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Article ; Online: Combining β-Carotene with 5-FU via Polymeric Nanoparticles as a Novel Therapeutic Strategy to Overcome uL3-Mediated Chemoresistance in p53-Deleted Colorectal Cancer Cells.

Carotenuto, Pietro / Pecoraro, Annalisa / Brignola, Chiara / Barbato, Anna / Franco, Brunella / Longobardi, Giuseppe / Conte, Claudia / Quaglia, Fabiana / Russo, Giulia / Russo, Annapina

Molecular pharmaceutics

2023 Volume 20, Issue 5, Page(s) 2326–2340

Abstract: Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Despite recent therapeutic advancements, resistance to 5-fluorouracil (5-FU) remains a major obstacle to the successful treatment of this disease. We have previously ... ...

Abstract	Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Despite recent therapeutic advancements, resistance to 5-fluorouracil (5-FU) remains a major obstacle to the successful treatment of this disease. We have previously identified the ribosomal protein uL3 as a key player in the cell response to 5-FU, and loss of uL3 is associated with 5-FU chemoresistance. Natural products, like carotenoids, have shown the ability to enhance cancer cell response to drugs and may provide a safer choice to defeat chemoresistance in cancer. Transcriptome analysis of a cohort of 594 colorectal patients revealed a correlation between uL3 expression and both progression-free survival and response to treatment. RNA-Seq data from uL3-silenced CRC cells demonstrated that a low uL3 transcriptional state was associated with an increased expression of specific
MeSH term(s)	Humans ; beta Carotene/pharmacology ; beta Carotene/metabolism ; beta Carotene/therapeutic use ; Tumor Suppressor Protein p53/genetics ; Drug Resistance, Neoplasm/genetics ; Cell Line, Tumor ; Fluorouracil/pharmacology ; Fluorouracil/therapeutic use ; Apoptosis ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Gene Expression Regulation, Neoplastic
Chemical Substances	beta Carotene (01YAE03M7J) ; Tumor Suppressor Protein p53 ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2023-03-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.2c00876
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Article ; Online: Synthesis and Antioxidative Properties of 1,2,3,4-Tetrahydropyridine Derivatives with Different Substituents in 4-Position.

Aiello, Daniele / Jonas, Hendrik / Carbone, Anna / Carbone, Daniela / Pecoraro, Camilla / Tesoriere, Luisa / Köhler, Jens / Wünsch, Bernhard / Diana, Patrizia

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 21

Abstract: Natural products are an excellent source of inspiration for the development of new drugs. Among them, betalains have been extensively studied for their antioxidant properties and potential application as natural food dyes. Herein, we describe the seven- ... ...

Abstract	Natural products are an excellent source of inspiration for the development of new drugs. Among them, betalains have been extensively studied for their antioxidant properties and potential application as natural food dyes. Herein, we describe the seven-step synthesis of new betalamic acid analogs without carboxy groups in the 2- and 6-position with an overall yield of ~70%. The Folin-Ciocalteu assay was used to determine the antioxidant properties of protected intermediate
MeSH term(s)	Antioxidants/pharmacology ; Antioxidants/chemistry ; Pyrrolidines ; Betalains/chemistry ; Pyridines/chemistry
Chemical Substances	betalamic acid (18766-66-0) ; Antioxidants ; Pyrrolidines ; Betalains (37279-84-8) ; Pyridines
Language	English
Publishing date	2022-11-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27217423
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Article: Anti-Herpes Zoster Vaccination of Fragile Patients in Hospital Setting: A Nudge Intervention in Italy.

De Caro, Francesco / Malatesta, Francesca / Pecoraro, Nadia / Capunzo, Mario / Carpinelli, Luna / Caruccio, Simona / Cersosimo, Giuseppina / Costantino, Maria / Giordano, Claudio / Longanella, Walter / Patella, Vincenzo / Saggese Tozzi, Arcangelo / Savarese, Giulia / Sinopoli, Pio / Vozzella, Emilia Anna / Moccia, Giuseppina

Vaccines

2024 Volume 12, Issue 4

Abstract: Background: A nudge intervention against Herpes Zoster, created and implemented in Italy, is presented in order to administer the Shingrix vaccine on a sample of frail patients, as required by the National Prevention Plan. Individual and contextual ... ...

