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Article ; Online: Stepwise removal compared to complete removal for deep carious lesions.

Massón, María / Viteri-García, Andrés / Verdugo-Paiva, Francisca

2022 Volume 22, Issue 1, Page(s) e8227

Abstract: Introduction: Carious lesions have traditionally been treated by non-selective (complete or total) removal of carious tissue. However, due to its risks and adverse effects, carious tissue removal techniques have been developed, based on the preservation ...

Title translation	Remoción en dos pasos (stepwise) comparado con remoción total para caries dentinarias profundas.
Abstract	Introduction: Carious lesions have traditionally been treated by non-selective (complete or total) removal of carious tissue. However, due to its risks and adverse effects, carious tissue removal techniques have been developed, based on the preservation of tooth tissue, including the stepwise removal. The objective of this summary is to clarify the uncertainty about the effectiveness and safety of the stepwise removal technique compared to complete removal. Methods: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by searching multiple sources of information, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from identified reviews, reanalyzed data from primary studies, performed a meta-analysis, and prepared summary tables of results using the GRADE method. Results and conclusions: We identified three systematic reviews that included five primary studies, four of them corresponding to randomized trials. We concluded that stepwise removal may reduce the risk of pulp exposure, the risk of signs and symptoms of pulp disease and the risk of restoration failure, but the certainty of the evidence is low.
MeSH term(s)	Databases, Factual ; Dental Caries/therapy ; Humans ; Systematic Reviews as Topic ; Treatment Outcome
Language	English
Publishing date	2022-01-24
Publishing country	Chile
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2818022-7
ISSN	0717-6384 ; 0717-6384
ISSN (online)	0717-6384
ISSN	0717-6384
DOI	10.5867/medwave.2022.01.8226
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Barriers to and facilitators for the creation, dissemination, implementation, monitoring, and evaluation of oral health policies in the WHO Africa region: A scoping review protocol.

Carrasco-Labra, Alonso / Verdugo-Paiva, Francisca / Matanhire-Zihanzu, Cleopatra N / Booth, Emmett / Kohler, Iliana V / Urquhart, Olivia / Makino, Yuka / Glick, Michael

F1000Research

2024 Volume 12, Page(s) 1160

Abstract: Background: Evidence-informed oral health policies (OHP) can be instrumental in ending the neglect of oral health globally. When appropriately developed and implemented, OHP can improve the efficiency of healthcare systems and the quality of health ... ...

Abstract	Background: Evidence-informed oral health policies (OHP) can be instrumental in ending the neglect of oral health globally. When appropriately developed and implemented, OHP can improve the efficiency of healthcare systems and the quality of health outcomes. However, more than half of the countries in the World Health Organization (WHO) African region do not have an oral health policy or even the existence of a policy in need of additional and more national-specific OHP as part of non-communicable diseases and universal health coverage agendas. The objective of this protocol's study is to determine the barriers to and facilitators for the creation, dissemination, implementation, monitoring, and evaluation of OHP in the WHO Africa region. Methods: We will conduct a systematic search in Global Health, Embase, PubMed, PAIS, ABI/Inform, Web of Science, Academic Search Complete, Scopus, databases that index gray literature, and the WHO policy repositories. We will include qualitative, quantitative, or mixed-methods research studies and OHP documents published since January 1, 2002, which address stakeholders' perceptions and experiences regarding barriers to and facilitators for the creation, dissemination, implementation, monitoring, and evaluation of OHP in countries part of the WHO African region. We will produce descriptive statistics (frequencies and proportions) for quantitative data and conduct descriptive content analysis for qualitative data. Discussion: To effectively establish evidence-based OHP in the WHO African region, it is crucial to recognize existing challenges and opportunities for progress. The findings of this review will be relevant for Chief Dental Officers at ministries of health, administrators of dental schools, or academic institutions in the WHO African region and will inform a stakeholder dialogue meeting in Kenya in November of 2023. Registration: Open Science Framework: https://doi.org/10.17605/OSF.IO/9KMWR.
MeSH term(s)	Oral Health ; Delivery of Health Care ; Health Policy ; World Health Organization ; Kenya ; Review Literature as Topic
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2699932-8
ISSN	2046-1402 ; 2046-1402
ISSN (online)	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.139689.2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Policymakers' perceived barriers and facilitators in the use of research evidence in oral health policies and guidelines: a qualitative study protocol.

Verdugo-Paiva, Francisca / Bonfill, Xavier / Ortuño, Duniel / Glick, Michael / Carrasco-Labra, Alonso

BMJ open

2023 Volume 13, Issue 2, Page(s) e066048

Abstract: Introduction: Evidence-informed oral health policies are crucial to improving patient and population outcomes, but policymakers and organisational leaders infrequently systematically incorporate research evidence. Although there is indirect evidence ... ...

