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Article ; Online: Methodological caveats regarding "Novel insights into surfactant protein C trafficking revealed through the study of a pathogenic mutant".

Mulugeta, Surafel / Weaver, Timothy E / Beers, Michael F

2022 Volume 59, Issue 3

MeSH term(s)	Humans ; Mutation ; Protein C ; Surface-Active Agents
Chemical Substances	Protein C ; Surface-Active Agents
Language	English
Publishing date	2022-03-31
Publishing country	England
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/13993003.02974-2021
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Article: Impact of a Standardized, Pharmacist-Initiated "Test-Claim" Workflow for Anticipating Barriers to Accessing Discharge Antimicrobials.

Mulugeta, Surafel G / MacDonald, Nancy C / El-Khoury, Caren J / Davis, Susan L / Kenney, Rachel M

The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians

2023 Volume 39, Issue 5, Page(s) 218–223

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-09-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	54478-4
ISSN	8755-1225
ISSN	8755-1225
DOI	10.1177/87551225231196047
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Article ; Online: The biology of the ABCA3 lipid transporter in lung health and disease.

Beers, Michael F / Mulugeta, Surafel

Cell and tissue research

2017 Volume 367, Issue 3, Page(s) 481–493

Abstract: The lipid transporter, ATP-binding cassette class A3 (ABCA3), is a highly conserved multi-membrane-spanning protein that plays a critical role in the regulation of pulmonary surfactant homeostasis. Mutations in ABCA3 have been increasingly recognized as ... ...

Abstract	The lipid transporter, ATP-binding cassette class A3 (ABCA3), is a highly conserved multi-membrane-spanning protein that plays a critical role in the regulation of pulmonary surfactant homeostasis. Mutations in ABCA3 have been increasingly recognized as one of the causes of inherited pulmonary diseases. These monogenic disorders produce familial lung abnormalities with pathological presentations ranging from neonatal surfactant-deficiency-induced respiratory failure to childhood or adult diffuse parenchymal lung diseases for which specific treatment modalities remain limited. More than 200 ABCA3 mutations have been reported to date with approximately three quarters of patients presenting as compound heterozygotes. Recent advances in our understanding of the molecular basis underlying normal ABCA3 biosynthesis and processing and of the mechanisms of alveolar epithelial cell dysregulation caused by the expression of its mutant forms are beginning to emerge. These insights and the role of environmental factors and modifier genes are discussed in the context of the considerable variability in disease presentation observed in patients with identical ABCA3 gene mutations. Moreover, the opportunities afforded by an enhanced understanding of ABCA3 biology for targeted therapeutic strategies are addressed.
MeSH term(s)	ATP-Binding Cassette Transporters/chemistry ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Animals ; Biological Transport ; Health ; Humans ; Lipids/chemistry ; Lung/metabolism ; Lung Diseases/genetics ; Lung Diseases/metabolism ; Surface-Active Agents/metabolism
Chemical Substances	ATP-Binding Cassette Transporters ; Lipids ; Surface-Active Agents
Language	English
Publishing date	2017
Publishing country	Germany
Document type	Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	125067-x
ISSN	1432-0878 ; 0302-766X
ISSN (online)	1432-0878
ISSN	0302-766X
DOI	10.1007/s00441-016-2554-z
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Article ; Online: Optimizing preoperative antibiotics in patients with β-lactam allergies: A role for pharmacy.

Kwiatkowski, Shaina / Mulugeta, Surafel / Davis, Susan / Kenney, Rachel / Kalus, James / Walton, Leslie / Patel, Nisha

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

2021 Volume 78, Issue Supplement_3, Page(s) S76–S82

Abstract: Purpose: Patients with a reported β-lactam allergy (BLA) are often given alternative perioperative antibiotic prophylaxis, increasing risk of surgical site infections (SSIs), acute kidney injury (AKI), and Clostridioides difficile infection (CDI). The ... ...

