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  1. Article ; Online: Antiphospholipid antibodies: crossroads between autoimmunity and infections?

    Sciascia, Savino / Radin, Massimo / Bazzan, Mario / Roccatello, Dario

    Internal and emergency medicine

    2017  Volume 12, Issue 4, Page(s) 557–558

    Language English
    Publishing date 2017
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-017-1664-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Low ADAMTS 13 plasma levels are predictors of mortality in COVID-19 patients.

    Bazzan, Mario / Montaruli, Barbara / Sciascia, Savino / Cosseddu, Domenico / Norbiato, Claudio / Roccatello, Dario

    Internal and emergency medicine

    2020  Volume 15, Issue 5, Page(s) 861–863

    MeSH term(s) ADAMTS13 Protein/blood ; Aged ; Betacoronavirus ; Blood Coagulation Disorders/mortality ; Blood Coagulation Disorders/virology ; COVID-19 ; Coronavirus Infections/mortality ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/mortality ; Predictive Value of Tests ; SARS-CoV-2 ; von Willebrand Factor/metabolism
    Chemical Substances von Willebrand Factor ; ADAMTS13 Protein (EC 3.4.24.87) ; ADAMTS13 protein, human (EC 3.4.24.87)
    Keywords covid19
    Language English
    Publishing date 2020-06-18
    Publishing country Italy
    Document type Letter
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-020-02394-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Problematiche cliniche in ematologia

    Bazzan, Mario

    (Collana di medicina specialistica per internisti e medici di medicina generale)

    2010  

    Author's details [a cura di] Mario Bazzan
    Series title Collana di medicina specialistica per internisti e medici di medicina generale
    MeSH term(s) Hematologic Diseases
    Language Italian
    Size xii, 357 p. :, ill.
    Publisher C.G. edizioni medico scientifiche
    Publishing place Torino
    Document type Book
    ISBN 9788871102313 ; 8871102312
    Database Catalogue of the US National Library of Medicine (NLM)

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  4. Article ; Online: Novel diagnostic and therapeutic frontiers in thrombotic anti-phospholipid syndrome.

    Sciascia, Savino / Radin, Massimo / Bazzan, Mario / Roccatello, Dario

    Internal and emergency medicine

    2017  Volume 12, Issue 1, Page(s) 1–7

    Abstract: The anti-phospholipid syndrome (APS) is an autoimmune disorder characterized by vascular thrombosis and/or pregnancy morbidity, associated with a persistent positivity for anti-phospholipid antibodies (aPL). The current classification criteria for APS ... ...

    Abstract The anti-phospholipid syndrome (APS) is an autoimmune disorder characterized by vascular thrombosis and/or pregnancy morbidity, associated with a persistent positivity for anti-phospholipid antibodies (aPL). The current classification criteria for APS include three laboratory tests: lupus anti-coagulant (LA), anti-cardiolipin (aCL), and anti-β2 glycoprotein-I (β2GPI). To date, the therapeutic approach for thrombotic APS mainly centers on long-term anti-coagulation with a vitamin K antagonist (VKA). APS management may represent a challenge for the treating physicians. Patients with different aPL profiles need a tailored risk-stratified approach. Moreover, in patients with recurrent thrombotic events despite therapy with VKA, or in those with microvascular involvement, new therapeutic options are highly needed. In this review, we aim to elucidate recent findings about new aPL specifities, available risk scoring models, and novel therapeutic approaches in APS management.
    MeSH term(s) Adult ; Antibodies, Anticardiolipin/analysis ; Antibodies, Anticardiolipin/blood ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Anticoagulants/pharmacology ; Anticoagulants/therapeutic use ; Antiphospholipid Syndrome/diagnosis ; Antiphospholipid Syndrome/therapy ; Female ; Fibrinolytic Agents/pharmacology ; Fibrinolytic Agents/therapeutic use ; Humans ; Hydroxychloroquine/pharmacology ; Hydroxychloroquine/therapeutic use ; Lupus Coagulation Inhibitor/analysis ; Lupus Coagulation Inhibitor/blood ; Pregnancy ; Pregnancy Complications/diagnosis ; Pregnancy Complications/prevention & control ; Pregnancy Complications/therapy ; Risk Assessment/methods ; Rivaroxaban/pharmacology ; Rivaroxaban/therapeutic use ; Thrombosis/diagnosis ; Thrombosis/therapy ; beta 2-Glycoprotein I/analysis ; beta 2-Glycoprotein I/blood
    Chemical Substances Antibodies, Anticardiolipin ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Anticoagulants ; Fibrinolytic Agents ; Lupus Coagulation Inhibitor ; beta 2-Glycoprotein I ; Hydroxychloroquine (4QWG6N8QKH) ; Rivaroxaban (9NDF7JZ4M3) ; eculizumab (A3ULP0F556)
    Language English
    Publishing date 2017-02
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-016-1596-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Low ADAMTS 13 plasma levels are predictors of mortality in COVID-19 patients

