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  1. Article ; Online: Extraintestinal pathogenic Escherichia coli (ExPEC) reservoirs, and antibiotics resistance trends: a one-health surveillance for risk analysis from "farm-to-fork".

    Meena, Prem Raj / Priyanka, Priyanka / Singh, Arvind Pratap

    Letters in applied microbiology

    2023  Volume 76, Issue 1

    Abstract: Extraintestinal pathogenic Escherichia coli (ExPEC) associated infections are significant health concerns for both animals and humans. ExPEC strains are associated with various infections in humans, i.e. urinary tract infections, meningitis, septicemia, ... ...

    Abstract Extraintestinal pathogenic Escherichia coli (ExPEC) associated infections are significant health concerns for both animals and humans. ExPEC strains are associated with various infections in humans, i.e. urinary tract infections, meningitis, septicemia, and other infections. Over the few years, several studies revealed, food animals act as a reservoir for ExPEC pathovars, but there is no information about the agricultural sector. In particular, the extensive use of antibiotics in food animals and agricultural settings could be significantly contributed to the emergence of antibiotic-resistant pathogens. However, global outbreaks of food-borne illnesses from contaminated food have made a significant concern for both public health and food safety. This review focuses on the reservoirs for ExPEC and their potential circulation between animals, humans, and environment. In this, we first report that the agricultural setting could be the reservoir of ExPEC and can play a role in disseminating antimicrobial-resistant ExPEC. A thorough understanding of ExPEC ecology, reservoirs, and transmission dynamics can significantly contribute to reducing the burden of ExPEC-associated infections. Overall, the study provides the important data on the current state of knowledge for different reservoirs with dynamic, dissemination, and transmission of antimicrobial-resistance ExPEC in animals, humans, and environment in the "One-Health" context.
    MeSH term(s) Animals ; Humans ; Extraintestinal Pathogenic Escherichia coli ; Escherichia coli ; Escherichia coli Infections/epidemiology ; Farms ; Drug Resistance, Multiple, Bacterial ; Anti-Bacterial Agents/pharmacology ; Risk Assessment ; Anti-Infective Agents
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2023-01-25
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 632584-1
    ISSN 1472-765X ; 0266-8254
    ISSN (online) 1472-765X
    ISSN 0266-8254
    DOI 10.1093/lambio/ovac016
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  2. Article ; Online: Atypical Neuroimaging Features of Herpes Simplex Virus-2 Encephalitis.

    Meena, Ankit Kumar / Choudhary, Puneet Kumar / Wander, Arvinder / Madaan, Priyanka

    Indian journal of pediatrics

    2024  

    Language English
    Publishing date 2024-02-23
    Publishing country India
    Document type Letter
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-024-05082-5
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  3. Article ; Online: Alarming level of single or multidrug resistance in poultry environments-associated extraintestinal pathogenic Escherichia coli pathotypes with potential to affect the One Health.

    Meena, Prem Raj / Priyanka, Priyanka / Rana, Anuj / Raj, Dharma / Singh, Arvind Pratap

    Environmental microbiology reports

    2022  Volume 14, Issue 3, Page(s) 400–411

    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Multiple ; Drug Resistance, Multiple, Bacterial/genetics ; Escherichia coli Infections/veterinary ; Escherichia coli Proteins ; Extraintestinal Pathogenic Escherichia coli ; One Health ; Poultry ; Virulence Factors
    Chemical Substances Anti-Bacterial Agents ; Escherichia coli Proteins ; Virulence Factors
    Language English
    Publishing date 2022-03-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1758-2229
    ISSN (online) 1758-2229
    DOI 10.1111/1758-2229.13055
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  4. Article: Neurological Manifestations of Scrub Typhus Infection in Pediatric Patient: A Case Report From Tertiary Care Hospital in Central India.

    Singh, Priyanka / Shete, Vishal / Choudhary, Abhijit / Gade, Neeta / Mishra, Meena

    Cureus

    2024  Volume 16, Issue 1, Page(s) e53060

    Abstract: Scrub typhus is a neglected tropical bacterial disease endemic in central India which can manifest as meningitis/meningoencephalitis in children. It is difficult to diagnose clinically, especially in the absence of eschar or rash. Scrub typhus is seldom ... ...

    Abstract Scrub typhus is a neglected tropical bacterial disease endemic in central India which can manifest as meningitis/meningoencephalitis in children. It is difficult to diagnose clinically, especially in the absence of eschar or rash. Scrub typhus is seldom considered the differential diagnosis of meningitis in the Indian subcontinent. Appropriate investigations can lead to early detection of infection and initiation of correct antibiotic treatment leading to better patient prognosis even when features of meningitis supervene. Here, we report a pediatric case of scrub typhus meningitis that could be saved due to timely investigations and initiation of appropriate antimicrobial agents.
    Language English
    Publishing date 2024-01-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.53060
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  5. Article ; Online: Elucidating the structural and functional prophecy of the Rv2326c gene, an ABC transporter of Mycobacterium tuberculosis H37Rv through computational approach.