Abstract	Background: A nudge intervention against Herpes Zoster, created and implemented in Italy, is presented in order to administer the Shingrix vaccine on a sample of frail patients, as required by the National Prevention Plan. Individual and contextual factors associated with vaccine adherence were investigated. Method: 300 frail adult subjects underwent a full vaccine cycle with recombinant-Shingrix vaccine (RZV vaccine). Hospital Presidia of the Salerno University Hospital Authority, a Hospital Presidium of the Salerno Local Health Authority, and the Public Health Laboratory of the University of Salerno (Campania) participated in the intervention. An ad hoc questionnaire was administered with the following scales: EQ-5D, PSS-10, MSPSS, and representations of HZ and its consequences. Results: Some variables, such as peer support, doctor-patient relationship, level of education, and perception of health, are important in vaccine adherence and information processing. The following factors emerged from the factor analysis: Trust in collective knowledge and collective responsibility (F1); beliefs about virus risk and vaccine function (F2); information about virus and symptomatology (F3); and vaccine distrust (F4). Factor 4 correlates negatively with social support indices (R = -0.363; Conclusions: Future vaccination campaigns should be built with the aim of personalizing information and developing contextualized strategies, starting from understanding the stakeholders involved, cultural contexts, and organizational settings.
Language	English
Publishing date	2024-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines12040442
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Article: Effects of carnosine on the embryonic development and TiO

Caruso, Giuseppe / Scalisi, Elena Maria / Pecoraro, Roberta / Cardaci, Vincenzo / Privitera, Anna / Truglio, Emanuela / Capparucci, Fabiano / Jarosova, Romana / Salvaggio, Antonio / Caraci, Filippo / Brundo, Maria Violetta

Frontiers in veterinary science

2023 Volume 10, Page(s) 1148766

Abstract: Oxidative stress is due to an unbalance between pro-oxidants, such as reactive oxygen (ROS) and nitrogen (RNS) species, and antioxidants/antioxidant system. Under physiological conditions these species are involved in different cellular processes such as ...

Abstract	Oxidative stress is due to an unbalance between pro-oxidants, such as reactive oxygen (ROS) and nitrogen (RNS) species, and antioxidants/antioxidant system. Under physiological conditions these species are involved in different cellular processes such as cellular homeostasis and immune response, while an excessive production of ROS/RNS has been linked to the development of various diseases such as cancer, diabetes, and Alzheimer's disease. In this context, the naturally occurring dipeptide carnosine has shown the ability to scavenge ROS, counteract lipid peroxidation, and inhibit proteins oxidation. Titanium dioxide nanoparticles (TiO
Language	English
Publishing date	2023-03-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2023.1148766
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Article ; Online: Main intrinsic factors driving land grabbing in the African countries’ agro-food industry

Tulone, Antonio / Galati, Antonino / Pecoraro, Simone / Carroccio, Anna / Siggia, Dario / Virzì, Michele / Crescimanno, Maria

Land Use Policy. 2022 Sept., v. 120 p.106225-

2022

Abstract: Land grabbing is a phenomenon that has spread widely over the last two decades and which involves rich and emerging countries and international companies as protagonists in the large-scale acquisition of land in developing countries. Through the ... ...

Abstract	Land grabbing is a phenomenon that has spread widely over the last two decades and which involves rich and emerging countries and international companies as protagonists in the large-scale acquisition of land in developing countries. Through the development of an econometric model that takes into account the annual size of land grabbing in the African countries, the research aims to understand the main intrinsic factors, linked to the hosting countries, that guide the large-scale acquisition of land by foreign investors. Results show that the presence of a high debt towards foreign organisations, the high availability of virgin lands, the strong vocation of the hosting country for the cultivation of cereals, and the dependence on foreign markets for the supply of food commodities would be some drivers that guide foreign investors to grab land in African countries for the cultivation of agricultural and food crops. In light of the economic, social, and environmental consequences of the phenomenon, the study provides interesting managerial implications for foreign investors and useful political indications for governments and policy-makers, and it lays the groundwork for future research.
Keywords	debt ; econometric models ; food industry ; land policy ; politics ; External debt ; Arable land ; Food crops ; Foreign investors ; Virgin land
Language	English
Dates of publication	2022-09
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	852476-2
ISSN	0264-8377
ISSN	0264-8377
DOI	10.1016/j.landusepol.2022.106225
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Investigation on Quantitative Structure-Activity Relationships of 1,3,4-Oxadiazole Derivatives as Potential Telomerase Inhibitors.