    Bazzan, Mario / Montaruli, Barbara / Sciascia, Savino / Cosseddu, Domenico / Norbiato, Claudio / Roccatello, Dario

    Intern Emerg Med

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #603715
    Database COVID19

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  6. Article ; Online: Low ADAMTS 13 plasma levels are predictors of mortality in COVID-19 patients

    Bazzan, Mario / Montaruli, Barbara / Sciascia, Savino / Cosseddu, Domenico / Norbiato, Claudio / Roccatello, Dario

    Internal and Emergency Medicine

    2020  Volume 15, Issue 5, Page(s) 861–863

    Keywords Internal Medicine ; Emergency Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-020-02394-0
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: "He is normal": phenomenological considerations of child/adolescent's perception of the disabled sibling.

    Freitag, Vera Lucia / Motta, Maria da Graça Corso / Milbrath, Viviane Marten / Bazzan, Jéssica Stragliotto / Debatin, Gabriel / Gabatz, Ruth Irmgard Bärtschi

    Revista gaucha de enfermagem

    2023  Volume 43, Page(s) e20220129

    Abstract: Objective: To understand the child/adolescent's perception of the disabled sibling.: Method: Qualitative research, with a phenomenological approach, conducted between 2018 and 2019, in a municipality in the south of Brazil, with 20 children/ ... ...

    Abstract Objective: To understand the child/adolescent's perception of the disabled sibling.
    Method: Qualitative research, with a phenomenological approach, conducted between 2018 and 2019, in a municipality in the south of Brazil, with 20 children/adolescents who are siblings of people with disabilities, through a phenomenological interview. Respecting ethical precepts, hermeneutics was used for interpretation.
    Results: The child/adolescent perceives his/her disabled sibling as a normal person, given his/her behavior, way of being and intellectual capacity. Still, it understands him as a special being, who has limitations regarding learning, but does not see him as different, thus, unlinks the idea of disability associated with the disease/abnormality.
    Final considerations: The perception of the disabled sibling occurs within the perception of normality. The child identifies his sibling's lower learning capacitor a way that is unique to him, a fact that does not condition him to be seen as abnormal, defining his being-in-the-world as a special way of existing.
    MeSH term(s) Humans ; Child ; Adolescent ; Male ; Female ; Siblings ; Disabled Persons ; Learning ; Qualitative Research ; Perception
    Language Portuguese
    Publishing date 2023-03-03
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2639673-7
    ISSN 1983-1447 ; 1983-1447
    ISSN (online) 1983-1447
    ISSN 1983-1447
    DOI 10.1590/1983-1447.2022.20220129.en
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Considerações fenomenológicas sobre a percepção de si da criança/adolescente convivendo com irmão com deficiência.

    Freitag, Vera Lucia / Motta, Maria da Graça Corso da / Debatin, Gabriel / Milbrath, Viviane Marten / Bazzan, Jéssica Stragliotto / Gabatz, Ruth Irmgard Bärtschi

    Ciencia & saude coletiva

    2023  Volume 28, Issue 9, Page(s) 2689–2698

    Abstract: The scope of this article was to understand the self-perception of children/adolescents who live with siblings with disabilities. It involved qualitative research, with a hermeneutic-phenomenological approach, with 20 children and adolescents who live ... ...

    Title translation Phenomenological considerations regarding the self-perception of children/adolescents living with siblings with disabilities.
    Abstract The scope of this article was to understand the self-perception of children/adolescents who live with siblings with disabilities. It involved qualitative research, with a hermeneutic-phenomenological approach, with 20 children and adolescents who live with a disabled sibling from a municipality in the state of Rio Grande do Sul/Brazil. Phenomenological interviews, field diaries and hermeneutic interpretations were used. There were gaps in care, need for attention and understanding on the part of the family, due to the attention given to the disabled sibling. Also, the fear and anguish of the death of the grandparents, the death of the disabled sibling, the nostalgia of the grandparents after their death. It was shown that these children/adolescents live together and question the birth and existence of the sibling. By shining a light on the child/adolescent's life experience, gaps and weaknesses in the relationship with parents, in health care, in situations of vulnerabilities experienced by the child/adolescent and family were revealed. Thus, attention needs to be devoted to this population, considering that they live with siblings with disabilities, and have several vulnerabilities that need to be discussed, aiming at developing inclusive and efficient care strategies.
    MeSH term(s) Humans ; Adolescent ; Child ; Siblings ; Disabled Persons ; Self Concept ; Brazil ; Fear
    Language Portuguese
    Publishing date 2023-01-26
    Publishing country Brazil
    Document type English Abstract ; Journal Article
    ZDB-ID 2078799-6
    ISSN 1678-4561 ; 1678-4561
    ISSN (online) 1678-4561
    ISSN 1678-4561
    DOI 10.1590/1413-81232023289.15182022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Systemic lupus erythematosus and thrombosis.

