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  1. Book: Nierenerkrankungen

    Mann, Johannes

    was Ihre Nieren schützt und stärkt

    2022  

    Author's details Johannes Mann; unter Mitarbeit von Priv.-Doz. Dr. med. Ulrich Dendorfer [und 5 weiteren]
    Keywords Nieren ; Nierenerkrankung ; Nierenerkrankung/Ratgeber ; Nierenerkrankungen ; Niereninsuffizienz ; Nierenkrankheit ; Nierenleiden ; Nierenschwäche ; chronische Nierenerkrankung ; Dialyse ; Lebensqualität ; Ernährung ; 600
    Subject Nephropathie ; Nierenerkrankung ; Nierenerkrankungen ; Niere ; Renopathie
    Language German
    Size 155 Seiten, Illustrationen, 21.7 cm x 16 cm
    Edition 3. Auflage
    Publisher TRIAS
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    Old title Vorangegangen ist
    HBZ-ID HT021322437
    ISBN 978-3-432-11527-6 ; 3-432-11527-X ; 9783432115283 ; 3432115288
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Vel 5 available for loan (reading room) Lesesaal EG Gesundheitsliteratur

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  2. Book: Nierenerkrankungen

    Mann, Johannes

    Was Ihre Nieren schützt und stärkt

    2014  

    Author's details Johannes Mann
    Keywords Nieren ; Nierenerkrankungen ; Niereninsuffizienz ; Nierenleiden ; nierenkrank ; Dialyse ; Nierenschwäche ; Nierenversagen ; Nierenerkrankung ; Nierenerkrankung/Ratgeber ; Niere ; Chronische Nierenerkrankung ; Ernährung ; Nierentransplantation ; Lebensqualität ; Nierenkrankheit
    Subject Nephropathie ; Nierenerkrankung ; Nierenerkrankungen ; Niere ; Renopathie
    Language German
    Size 155 S. : Ill., graph. Darst., 24 mm x 17 mm
    Edition 2. Auflage
    Publisher TRIAS
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT018452596
    ISBN 978-3-8304-8026-6 ; 3-8304-8026-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 11759 order for loan Magazin

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  3. Book: Der große TRIAS-Ratgeber für Nierenkranke

    Mann, Johannes

    Erkrankungen, Untersuchungen, Therapien ; aktiver Schutz für Ihre Nieren - den Alltag besser meistern

    2008  

    Author's details Johannes Mann
    Keywords Nierenkrankheit
    Subject Nephropathie ; Nierenerkrankung ; Nierenerkrankungen ; Niere ; Renopathie
    Language German
    Size 192 S. : Ill., graph. Darst.
    Edition 1. Aufl.
    Publisher Trias
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT015493597
    ISBN 978-3-8304-3407-8 ; 3-8304-3407-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 6693 order for loan Magazin

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  4. Article: Cerebellar Compression by Giant Extracanalicular Osteoma with Central Cholesterol Granuloma.

    Smith, Caroline F / Massey, Conner J / Mann, Scott E

    Case reports in otolaryngology

    2023  Volume 2023, Page(s) 6652012

    Abstract: Temporal bone osteomas comprise 0.1-1% of benign tumors involving the skull, the majority of which arise in the external auditory canal. More rarely, they can arise from the mastoid portion of the temporal bone. These generally present as a slow growing ... ...

    Abstract Temporal bone osteomas comprise 0.1-1% of benign tumors involving the skull, the majority of which arise in the external auditory canal. More rarely, they can arise from the mastoid portion of the temporal bone. These generally present as a slow growing skull base lesion that can cause cosmetic deformity, headache, and/or hearing loss. Here, we report a case of extracanalicular mastoid osteoma uniquely presenting with posterior fossa and cerebellar compression with associated dizziness and imbalance.
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2648756-1
    ISSN 2090-6773 ; 2090-6765
    ISSN (online) 2090-6773
    ISSN 2090-6765
    DOI 10.1155/2023/6652012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T cell responses.

    Heuberger, C E / Janney, A / Ilott, N / Bertocchi, A / Pott, S / Gu, Y / Pohin, M / Friedrich, M / Mann, E H / Pearson, C / Powrie, F M / Pott, J / Thornton, E / Maloy, K J

    Mucosal immunology

    2023  

    Abstract: Although intestinal epithelial cells (IECs) can express major histocompatibility complex class II (MHC II), especially during intestinal inflammation, it remains unclear if antigen presentation by IECs favours pro- or anti-inflammatory ... ...

