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  1. Book ; Online: Neurofibromatosis : Current Trends and Future Directions

    Signorelli, Francesco / Messina, Raffaella / Messina, Raffaella

    2020  

    Keywords Oncology
    Size 1 electronic resource (120 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021045836
    ISBN 9781838805760 ; 1838805761
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Septostomy and Monroplasty in Isolated Lateral Ventricle After Removal of a Third Ventricle Colloid Cyst: 2-Dimensional Operative Video.

    Tengattini, Francesco / Messina, Andrea / Fontanella, Marco Maria / Borghesi, Ignazio / Calbucci, Fabio / Draghi, Riccardo

    World neurosurgery

    2024  Volume 184, Page(s) 125

    Abstract: Isolated unilateral hydrocephalus (IUH) is a condition caused by unilateral obstruction of the foramen of Monro. ...

    Abstract Isolated unilateral hydrocephalus (IUH) is a condition caused by unilateral obstruction of the foramen of Monro.
    MeSH term(s) Humans ; Lateral Ventricles ; Third Ventricle/surgery ; Colloid Cysts/diagnostic imaging ; Colloid Cysts/surgery ; Colloid Cysts/complications ; Cerebral Ventricles/surgery ; Hydrocephalus/diagnostic imaging ; Hydrocephalus/etiology ; Hydrocephalus/surgery ; Neuroendoscopy/methods
    Language English
    Publishing date 2024-01-13
    Publishing country United States
    Document type Video-Audio Media
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2024.01.046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1159: Show issues Location:
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  3. Article: Pituitary Stalk Hemangioblastoma: Complete Resection through Orbitozygomatic Approach with Extradural Anterior Clinoidectomy.

    Messina, Raffaella / Cirrottola, Giovanni / Tacconi, Leonello / Guyotat, Jacques / Signorelli, Francesco

    Journal of neurological surgery. Part B, Skull base

    2022  Volume 83, Issue Suppl 3, Page(s) e661–e662

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2022-10-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0042-1757618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3425: Show issues Location:
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  4. Article: Wirksamkeit und pharmakologische Eignung von Cinnarizin und Dimenhydrinat zur Behandlung von Schwindel und damit verbundenen Symptomen

    Plescia, Fluvio / Salvago, Pietro / Dispenza, Francesco / Messina, Giuseppe / Cannizzaro, Emanuele / Martines, Francesco

    Nervenheilkunde

    2022  Volume 41, Issue 11, Page(s) 789

    Language German
    Document type Article
    ZDB-ID 604504-2
    ISSN 0722-1541
    Database Current Contents Medicine

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    Zs.A 1715: Show issues Location:
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  5. Article ; Online: Immune checkpoint inhibitors plus chemotherapy in first-line endometrial cancer treatment: Still the era of microsatellites?

    Maiorano, Mauro Francesco Pio / Messina, Carlo / Maiello, Evaristo / Cormio, Gennaro / Maiorano, Brigida Anna

    BJOG : an international journal of obstetrics and gynaecology

    2024  

    Abstract: Objective: The combination of immune checkpoint inhibitors (ICIs) plus chemotherapy is currently being tested as the first-line treatment of advanced endometrial. We aimed to evaluate the efficacy and safety of this combination.: Design: We performed ...

    Abstract Objective: The combination of immune checkpoint inhibitors (ICIs) plus chemotherapy is currently being tested as the first-line treatment of advanced endometrial. We aimed to evaluate the efficacy and safety of this combination.
    Design: We performed a meta-analysis of randomized clinical trials.
    Population and setting: Patients with advanced endometrial carcinoma receiving ICIs plus chemotherapy in the experimental arm, compared with chemotherapy plus placebo in the control arm, were included.
    Methods and outcomes: We evaluated the progression-free survival (PFS) as an efficacy outcome and the number and grades of adverse events (AEs) for safety. Hazard ratios (HR) for PFS and risk ratios (RR) for AEs, with 95% confidence intervals (CI), were calculated.
    Results: 1303 patients were treated in the included studies. Adding ICIs to chemotherapy significantly improved PFS in mismatch repair deficient (dMMR-HR 0.29; 95% CI, 0.20-0.42; p < 0.00001) and in mismatch repair proficient (pMMR-HR 0.64; 95% CI, 0.46-0.90; p = 0.01) patients. No difference emerged for all-grades AEs (RR 1.00; p = 0.98), but the risk of ≥G3 AEs was increased in the ICIs + chemotherapy group (RR 1.22; 95% CI, 1.11-1.34; p < 0.0001).
    Conclusions: Adding ICIs to chemotherapy significantly improves PFS in first-line endometrial cancer, regardless of MMR status.
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2000931-8
    ISSN 1471-0528 ; 0306-5456 ; 1470-0328
    ISSN (online) 1471-0528
    ISSN 0306-5456 ; 1470-0328
    DOI 10.1111/1471-0528.17749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Um I Zs.121: Show issues Location:
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  6. Article ; Online: Effects of Proprioceptive Insoles and Specific Core Training on Postural Stability for Preventing Injuries in Tennis.

