...

    Abstract Aims/introduction: This study aimed to characterize the global cognition and executive functions of older adults with type 1 diabetes mellitus in comparison with type 2 diabetes mellitus.
    Materials and methods: This study included 37 patients with type 1 diabetes mellitus aged ≥65 years and 37 age- and sex-matched patients with type 2 diabetes mellitus. Patients with dementia scoring <24 on the Mini-Mental State Examination were excluded. General cognition, memory, classic, and practical executive function were investigated.
    Results: Patients with type 1 diabetes mellitus demonstrated lower psychomotor speed scores on Trail Making Tests A and B (P < 0.001, P < 0.013) than those with type 2 diabetes mellitus. The dysexecutive syndrome behavioral assessment revealed similar results in patients with types 1 and 2 diabetes mellitus. The Wechsler Memory Scale-Revised verbal episodic memory and Montreal Cognitive Assessment Japanese version were similar in terms of general cognition, but worse delayed recall subset on the latter was associated with type 2 diabetes mellitus (P = 0.038). A worse Trail Making Test-A performance was associated with type 1 diabetes mellitus and age (P < 0.004, P < 0.029).
    Conclusions: Executive function of psychomotor speed was worse in older outpatient adults without dementia with type 1 diabetes mellitus than in those with type 2 diabetes mellitus but with no significant differences in the comprehensive and practical behavioral assessment of dysexecutive syndrome. Patients with type 1 diabetes had more severely impaired executive function, whereas those with type 2 had greater impaired memory than executive function.
    Language English
    Publishing date 2024-03-25
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.14191
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  9. Article ; Online: A Nationwide Survey of Spinal Cord-Related Pain Syndrome in Japan: Clinical Characteristics and Treatment.

    Nakajima, Hideaki / Uchida, Kenzo / Takayasu, Masakazu / Ushida, Takahiro

    Spine surgery and related research

    2019  Volume 3, Issue 4, Page(s) 319–326

    Abstract: Introduction: In this study, we defined chronic neuropathic pain (NeP) in patients with diseases associated with spinal cord damage, such as spinal cord-related pain syndrome, and performed a nationwide survey investigating the prevalence, actual status, ...

    Abstract Introduction: In this study, we defined chronic neuropathic pain (NeP) in patients with diseases associated with spinal cord damage, such as spinal cord-related pain syndrome, and performed a nationwide survey investigating the prevalence, actual status, and features of this syndrome in Japan in order to gather basic information needed for planning control measures.
    Methods: In this nationwide epidemiologic survey, a mail-in questionnaire was sent to 3,206 institutions throughout Japan certified by the Japanese Orthopaedic Association (2,065 institutions) and the Japan Neurosurgical Society (1,141 institutions). The survey included the number of patients, frequency, and type of allodynia, concomitant diseases, and types of and responses to treatment.
    Results: Valid responses were obtained from 552 institutions on 3,401 patients. Of these, 1,719 (50.5%) patients experienced no pain, and thus the study involved the analysis of data of the remaining 1,682 patients with pain. The most frequent underlying conditions were cervical spondylotic myelopathy (26.7%), spinal cord injury (17.4%), and ossification of the posterior longitudinal ligament (OPLL) of the cervical spine (14.1%). Among the 1,682 patients, 62.5% reported at-level pain, among which 43.0% presented with allodynia. On the other hand, 38.7% presented with below-level pain. The majority of patients (73.4%) used nonsteroidal anti-inflammatory drugs (NSAIDs) and muscle relaxants (46.6%). The effectiveness of treatment was significantly higher in patients using anticonvulsants (31.1%) than in those using other medications. About a third of the patients stopped the treatment for either lack of effect or adverse effects.
    Conclusions: The characteristics of NeP in patients with spinal cord-related pain syndrome varied according to its level in relation to the affected spinal segment (at-level and/or below-level). Unfortunately, medications are sometimes ineffective and have potential adverse effects. Further classification of allodynia is needed for effective symptom-based treatment.
    Language English
    Publishing date 2019-02-28
    Publishing country Japan
    Document type Journal Article
    ISSN 2432-261X
    ISSN (online) 2432-261X
    DOI 10.22603/ssrr.2018-0096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A case of unexpected diagnosis of fibronectin glomerulopathy with histological features of membranoproliferative glomerulonephritis.

    Hata, Misa / Mori, Takayasu / Hirose, Yurika / Nishida, Yuriko / Mandai, Shintaro / Ando, Fumiaki / Susa, Koichiro / Iimori, Soichiro / Naito, Shotaro / Sohara, Eisei / Rai, Tatemitsu / Taguchi, Towako / Tomii, Shohei / Ohashi, Kenichi / Uchida, Shinichi

    BMC nephrology

    2024  Volume 25, Issue 1, Page(s) 25

    Abstract: Fibronectin (FN) glomerulopathy (FNG), a rare autosomal hereditary renal disease, is characterized by proteinuria resulting from the massive accumulation of FN in the glomeruli. It typically affects individuals aged 10-50 years. In this report, we ... ...

    Abstract Fibronectin (FN) glomerulopathy (FNG), a rare autosomal hereditary renal disease, is characterized by proteinuria resulting from the massive accumulation of FN in the glomeruli. It typically affects individuals aged 10-50 years. In this report, we describe the case of a 57-year-old man who was diagnosed with FNG through genetic analysis and histological examination that revealed membranoproliferative glomerulonephritis. Despite treatment with prednisolone, the therapeutic response was unsatisfactory. Prednisolone was subsequently tapered and discontinued because the patient had pulmonary thromboembolism. Subsequent comprehensive genetic testing, which was initially not conducted because the patient's parents did not have a history of kidney disease, identified a known disease-causing variant in the FN1 gene, indicating a de novo variant. FNG was further confirmed by positive staining of glomeruli with FN using an IST-4 antibody. Although corticosteroid therapy is commonly employed as the initial treatment for MPGN, its appropriateness depends on the underlying etiology. Thus, clinicians must be aware of potential rare genetic causes underlying MPGN.
    MeSH term(s) Male ; Humans ; Middle Aged ; Glomerulonephritis, Membranoproliferative/diagnosis ; Glomerulonephritis, Membranoproliferative/drug therapy ; Glomerulonephritis, Membranoproliferative/genetics ; Kidney Glomerulus ; Kidney ; Prednisolone/therapeutic use
    Chemical Substances Prednisolone (9PHQ9Y1OLM)
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-024-03456-7
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