Article ; Online: Ligand-Based Regulation of Dynamics and Reactivity of Hemoproteins.
2023 Volume 13, Issue 4
Abstract: Hemoproteins include several heme-binding proteins with distinct structure and function. The presence of the heme group confers specific reactivity and spectroscopic properties to hemoproteins. In this review, we provide an overview of five families of ... ...
| Abstract | Hemoproteins include several heme-binding proteins with distinct structure and function. The presence of the heme group confers specific reactivity and spectroscopic properties to hemoproteins. In this review, we provide an overview of five families of hemoproteins in terms of dynamics and reactivity. First, we describe how ligands modulate cooperativity and reactivity in globins, such as myoglobin and hemoglobin. Second, we move on to another family of hemoproteins devoted to electron transport, such as cytochromes. Later, we consider heme-based reactivity in hemopexin, the main heme-scavenging protein. Then, we focus on heme-albumin, a chronosteric hemoprotein with peculiar spectroscopic and enzymatic properties. Eventually, we analyze the reactivity and dynamics of the most recently discovered family of hemoproteins, i.e., nitrobindins. |
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| MeSH term(s) | Heme/metabolism ; Ligands ; Hemeproteins/chemistry ; Hemeproteins/metabolism |
| Chemical Substances | Heme (42VZT0U6YR) ; Ligands ; Hemeproteins |
| Language | English |
| Publishing date | 2023-04-17 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2701262-1 |
| ISSN | 2218-273X ; 2218-273X |
| ISSN (online) | 2218-273X |
| ISSN | 2218-273X |
| DOI | 10.3390/biom13040683 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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