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  1. Article ; Online: T

    Wang, Tong / Yan, Jinsong / Yuan, Hailin / Xu, Jianquan / Lam, Ho Yi / Yu, Xuanji / Lv, Chao / Du, Binyang / Tsui, Ophelia K C

    ACS macro letters

    2019  Volume 8, Issue 10, Page(s) 1280–1284

    Abstract: We observe that ... ...

    Abstract We observe that the
    Language English
    Publishing date 2019-09-18
    Publishing country United States
    Document type Journal Article
    ISSN 2161-1653
    ISSN (online) 2161-1653
    DOI 10.1021/acsmacrolett.9b00568
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  2. Article ; Online: T

    Zheng, Wanglong / Fan, Wentong / Feng, Nannan / Lu, Nanyan / Zou, Hui / Gu, Jianhong / Yuan, Yan / Liu, Xuezhong / Bai, Jianfa / Bian, Jianchun / Liu, Zongping

    International journal of environmental research and public health

    2019  Volume 16, Issue 9

    Abstract: Zearalenone (ZEA) is a non-steroidal estrogen mycotoxin produced by ... ...

    Abstract Zearalenone (ZEA) is a non-steroidal estrogen mycotoxin produced by several
    MeSH term(s) Animals ; Cell Cycle/drug effects ; Cell Line ; Cell Proliferation/drug effects ; Estrogens, Conjugated (USP) ; Gene Expression Regulation/drug effects ; MAP Kinase Signaling System/drug effects ; Mice ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Signal Transduction/drug effects ; Zearalenone/toxicity
    Chemical Substances Estrogens, Conjugated (USP) ; MicroRNAs ; Zearalenone (5W827M159J)
    Language English
    Publishing date 2019-04-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph16091517
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  3. Article ; Online: T

    Han, Xiaorui / Hong, Guoju / Chen, Leilei / Zhao, Man / Guo, Yuan / Xu, Ling / Wu, Mei / Leng, Xiaoming / Sun, Ping

    Journal of magnetic resonance imaging : JMRI

    2018  Volume 49, Issue 3, Page(s) 760–767

    Abstract: ... Purpose: To investigate the diagnostic performance of T: Study type: Prospective.: Subjects: Forty ... gradient echo (MERGE), and T: Assessment: Pseudocolor images and MERGE images were combined in the AW4.5 ... workstation. The region of interest (ROI) of the hip cartilage was 4-6 mm². The sagittal T: Statistical ...

    Abstract Background: In the future, biochemical MRI might provide a valuable noninvasive quantitative analysis of the biochemical composition of cartilage in osteonecrosis of the femoral head (ONFH).
    Purpose: To investigate the diagnostic performance of T
    Study type: Prospective.
    Subjects: Forty-seven patients with ONFH (stage I to III according to the ARCO criteria) and 24 volunteers (control group) were recruited for the prospective study.
    Sequence: Conventional MRI, multiple echo recalled gradient echo (MERGE), and T
    Assessment: Pseudocolor images and MERGE images were combined in the AW4.5 workstation. The region of interest (ROI) of the hip cartilage was 4-6 mm². The sagittal T
    Statistical tests: One-way analysis of variance (ANOVA), LSD t-tests, Pearson correlation analysis, and receiver operator characteristic (ROC) curves. The significance level was set at P < 0.05.
    Results: The T
    Data conclusion: Both T
    Level of evidence: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:760-767.
    MeSH term(s) Adolescent ; Adult ; Algorithms ; Cartilage, Articular/pathology ; Case-Control Studies ; Female ; Femur Head/diagnostic imaging ; Humans ; Image Processing, Computer-Assisted/methods ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Osteonecrosis/diagnostic imaging ; Prospective Studies ; ROC Curve ; Reproducibility of Results ; Young Adult
    Language English
    Publishing date 2018-11-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.26267
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  4. Article ; Online: T

    Wang, Wen-Tao / Zhu, Shuo / Ding, Ying / Yang, Li / Chen, Cai-Zhong / Ye, Qing-Hai / Ji, Yuan / Zeng, Meng-Su / Rao, Sheng-Xiang

    European journal of radiology

    2018  Volume 103, Page(s) 25–31

    Abstract: Purpose: Our purpose was to demonstrate the prognostic significance of T: Materials and methods ... acid-enhanced MRI were included in the study. T: Results: Reduction rate of T: Conclusions ... Reduction rate of T ...

    Abstract Purpose: Our purpose was to demonstrate the prognostic significance of T
    Materials and methods: One hundred and seven patients with single nodular HCC (≤3 cm) who underwent preoperative gadoxetic acid-enhanced MRI were included in the study. T
    Results: Reduction rate of T
    Conclusions: Reduction rate of T
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/surgery ; Contrast Media ; Female ; Gadolinium DTPA ; Hepatectomy ; Humans ; Image Enhancement/methods ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Neoplasm Recurrence, Local/diagnostic imaging ; Prognosis ; Retrospective Studies ; Risk Factors ; Young Adult
    Chemical Substances Contrast Media ; gadolinium ethoxybenzyl DTPA ; Gadolinium DTPA (K2I13DR72L)
    Language English
    Publishing date 2018-03-28
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 138815-0
    ISSN 1872-7727 ; 0720-048X
    ISSN (online) 1872-7727
    ISSN 0720-048X
    DOI 10.1016/j.ejrad.2018.03.027
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  5. Article ; Online: Targeting T

    Ma, Ning / Wu, Wei-Bing / Zhao, Xiang-Yu / Xu, Lan-Ping / Zhang, Xiao-Hui / Wang, Yu / Mo, Xiao-Dong / Zhang, Yuan-Yuan / Zhao, Xiao-Su / Sun, Yu-Qian / Cheng, Yi-Fei / Liu, Kai-Yan / Chang, Ying-Jun / Huang, Xiao-Jun

    Haematologica

    2024  Volume 109, Issue 4, Page(s) 1233–1246

    Abstract: ... reports of failure. T-follicular helper (Tfh) cells assist B cells in differentiating into antibody ...

    Abstract The presence of donor-specific antibodies (DSA) are associated with graft failure either following human leukocyte antigen (HLA)-mismatched allogeneic stem cell transplantation or after organ transplantation. Although targeting B cells and plasma cells have been used for desensitization, there have been reports of failure. T-follicular helper (Tfh) cells assist B cells in differentiating into antibody-secreting plasma cells. We used haploidentical allograft as a platform to investigate the possibility of targeting Tfh cells to desensitize DSA. The quantities of circulating Tfh (cTfh) cell subsets in allograft candidates were abnormal, and these cells, including the cTfh2 and cTfhem cell subsets, were positively related to the production of anti-HLA antibodies. Ex vivo experiments showed that the cTfh cells of anti-HLA antibody-positive allograft candidates could induce B cells to differentiate into DSA-producing plasmablasts. The immune synapse could be involved in the assistance of cTfh cells to B cells in antibody production. In vitro experiments and in vivo clinical pilot studies indicated that targeting cTfh cells with sirolimus can inhibit their auxiliary function in assisting B cells. Ex vivo and in vivo studies demonstrated the effect of sirolimus and rituximab on DSA desensitization compared with either sirolimus or rituximab alone (60%, 43.75%, and 30%, respectively). Our findings provide new insight into the role of Tfh cells in the pathogenesis of DSA production in HLA-mismatched transplant candidates. Our data also indicate that targeting Tfh cells is a novel strategy for DSA desensitization and combination of sirolimus and rituximab might be a potential therapy. The prospective cohort of this study is registered at http://www.chictr.org.cn as #ChiCTR-OPC-15006672.
    MeSH term(s) Humans ; T-Lymphocytes, Helper-Inducer ; Rituximab ; Prospective Studies ; Antibodies ; HLA Antigens ; Histocompatibility Antigens Class II ; Allografts ; Sirolimus
    Chemical Substances Rituximab (4F4X42SYQ6) ; Antibodies ; HLA Antigens ; Histocompatibility Antigens Class II ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2024-04-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2023.283698
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  6. Article ; Online: Correlation of T-cell receptor constant beta-chain 1 by flow cytometry with molecular T-cell receptor clonality for the investigation of T-cell lymphoproliferation.

    Dexter, Tania / Taiwo, Tosin / Dearden, Claire / Chan, Li Yuan / Taussig, David / El-Sharkawi, Dima / Dunlop, Alan / Iyengar, Sunil

    British journal of haematology

    2024  Volume 204, Issue 4, Page(s) 1554–1556

    MeSH term(s) Humans ; T-Lymphocytes ; Flow Cytometry ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor ; Receptors, Antigen, T-Cell/genetics ; Clone Cells
    Chemical Substances Receptors, Antigen, T-Cell, alpha-beta ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19299
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  7. Article ; Online: An intelligent T

    Pan, Chunshu / Lin, Junjie / Zheng, Jianjun / Liu, Chuang / Yuan, Bo / Akakuru, Ozioma Udochukwu / Zubair Iqbal, M / Fang, Qianlan / Hu, Jiapeng / Chen, Jia / Lin, Jie / Dai, Qi / Guo, Xiuyu / Li, Zihou / Zhang, Tao / Xu, Chen / Ma, Xuehua / Chen, Tianxiang / Wu, Aiguo /
    Jin, Yinhua

    Nanoscale

    2021  Volume 13, Issue 13, Page(s) 6461–6474

    Abstract: ... stimuli-triggered T ...

