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Article: ‘Yan Dong’: A New Cultivar of Xanthoceras sorbifolium Bunge

Lian, Chen / Li, Yuyan / Li, Haiying / Zhao, Yaxin / Zhou, Juan / Wang, Sijie / Lian, Jingran / Ao, Yan

HortScience. 2022 Sept., v. 57, no. 9

2022

Abstract: Yellow-horn (Xanthoceras sorbifolium Bunge), a plant endemic to northern China, is resistant to drought, cold, saline stress, and barren soil, but cannot withstand excess moisture (Ao et al., 2012). Yellow-horn has been cultivated for more than 6000 ... ...

Abstract	Yellow-horn (Xanthoceras sorbifolium Bunge), a plant endemic to northern China, is resistant to drought, cold, saline stress, and barren soil, but cannot withstand excess moisture (Ao et al., 2012). Yellow-horn has been cultivated for more than 6000 years in China. It is an oilseed crop, and the oil content of the seeds can be as high as 65%. The oil can be used for cooking, as well as for medicine and biofuel production (Liu et al., 2017). The seed oil has traditionally been used for cooking and lighting. In recent years, the development and use of biodiesel produced from yellow-horn have received increased attention as a result of the energy crisis. The seed kernels of yellow-horn are rich in nutrients and contain 55% crude fat, 15% soluble sugar, and mineral elements (Xie and Zhang, 2018). Yellow-horn is widely distributed and shows extensive morphological variation, especially in flower type and color. It is also widely used as a landscaping tree species (Gao et al., 2002; Xu et al., 2010). Because of its high ecological, economic, and ornamental value, the cultivation of yellow-horn has received much attention in China in recent years.
Keywords	Xanthoceras sorbifolium ; biodiesel ; cold ; color ; crude fat ; cultivars ; drought ; energy ; flowers ; fuel production ; medicine ; oilseed crops ; ornamental value ; salt stress ; seed oils ; soil ; sugars ; trees ; China
Language	English
Dates of publication	2022-09
Size	p. 1057-1058.
Publishing place	American Society for Horticultural Science
Document type	Article
ISSN	2327-9834
DOI	10.21273/HORTSCI16695-22
Database	NAL-Catalogue (AGRICOLA)

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Article: "Fei Yan No. 1" as a Combined Treatment for COVID-19: An Efficacy and Potential Mechanistic Study.

Ai, Zhongzhu / Zhou, Shanshan / Li, Weinan / Wang, Mengfan / Wang, Linqun / Hu, Gangming / Tao, Ran / Wang, Xiaoqin / Shen, Yinfeng / Xie, Lihan / Ba, Yuanming / Wu, Hezhen / Yang, YanFang

Frontiers in pharmacology

2020 Volume 11, Page(s) 581277

Abstract: ... Fei Yan No. 1" (QFDYG) is a formula recommended by the Hubei Government to treat COVID-19 ...

Abstract	There has been a large global outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), representing a major public health issue. In China, combination therapy, including traditional Chinese medicine (TCM) as a treatment for COVID-19 has been used widely. "Fei Yan No. 1" (QFDYG) is a formula recommended by the Hubei Government to treat COVID-19. A retrospective study of 84 COVID-19 patients from Hubei Provincial Hospital of TCM and Renmin Hospital of Hanchuan was conducted to explore the clinical efficacy of QFDYG combination therapy. TCMSP and YaTCM databases were used to determine the components of all Chinese herbs in QFDYG. Oral bioavailability (OB) ≥ 30% and drug-like (DL) quality ≥ 0.18 were selected as criteria for screening the active compounds identified within the TCMSP database. The targets of active components in QFDYG were determined using the Swiss TargetPrediction (SIB) and Targetnet databases. The STRING database and the Network Analyzer plugin in Cytoscape were used to obtain protein-protein interaction (PPI) network topology parameters and to identify hub targets. Gene Ontology (GO) enrichment was conducted using FunRich version 3.1.3, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment using ClueGO version 2.5.6 software. PPI and compound-pathway (C-T) networks were constructed using Cytoscape 3.6.0. Compared with the control group, combined treatment with QFDYG resulted in a significantly higher rate of patients recovering from symptoms and shorter the time. After 14 days of treatment, QFDYG combined treatment increased the proportion of patients testing negative for SARS-CoV-2 nucleic acid by RT-PCR. Compared with the control group, promoting focal absorption and inflammation as viewed on CT images. GO and KEGG pathway enrichment indicated that QFDYG principally regulated biological processes, such as inflammation, an immune response, and apoptosis. The present study revealed that QFDYG combination therapy offered particular therapeutic advantages, indicating that the theoretical basis for the treatment of COVID-19 by QFDYG may play an antiviral and immune response regulation through multiple components, targets, and pathways, providing reference for the clinical treatment of COVID-19.
Keywords	covid19
Language	English
Publishing date	2020-10-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.581277
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: “Fei Yan No. 1” as a Combined Treatment for COVID-19

