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  1. AU=Kobayashi Tetsuo
  2. AU="Grabauskas, Titas"
  3. AU=Sra Harnoor Kaur
  4. AU="Petra Macaskill"
  5. AU=Bramwell Edwin
  6. AU="Enríquez, Paula"
  7. AU="Uysal, Ismihan Ilknur"
  8. AU="Fernandes, Adriana Barrinha"
  9. AU="Goodwin, David G"
  10. AU="Hill, Jonathan C"
  11. AU="Chankasingh, Kyle"
  12. AU="Narayanasami, Uma"
  13. AU="Chen, Ruichao"
  14. AU=Li Xuefeng AU=Li Xuefeng
  15. AU="Stef J.F. Letteboer"
  16. AU="Gewurz, H"
  17. AU="Linares, Mauricio"
  18. AU="Gnesi, Marco"
  19. AU="Park, Jinny"
  20. AU="Hill, Benjamin D"
  21. AU=Huang Chunfa
  22. AU="Skonieczny, Paul"
  23. AU="LIVINGSTON, M S"
  24. AU="Lidia Gonzalez-Quereda"
  25. AU="Korkmaz, Asli"
  26. AU="Patel, Mrinal"
  27. AU="Louis Chauvel"
  28. AU="Jampen, Laurent"
  29. AU="Tan, Jiacheng"
  30. AU="Weiss, Jonathan D"

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  1. Artikel: Periodontitis and periodontopathic bacteria as risk factors for rheumatoid arthritis: A review of the last 10 years.

    Kobayashi, Tetsuo / Bartold, Peter Mark

    The Japanese dental science review

    2023  Band 59, Seite(n) 263–272

    Abstract: Rheumatoid arthritis (RA) is characterized by chronic inflammatory destruction of joint tissue and is caused by an abnormal autoimmune response triggered by interactions between genetics, environmental factors, and epigenetic and posttranslational ... ...

    Abstract Rheumatoid arthritis (RA) is characterized by chronic inflammatory destruction of joint tissue and is caused by an abnormal autoimmune response triggered by interactions between genetics, environmental factors, and epigenetic and posttranslational modifications. RA has been suggested to be interrelated with periodontitis, a serious form or stage of chronic inflammatory periodontal disease associated with periodontopathic bacterial infections, genetic predisposition, environmental factors, and epigenetic influences. Over the last decade, a number of animal and clinical studies have been conducted to assess whether or not periodontitis and associated periodontopathic bacteria constitute risk factors for RA. The present review introduces recent accumulating evidence to support the associations of periodontitis and periodontopathic bacteria with the risk of RA or the outcome of RA pharmacological treatment with disease-modifying antirheumatic drugs. In addition, the results from intervention studies have suggested an improvement in RA clinical parameters after nonsurgical periodontal treatment. Furthermore, the potential causal mechanisms underlying the link between periodontitis and periodontopathic bacteria and RA are summarized.
    Sprache Englisch
    Erscheinungsdatum 2023-08-26
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2439945-0
    ISSN 1882-7616
    ISSN 1882-7616
    DOI 10.1016/j.jdsr.2023.08.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Effect of Carbon Nanofiber Distribution on Mechanical Properties of Injection-Molded Aramid-Fiber-Reinforced Polypropylene.

    Takayama, Tetsuo / Kobayashi, Shunsuke / Yuasa, Yuuki / Jiang, Quan

    Polymers

    2024  Band 16, Heft 8

    Abstract: The mechanical recycling of discarded plastic products as resources for environmental preservation has recently gained research attention. In this context, it is necessary to use waste materials for fiber-reinforced thermoplastics (FRTP). Glass and ... ...