    Bazzan, Mario / Vaccarino, Antonella / Marletto, Fabio

    Thrombosis journal

    2015  Volume 13, Page(s) 16

    Abstract: Systemic Lupus Erythematosus (SLE) is an acquired, multiorgan, autoimmune disease. Clinical presentation is extremely variable and heterogeneous. It has been shown that SLE itself is an independent risk factor for developing both arterial and venous ... ...

    Abstract Systemic Lupus Erythematosus (SLE) is an acquired, multiorgan, autoimmune disease. Clinical presentation is extremely variable and heterogeneous. It has been shown that SLE itself is an independent risk factor for developing both arterial and venous thrombotic events since SLE patients have an Odds Ratio (OR) for thrombosis that varies depending on the clinical and laboratory characteristics of each study cohort. The risk of developing a thrombotic event is higher in this setting than in the general population and may further increase when associated with other risk factors, or in the presence of inherited or acquired pro-thrombotic abnormalities, or trigger events. In particular, a striking increase in the number of thrombotic events was observed when SLE was associated with antiphospholipid antibodies (aPL). The presence of aPLs has been described in about 50% of SLE patients, while about 20% of antiphospholipid syndrome (APS) patients have SLE. While APS patients (with or without an autoimmune disease) have been widely studied in the last years, fewer studies are available for SLE patients and thrombosis in the absence of APS. Although the available literature undoubtedly shows that SLE patients have a greater prevalence of thrombotic events as compared to healthy subjects, it is difficult to obtain a definite result from these studies because in some cases the study cohort was too small, in others it is due to the varied characteristics of the study population, or because of the different (and very copious) laboratory assays and methods that were used. When an SLE patient develops a thrombotic event, it is of great clinical relevance since it is potentially life-threatening. Moreover, it worsens the quality of life and is a clinical challenge for the clinician.
    Language English
    Publishing date 2015-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118392-2
    ISSN 1477-9560
    ISSN 1477-9560
    DOI 10.1186/s12959-015-0043-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Extracellular Vesicles (EVs) as Crucial Mediators of Cell-Cell Interaction in Asthma.

    Tinè, Mariaenrica / Padrin, Ylenia / Bonato, Matteo / Semenzato, Umberto / Bazzan, Erica / Conti, Maria / Saetta, Marina / Turato, Graziella / Baraldo, Simonetta

    International journal of molecular sciences

    2023  Volume 24, Issue 5

    Abstract: Asthma is the most common chronic respiratory disorder worldwide and accounts for a huge health and economic burden. Its incidence is rapidly increasing but, in parallel, novel personalized approaches have emerged. Indeed, the improved knowledge of cells ...

    Abstract Asthma is the most common chronic respiratory disorder worldwide and accounts for a huge health and economic burden. Its incidence is rapidly increasing but, in parallel, novel personalized approaches have emerged. Indeed, the improved knowledge of cells and molecules mediating asthma pathogenesis has led to the development of targeted therapies that significantly increased our ability to treat asthma patients, especially in severe stages of disease. In such complex scenarios, extracellular vesicles (EVs i.e., anucleated particles transporting nucleic acids, cytokines, and lipids) have gained the spotlight, being considered key sensors and mediators of the mechanisms controlling cell-to-cell interplay. We will herein first revise the existing evidence, mainly by mechanistic studies in vitro and in animal models, that EV content and release is strongly influenced by the specific triggers of asthma. Current studies indicate that EVs are released by potentially all cell subtypes in the asthmatic airways, particularly by bronchial epithelial cells (with different cargoes in the apical and basolateral side) and inflammatory cells. Such studies largely suggest a pro-inflammatory and pro-remodelling role of EVs, whereas a minority of reports indicate protective effects, particularly by mesenchymal cells. The co-existence of several confounding factors-including technical pitfalls and host and environmental confounders-is still a major challenge in human studies. Technical standardization in isolating EVs from different body fluids and careful selection of patients will provide the basis for obtaining reliable results and extend their application as effective biomarkers in asthma.
    MeSH term(s) Animals ; Humans ; Asthma/pathology ; Extracellular Vesicles/pathology ; Cytokines ; Nucleic Acids ; Cell Communication
    Chemical Substances Cytokines ; Nucleic Acids
    Language English
    Publishing date 2023-02-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24054645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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