Zhongzhu Ai / Shanshan Zhou / Weinan Li / Mengfan Wang / Linqun Wang / Gangming Hu / Ran Tao / Xiaoqin Wang / Yinfeng Shen / Lihan Xie / Yuanming Ba / Hezhen Wu / YanFang Yang

Frontiers in Pharmacology, Vol

An Efficacy and Potential Mechanistic Study

2020 Volume 11

Abstract: ... Fei Yan No. 1” (QFDYG) is a formula recommended by the Hubei Government to treat COVID-19 ...

Abstract	There has been a large global outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), representing a major public health issue. In China, combination therapy, including traditional Chinese medicine (TCM) as a treatment for COVID-19 has been used widely. “Fei Yan No. 1” (QFDYG) is a formula recommended by the Hubei Government to treat COVID-19. A retrospective study of 84 COVID-19 patients from Hubei Provincial Hospital of TCM and Renmin Hospital of Hanchuan was conducted to explore the clinical efficacy of QFDYG combination therapy. TCMSP and YaTCM databases were used to determine the components of all Chinese herbs in QFDYG. Oral bioavailability (OB) ≥ 30% and drug-like (DL) quality ≥ 0.18 were selected as criteria for screening the active compounds identified within the TCMSP database. The targets of active components in QFDYG were determined using the Swiss TargetPrediction (SIB) and Targetnet databases. The STRING database and the Network Analyzer plugin in Cytoscape were used to obtain protein-protein interaction (PPI) network topology parameters and to identify hub targets. Gene Ontology (GO) enrichment was conducted using FunRich version 3.1.3, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment using ClueGO version 2.5.6 software. PPI and compound-pathway (C-T) networks were constructed using Cytoscape 3.6.0. Compared with the control group, combined treatment with QFDYG resulted in a significantly higher rate of patients recovering from symptoms and shorter the time. After 14 days of treatment, QFDYG combined treatment increased the proportion of patients testing negative for SARS-CoV-2 nucleic acid by RT-PCR. Compared with the control group, promoting focal absorption and inflammation as viewed on CT images. GO and KEGG pathway enrichment indicated that QFDYG principally regulated biological processes, such as inflammation, an immune response, and apoptosis. The present study revealed that QFDYG combination therapy offered particular therapeutic advantages, indicating that the theoretical basis for the treatment of COVID-19 by QFDYG may play an antiviral and immune response regulation through multiple components, targets, and pathways, providing reference for the clinical treatment of COVID-19.
Keywords	Fei Yan NO1 ; COVID-19 ; SARS-CoV-2 ; clinical efficacy ; network pharmacology ; Therapeutics. Pharmacology ; RM1-950 ; covid19
Subject code	610
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: “Fei Yan No. 1” as a Combined Treatment for COVID-19

Ai, Zhongzhu / Zhou, Shanshan / Li, Weinan / Wang, Mengfan / Wang, Linqun / Hu, Gangming / Tao, Ran / Wang, Xiaoqin / Shen, Yinfeng / Xie, Lihan / Ba, Yuanming / Wu, Hezhen / Yang, YanFang

Frontiers in Pharmacology

An Efficacy and Potential Mechanistic Study

2020 Volume 11

Keywords	Pharmacology (medical) ; Pharmacology ; covid19
Publisher	Frontiers Media SA
Publishing country	ch
Document type	Article ; Online
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.581277
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription modified Shen-Yan-Fang-Shuai formula in treating diabetic nephropathy.

