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  1. Article ; Online: Nephrologists Rather Than Intensivists Should Manage Kidney Replacement Therapy in the ICU: CON.

    Bagshaw, Sean M

    Kidney360

    2023  Volume 4, Issue 1, Page(s) 10–12

    MeSH term(s) Humans ; Nephrologists ; Renal Replacement Therapy ; Intensive Care Units
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000092022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial: Renal system section in current opinion in critical care: pathways forward for innovation in acute kidney injury.

    Bagshaw, Sean M

    Current opinion in critical care

    2022  Volume 28, Issue 6, Page(s) 581–582

    MeSH term(s) Humans ; Acute Kidney Injury/therapy ; Critical Care
    Language English
    Publishing date 2022-09-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000000989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tackling sepsis-associated AKI: are there any chances of REVIVAL with new approaches?

    Prowle, John R / Bagshaw, Sean M / Forni, Lui G

    Intensive care medicine

    2024  Volume 50, Issue 1, Page(s) 131–133

    MeSH term(s) Humans ; Acute Kidney Injury/therapy ; Acute Kidney Injury/complications ; Sepsis/complications
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07294-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Making (numerical) sense of recent trials comparing balanced and normal saline intravenous solutions in the critically ill.

    Zampieri, Fernando G / Bagshaw, Sean M

    British journal of anaesthesia

    2023  Volume 131, Issue 1, Page(s) e10–e13

    MeSH term(s) Humans ; Saline Solution ; Critical Illness/therapy ; Crystalloid Solutions ; Fluid Therapy ; Administration, Intravenous ; Isotonic Solutions
    Chemical Substances Saline Solution ; Crystalloid Solutions ; Isotonic Solutions
    Language English
    Publishing date 2023-04-17
    Publishing country England
    Document type Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2023.03.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Admission to intensive care unit after major surgery.

    Zampieri, Fernando G / Lone, Nazir I / Bagshaw, Sean M

    Intensive care medicine

    2023  Volume 49, Issue 5, Page(s) 575–578

    MeSH term(s) Humans ; Hospitalization ; Intensive Care Units
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07026-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Integration of Equipoise into Eligibility Criteria in the STARRT-AKI Trial.

    Wald, Ron / Bagshaw, Sean M

    American journal of respiratory and critical care medicine

    2021  Volume 204, Issue 2, Page(s) 234–237

    MeSH term(s) Acute Kidney Injury ; Humans ; Patient Selection ; Therapeutic Equipoise
    Language English
    Publishing date 2021-05-03
    Publishing country United States
    Document type Letter ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202009-3425LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Fluid Therapy for Critically Ill Adults With Sepsis: A Review.

    Zampieri, Fernando G / Bagshaw, Sean M / Semler, Matthew W

    JAMA

    2023  Volume 329, Issue 22, Page(s) 1967–1980

    Abstract: Importance: Approximately 20% to 30% of patients admitted to an intensive care unit have sepsis. While fluid therapy typically begins in the emergency department, intravenous fluids in the intensive care unit are an essential component of therapy for ... ...

    Abstract Importance: Approximately 20% to 30% of patients admitted to an intensive care unit have sepsis. While fluid therapy typically begins in the emergency department, intravenous fluids in the intensive care unit are an essential component of therapy for sepsis.
    Observations: For patients with sepsis, intravenous fluid can increase cardiac output and blood pressure, maintain or increase intravascular fluid volume, and deliver medications. Fluid therapy can be conceptualized as 4 overlapping phases from early illness through resolution of sepsis: resuscitation (rapid fluid administered to restore perfusion); optimization (the risks and benefits of additional fluids to treat shock and ensure organ perfusion are evaluated); stabilization (fluid therapy is used only when there is a signal of fluid responsiveness); and evacuation (excess fluid accumulated during treatment of critical illness is eliminated). Among 3723 patients with sepsis who received 1 to 2 L of fluid, 3 randomized clinical trials (RCTs) reported that goal-directed therapy administering fluid boluses to attain a central venous pressure of 8 to 12 mm Hg, vasopressors to attain a mean arterial blood pressure of 65 to 90 mm Hg, and red blood cell transfusions or inotropes to attain a central venous oxygen saturation of at least 70% did not decrease mortality compared with unstructured clinical care (24.9% vs 25.4%; P = .68). Among 1563 patients with sepsis and hypotension who received 1 L of fluid, an RCT reported that favoring vasopressor treatment did not improve mortality compared with further fluid administration (14.0% vs 14.9%; P = .61). Another RCT reported that among 1554 patients in the intensive care unit with septic shock treated with at least 1 L of fluid compared with more liberal fluid administration, restricting fluid administration in the absence of severe hypoperfusion did not reduce mortality (42.3% vs 42.1%; P = .96). An RCT of 1000 patients with acute respiratory distress during the evacuation phase reported that limiting fluid administration and administering diuretics improved the number of days alive without mechanical ventilation compared with fluid treatment to attain higher intracardiac pressure (14.6 vs 12.1 days; P < .001), and it reported that hydroxyethyl starch significantly increased the incidence of kidney replacement therapy compared with saline (7.0% vs 5.8%; P = .04), Ringer lactate, or Ringer acetate.
    Conclusions and relevance: Fluids are an important component of treating patients who are critically ill with sepsis. Although optimal fluid management in patients with sepsis remains uncertain, clinicians should consider the risks and benefits of fluid administration in each phase of critical illness, avoid use of hydroxyethyl starch, and facilitate fluid removal for patients recovering from acute respiratory distress syndrome.
    MeSH term(s) Adult ; Humans ; Critical Illness/therapy ; Fluid Therapy/adverse effects ; Fluid Therapy/methods ; Sepsis/complications ; Sepsis/therapy ; Shock, Septic/therapy ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.7560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Starting Kidney Replacement Therapy in Critically III Patients with Acute Kidney Injury.

    Bagshaw, Sean M / Wald, Ron

    Critical care clinics

    2021  Volume 37, Issue 2, Page(s) 409–432

    Abstract: Kidney replacement therapy (KRT) is a core organ support in critical care settings. In patients suitable for escalation in support, who develop acute kidney injury (AKI) complications and urgent indications, there is consensus that KRT should be promptly ...

    Abstract Kidney replacement therapy (KRT) is a core organ support in critical care settings. In patients suitable for escalation in support, who develop acute kidney injury (AKI) complications and urgent indications, there is consensus that KRT should be promptly initiated. In the absence of such urgent indications, the optimal timing has been less certain. Current clinical practice guidelines do not present strong recommendations for when to start KRT for patients with AKI in the absence of life-threatening and urgent indications. This article discusses how best to provide KRT to critically ill patients with severe AKI.
    MeSH term(s) Acute Kidney Injury/therapy ; Critical Care ; Critical Illness ; Humans ; Renal Replacement Therapy
    Language English
    Publishing date 2021-02-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1006423-0
    ISSN 1557-8232 ; 0749-0704
    ISSN (online) 1557-8232
    ISSN 0749-0704
    DOI 10.1016/j.ccc.2020.11.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: [No title information]

    Ling, Ling / Bagshaw, Sean M / Villeneuve, Pierre-Marc

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2022  Volume 194, Issue 3, Page(s) E99–E103

    Title translation Syndrome de Guillain–Barré consécutif à la vaccination contre le SRAS-CoV-2 chez un patient ayant déjà présenté ce syndrome en lien avec un vaccin.
    Language French
    Publishing date 2022-01-15
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.210947-f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury. Reply.

    Wald, Ron / Bagshaw, Sean M

    The New England journal of medicine

    2020  Volume 383, Issue 18, Page(s) 1797–1798

    MeSH term(s) Acute Kidney Injury/therapy ; Humans ; Renal Replacement Therapy
    Language English
    Publishing date 2020-10-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2027489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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