Abstract	Introduction: Evidence-informed oral health policies are crucial to improving patient and population outcomes, but policymakers and organisational leaders infrequently systematically incorporate research evidence. Although there is indirect evidence regarding challenges in other healthcare sectors, the use of evidence-informed oral health policies remains unstudied in oral health. This study aims to assess policymakers' perceived needs, barriers and facilitators in using research evidence to inform policies in oral health. Methods and analysis: This is a qualitative study situated within a phenomenological paradigm. We will conduct semistructured interviews with policymakers (5-10) affiliated with key organisations conducting guidance, policy statements, guidelines or any knowledge transfer deliverables in oral health. Organisations will be sampled purposively and with no geographical restrictions. All interviews will be recorded, and an audio transcript will be generated. Subsequently, a researcher will review and validate the transcripts. Data will be analysed using thematic analysis supported by ATLAS.ti software. Ethics and dissemination: Ethical approval was not sought because the study protocol met the criteria for exemption from such review according to the Clinical Research Ethics Committee of the Hospital de la Santa Creu i Sant Pau and the Spanish legislation (Law 14/2007 of 3 July, on biomedical research). Informed consent will be obtained from all subjects involved in this study. The findings of this study will be shared with participating organisations for feedback, disseminated in conferences and published in a peer-reviewed journal adopting open science practices. Study registration: Open Science Framework (DOI:10.17605/OSF.IO/W4KG7).
MeSH term(s)	Humans ; Oral Health ; Health Policy ; Qualitative Research ; Biomedical Research ; Research Design
Language	English
Publishing date	2023-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-066048
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chemo-mechanical removal versus conventional removal for deep caries lesion.

Zambrano-Achig, Paula / Viteri-García, Andrés / Verdugo-Paiva, Francisca

Medwave

2022 Volume 22, Issue 1, Page(s) e8320

Abstract: Introduction: Dental caries have been traditionally managed with the non-selective removal of carious tissue (total removal). However, the adverse effects and fear that this technique produces in patients has promoted the use of more conservative caries ...

Title translation	Remoción química mecánica comparada con remoción total convencional para lesiones de caries dentinarias profundas.
Abstract	Introduction: Dental caries have been traditionally managed with the non-selective removal of carious tissue (total removal). However, the adverse effects and fear that this technique produces in patients has promoted the use of more conservative caries removal techniques such as chemo-mechanical removal, but there is still controversy regarding its effectiveness and safety. Methods: We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings tables using the GRADE approach. Results and conclusions: We identified seven systematic reviews including 34 studies overall, of which 30 correspond to randomized trials. We concluded that chemo-mechanical caries removal probably reduces the need for anesthesia. Additionally, chemo-mechanical caries removal may decrease the pain experienced by the patient, decrease the risk of restoration failure and increase the time of the procedure for the removal of deep caries, but the certainty of the evidence is low. We are uncertain whether chemo-mechanical caries removal reduces the risk of pulp exposure as the certainty of the evidence has been assessed as very low.
MeSH term(s)	Databases, Factual ; Dental Caries/therapy ; Dental Caries Susceptibility ; Humans ; Pain ; Systematic Reviews as Topic
Language	English
Publishing date	2022-01-28
Publishing country	Chile
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2818022-7
ISSN	0717-6384 ; 0717-6384
ISSN (online)	0717-6384
ISSN	0717-6384
DOI	10.5867/medwave.2022.01.8320
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: How oral health care organizations formulate actionable statements to inform practice and policy: A protocol for a systematic survey.

Verdugo-Paiva, Francisca / Bonfill Cosp, Xavier / Alonso-Coello, Pablo / Ávila-Oliver, Camila / Glick, Michael / Carrasco-Labra, Alonso

F1000Research

2023 Volume 12, Page(s) 1261

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Quality of Life ; Public Health ; Policy ; Databases, Factual ; Delivery of Health Care
Language	English
Publishing date	2023-10-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2699932-8
ISSN	2046-1402 ; 2046-1402
ISSN (online)	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.141423.1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chemo-mechanical removal versus conventional removal for deep caries lesion

Paula Zambrano-Achig / Andrés Viteri-García / Francisca Verdugo-Paiva

Medwave, Vol 22, Iss 01, Pp e8319-e

2022 Volume 8319

Abstract: INTRODUCTION Dental caries have been traditionally managed with the non-selective removal of carious tissue (total removal). However, the adverse effects and fear that this technique produces in patients has promoted the use of more conservative caries ... ...

