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  1. Article ; Online: Imaging features of adenosquamous carcinoma of the breast - A rare variant of metaplastic breast carcinoma.

    Sae-Kho, Tiffany Marian / Bhatt, Asha / Solanki, Malvika H / Jeans, Elizabeth B / Corbin, Kimberly S / Fazzio, Robert T / Glazebrook, Katrina N

    BJR case reports

    2022  Volume 7, Issue 6, Page(s) 20210108

    Abstract: Adenosquamous carcinoma of the breast is a rare subtype of metaplastic carcinoma, which accounts for <1% of invasive breast malignancy. Metaplastic carcinoma is usually high grade and aggressive with typically reported benign imaging features when ... ...

    Abstract Adenosquamous carcinoma of the breast is a rare subtype of metaplastic carcinoma, which accounts for <1% of invasive breast malignancy. Metaplastic carcinoma is usually high grade and aggressive with typically reported benign imaging features when compared to invasive ductal carcinoma. However, the adenosquamous variant is a subtype with a more favorable prognosis. Within the literature, there is limited imaging description with case studies focusing on metaplastic carcinoma. Herein, we report seven cases of the adenosquamous subtype describing the imaging findings with correlation to clinical history and pathology. The majority of patients (
    Language English
    Publishing date 2022-03-09
    Publishing country England
    Document type Case Reports
    ISSN 2055-7159
    ISSN (online) 2055-7159
    DOI 10.1259/bjrcr.20210108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Prospective, Longitudinal and Exploratory Study of Head and Neck Lymphoedema and Dysphagia Following Chemoradiotherapy for Head and Neck Cancer.

    Jeans, Claire / Brown, Bena / Ward, Elizabeth C / Vertigan, Anne E / Pigott, Amanda E / Nixon, Jodie L / Wratten, Chris / Boggess, May

    Dysphagia

    2022  Volume 38, Issue 4, Page(s) 1059–1071

    Abstract: ... chemoradiotherapy (CRT) and (b) the relationship between HNL and swallowing function. Using a prospective ...

    Abstract The aim of the study was to examine the following: (a) the trajectory of external and internal head and neck lymphoedema (HNL) in patients with head and neck cancer (HNC) up to 12 months post-chemoradiotherapy (CRT) and (b) the relationship between HNL and swallowing function. Using a prospective longitudinal cohort study, external/internal HNL and swallowing were examined in 33 participants at 3, 6 and 12 months post-CRT. External HNL was assessed using the Assessment of Lymphoedema of the Head and Neck and the MD Anderson Cancer Centre Lymphoedema Rating Scale. Internal HNL was rated using Patterson's Radiotherapy Oedema Rating Scale. Swallowing was assessed via clinical, instrumental and patient-reported measures. Associations between HNL and swallowing were examined using multivariable regression models. External HNL was prevalent at 3 months (71%), improved by 6 months (58%) and largely resolved by 12 months (10%). In contrast, moderate/severe internal HNL was prevalent at 3 months (96%), 6 months (84%) and at 12 months (65%). More severe penetration/aspiration and increased diet modification were associated with higher severities of external HNL (p=0.006 and p=0.031, respectively) and internal HNL (p<0.001 and p=0.007, respectively), and more diffuse internal HNL (p=0.043 and p=0.001, respectively). Worse patient-reported swallowing outcomes were associated with a higher severity of external HNL (p=0.001) and more diffuse internal HNL (p=0.002). External HNL largely resolves by 12 months post-CRT, but internal HNL persists. Patients with a higher severity of external and/or internal HNL and those with more diffuse internal HNL can be expected to have more severe dysphagia.
    MeSH term(s) Humans ; Deglutition Disorders/etiology ; Deglutition Disorders/therapy ; Prospective Studies ; Longitudinal Studies ; Head and Neck Neoplasms/radiotherapy ; Deglutition ; Chemoradiotherapy/adverse effects ; Lymphedema/etiology ; Lymphedema/therapy
    Language English
    Publishing date 2022-10-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632764-3
    ISSN 1432-0460 ; 0179-051X
    ISSN (online) 1432-0460
    ISSN 0179-051X
    DOI 10.1007/s00455-022-10526-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: In Reply to Taunk et al.

    Dooley, Sarah / Sim, Austin J / Campbell, Shauna R / Jeans, Elizabeth B / Anderson, Justin D / