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  1. Book ; Conference proceedings: Defining optimal immunotherapies for type 1 diabetes

    Herrath, Matthias G. von

    (Novartis Foundation symposium ; 292)

    2008  

    Institution Novartis Foundation
    Event/congress Symposium on Defining Optimal Immunotherapies for Type 1 Diabetes (2007, London)
    Author's details [Novartis Foundation Symposium on Defining Optimal Imunotherapies for Type 1 Diabetes, held at the Novartis Foundation, London, 11 - 12 July 2007. Ed. by Matthias von Herrath]
    Series title Novartis Foundation symposium ; 292
    Collection
    Language English
    Size IX, 212 S. : Ill., graph. Darst.
    Publisher Wiley-Blackwell
    Publishing place Chichester
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT015399895
    ISBN 978-0-470-72325-8 ; 0-470-51900-2 ; 0-470-72325-4 ; 978-0-470-51900-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 3576 order for loan Magazin

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  2. Book ; Conference proceedings: How do we best employ animal models for type 1 diabetes and multiple sclerosis?

    Herrath, Matthias G. von

    [result of a Conference Entitled How Do We Best Employ Animal Models for Type 1 Diabetes and Multiple Sclerosis? ... held on November 8 - 9, 2006 in San Francisco, California]

    (Annals of the New York Academy of Sciences ; 1103)

    2007  

    Event/congress Conference Entitled How Do We Best Employ Animal Models for Type 1 Diabetes and Multiple Sclerosis? (2006, SanFranciscoCalif.)
    Author's details ed. by Matthias von Herrath
    Series title Annals of the New York Academy of Sciences ; 1103
    Collection
    Language English
    Size XII, 220 S. : Ill., graph. Darst.
    Publisher Blackwell
    Publishing place Boston, Mass. u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT015120451
    ISBN 1-57331-678-4 ; 978-1-57331-678-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 110 -1103- verfügbar in Königswinter Königswinter

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  3. Book ; Online: Molecular pathology of type 1 diabetes mellitus

    Herrath, Matthias G. von

    an authoritative and up-to-date overview

    2001  

    Author's details vol. ed.: Matthias G. von Herrath
    Language English
    Size X + 360 S.
    Publisher Karger
    Publishing place Basel
    Publishing country Switzerland
    Document type Book ; Online
    HBZ-ID TT050388251
    ISBN 978-3-318-00715-2 ; 3-318-00715-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  4. Book: Molecular pathology of type 1 diabetes mellitus

    Herrath, Matthias G. von

    10 tables

    (Current directions in autoimmunity ; 4)

    2001  

    Author's details vol. ed. Matthias G. von Herrath
    Series title Current directions in autoimmunity ; 4
    Collection
    Keywords Diabetes Mellitus, Insulin-Dependent / genetics ; Autoimmune Diseases / immunology ; Diabetes Mellitus, Insulin-Dependent / immunology ; Diabetes mellitus ; Typ 1 ; Molekulare Medizin
    Subject Medizin ; Genmedizin ; Typ I ; Diabetes verus ; Zuckerharnruhr ; Zuckerkrankheit
    Language English
    Size X, 360 S. : Ill.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT013144809
    ISBN 3-8055-7240-9 ; 978-3-8055-7240-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 A 4793 order for loan Magazin

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  5. Article: New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes.

    Bender, Christine / Rajendran, Sakthi / von Herrath, Matthias G

    Frontiers in endocrinology

    2021  Volume 11, Page(s) 606434

    Abstract: Since the establishment of the network for pancreatic organ donors with diabetes (nPOD), we have gained unprecedented insight into the pathology of human type 1 diabetes. Many of the pre-existing "dogmas", mostly derived from studies of animal models and ...

    Abstract Since the establishment of the network for pancreatic organ donors with diabetes (nPOD), we have gained unprecedented insight into the pathology of human type 1 diabetes. Many of the pre-existing "dogmas", mostly derived from studies of animal models and sometimes limited human samples, have to be revised now. For example, we have learned that autoreactive CD8 T cells are present even in healthy individuals within the exocrine pancreas. Furthermore, their "attraction" to islets probably relies on beta-cell intrinsic events, such as the over-expression of MHC class I and resulting presentation of autoantigens such as (prepro)insulin. In addition, we are discovering other signs of beta-cell dysfunction, possibly at least in part due to stress, such as the over-expression of certain cytokines. This review summarizes the latest developments focusing on cytokines and autoreactive CD8 T cells in human type 1 diabetes pathogenesis.
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/immunology ; Cytokines ; Diabetes Mellitus, Type 1/immunology ; Diabetes Mellitus, Type 1/metabolism ; Diabetes Mellitus, Type 1/pathology ; Humans ; Pancreas/immunology ; Pancreas/pathology
    Chemical Substances Cytokines
    Language English
    Publishing date 2021-01-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2020.606434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Interference with pancreatic sympathetic signaling halts the onset of diabetes in mice.

    Christoffersson, Gustaf / Ratliff, Sowbarnika S / von Herrath, Matthias G

    Science advances

    2020  Volume 6, Issue 35

    Abstract: The notably lobular distribution of immune lesions in type 1 diabetes (T1D) has been hypothesized to be the result of innervation within the pancreas. To investigate whether neuroimmune interactions could explain this phenomenon, we explored the impact ... ...

    Abstract The notably lobular distribution of immune lesions in type 1 diabetes (T1D) has been hypothesized to be the result of innervation within the pancreas. To investigate whether neuroimmune interactions could explain this phenomenon, we explored the impact of sympathetic signaling in the RIP-LCMV-GP mouse model of autoimmune diabetes. In this model, the CD8
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes ; Diabetes Mellitus, Type 1 ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Pancreas/pathology ; Receptors, Adrenergic
    Chemical Substances Receptors, Adrenergic
    Language English
    Publishing date 2020-08-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abb2878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Strategies to treat autoimmune diabetes.