    Abstract Although intestinal epithelial cells (IECs) can express major histocompatibility complex class II (MHC II), especially during intestinal inflammation, it remains unclear if antigen presentation by IECs favours pro- or anti-inflammatory CD4
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2411370-0
    ISSN 1935-3456 ; 1933-0219
    ISSN (online) 1935-3456
    ISSN 1933-0219
    DOI 10.1016/j.mucimm.2023.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6796: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: In memoriam: Emeritus Professor Robin L. Willson.

    Davies, Michael J / Davies, Kelvin J A / Halliwell, Barry / Jackson, Malcolm J / Mann, Giovanni E / Poli, Giuseppe / Radi, Rafael / Riley, Patrick A / Sies, Helmut / Ward, John F / Wardman, Peter / Willson, John

    Free radical research

    2023  Volume 56, Issue 7-8, Page(s) 572–576

    Language English
    Publishing date 2023-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1194130-3
    ISSN 1029-2470 ; 1071-5762
    ISSN (online) 1029-2470
    ISSN 1071-5762
    DOI 10.1080/10715762.2022.2140273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2236: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Sex bias in mortality risk changes over the lifespan of bottlenose dolphins.

    McEntee, Molly H F / Foroughirad, Vivienne / Krzyszczyk, Ewa / Mann, Janet

    Proceedings. Biological sciences

    2023  Volume 290, Issue 2003, Page(s) 20230675

    Abstract: Research on sex biases in longevity in mammals often assumes that male investment in competition results in a female survival advantage that is constant throughout life. We use 35 years of longitudinal data on 1003 wild bottlenose dolphins ( ...

    Abstract Research on sex biases in longevity in mammals often assumes that male investment in competition results in a female survival advantage that is constant throughout life. We use 35 years of longitudinal data on 1003 wild bottlenose dolphins (
    MeSH term(s) Animals ; Male ; Female ; Bottle-Nosed Dolphin ; Longevity ; Sexism ; Reproduction ; Social Behavior
    Language English
    Publishing date 2023-07-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2023.0675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1364: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Production and use of antigen tetramers to study antigen-specific B cells.

    Phelps, Allyssa / Pazos-Castro, Diego / Urselli, Francesca / Grydziuszko, Emily / Mann-Delany, Olivia / Fang, Allison / Walker, Tina D / Guruge, Rangana Talpe / Tome-Amat, Jaime / Diaz-Perales, Araceli / Waserman, Susan / Boonyaratanakornkit, Jim / Jordana, Manel / Taylor, Justin J / Koenig, Joshua F E

    Nature protocols

    2024  Volume 19, Issue 3, Page(s) 727–751

    Abstract: B cells generate antibodies that provide protection from infection, but also cause pathology in autoimmune and allergic conditions. Antigen-specific B cells can be detected by binding their surface antibody receptors with native antigens conjugated to ... ...

    Abstract B cells generate antibodies that provide protection from infection, but also cause pathology in autoimmune and allergic conditions. Antigen-specific B cells can be detected by binding their surface antibody receptors with native antigens conjugated to fluorescent probes, a technique that has revealed substantial insight into B cell activation and function. This protocol describes the process of generating fluorescent antigen tetramer probes and delineates a process of enriching large samples based on antigen-specificity for high-resolution analyses of the antigen-specific B cell repertoire. Enrichment of tetramer-binding cells allows for detection of antigen-specific B cells as rare as 1 in 100 million cells, providing sufficient resolution to study naive B cells and IgE-expressing cells by flow cytometry. The generation of antigen tetramers involves antigen biotinylation, assessment of biotin:antigen ratio for optimal tetramer loading and polymerization around a streptavidin-fluorophore backbone. We also describe the construction of a control tetramer to exclude B cells binding to the tetramer backbone. We provide a framework to validate whether tetramer probes are detecting true antigen-specific B cells and discuss considerations for experimental design. This protocol can be performed by researchers trained in basic biomedical/immunological research techniques, using instrumentation commonly found in most laboratories. Constructing the antigen and control tetramers takes 9 h, though their specificity should be assessed before experimentation and may take weeks to months depending on the method of validation. Sample enrichment requires ~2 h but is generally time and cost neutral as fewer cells are run through the flow cytometer.
    MeSH term(s) Antigens ; B-Lymphocytes ; Flow Cytometry/methods
    Chemical Substances Antigens
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2244966-8
    ISSN 1750-2799 ; 1754-2189
    ISSN (online) 1750-2799
    ISSN 1754-2189
    DOI 10.1038/s41596-023-00930-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Changes in cardiac and vascular haemodynamics as potential mediators of improvements in cardiovascular and kidney outcomes with empagliflozin in type 2 diabetes.