    Sharma, Priyanka / Kumar, Ajit / Meena, Laxman S

    Biotechnology and applied biochemistry

    2023  Volume 70, Issue 6, Page(s) 2025–2037

    Abstract: Tuberculosis is a fatal disease caused by Mycobacterium tuberculosis. M. tuberculosis becoming drug-resistant day by day, necessitating to know the mechanism behind the drug resistance and how to overcome this deadly malady. Drug resistance and reduced ... ...

    Abstract Tuberculosis is a fatal disease caused by Mycobacterium tuberculosis. M. tuberculosis becoming drug-resistant day by day, necessitating to know the mechanism behind the drug resistance and how to overcome this deadly malady. Drug resistance and reduced drug bioavailability are caused by a class of transporter proteins called the ATP-binding cassette (ABC) transporters, which pump a range of medicines out of cells at the price of ATP hydrolysis. By using computational approaches, we tried to elaborate the probable function of the Rv2326c gene of M. tuberculosis, perhaps involved in drug resistance mechanism. The presence of the signature motif of ABC transporters (LSGGELQRLALAAAL and LSGGQMRRVVLAGLL) and ATP binding motif (GXXXXGKT and GXXXXGKS) in the protein sequence signifying its importance in the ATP binding and transportation of molecules. Further, this manuscript elaborated about tertiary structure and validation, functional category, localization, phosphorylation site prediction, mutational analysis of conserved motifs. Ligand docking study shows the highest affinity with ATP than GTP justified its function as an ATP binding protein. The Rv2326c protein is present in the inner membrane and working as an ATP binding protein and might be playing a dynamic role in transportation. In this study, we found that Rv2326c protein might be working as an ABC transporter by which the drugs and other molecules are imported or exported into the bacterium. As a result, the current study provides a means to better understand its normal functioning and basic biology, which can help in the development of novel therapeutic targeting approaches for Rv2326c protein.
    MeSH term(s) Humans ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/chemistry ; ATP-Binding Cassette Transporters/metabolism ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/metabolism ; Amino Acid Sequence ; Adenosine Triphosphate/metabolism ; Tuberculosis
    Chemical Substances ATP-Binding Cassette Transporters ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2023-08-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 883433-7
    ISSN 1470-8744 ; 0885-4513
    ISSN (online) 1470-8744
    ISSN 0885-4513
    DOI 10.1002/bab.2507
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  6. Article ; Online: Corset suture: A novel technique of overlay appositional continuous sutures with air tamponade for management of large acute corneal hydrops.

    Parmar, Gautam Singh / Agrawal, Ashish / Meena, Ashok / Mutha, Priyanka / Gurnani, Bharat

    Indian journal of ophthalmology

    2024  Volume 72, Issue 4, Page(s) 592–595

    Abstract: Management of large acute corneal hydrops (ACH) has always been a challenge. Various medical and surgical management options have been used, such as topical steroids, cycloplegics, antiglaucoma medications, antibiotics, Descemet's membrane reposition, ... ...

    Abstract Management of large acute corneal hydrops (ACH) has always been a challenge. Various medical and surgical management options have been used, such as topical steroids, cycloplegics, antiglaucoma medications, antibiotics, Descemet's membrane reposition, and pre-Descematic sutures, for the management of acute hydrops, but have shown limited benefit. We hereby describe a novel technique of appositional continuous overlay sutures along with air tamponade for surgical management of corneal edema following large ACH. In this technique, the epithelium is scraped to visualize the stromal cleft, and then corneal marking is done to locate the suture placement site. Next, a continuous overlay, 10-0 nylon suture is passed in a crisscross fashion, just like the laces of a corset. A small paracentesis is made to lower the intraocular pressure. Stromal fluid is milked out using two iris spatulas, simultaneous suture tension adjustment is done, and the knot is secured. Appropriate anterior chamber tamponade is achieved using air, paracentesis is hydrated, and a bandage contact lens is applied. We noted complete resolution of corneal edema within 2 weeks of the procedure, with significant improvement in visual acuity.
    MeSH term(s) Humans ; Corneal Edema/diagnosis ; Corneal Edema/etiology ; Corneal Edema/surgery ; Cornea/surgery ; Neurosurgical Procedures ; Sutures ; Edema
    Language English
    Publishing date 2024-03-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/IJO.IJO_1006_23
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  7. Article ; Online: A Rare Cause of Acute Recurrent Pancreatitis in a Child.