    Messina, Giuseppe / Francavilla, Vincenzo Cristian / Lima, Francesco / Padua, Elvira / Secolo, Giuseppe / Secolo, Innocenzo / Iovane, Angelo / Parisi, Maria Chiara / Di Corrado, Donatella

    Journal of functional morphology and kinesiology

    2024  Volume 9, Issue 1

    Abstract: Tennis is a complex sport based on unpredictability that requires adequate physical and psychological preparation to prevent injuries. The aim of this study was to investigate the effects of 8-week specific core stability training on postural stability ... ...

    Abstract Tennis is a complex sport based on unpredictability that requires adequate physical and psychological preparation to prevent injuries. The aim of this study was to investigate the effects of 8-week specific core stability training on postural stability in competitive adolescent tennis players, aged between 14 and 19 years old. Sixty-one participants were randomly allocated into two groups: experimental (
    Language English
    Publishing date 2024-02-19
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2411-5142
    ISSN (online) 2411-5142
    DOI 10.3390/jfmk9010034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The dark side of the moon: the immune-mediated adverse events of IL-17A/IL-17R inhibition.

    Messina, Francesco / Piaserico, Stefano

    The Journal of dermatological treatment

    2022  Volume 33, Issue 5, Page(s) 2443–2454

    Abstract: As aberrant IL-17 signaling plays a critical role in the pathogenesis of psoriasis, biologic agents targeting this pathway have become an important weapon against this disease. Some biologic agents such as IL-17 inhibitors (secukinumab and ixekizumab) ... ...

    Abstract As aberrant IL-17 signaling plays a critical role in the pathogenesis of psoriasis, biologic agents targeting this pathway have become an important weapon against this disease. Some biologic agents such as IL-17 inhibitors (secukinumab and ixekizumab) and the IL-17 receptor (IL17R) inhibitor (brodalumab) are relatively safe, tolerable and efficacious drugs. Nevertheless, side effects of IL-17 pathway inhibition occur. This review focuses on the dermatological manifestations linked to these treatments. Paradoxical psoriasis and atopic-like eczema may be the most common cutaneous adverse events, while manifestations such as neutrophilic dermatoses, hypersensitivity reactions, lichenoid eruptions, vasculitides, bullous diseases, lupus-like reactions, pigmentation disorders, adnexal diseases and granulomatous dermatoses have been described less frequently.
    MeSH term(s) Antibodies, Monoclonal ; Biological Factors/adverse effects ; Biological Factors/therapeutic use ; Female ; Humans ; Interleukin-17/antagonists & inhibitors ; Psoriasis/chemically induced ; Psoriasis/drug therapy ; Receptors, Interleukin/antagonists & inhibitors
    Chemical Substances Antibodies, Monoclonal ; Biological Factors ; Interleukin-17 ; Receptors, Interleukin
    Language English
    Publishing date 2022-04-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1036299-x
    ISSN 1471-1753 ; 0954-6634
    ISSN (online) 1471-1753
    ISSN 0954-6634
    DOI 10.1080/09546634.2022.2062281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Pharmacological management of severe plaque psoriasis in patients with cardiovascular disease.

    Piaserico, Stefano / Messina, Francesco

    Expert opinion on pharmacotherapy

    2022  Volume 23, Issue 7, Page(s) 853–864

    Abstract: Introduction: There is compelling evidence about the independent association between psoriasis and an increased risk of cardiovascular diseases, in particular myocardial infarction, chronic heart failure and cardiac arrythmia. This is due to both the ... ...