    Abstract The mechanical recycling of discarded plastic products as resources for environmental preservation has recently gained research attention. In this context, it is necessary to use waste materials for fiber-reinforced thermoplastics (FRTP). Glass and carbon fibers are often damaged by shear and compression during melt-forming processes. To achieve a sustainable society, it is necessary for thermal recycling to produce minimal to no residue and for mechanical recycling to maintain the length of fibers used in FRTP to preserve their performance as a reinforcing agent. Aramid fibers (AFs) do not shorten during the melt-molding process, and their composites have excellent impact strength. On the other hand, plastics reinforced with glass or carbon fibers are reported to have a superior strength and modulus of elasticity compared to aramid fibers. This study investigates the dispersion of a carbon nanofiber (CNF), a whisker, as the third component in aramid-fiber-reinforced polypropylene (PP/AF). The results and discussion sections demonstrate how the dispersion of CNF in PP/AF can enhance the mechanical properties of injection-molded products without compromising their impact resistance. The proposed composition will have excellent material recyclability and initial mechanical properties compared to glass-fiber-reinforced thermoplastics.
    Sprache Englisch
    Erscheinungsdatum 2024-04-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym16081110
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Development and Reproductive Capacity of the Miyake Spider Mite

    Ullah, Mohammad Shaef / Kobayashi, Yurina / Gotoh, Tetsuo

    Insects

    2022  Band 13, Heft 10

    Abstract: Eotetranychus ... ...

    Abstract Eotetranychus kankitus
    Sprache Englisch
    Erscheinungsdatum 2022-10-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662247-6
    ISSN 2075-4450
    ISSN 2075-4450
    DOI 10.3390/insects13100910
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  4. Artikel: Successful treatment with ivabradine in a β-blocker-refractory patient with acute decompensated heart failure with reduced ejection fraction.

    Inoue, Tomoko / Matsunaga, Keiji / Kobayashi, Waki / Minamino, Tetsuo

    Clinical case reports

    2023  Band 11, Heft 3, Seite(n) e6890

    Abstract: Ivabradine is an established treatment for chronic heart failure with reduced ejection fraction (HFrEF); however, it is not used for acute heart failure treatment. Negative inotropic effects (NIE) often limit the up-titration of β-blockers. Contrarily, ... ...

    Abstract Ivabradine is an established treatment for chronic heart failure with reduced ejection fraction (HFrEF); however, it is not used for acute heart failure treatment. Negative inotropic effects (NIE) often limit the up-titration of β-blockers. Contrarily, ivabradine has no NIE, and enables β-blockers usage for treating patients with acute decompensated HFrEF.
    Sprache Englisch
    Erscheinungsdatum 2023-03-04
    Erscheinungsland England
    Dokumenttyp Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.6890
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  5. Artikel ; Online: Successful treatment with ivabradine in a β‐blocker‐refractory patient with acute decompensated heart failure with reduced ejection fraction

    Tomoko Inoue / Keiji Matsunaga / Waki Kobayashi / Tetsuo Minamino

    Clinical Case Reports, Vol 11, Iss 3, Pp n/a-n/a (2023)

    2023  

    Abstract: Abstract Ivabradine is an established treatment for chronic heart failure with reduced ejection fraction (HFrEF); however, it is not used for acute heart failure treatment. Negative inotropic effects (NIE) often limit the up‐titration of β‐blockers. ... ...

    Abstract Abstract Ivabradine is an established treatment for chronic heart failure with reduced ejection fraction (HFrEF); however, it is not used for acute heart failure treatment. Negative inotropic effects (NIE) often limit the up‐titration of β‐blockers. Contrarily, ivabradine has no NIE, and enables β‐blockers usage for treating patients with acute decompensated HFrEF.
    Schlagwörter acute decompensated heart failure ; cancer therapy‐related cardiac dysfunction ; inappropriate tachycardia ; ivabradine ; up‐titration ; β‐Blocker ; Medicine ; R ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Diagnostic Performance of an Automated Blood Pressure Monitor With an Irregular Heartbeat Algorithm Designed to Detect Atrial Fibrillation.

    Ishihara, Yu / Ishizawa, Makoto / Noma, Takahisa / Ohara, Minako / Tani, Ryosuke / Kurashita, Genki / Toda, Yuta / Kobayashi, Waki / Minamino, Tetsuo

    Circulation reports

    2024  Band 6, Heft 4, Seite(n) 110–117

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2024-03-22
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ISSN 2434-0790
    ISSN (online) 2434-0790
    DOI 10.1253/circrep.CR-24-0008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: CEP164-GLI2 association ensures the hedgehog signaling in pancreatic cancer cells.