Yu, Borui / Zhou, Mengqi / Dong, Zhaocheng / Zheng, Huijuan / Zhao, Yuxue / Zhou, Jingwei / Zhang, Chao / Wei, Fudong / Yu, Guoyong / Liu, Wei Jing / Liu, Hongfang / Wang, Yaoxian

Pharmaceutical biology

2023 Volume 61, Issue 1, Page(s) 1222–1233

Abstract: Context: Diabetic nephropathy (DN) is the main cause of end-stage renal disease. Modified Shen-Yan ...

Abstract	Context: Diabetic nephropathy (DN) is the main cause of end-stage renal disease. Modified Shen-Yan-Fang-Shuai formula (M-SYFSF) has excellent clinical efficacy in treating diabetic kidney disease. However, the potential mechanism of M-SYFSF remains unknown. Objective: To investigate the mechanism of M-SYFSF against DN by network pharmacological analysis and biological experiments. Materials and methods: Utilizing a web-based pharmacology database, the potential mechanisms of M-SYFSF against DN were identified. Results: Network pharmacological analysis showed that MAPK pathway was the potential pathway. Results showed that compared with the Model group, M-SYFSF significantly reduced 24h urine albumin, UACR, and serum creatinine levels (54.90 ± 26.67 vs. 111.78 ± 4.28, 8.87 ± 1.69 vs. 53.94 ± 16.01, 11.56 ± 1.70 vs. 118.70 ± 49.57, respectively), and improved renal pathological changes. Furthermore, the intervention of M-SYFSF reduced the expression of pro-inflammatory cytokines and inhibited the activation of MAPK pathway in AGEs-treated HK-2 cells. Discussion and conclusion: M-SYFSF is likely to reduce inflammation in DN by inhibiting the MAPK pathway. It provides a theoretical basis for the clinical application of M-SYFSF in the treatment of DN.
MeSH term(s)	Rats ; Male ; Humans ; Animals ; Diabetic Nephropathies/metabolism ; Network Pharmacology ; Rats, Sprague-Dawley ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Glycation End Products, Advanced/metabolism
Chemical Substances	Drugs, Chinese Herbal ; Glycation End Products, Advanced
Language	English
Publishing date	2023-08-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2023.2241521
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Article ; Online: Rediscovery of Perlodinella microlobata Wu, 1938, with notes on Tibetisoperla sclerotica Yan, Chen, Bozdogan & Li, 2022 (Plecoptera: Perlodidae).

Huo, Qing-Bo / Rehman, Abdur / DU, Yu-Zhou / Chen, Zhen-Ning

Zootaxa

2022 Volume 5205, Issue 1, Page(s) 26–34

Abstract: ... sclerotica Yan, Chen, Bozdogan & Li, 2022, is partially revised because the adult female belongs ...

Abstract	Perlodinella microlobata Wu, 1938 is rediscovered in Qinghai and Sichuan provinces with a supplementary description in this paper. Another species collected from Qinghai at the same time, Tibetisoperla sclerotica Yan, Chen, Bozdogan & Li, 2022, is partially revised because the adult female belongs to the chloroperlid genus Sweltsa Ricker, 1943.
MeSH term(s)	Female ; Animals ; Animal Distribution ; Insecta ; Neoptera
Language	English
Publishing date	2022-11-04
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5205.1.2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The anti-MDR efficacy of YAN against A549/Taxol cells is associated with its inhibition on glycolysis and is further enhanced by 2-deoxy-d-glucose.