Abstract	INTRODUCTION Dental caries have been traditionally managed with the non-selective removal of carious tissue (total removal). However, the adverse effects and fear that this technique produces in patients has promoted the use of more conservative caries removal techniques such as chemo-mechanical removal, but there is still controversy regarding its effectiveness and safety. METHODS We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings tables using the GRADE approach. RESULTS AND CONCLUSIONS We identified seven systematic reviews including 34 studies overall, of which 30 correspond to randomized trials. We concluded that chemo-mechanical caries removal probably reduces the need for anesthesia. Additionally, chemo-mechanical caries removal may decrease the pain experienced by the patient, decrease the risk of restoration failure and increase the time of the procedure for the removal of deep caries, but the certainty of the evidence is low. We are uncertain whether chemo-mechanical caries removal reduces the risk of pulp exposure as the certainty of the evidence has been assessed as very low.
Keywords	chemomechanical caries removal ; caries removal ; dental caries ; minimally invasive dentistry ; epistemonikos ; grade ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	332
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Medwave Estudios Limitada
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Assessment of Duplicate Evidence in Systematic Reviews of Imaging Findings of Children With COVID-19.

Pérez-Gaxiola, Giordano / Verdugo-Paiva, Francisca / Rada, Gabriel / Flórez, Iván D

JAMA network open

2021 Volume 4, Issue 1, Page(s) e2032690

MeSH term(s)	Adolescent ; COVID-19/diagnostic imaging ; Child ; Child, Preschool ; Cross-Sectional Studies ; Data Collection ; Databases, Factual ; Evidence-Based Medicine ; Female ; Humans ; Infant ; Lung/diagnostic imaging ; Male ; Registries ; SARS-CoV-2 ; Systematic Reviews as Topic
Language	English
Publishing date	2021-01-04
Publishing country	United States
Document type	Journal Article
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2020.32690
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Long-term antibiotic prophylaxis regimen compared to short-term antibiotic prophylaxis regimen in patients undergoing orthognathic surgery.

Wallach, Matthias / Cuéllar, Javier / Verdugo-Paiva, Francisca / Alarcón, Ana

Medwave

2020 Volume 20, Issue 11, Page(s) e8072

Abstract: Introduction: Orthognathic surgery, being an invasive surgical procedure, may present significant postoperative morbidities for the patient. Among the most frequently described complications is surgical site infection. The administration of prophylactic ...

Title translation	Profilaxis antibiótica de esquema largo comparado con esquema corto en pacientes sometidos a cirugía ortognática.
Abstract	Introduction: Orthognathic surgery, being an invasive surgical procedure, may present significant postoperative morbidities for the patient. Among the most frequently described complications is surgical site infection. The administration of prophylactic antibiotics prior to this type of procedure is a common practice, however, the cost-benefit of the use of antibiotics, the type of antibiotics, the route of administration, the dosage, and the regimen to be used have not been clearly defined and are still considered a controversial issue. In this summary of evidence, we will compare long-term antibiotic prophylaxis with short-term prophylaxis. Methods: We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. Results and conclusions: We identified five systematic reviews including nine studies overall, of which all nine were randomized trials. We conclude that administering a long-term prophylactic antibiotic regimen probably decreases the risk of surgical site infection and that it may increase the risk of hospital stay longer than two days, nevertheless, regarding this last point, the certainty of the evidence is low.
MeSH term(s)	Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Antibiotic Prophylaxis/methods ; Humans ; Orthognathic Surgical Procedures/methods ; Surgical Wound Infection/prevention & control ; Systematic Reviews as Topic ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2020-12-11
Publishing country	Chile
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2818022-7
ISSN	0717-6384 ; 0717-6384
ISSN (online)	0717-6384
ISSN	0717-6384
DOI	10.5867/medwave.2020.11.8071
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Silver diamine fluoride compared to atraumatic restorative technique for the treatment of caries in primary and mixed first phase dentition.

Vargas, Juan Pablo / Uribe, Macarena / Ortuño, Duniel / Verdugo-Paiva, Francisca

Medwave

2020 Volume 20, Issue 7, Page(s) e8003

Abstract: Introduction: Cavitated carious lesions in primary and mixed dentition require prompt treatment to control caries progression. Silver diamine fluoride has emerged as an alternative to the atraumatic restorative technique due to its easy application. ... ...