    Fushimi, Toshihiko / Kobayashi, Tetsuo / Itoh, Hiroshi

    Biochemical and biophysical research communications

    2023  Band 666, Seite(n) 179–185

    Abstract: Hedgehog (Hh) signaling is involved in multiple biological events including development and cancers. It is processed through primary cilia, which are assembled from the mother centriole in most mammalian cells. Pancreatic ductal adenocarcinoma (PDAC) ... ...

    Abstract Hedgehog (Hh) signaling is involved in multiple biological events including development and cancers. It is processed through primary cilia, which are assembled from the mother centriole in most mammalian cells. Pancreatic ductal adenocarcinoma (PDAC) cells generally lose their primary cilia; thus, the Hh signaling pathway is postulated to be independent of the organelle in PDAC. We previously reported that the mother centriole-specific protein, centrosomal protein 164 (CEP164), is required for centriolar localization of the GLI2 transcription factor in Hh signaling and for suppressing the expression of Hh-target genes. In this study, we demonstrated the physical interaction between CEP164 and GLI2, and delineated their binding modes at the mother centriole. The ectopically expressed GLI2-binding region of CEP164 reduced the centriolar GLI2 localization and enhanced the expression of Hh-target genes in PDAC cells. Furthermore, similar phenotypes were observed in PDAC cells lacking primary cilia. These results suggest that the CEP164-GLI2 association at the mother centriole is responsible for controlling Hh signaling, independent of primary cilia in PDAC cells.
    Mesh-Begriff(e) Animals ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism ; Zinc Finger Protein Gli2/genetics ; Zinc Finger Protein Gli2/metabolism ; Cilia/metabolism ; Signal Transduction ; Pancreatic Neoplasms/pathology ; Carcinoma, Pancreatic Ductal/pathology ; Kruppel-Like Transcription Factors/metabolism ; Mammals/metabolism ; Pancreatic Neoplasms
    Chemische Substanzen Hedgehog Proteins ; Zinc Finger Protein Gli2 ; Kruppel-Like Transcription Factors
    Sprache Englisch
    Erscheinungsdatum 2023-05-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.05.031
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: CEP164-GLI2 association ensures the hedgehog signaling in pancreatic cancer cells

    Fushimi, Toshihiko / Kobayashi, Tetsuo / Itoh, Hiroshi

    Biochemical and Biophysical Research Communications. 2023 July, v. 666 p.179-185

    2023  

    Abstract: Hedgehog (Hh) signaling is involved in multiple biological events including development and cancers. It is processed through primary cilia, which are assembled from the mother centriole in most mammalian cells. Pancreatic ductal adenocarcinoma (PDAC) ... ...

    Abstract Hedgehog (Hh) signaling is involved in multiple biological events including development and cancers. It is processed through primary cilia, which are assembled from the mother centriole in most mammalian cells. Pancreatic ductal adenocarcinoma (PDAC) cells generally lose their primary cilia; thus, the Hh signaling pathway is postulated to be independent of the organelle in PDAC. We previously reported that the mother centriole-specific protein, centrosomal protein 164 (CEP164), is required for centriolar localization of the GLI2 transcription factor in Hh signaling and for suppressing the expression of Hh-target genes. In this study, we demonstrated the physical interaction between CEP164 and GLI2, and delineated their binding modes at the mother centriole. The ectopically expressed GLI2-binding region of CEP164 reduced the centriolar GLI2 localization and enhanced the expression of Hh-target genes in PDAC cells. Furthermore, similar phenotypes were observed in PDAC cells lacking primary cilia. These results suggest that the CEP164-GLI2 association at the mother centriole is responsible for controlling Hh signaling, independent of primary cilia in PDAC cells.
    Schlagwörter Erinaceidae ; adenocarcinoma ; centrioles ; mammals ; pancreatic neoplasms ; research ; transcription factors ; Pancreatic cancer ; Hedgehog signaling ; Centriole ; CEP164 ; GLI2
    Sprache Englisch
    Erscheinungsverlauf 2023-07
    Umfang p. 179-185.
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel ; Online
    ZDB-ID 205723-2
    ISSN 0006-291X ; 0006-291X
    ISSN (online) 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.05.031
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Artikel ; Online: Generation of mitochondrial reactive oxygen species through a histidine kinase, HysA in Aspergillus nidulans.