Gao, Minghuan / Yang, Yuying / Gao, Ying / Liu, Tong / Guan, Qi / Zhou, Tianhao / Shi, Yani / Hao, Mingjing / Li, Zengqiang / Zuo, Daiying / Zhang, Weige / Wu, Yingliang

Chemico-biological interactions

2022 Volume 354, Page(s) 109843

Abstract: ... drug resistance. 5-(4-ethoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazol-3-amine (YAN), a newly synthesized ... related with the apoptosis resistance. The effects of YAN above were relevant to the down-regulation ... of PI3K-Akt-c-Myc/HIF-1α pathway. Moreover, YAN induced the reactive oxygen species generation in A549 and ...

Abstract	Aerobic glycolysis is a hallmark of malignant tumor. Here, the hyperactive glycolysis in multidrug-resistant A549/Taxol cells was demonstrated to be essential for maintaining the vigorous cell viability and drug resistance. 5-(4-ethoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazol-3-amine (YAN), a newly synthesized tubulin inhibitor, could not only inhibit the glycolysis in A549 and A549/Taxol cells through down-regulating the glycolysis-related proteins, but also disrupt the mitochondrial localization of hexokinase-2 (HK-2) which is related with the apoptosis resistance. The effects of YAN above were relevant to the down-regulation of PI3K-Akt-c-Myc/HIF-1α pathway. Moreover, YAN induced the reactive oxygen species generation in A549 and A549/Taxol cells, which only mediated the apoptosis in A549 cells. We also showed that 2-DG, the glycolysis inhibitor, synergistically enhanced YAN-triggered apoptosis in A549/Taxol cells via further suppressing glycolysis and reducing mitotic slippage. Collectively, we illustrate the inhibition effect of YAN on the glycolysis in A549 and A549/Taxol cells, and provide a fresh insight into the mechanism for the development of YAN as a candidate for multidrug resistant cancer treatment. The finding that 2-DG improved the anti-tumor efficacy of YAN against A549/Taxol cells, offers a reference for solving mitotic slippage-mediated drug resistance.
MeSH term(s)	Paclitaxel
Chemical Substances	Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2022-02-02
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2022.109843
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Article ; Online: Study on Carbon Sequestration Benefit of Converting Farmland to Forest in Yan’an

Zhou M.C / Han H.Z / Yang X.J / Chen C

E3S Web of Conferences, Vol 275, p

2021 Volume 02005

Abstract: This paper takes Yan’anas the study area, analyses the current situation of the policy, calculates ... by 203575.5 t due to the afforestation in 2019 in Yan’an. The green economy income of Yan’an can be ... million RMB, which can increase the forestry output value of Yan’an by 19.32%. (2) The new ...

Abstract	This paper takes Yan’anas the study area, analyses the current situation of the policy, calculates the carbon sequestration value by using the afforestation area and woodland area in Yanan in 2019, and explores its carbon emission trading potential. The conclusions are as follows: (1) the amount of carbon sequestration increased by 203575.5 t due to the afforestation in 2019 in Yan’an. The green economy income of Yan’an can be increased by 5.8528 million RMB, because of it. The carbon sequestration value of total woodland is 120 million RMB, which can increase the forestry output value of Yan’an by 19.32%. (2) The new carbon sequestration benefit of northern area is higher than that of southern area in Yan’an; the highest carbon sequestration benefit of returning farmland to forest isWuqi County’s 35307.29t, and its value is 1.015 million RMB, it can be increased by 0.15% of the green economy income. (3) The industrial counties Huangling County and Huanglong County, the industrial counties Luochuan County and Yichuan County carry out carbon trading respectively, under the condition of ensuring the output value of the secondary industry in the industrial county, it can increase the green economy income of the total output value of Huanglong County and Yichuan County by 0.73% respectively.
Keywords	Environmental sciences ; GE1-350
Subject code	941
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: On the One-Point Model for the Productivity Evaluation in Jingbian Sector of Yan’an Gas Field

Liu Er-hu / Liu Yang-yang / Gao Li-jun / Zhou De-sheng / Liu Xiong / Xu Jin-ze

Frontiers in Earth Science, Vol

2021 Volume 9

Abstract: ... of the Yan’an gas field. The field experience formula and production data are used to verify ... for productivity analysis of gas wells in paleozoic reservoirs in the Jingbian sector of the Yan’an gas field ...