    Abstract Unlike stable atherosclerotic plaques, vulnerable plaques are very likely to cause serious cardio-cerebrovascular diseases. Meanwhile, how to non-invasively identify vulnerable plaques at early stages has been an urgent but challenging problem in clinical practices. Here, we propose a macrophage-targeted and in situ stimuli-triggered T
    MeSH term(s) Contrast Media ; Humans ; Magnetic Resonance Imaging ; Plaque, Amyloid ; Plaque, Atherosclerotic/diagnostic imaging
    Chemical Substances Contrast Media
    Language English
    Publishing date 2021-03-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d0nr08039j
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  8. Article ; Online: Improvements in Between-Vendor MRI Harmonization of Renal T

    Li, Hao / Daniel, Alexander J / Buchanan, Charlotte E / Nery, Fábio / Morris, David M / Li, Shaohang / Huang, Yuan / Sousa, João A / Sourbron, Steven / Mendichovszky, Iosif A / Thomas, David L / Priest, Andrew N / Francis, Susan T

    Journal of magnetic resonance imaging : JMRI

    2024  

    Abstract: Background: T: Purpose: To harmonize renal T: Study type: Prospective.: Subjects: 8 ... on a given MR scanner for repeatability evaluation. ISMRM/NIST system phantom scanned for evaluation of T ... Field strength/sequence: 3T, multiecho spin-echo sequence.: Assessment: T: Statistical tests ...

    Abstract Background: T
    Purpose: To harmonize renal T
    Study type: Prospective.
    Subjects: 8 healthy "travelling" volunteers (37.5% female, 32 ± 6 years) imaged on four MRI systems across three vendors at four sites, 10 healthy volunteers (50% female, 32 ± 8 years) scanned multiple times on a given MR scanner for repeatability evaluation. ISMRM/NIST system phantom scanned for evaluation of T
    Field strength/sequence: 3T, multiecho spin-echo sequence.
    Assessment: T
    Statistical tests: Coefficient of variation (CV), linear mixed-effects model, analysis of variance, student's t-tests, Bland-Altman plots, P-value <0.05 considered statistically significant.
    Results: In the ISMRM/NIST phantom, "StimFit" reduced the MAPE from 4.9%, 9.1%, 24.4%, and 18.1% for the four sites (three vendors) to 3.3%, 3.0%, 6.6%, and 4.1%, respectively. In vivo, there was a significant difference in kidney T
    Data conclusion: Stimulated-echo correction reduces renal T
    Level of evidence: 2 TECHNICAL EFFICACY: Stage 1.
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.29282
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  9. Article: T-ALL Cells as Tool Cells for CAR T Therapy.

    Ren, Anqi / Zhao, Yuan / Zhu, Haichuan

    Vaccines

    2023  Volume 11, Issue 4

    Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is a hematologic malignancy derived from T ... cells. Numerous CAR T therapies have been successfully applied to treat hematologic malignancies in the clinic ... Nevertheless, there remain several challenges to the extensive application of CAR T cell therapy in T cell ...

    Abstract T-cell acute lymphoblastic leukemia (T-ALL) is a hematologic malignancy derived from T cells. Numerous CAR T therapies have been successfully applied to treat hematologic malignancies in the clinic. Nevertheless, there remain several challenges to the extensive application of CAR T cell therapy in T cell malignancies, especially in T-ALL. The main reason for CAR T therapy limitations is that T-ALL cells and normal T cells share antigens, which improves the difficulty of sorting pure T cells, resulting in product contamination, and would lead to CAR T cell fratricide. Thus, we considered creating a CAR on T-ALL tumor cells (CAR T-ALL) to prevent fratricide and eliminate tumor cells. We found that T-ALL cells transduced with CAR would actually commit fratricide. However, CAR T-ALL could kill only tumor cells on T-ALL cell lines, and other types of tumor cells had no killing function after being transferred with CAR. Furthermore, we created CD99 CAR with expression controlled by the Tet-On system on Jurkat cells, which could avoid the fratricide of CAR T-ALL during proliferation, ensuring the controllability of the killing time and effect. Jurkat transduced with a CAR-targeting antigen, which was expressed on other cancer cells, could kill other cancer cell lines, demonstrating that T-ALL cells could be used as tool cells for cancer therapy. Our study supplied a new feasible treatment regimen for cancer treatment in the clinic.
    Language English
    Publishing date 2023-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11040854
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  10. Article ; Online: Augmented T

    Ye, Yongquan / Lyu, Jingyuan / Hu, Yichen / Zhang, Zhongqi / Xu, Jian / Zhang, Weiguo / Yuan, Jianmin / Zhou, Chao / Fan, Wei / Zhang, Xu

    NMR in biomedicine

    2022  Volume 35, Issue 8, Page(s) e4729

    Abstract: T ...

    Abstract T
    MeSH term(s) Computer Simulation ; Magnetic Resonance Imaging/methods ; Phantoms, Imaging ; Protons ; Signal-To-Noise Ratio
    Chemical Substances Protons
    Language English
    Publishing date 2022-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1000976-0
    ISSN 1099-1492 ; 0952-3480
    ISSN (online) 1099-1492
    ISSN 0952-3480
    DOI 10.1002/nbm.4729
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