    Kanamaru, Kyoko / Izuhara, Kiyoshiro / Kimura, Makoto / Kobayashi, Tetsuo

    The Journal of general and applied microbiology

    2022  Band 68, Heft 1, Seite(n) 17–23

    Abstract: The His-Asp phosphorelay signal transduction from histidine kinase (HK) to the response regulator (RR) is an important mechanism for adaptation to environmental changes. Aspergillus nidulans expresses 15 different HKs, which may be involved in different ... ...

    Abstract The His-Asp phosphorelay signal transduction from histidine kinase (HK) to the response regulator (RR) is an important mechanism for adaptation to environmental changes. Aspergillus nidulans expresses 15 different HKs, which may be involved in different types of adaptations. As reactive oxygen species (ROS) are a key signal of environmental changes, some HKs might be involved in ROS generation through transcriptional regulation. Previously, we identified 3 HK (NikA, FphA, and HysA) deletion strains that showed increased ROS production during growth. We also showed that the phosphorylation function of HysA is involved in ROS generation. Here, we investigated the role of HysA in ROS production in A. nidulans cells. HysA protein was detected in both the cytosol and mitochondria by biological fractionation of the vegetative cell lysate of A. nidulans. The subcellular localization analysis by expressing the the HysA-GFP fusion protein along with MitoTracker Red staining did not clearly reveal mitochondrial localization of HysA at the conidiophore during asexual development. However, mitochondrial ROS in hysA mutant strains were detected by MitoSOX Red staining, and their excess levels possibly caused morphological changes during asexual development.
    Mesh-Begriff(e) Aspergillus nidulans/genetics ; Aspergillus nidulans/metabolism ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Histidine Kinase/genetics ; Histidine Kinase/metabolism ; Mitochondria/metabolism ; Protein Kinases/genetics ; Protein Kinases/metabolism ; Reactive Oxygen Species/metabolism
    Chemische Substanzen Fungal Proteins ; Reactive Oxygen Species ; Protein Kinases (EC 2.7.-) ; Histidine Kinase (EC 2.7.13.1)
    Sprache Englisch
    Erscheinungsdatum 2022-04-06
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 218355-9
    ISSN 1349-8037 ; 0022-1260
    ISSN (online) 1349-8037
    ISSN 0022-1260
    DOI 10.2323/jgam.2021.09.001
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  10. Artikel ; Online: Impact of the width and shape of the sliding board on design evaluation.

    Katamoto, Ryuji / Komiya, Masami / Ariji, Yuto / Iwahashi, Kenji / Terashi, Yoshiteru / Kobayashi, Hiromitsu / Ehara, Yoshito / Hayashi, Tetsuo

    Assistive technology : the official journal of RESNA

    2024  , Seite(n) 1–9

    Abstract: This study aimed to investigate how width affects the design evaluation of sliding boards with a new shape. Ten caregivers at a senior facility evaluated five types of boards every two weeks. The new shape board received high ratings as the width ... ...

    Abstract This study aimed to investigate how width affects the design evaluation of sliding boards with a new shape. Ten caregivers at a senior facility evaluated five types of boards every two weeks. The new shape board received high ratings as the width increased, with a SUS (System Usability Scale) score of 68.5 points (95% CI 60.6-76.4). Compared to the traditional rectangular board, which had a width of 250 mm and a thickness of 5 mm, the new shape board (with a central width of 163 mm and a thickness of 8 mm) received higher ratings by 0.68 points (95% CI 0.31-1.05)using a paired comparison method. The results of a quantitative study on the usability of sliding boards from the perspective of caregivers indicated that for similar board shapes with a length of 650 mm and a thickness of 8 mm, the evaluation increases as the width increases in the range of 130 mm to 163 mm at the center.
    Sprache Englisch
    Erscheinungsdatum 2024-05-09
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1014913-2
    ISSN 1949-3614 ; 1040-0435
    ISSN (online) 1949-3614
    ISSN 1040-0435
    DOI 10.1080/10400435.2024.2340669
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