Title translation	Fluoruro diamino de plata comparado con técnica de restauración atraumática para el tratamiento de caries cavitadas en dentición primaria y mixta primera fase.
Abstract	Introduction: Cavitated carious lesions in primary and mixed dentition require prompt treatment to control caries progression. Silver diamine fluoride has emerged as an alternative to the atraumatic restorative technique due to its easy application. However, there is still uncertainty regarding its effectiveness and safety. Methods: We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a metanalysis and generated a summary of findings table using the GRADE approach. Results and conclusions: We identified ten systematic reviews, including two studies overall, which are randomized trials. We concluded that silver diamine fluoride compared to the atraumatic restorative technique may increase the arrest of caries in primary and mixed first phase dentition, however, the certainty of the evidence has been assessed as low. On the other hand, treatment with silver diamine fluoride compared to the atraumatic restorative technique (ART) probably increases the risk of adverse events.
MeSH term(s)	Cariostatic Agents/administration & dosage ; Cariostatic Agents/adverse effects ; Databases, Factual ; Dental Atraumatic Restorative Treatment/methods ; Dental Caries/prevention & control ; Dentition, Mixed ; Fluorides, Topical/administration & dosage ; Fluorides, Topical/adverse effects ; Humans ; Quaternary Ammonium Compounds/administration & dosage ; Quaternary Ammonium Compounds/adverse effects ; Randomized Controlled Trials as Topic ; Silver Compounds/administration & dosage ; Silver Compounds/adverse effects
Chemical Substances	Cariostatic Agents ; Fluorides, Topical ; Quaternary Ammonium Compounds ; Silver Compounds ; silver diamine fluoride (DDU19UEV1Y)
Language	English
Publishing date	2020-08-25
Publishing country	Chile
Document type	Comparative Study ; Journal Article ; Meta-Analysis
ZDB-ID	2818022-7
ISSN	0717-6384 ; 0717-6384
ISSN (online)	0717-6384
ISSN	0717-6384
DOI	10.5867/medwave.2020.07.8002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Lopinavir-ritonavir for COVID-19: A living systematic review.

Verdugo-Paiva, Francisca / Izcovich, Ariel / Ragusa, Martín / Rada, Gabriel

Medwave

2020 Volume 20, Issue 6, Page(s) e7967

Abstract: Objective: Provide a timely, rigorous, and continuously updated summary of the evidence on the role of lopinavir/ritonavir in the treatment of patients with COVID-19.: Methods: We conducted searches in the special L·OVE (Living OVerview of Evidence) ... ...

Title translation	Lopinavir-ritonavir para COVID-19: una revisión sistemática viva.
Abstract	Objective: Provide a timely, rigorous, and continuously updated summary of the evidence on the role of lopinavir/ritonavir in the treatment of patients with COVID-19. Methods: We conducted searches in the special L·OVE (Living OVerview of Evidence) platform for COVID-19, a system that performs regular searches in PubMed, Embase, CENTRAL, and other 33 sources. We searched for randomized trials and non-randomized studies evaluating the effect of lopinavir/ritonavir versus placebo or no treatment in patients with COVID-19. Two reviewers independently evaluated potentially eligible studies, according to predefined selection criteria, and extracted data using a predesigned standardized form. We performed meta-analyses using random-effect models and assessed overall certainty in evidence using the GRADE approach. A living, web-based version of this review will be openly available during the COVID-19 pandemic. Results: Our search strategy yielded 862 references. Finally, we identified 12 studies, including two randomized trials, evaluating lopinavir/ritonavir, in addition to standard care versus standard care alone in 250 adult inpatients with COVID-19. The evidence from randomized trials shows lopinavir/ritonavir may reduce mortality (relative risk: 0.77; 95% confidence interval: 0.45 to 1.3; low certainty evidence), but the anticipated magnitude of the absolute reduction in mortality, varies across different risk groups. Lopinavir/ritonavir also had a slight reduction in the risk of requiring invasive mechanical ventilation, developing respiratory failure, or acute respiratory distress syndrome. However, it did not lead to any difference in the duration of hospitalization and may lead to an increase in the number of total adverse effects. The overall certainty of the evidence was low or very low. Conclusions: For severe and critical patients with COVID-19, lopinavir/ritonavir might play a role in improving outcomes, but the available evidence is still limited. A substantial number of ongoing studies should provide valuable evidence to inform researchers and decision-makers soon.
MeSH term(s)	Adult ; Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; COVID-19 ; Coronavirus Infections/drug therapy ; Drug Combinations ; Humans ; Lopinavir/administration & dosage ; Lopinavir/adverse effects ; Pandemics ; Pneumonia, Viral/drug therapy ; Randomized Controlled Trials as Topic ; Ritonavir/administration & dosage ; Ritonavir/adverse effects ; Treatment Outcome
Chemical Substances	Antiviral Agents ; Drug Combinations ; lopinavir-ritonavir drug combination ; Lopinavir (2494G1JF75) ; Ritonavir (O3J8G9O825)
Keywords	covid19
Language	English
Publishing date	2020-07-15
Publishing country	Chile
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2818022-7
ISSN	0717-6384 ; 0717-6384
ISSN (online)	0717-6384
ISSN	0717-6384
DOI	10.5867/medwave.2020.06.7966
Database	MEDical Literature Analysis and Retrieval System OnLINE

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