Abstract	Purpose: Patients with a reported β-lactam allergy (BLA) are often given alternative perioperative antibiotic prophylaxis, increasing risk of surgical site infections (SSIs), acute kidney injury (AKI), and Clostridioides difficile infection (CDI). The purpose of this study was to implement and evaluate a pharmacist-led BLA clarification interview service in the preoperative setting. Methods: A pharmacist performed BLA clarification telephone interviews before elective procedures from November 2018 to March 2019. On the basis of allergy history and a decision algorithm, first-line preoperative antibiotics, alternative antibiotics, or allergy testing referral was recommended. The pharmacist intervention (PI) group was compared to a standard of care (SOC) group who underwent surgery from November 2017 to March 2018. Results: Eighty-seven patients were included, with 50 (57%) and 37 (43%) in the SOC and PI groups, respectively. The most common surgeries included orthopedic surgery in 41 patients (47%) and neurosurgery in 17 patients (20%). In the PI group, all BLA labels were updated after interview. Twenty-three patients were referred for allergy testing, 12 of the 23 (52%) completed BLA testing, and penicillin allergies were removed for 9 of the 12 patients. Overall, 28 of the 37 (76%) pharmacy antibiotic recommendations were accepted. Cefazolin use significantly increased from 28% to 65% after the intervention (P = 0.001). SSI occurred in 5 (10%) patients in the SOC group and no patients in the PI group (P = 0.051). All of these SSIs were associated with alternative antibiotics. Incidence of AKI and CDI was similar between the groups. No allergic reactions occurred in either group. Conclusion: Implementation of a pharmacy-driven BLA reconciliation significantly increased β-lactam preoperative use without negative safety outcomes.
MeSH term(s)	Anti-Bacterial Agents/adverse effects ; Antibiotic Prophylaxis ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/epidemiology ; Drug Hypersensitivity/prevention & control ; Humans ; Lactams ; Pharmacy ; Retrospective Studies ; beta-Lactams/adverse effects
Chemical Substances	Anti-Bacterial Agents ; Lactams ; beta-Lactams
Language	English
Publishing date	2021-05-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1224627-x
ISSN	1535-2900 ; 1079-2082
ISSN (online)	1535-2900
ISSN	1079-2082
DOI	10.1093/ajhp/zxab218
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Article: The biology of the ABCA3 lipid transporter in lung health and disease

Beers, Michael F / Surafel Mulugeta

Cell and tissue research. 2017 Mar., v. 367, no. 3

2017

Abstract	The lipid transporter, ATP-binding cassette class A3 (ABCA3), is a highly conserved multi-membrane-spanning protein that plays a critical role in the regulation of pulmonary surfactant homeostasis. Mutations in ABCA3 have been increasingly recognized as one of the causes of inherited pulmonary diseases. These monogenic disorders produce familial lung abnormalities with pathological presentations ranging from neonatal surfactant-deficiency-induced respiratory failure to childhood or adult diffuse parenchymal lung diseases for which specific treatment modalities remain limited. More than 200 ABCA3 mutations have been reported to date with approximately three quarters of patients presenting as compound heterozygotes. Recent advances in our understanding of the molecular basis underlying normal ABCA3 biosynthesis and processing and of the mechanisms of alveolar epithelial cell dysregulation caused by the expression of its mutant forms are beginning to emerge. These insights and the role of environmental factors and modifier genes are discussed in the context of the considerable variability in disease presentation observed in patients with identical ABCA3 gene mutations. Moreover, the opportunities afforded by an enhanced understanding of ABCA3 biology for targeted therapeutic strategies are addressed.
Keywords	adults ; biosynthesis ; childhood ; environmental factors ; epithelial cells ; heterozygosity ; homeostasis ; lipids ; modifiers (genes) ; mutants ; mutation ; patients ; respiratory tract diseases ; surfactants
Language	English
Dates of publication	2017-03
Size	p. 481-493.
Publishing place	Springer Berlin Heidelberg
Document type	Article
Note	Review
ZDB-ID	125067-x
ISSN	1432-0878 ; 0302-766X
ISSN (online)	1432-0878
ISSN	0302-766X
DOI	10.1007/s00441-016-2554-z
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Role of CCR2

Venosa, Alessandro / Cowman, Sophie / Katzen, Jeremy / Tomer, Yaniv / Armstrong, Brittnie S / Mulugeta, Surafel / Beers, Michael F

Frontiers in immunology

2021 Volume 12, Page(s) 665818

Abstract: Acute inflammatory exacerbations (AIE) represent precipitous deteriorations of a number of chronic lung conditions, including pulmonary fibrosis (PF), chronic obstructive pulmonary disease and asthma. AIEs are marked by diffuse and persistent ... ...