Abstract	The productivity equation of a gas well is, in the final analysis, an expression that describes the relationship between the production of a gas well and its bottom-hole flowing pressure. There are two kinds of productivity equations in common use at present: binomial productivity equation and exponential productivity equation. Combined with the modified isochronal well test, the test data are interpreted, and it is found that the open flow rates calculated by the two productivity equations are basically the same when the pressure difference at the test point is large, and the deviation of the exponential productivity equation is large when the pressure difference at the test point is small. Using binomial productivity equation and modifying isochronous well test, we established the single-point deliverability formula for the Jingbian sector of the Yan’an gas field. The field experience formula and production data are used to verify it. Their average errors are 2.59% and 7.12%, respectively; and the coincidence rate of productivity evaluation is 90%. The one-point productivity formula established has high precision and is suitable for productivity analysis of gas wells in paleozoic reservoirs in the Jingbian sector of the Yan’an gas field. This paper provides insights into the one-point productivity evaluation and its future application in the gas field.
Keywords	productivity equation ; gas field ; modified isochronal test ; one-point deliverability formula ; open flow ; Science ; Q
Subject code	621
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription modified Shen-Yan-Fang-Shuai formula in treating diabetic nephropathy

Borui Yu / Mengqi Zhou / Zhaocheng Dong / Huijuan Zheng / Yuxue Zhao / Jingwei Zhou / Chao Zhang / Fudong Wei / Guoyong Yu / Wei Jing Liu / Hongfang Liu / Yaoxian Wang

Pharmaceutical Biology, Vol 61, Iss 1, Pp 1222-

2023 Volume 1233

Abstract: ... Shen-Yan-Fang-Shuai formula (M-SYFSF) has excellent clinical efficacy in treating ...

Abstract	AbstractContext Diabetic nephropathy (DN) is the main cause of end-stage renal disease. Modified Shen-Yan-Fang-Shuai formula (M-SYFSF) has excellent clinical efficacy in treating diabetic kidney disease. However, the potential mechanism of M-SYFSF remains unknown.Objective To investigate the mechanism of M-SYFSF against DN by network pharmacological analysis and biological experiments.Materials and methods Utilizing a web-based pharmacology database, the potential mechanisms of M-SYFSF against DN were identified. In vivo experiments, male SD rats were injected with streptozotocin (50 mg/kg) and got uninephrectomy to construct a model of DN. M-SYFSF (11.34 g/kg/d) was gavaged once per day for 12 weeks after model establishment. In vitro experiments, human proximal tubular cells (HK-2) were performed with advanced glycation end-products (AGEs) (100 μg/mL), then intervened with M-SYFSF freeze-dried powder. Pathological staining, WB, IHC, ELISA were conducted to explore the mechanism of M-SYFSF against DN.Results Network pharmacological analysis showed that MAPK pathway was the potential pathway. Results showed that compared with the Model group, M-SYFSF significantly reduced 24h urine albumin, UACR, and serum creatinine levels (54.90 ± 26.67 vs. 111.78 ± 4.28, 8.87 ± 1.69 vs. 53.94 ± 16.01, 11.56 ± 1.70 vs. 118.70 ± 49.57, respectively), and improved renal pathological changes. Furthermore, the intervention of M-SYFSF reduced the expression of pro-inflammatory cytokines and inhibited the activation of MAPK pathway in AGEs-treated HK-2 cells.Discussion and conclusion M-SYFSF is likely to reduce inflammation in DN by inhibiting the MAPK pathway. It provides a theoretical basis for the clinical application of M-SYFSF in the treatment of DN.
Keywords	Traditional Chinese medicine formula ; protein-protein interaction network ; MAPK signaling pathway ; inflammation ; Therapeutics. Pharmacology ; RM1-950
Subject code	616
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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