    Kumar, Ishan / Meena, Sunil / Singh, Pramod Kumar / Aggarwal, Priyanka / Verma, Ashish

    Indian journal of pediatrics

    2023  Volume 91, Issue 4, Page(s) 404–405

    MeSH term(s) Child ; Humans ; Pancreatitis/etiology ; Acute Disease ; Recurrence
    Language English
    Publishing date 2023-07-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-023-04764-w
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  8. Article ; Online: Transition-metal-free regioselective hydroamination of styrenes with amino-heteroarenes.

    Meena, Priyanka / Ayushee / Patel, Monika / Verma, Akhilesh K

    Chemical communications (Cambridge, England)

    2022  Volume 58, Issue 60, Page(s) 8424–8427

    Abstract: The base-mediated anti-Markovnikov hydroamination of functionally varied styrenes with amino-substituted pyridine, quinoline, pyrimidine, pyrazine, and phenanthridine with excellent regioselectivity has been described. Double hydroamination was observed ... ...

    Abstract The base-mediated anti-Markovnikov hydroamination of functionally varied styrenes with amino-substituted pyridine, quinoline, pyrimidine, pyrazine, and phenanthridine with excellent regioselectivity has been described. Double hydroamination was observed chemoselectively on the secondary amine, leaving the primary amine intact. Experimental evidence suggests that the proposed reaction involves the nucleophilic addition of the aminopyridyl radical onto vinyl arenes
    MeSH term(s) Amination ; Amines ; Catalysis ; Molecular Structure ; Styrenes ; Transition Elements
    Chemical Substances Amines ; Styrenes ; Transition Elements
    Language English
    Publishing date 2022-07-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc02781j
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  9. Article ; Online: miR-107 and miR-126 and Risk of Breast Cancer: A Case-Control Study.

    Gupta, Priyanka / Sambyal, Vasudha / Bali, Jagmohan Singh / Guleria, Kamlesh / Uppal, Manjit Singh / Sudan, Meena

    Genetic testing and molecular biomarkers

    2024  Volume 28, Issue 4, Page(s) 165–168

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Breast Neoplasms/genetics ; Female ; Case-Control Studies ; Middle Aged ; Adult ; Biomarkers, Tumor/genetics ; Gene Expression Regulation, Neoplastic/genetics ; India/epidemiology ; Risk Factors ; Aged ; Genetic Predisposition to Disease/genetics
    Chemical Substances MicroRNAs ; MIRN126 microRNA, human ; MIRN107 microRNA, human ; Biomarkers, Tumor
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2486664-7
    ISSN 1945-0257 ; 1945-0265
    ISSN (online) 1945-0257
    ISSN 1945-0265
    DOI 10.1089/gtmb.2023.0606
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  10. Article ; Online: A novel case of left atrial and right lung mass turned out to be unconventional metastasis of uterine leiomyosarcoma with a review of literature.

    Patel, Tarang / Aswal, Priyanka / Jakhetiya, Ashish / Meena, Virendrakumar / Pandey, Arun

    Indian journal of pathology & microbiology

    2023  Volume 66, Issue 3, Page(s) 601–604

    Abstract: Uterine leiomyosarcoma (ULMS) is a rare malignancy arising from the myometrial smooth muscle wall, and cardiac metastases are extremely rare. Metastasis to the heart is a very unusual finding, and atrial metastasis is even rarer. Here, we report a case ... ...

    Abstract Uterine leiomyosarcoma (ULMS) is a rare malignancy arising from the myometrial smooth muscle wall, and cardiac metastases are extremely rare. Metastasis to the heart is a very unusual finding, and atrial metastasis is even rarer. Here, we report a case of a 45 year old woman who presented with dyspnea and pleural effusion and had a significant history of hysterectomy done for ULMS. Magnetic resonance imaging revealed a left atrial mass, which was resected and revealed to be a metastasis of leiomyosarcoma on histopathology and immunohistochemistry. Metastatic ULMS may rarely present as a left atrial mass with acute clinical presentation. Detailed clinical history and accurate diagnosis are vital for further management.
    MeSH term(s) Female ; Humans ; Middle Aged ; Leiomyosarcoma/diagnosis ; Leiomyosarcoma/pathology ; Atrial Fibrillation ; Uterine Neoplasms/diagnosis ; Uterine Neoplasms/pathology ; Heart Atria/pathology ; Lung/pathology
    Language English
    Publishing date 2023-08-24
    Publishing country India
    Document type Review ; Case Reports
    ZDB-ID 197621-7
    ISSN 0974-5130 ; 0377-4929
    ISSN (online) 0974-5130
    ISSN 0377-4929
    DOI 10.4103/ijpm.ijpm_577_21
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