Abstract	Acute inflammatory exacerbations (AIE) represent precipitous deteriorations of a number of chronic lung conditions, including pulmonary fibrosis (PF), chronic obstructive pulmonary disease and asthma. AIEs are marked by diffuse and persistent polycellular alveolitis that profoundly accelerate lung function decline and mortality. In particular, excess monocyte mobilization during AIE and their persistence in the lung have been linked to poor disease outcome. The etiology of AIEs remains quite uncertain, but environmental exposure and genetic predisposition/mutations have been identified as two contributing factors. Guided by clinical evidence, we have developed a mutant model of pulmonary fibrosis leveraging the PF-linked missense isoleucine to threonine substitution at position 73 [I73T] in the alveolar type-2 cell-restricted Surfactant Protein-C [SP-C] gene [
MeSH term(s)	Animals ; Epithelium/metabolism ; Female ; Inflammation/metabolism ; Lung Diseases, Interstitial/drug therapy ; Lung Diseases, Interstitial/genetics ; Lung Diseases, Interstitial/immunology ; Lung Diseases, Interstitial/pathology ; Male ; Mice ; Mice, Transgenic ; Mutation ; Myeloid Cells/immunology ; Myeloid Cells/pathology ; Pulmonary Surfactant-Associated Protein C/genetics ; Pulmonary Surfactant-Associated Protein C/metabolism ; Receptors, CCR2/genetics ; Receptors, CCR2/immunology ; Respiratory Mucosa/immunology ; Respiratory Mucosa/pathology ; Sequence Analysis, RNA ; Signal Transduction ; Tamoxifen/pharmacology ; Transforming Growth Factor beta1/genetics ; Transforming Growth Factor beta1/metabolism
Chemical Substances	Ccr2 protein, mouse ; Pulmonary Surfactant-Associated Protein C ; Receptors, CCR2 ; Sftpc protein, mouse ; Tgfb1 protein, mouse ; Transforming Growth Factor beta1 ; Tamoxifen (094ZI81Y45)
Language	English
Publishing date	2021-04-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.665818
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Article: The Antimicrobial Stewardship Approach to Combating Clostridium Difficile.

Wenzler, Eric / Mulugeta, Surafel G / Danziger, Larry H

Antibiotics (Basel, Switzerland)

2015 Volume 4, Issue 2, Page(s) 198–215

Abstract: Clostridium difficile remains a major public health threat and continues to contribute to excess morbidity, mortality and healthcare costs. Antimicrobial stewardship programs have demonstrated success in combating C. difficile, primarily through ... ...

Abstract	Clostridium difficile remains a major public health threat and continues to contribute to excess morbidity, mortality and healthcare costs. Antimicrobial stewardship programs have demonstrated success in combating C. difficile, primarily through antibiotic restrictive strategies. As the incidence and prevalence of C. difficile associate disease continues to increase both in the hospital and community setting, additional stewardship approaches are needed. This manuscript reviews stewardship interventions that have been successful against C. difficile associated disease and proposes future tactics that antimicrobial stewardship programs may employ to develop a more global approach to combat this difficult pathogen.
Language	English
Publishing date	2015-06-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics4020198
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Article ; Online: Congenital Deletion of

Leitz, Dominik H W / Duerr, Julia / Mulugeta, Surafel / Seyhan Agircan, Ayça / Zimmermann, Stefan / Kawabe, Hiroshi / Dalpke, Alexander H / Beers, Michael F / Mall, Marcus A

International journal of molecular sciences

2021 Volume 22, Issue 11

Abstract: Recent studies found that expression of NEDD4-2 is reduced in lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and that the conditional deletion ... ...