Tutone, Marco / Pecoraro, Beatrice / Almerico, Anna M

Current drug discovery technologies

2018 Volume 17, Issue 1, Page(s) 79–86

Abstract: Background: Telomerase, a reverse transcriptase, maintains telomere and chromosomes integrity of dividing cells, while it is inactivated in most somatic cells. In tumor cells, telomerase is highly activated, and works in order to maintain the length of ... ...

Abstract	Background: Telomerase, a reverse transcriptase, maintains telomere and chromosomes integrity of dividing cells, while it is inactivated in most somatic cells. In tumor cells, telomerase is highly activated, and works in order to maintain the length of telomeres causing immortality, hence it could be considered as a potential marker to tumorigenesis.A series of 1,3,4-oxadiazole derivatives showed significant broad-spectrum anticancer activity against different cell lines, and demonstrated telomerase inhibition. Methods: This series of 24 N-benzylidene-2-((5-(pyridine-4-yl)-1,3,4-oxadiazol-2yl)thio)acetohydrazide derivatives as telomerase inhibitors has been considered to carry out QSAR studies. The endpoint to build QSAR models is determined by the IC50 values for telomerase inhibition, i.e., the concentration (μM) of inhibitor that produces 50% inhibition. These values were converted to pIC50 (- log IC50) values. We used the most common and transparent method, where models are described by clearly expressed mathematical equations: Multiple Linear Regression (MLR) by Ordinary Least Squares (OLS). Results: Validated models with high correlation coefficients were developed. The Multiple Linear Regression (MLR) models, by Ordinary Least Squares (OLS), showed good robustness and predictive capability, according to the Multi-Criteria Decision Making (MCDM = 0.8352), a technique that simultaneously enhances the performances of a certain number of criteria. The descriptors selected for the models, such as electrotopological state (E-state) descriptors, and extended topochemical atom (ETA) descriptors, showed the relevant chemical information contributing to the activity of these compounds. Conclusion: The results obtained in this study make sure about the identification of potential hits as prospective telomerase inhibitors.
MeSH term(s)	Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Datasets as Topic ; Drug Screening Assays, Antitumor/methods ; Inhibitory Concentration 50 ; Least-Squares Analysis ; Models, Biological ; Models, Molecular ; Molecular Structure ; Oxadiazoles/chemistry ; Oxadiazoles/pharmacology ; Quantitative Structure-Activity Relationship ; Telomerase/antagonists & inhibitors
Chemical Substances	Antineoplastic Agents ; Oxadiazoles ; 1,3,4-oxadiazole (20O2F20OUR) ; TERT protein, human (EC 2.7.7.49) ; Telomerase (EC 2.7.7.49)
Language	English
Publishing date	2018-07-23
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
ISSN	1875-6220
ISSN (online)	1875-6220
DOI	10.2174/1570163815666180724113208
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Article ; Online: A Green Bioactive By-Product Almond Skin Functional Extract for Developing Nutraceutical Formulations with Potential Antimetabolic Activity.

Picerno, Patrizia / Crascì, Lucia / Iannece, Patrizia / Esposito, Tiziana / Franceschelli, Silvia / Pecoraro, Michela / Giannone, Virgilio / Panico, Anna Maria / Aquino, Rita Patrizia / Lauro, Maria Rosaria

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 23

Abstract: 1) Background: almond peels are rich in polyphenols such as catechin and epicatechin, which are important anti-free-radical agents, anti-inflammatory compounds, and capable of breaking down cholesterol plaques. This work aims to evaluate the biological ... ...

Abstract	(1) Background: almond peels are rich in polyphenols such as catechin and epicatechin, which are important anti-free-radical agents, anti-inflammatory compounds, and capable of breaking down cholesterol plaques. This work aims to evaluate the biological and technological activity of a "green" dry aqueous extract from Sicilian almond peels, a waste product of the food industry, and to develop healthy nutraceuticals with natural ingredients. Eudraguard
MeSH term(s)	Antioxidants/pharmacology ; Antioxidants/chemistry ; Prunus dulcis ; Matrix Metalloproteinase 2 ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Dietary Supplements ; Free Radicals/chemistry
Chemical Substances	Antioxidants ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Plant Extracts ; Free Radicals
Language	English
Publishing date	2023-12-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28237913
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Article ; Online: Pt-TiO

Pecoraro, Claudio Maria / Mino, Lorenzo / Kozyr, Elizaveta / Palmisano, Leonardo / di Franco, Francesco / Loddo, Vittorio / Santamaria, Monica / Bellardita, Marianna

Chemical communications (Cambridge, England)

2024 Volume 60, Issue 28, Page(s) 3782–3785

Abstract: We compared the ... ...