    Abstract Introduction: There is compelling evidence about the independent association between psoriasis and an increased risk of cardiovascular diseases, in particular myocardial infarction, chronic heart failure and cardiac arrythmia. This is due to both the higher prevalence of traditional cardiovascular risk factors and an independent contribution of chronic inflammation associated with psoriasis. Inflammation is not only important in atherosclerosis, but also is increasingly recognized as a contributing factor to heart failure and arrythmia through microvascular dysfunction and myocardial fibrosis. This enhanced risk should be considered when treating a patient with severe psoriasis. Moreover, the
    Areas covered: Herein, the authors review the pharmacological management of severe plaque psoriasis in patients with cardiovascular disease, providing their expert opinion and future perspectives on the subject.
    Expert opinion: Theoretically, anti-inflammatory drugs may not only dampen the systemic burden associated with psoriasis, but also potentially contribute to prevent long-term cardiovascular events in psoriasis. On the other hand, some treatments may negatively affect the cardiovascular system.Whether findings from observational studies or ones evaluating surrogates of cardiovascular risk translate into reductions in cardiovascular events needs to be investigated by long-term clinical trials with clinically meaningful endpoints.
    MeSH term(s) Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Comorbidity ; Heart Failure/complications ; Humans ; Inflammation ; Psoriasis/complications ; Psoriasis/drug therapy ; Psoriasis/epidemiology
    Language English
    Publishing date 2022-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2022.2060739
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5130: Show issues Location:
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  9. Article: Polyphenolic Profile and Antioxidant Activity of Green Extracts from Grape Pomace Skins and Seeds of Italian Cultivars.

    Guaita, Massimo / Motta, Silvia / Messina, Stefano / Casini, Francesco / Bosso, Antonella

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 20

    Abstract: The possibility of industrial exploitation of winemaking products, as for all byproducts of vegetal origin, constantly deals with a raw material (grape pomace, GP) whose chemical composition and functional properties vary over time depending on the ... ...

    Abstract The possibility of industrial exploitation of winemaking products, as for all byproducts of vegetal origin, constantly deals with a raw material (grape pomace, GP) whose chemical composition and functional properties vary over time depending on the varietal and geographical origin of the grapes, the climatic conditions (vintage effect), and the winemaking technique. This work studied the compositional variability of polyphenolic skin and seed extracts from GP derived from white and red winemaking of different Italian grape varieties. The total polyphenolic content (GAE), the main classes of polyphenolic compounds, and the DPPH index were determined. Seed extracts were always richer in total polyphenols and condensed tannins and had higher antiradical activity (DPPH) than skin extracts: 144-298 mg GAE/g d.w. extract for skins and 327-540 mg GAE/g for seeds; the DPPH values were 1.77-3.40 mg AAE/g for skins and 3.10-10.48 mg AAE/g for seeds. Furthermore, it was verified that the evaluation of the GAE index of seed extracts, offering a good estimate of the antiradical properties (DPPH index), could represent a simple and rapid method for selecting the best lots of seeds to be used. Conversely, GP skins could be used as flour in the food industry due to their high content of dietary fiber and the presence of flavonols, which possess very interesting functional properties. Important differences in the flavonols profile were observed both between cultivars and between unfermented and fermented pomace.
    Language English
    Publishing date 2023-10-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12203880
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Thérapie du psoriasis pédiatrique : présent et futur.

    Messina, Francesco / Conrad, Curdin / Morren, Marie-Anne

    Revue medicale suisse

    2023  Volume 20, Issue 867, Page(s) 631–635

    Abstract: Psoriasis may present in childhood with skin, nail and scalp lesions but sometimes also articular involvement. It has an import impact on the quality of life of young patients. In this article we present an overview of the treatments that may be used in ... ...

    Title translation Treatment of childhood psoriasis: present and future.
    Abstract Psoriasis may present in childhood with skin, nail and scalp lesions but sometimes also articular involvement. It has an import impact on the quality of life of young patients. In this article we present an overview of the treatments that may be used in children according to skin area involved and severity of lesions with special interest for the biological treatments, already available and under investigation.
    MeSH term(s) Child ; Humans ; Quality of Life ; Severity of Illness Index ; Psoriasis/therapy ; Skin ; Nails/pathology
    Language French
    Publishing date 2023-10-26
    Publishing country Switzerland
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    DOI 10.53738/REVMED.2024.20.867.631
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5998: Show issues Location:
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