Abstract	Recent studies found that expression of NEDD4-2 is reduced in lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and that the conditional deletion of
MeSH term(s)	Animals ; Animals, Newborn ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Female ; Inflammation Mediators/metabolism ; Lung/immunology ; Lung/metabolism ; Lung/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nedd4 Ubiquitin Protein Ligases/physiology ; Pulmonary Alveoli/immunology ; Pulmonary Alveoli/metabolism ; Pulmonary Alveoli/pathology ; Pulmonary Fibrosis/etiology ; Pulmonary Fibrosis/pathology
Chemical Substances	Inflammation Mediators ; Nedd4 Ubiquitin Protein Ligases (EC 2.3.2.26) ; Nedd4l protein, mouse (EC 2.3.2.26)
Language	English
Publishing date	2021-06-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22116146
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Article ; Online: The common ABCA3

Tomer, Yaniv / Wambach, Jennifer / Knudsen, Lars / Zhao, Ming / Rodriguez, Luis R / Murthy, Aditi / White, Frances V / Venosa, Alessandro / Katzen, Jeremy / Ochs, Matthias / Hamvas, Aaron / Beers, Michael F / Mulugeta, Surafel

American journal of physiology. Lung cellular and molecular physiology

2021 Volume 321, Issue 2, Page(s) L291–L307

Abstract: ATP-binding cassette class A3 (ABCA3) is a lipid transporter that plays a critical role in pulmonary surfactant function. The substitution of valine for glutamic acid at codon 292 (E292V) produces a hypomorphic variant that accounts for a significant ... ...

Abstract	ATP-binding cassette class A3 (ABCA3) is a lipid transporter that plays a critical role in pulmonary surfactant function. The substitution of valine for glutamic acid at codon 292 (E292V) produces a hypomorphic variant that accounts for a significant portion of
MeSH term(s)	ATP-Binding Cassette Transporters/biosynthesis ; ATP-Binding Cassette Transporters/genetics ; Alveolar Epithelial Cells/metabolism ; Alveolar Epithelial Cells/pathology ; Amino Acid Substitution ; Animals ; Autophagy ; Gene Expression Regulation ; Lung Injury/genetics ; Lung Injury/metabolism ; Lung Injury/pathology ; Mice ; Mice, Mutant Strains ; Mutation, Missense ; Pulmonary Fibrosis/genetics ; Pulmonary Fibrosis/metabolism ; Pulmonary Fibrosis/pathology ; Respiratory Distress Syndrome, Newborn/metabolism ; Respiratory Distress Syndrome, Newborn/pathology
Chemical Substances	ATP-Binding Cassette Transporters ; Abca3 protein, mouse
Language	English
Publishing date	2021-06-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1013184-x
ISSN	1522-1504 ; 1040-0605
ISSN (online)	1522-1504
ISSN	1040-0605
DOI	10.1152/ajplung.00400.2020
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Article ; Online: The Antimicrobial Stewardship Approach to Combating Clostridium Difficile

Eric Wenzler / Surafel G. Mulugeta / Larry H. Danziger

Antibiotics, Vol 4, Iss 2, Pp 198-

2015 Volume 215

Abstract	Clostridium difficile remains a major public health threat and continues to contribute to excess morbidity, mortality and healthcare costs. Antimicrobial stewardship programs have demonstrated success in combating C. difficile, primarily through antibiotic restrictive strategies. As the incidence and prevalence of C. difficile associate disease continues to increase both in the hospital and community setting, additional stewardship approaches are needed. This manuscript reviews stewardship interventions that have been successful against C. difficile associated disease and proposes future tactics that antimicrobial stewardship programs may employ to develop a more global approach to combat this difficult pathogen.
Keywords	antimicrobial stewardship ; Clostridium difficile ; restriction ; diarrhea ; rapid diagnostics ; treatment ; infection control ; Therapeutics. Pharmacology ; RM1-950 ; Medicine ; R
Language	English
Publishing date	2015-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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