Abstract	We compared the H
Language	English
Publishing date	2024-04-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d4cc00353e
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Article ; Online: STING is a prognostic factor related to tumor necrosis, sarcomatoid dedifferentiation, and distant metastasis in clear cell renal cell carcinoma.

Marletta, Stefano / Caliò, Anna / Bogina, Giuseppe / Rizzo, Mimma / Brunelli, Matteo / Pedron, Serena / Marcolini, Lisa / Stefanizzi, Lavinia / Gobbo, Stefano / Princiotta, Alessandro / Porta, Camillo / Pecoraro, Angela / Antonelli, Alessandro / Martignoni, Guido

Virchows Archiv : an international journal of pathology

2023 Volume 483, Issue 1, Page(s) 87–96

Abstract: STING is a molecule involved in immune reactions against double-stranded DNA fragments, released in infective and neoplastic diseases, whose role in the interactions between immune and neoplastic cells in clear cell renal cell carcinoma has not been ... ...

Abstract	STING is a molecule involved in immune reactions against double-stranded DNA fragments, released in infective and neoplastic diseases, whose role in the interactions between immune and neoplastic cells in clear cell renal cell carcinoma has not been studied yet. We investigated the immunohistochemical expression of STING in a series of 146 clear-cell renal cell carcinomas and correlated it with the main pathological prognostic factors. Furthermore, tumoral inflammatory infiltrate was evaluated and studied for the subpopulations of lymphocytes. Expression of STING was observed in 36% (53/146) of the samples, more frequently in high-grade (G3-G4) tumors (48%,43/90) and recurrent/metastatic ones (75%, 24/32) than in low grade (G1-G2) and indolent neoplasms (16%, 9/55). STING staining correlated with parameters of aggressive behavior, including coagulative granular necrosis (p = 0.001), stage (p < 0.001), and development of metastases (p < 0.001). Among prognostic parameters, STING immune expression reached an independent statistical significance (p = 0.029) in multivariable analysis, along with the stage and the presence of coagulative granular necrosis. About tumor immune-environment, no significant statistical association has been demonstrated between tumor-infiltrating lymphocytes and STING. Our results provide novel insights regarding the role of STING in aggressive clear cell renal cell carcinomas, suggesting its adoption as a prognostic marker and a potentially targetable molecule for specific immunotherapies.
MeSH term(s)	Humans ; Carcinoma, Renal Cell/pathology ; Kidney Neoplasms/pathology ; Prognosis ; Sarcoma ; Necrosis
Language	English
Publishing date	2023-04-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1184867-4
ISSN	1432-2307 ; 0945-6317
ISSN (online)	1432-2307
ISSN	0945-6317
DOI	10.1007/s00428-023-03549-y
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Article ; Online: Synthesis and Antioxidative Properties of 1,2,3,4-Tetrahydropyridine Derivatives with Different Substituents in 4-Position

Daniele Aiello / Hendrik Jonas / Anna Carbone / Daniela Carbone / Camilla Pecoraro / Luisa Tesoriere / Jens Köhler / Bernhard Wünsch / Patrizia Diana

Molecules, Vol 27, Iss 7423, p

2022 Volume 7423

Abstract	Natural products are an excellent source of inspiration for the development of new drugs. Among them, betalains have been extensively studied for their antioxidant properties and potential application as natural food dyes. Herein, we describe the seven-step synthesis of new betalamic acid analogs without carboxy groups in the 2- and 6-position with an overall yield of ~70%. The Folin–Ciocalteu assay was used to determine the antioxidant properties of protected intermediate 21 . Additionally, the five-step synthesis of betalamic acid analog 35 with three ester moieties was performed. Using NMR techniques, the stability of the obtained compounds towards oxygen was analyzed.
Keywords	indicaxanthins ; betalamic acid ; antioxidant ; dehydrobromination ; TEMPO oxidation ; (E)-(Z) configuration ; Organic chemistry ; QD241-441
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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