    Filippi, Christophe M / von Herrath, Matthias G

    Expert review of endocrinology & metabolism

    2019  Volume 2, Issue 2, Page(s) 185–194

    Abstract: Type 1 diabetes results from autoimmune destruction of insulin-producing β cells in the pancreatic islets, leading to deficiency in glucose uptake by the cells of the body. The resulting complications and mortality call into attention the need for ... ...

    Abstract Type 1 diabetes results from autoimmune destruction of insulin-producing β cells in the pancreatic islets, leading to deficiency in glucose uptake by the cells of the body. The resulting complications and mortality call into attention the need for therapeutic strategies to treat this disease. While general immunosuppressive treatment and antigen-based therapy have both proven effective in aborting the autoimmune attack on β cells, cellular therapy and synergistic combination of agents probably represent the most promising approaches for efficient targeting of autoreactive cells. The underlying challenge is fine tuning of immune therapy to avoid harmful side effects on the immune system or other host-defense functions. This should be rendered possible by identifying the optimal regimen and underlying mechanisms of action.
    Language English
    Publishing date 2019-02-12
    Publishing country England
    Document type Journal Article
    ISSN 1744-8417
    ISSN (online) 1744-8417
    DOI 10.1586/17446651.2.2.185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: OAS1 is not associated with MHC class I hyperexpression in the islets of donors with T1D regardless of disease duration.

    Sabouri, Somayeh / Mikulski, Zbigniew / von Herrath, Matthias G

    Clinical immunology (Orlando, Fla.)

    2018  Volume 191, Page(s) 34–36

    MeSH term(s) 2',5'-Oligoadenylate Synthetase/analysis ; 2',5'-Oligoadenylate Synthetase/physiology ; Diabetes Mellitus, Type 1/etiology ; Diabetes Mellitus, Type 1/immunology ; Genes, MHC Class I ; Humans ; Islets of Langerhans/chemistry
    Chemical Substances OAS1 protein, human (EC 2.7.7.-) ; 2',5'-Oligoadenylate Synthetase (EC 2.7.7.84)
    Language English
    Publishing date 2018-03-15
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2018.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 880: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Interleukin 6 in diabetes, chronic kidney disease, and cardiovascular disease: mechanisms and therapeutic perspectives.

    Kreiner, Frederik Flindt / Kraaijenhof, Jordan M / von Herrath, Matthias / Hovingh, G Kees Kornelis / von Scholten, Bernt Johan

    Expert review of clinical immunology

    2022  Volume 18, Issue 4, Page(s) 377–389

    Abstract: Introduction: Diabetes, chronic kidney disease (CKD) and cardiovascular disease (CVD) are cardiometabolic diseases that remain amongst the leading causes of morbidity and premature mortality. Here, we review the current understanding of how anti- ... ...

    Abstract Introduction: Diabetes, chronic kidney disease (CKD) and cardiovascular disease (CVD) are cardiometabolic diseases that remain amongst the leading causes of morbidity and premature mortality. Here, we review the current understanding of how anti-inflammatory intervention via inhibition of the pro-inflammatory but pleiotropic cytokine interleukin (IL) 6 may benefit patients with these or related diseases or complications.
    Areas covered: Based on a PubMed literature search, this review integrates and contextualizes evidence regarding the clinical utility of anti-IL-6 intervention in the treatment of cardiometabolic diseases, as well as of the associated condition nonalcoholic hepatosteatosis.
    Expert opinion: Evidence implicates the pro-inflammatory effects of IL-6 in the pathophysiology of diabetes, CKD and CVD. Thus, targeting the IL-6 pathway holds a therapeutic potential in these cardiometabolic disorders. However, because IL-6 has multiple homeostatic roles, antagonizing this cytokine may be associated with side effects, such as increased risk of infection as seen with other anti-inflammatory drugs. Additional studies are required to establish the benefit-risk profile of anti-IL-6 intervention in the cardiometabolic diseases, whilst also considering alternative interventions such as lifestyle changes. IL-6 is also elevated in NASH, but the clinical usefulness of targeting IL-6 in this hepatic disorder remains largely unexplored.
    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; Cardiovascular Diseases/drug therapy ; Diabetes Mellitus ; Humans ; Interleukin-6 ; Renal Insufficiency, Chronic/drug therapy
    Chemical Substances Anti-Inflammatory Agents ; Interleukin-6
    Language English
    Publishing date 2022-03-01
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2022.2045952
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6661: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes.

    Bender, Christine / Rodriguez-Calvo, Teresa / Amirian, Natalie / Coppieters, Ken T / von Herrath, Matthias G

    Science advances

    2020  Volume 6, Issue 42

    Abstract: Preproinsulin (PPI) is presumably a crucial islet autoantigen found in patients with type 1 diabetes (T1D) but is also recognized by ... ...

    Abstract Preproinsulin (PPI) is presumably a crucial islet autoantigen found in patients with type 1 diabetes (T1D) but is also recognized by CD8
    MeSH term(s) Autoantigens ; CD8-Positive T-Lymphocytes ; Diabetes Mellitus, Type 1 ; Humans ; Insulin ; Pancreas, Exocrine ; Protein Precursors
    Chemical Substances Autoantigens ; Insulin ; Protein Precursors ; preproinsulin (61116-24-3)
    Language English
    Publishing date 2020-10-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abc5586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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