    Krämer, Bernhard K / Hauske, Sibylle J / Chilton, Robert / Mann, Johannes F E / Gullestad, Lars / Fitchett, David / Mattheus, Michaela / Steubl, Dominik / Wanner, Christoph

    Journal of diabetes and its complications

    2023  Volume 37, Issue 9, Page(s) 108588

    Abstract: Aims: Evaluate changes in haemodynamic markers as mediators of cardiovascular (CV) and kidney benefits with empagliflozin.: Methods: Post-hoc analysis of EMPA-REG OUTCOME in patients with type 2 diabetes (T2D) and established CV disease receiving ... ...

    Abstract Aims: Evaluate changes in haemodynamic markers as mediators of cardiovascular (CV) and kidney benefits with empagliflozin.
    Methods: Post-hoc analysis of EMPA-REG OUTCOME in patients with type 2 diabetes (T2D) and established CV disease receiving empagliflozin (10 and 25 mg) or placebo. Outcomes were CV death, hospitalisation for heart failure [HF], HF death, incident/worsening nephropathy, new onset macroalbuminuria, and the composite of sustained estimated glomerular filtration rate decline ≥40 % from baseline, renal replacement therapy or renal death. To be considered a mediator, changes in variable (pulse pressure, mean arterial pressure and cardiac workload) over time had to be (1) affected by active treatment, (2) associated with the outcome, and (3) adjustment for changes over time must reduce treatment effect versus an unadjusted analysis. Variables were evaluated in Cox regression analyses.
    Results: Pulse pressure, mean arterial pressure and cardiac workload were significantly reduced by empagliflozin vs placebo. Using change from baseline to Week 12 or sensitivity analyses (time-dependent updated mean and current change from baseline) of these CV parameters, only small impacts on empagliflozin effect on CV and kidney outcomes were shown.
    Conclusions: Improvements in haemodynamic parameters did not substantially mediate empagliflozin benefits on CV and kidney outcomes in patients with T2DM and established CV disease.
    MeSH term(s) Humans ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Cardiovascular System ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Heart Failure ; Hemodynamics ; Kidney
    Chemical Substances empagliflozin (HDC1R2M35U)
    Language English
    Publishing date 2023-08-17
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1105840-7
    ISSN 1873-460X ; 1056-8727
    ISSN (online) 1873-460X
    ISSN 1056-8727
    DOI 10.1016/j.jdiacomp.2023.108588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2225: Show issues Location:
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  10. Article ; Online: Intramuscular ketamine vs. midazolam for rapid risk-reduction in suicidal, depressed emergency patients: Clinical trial design and rationale.

    Sajid, Sumra / Lawrence, Ryan E / Galfalvy, Hanga C / Keilp, John G / Moitra, Vivek K / Mann, J John / Grunebaum, Michael F

    Journal of affective disorders reports

    2023  Volume 15

    Abstract: Emergency department (ED) visits for suicidal ideation or behavior have been increasing in all age groups, particularly younger adults. A rapid-acting treatment to reduce suicidal thinking, adapted for ED use, is needed. Previous studies have shown a ... ...

    Abstract Emergency department (ED) visits for suicidal ideation or behavior have been increasing in all age groups, particularly younger adults. A rapid-acting treatment to reduce suicidal thinking, adapted for ED use, is needed. Previous studies have shown a single dose of ketamine can improve depression and suicidal ideation within hours. However, most studies used 40 min intravenous infusions which can be impractical in a psychiatric ED. The ER-Ketamine study we describe here is a randomized midazolam-controlled clinical trial (RCT; NCT04640636) testing intramuscular (IM) ketamine's feasibility, safety, and effectiveness to rapidly reduce suicidal ideation and depression in a psychiatric ED. A pre-injection phase involves screening, informed consent, eligibility confirmation, and baseline assessment of suicidal ideation, depression, and comorbidities. The randomized double-blind IM injection is administered in the ED under research staff supervision, vital sign monitoring, pharmacokinetic blood sampling, and clinical assessments. The post-injection phase occurs on a psychiatric inpatient unit with follow-up research assessments through four weeks post-discharge. Outcome measures are feasibility, safety, and effects on suicidal ideation and depression at 24 h post-injection, and through follow-up. The target sample is
    Language English
    Publishing date 2023-12-02
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-9153
    ISSN (online) 2666-9153
    DOI 10.1016/j.jadr.2023.100690
    Database MEDical Literature Analysis and Retrieval System OnLINE

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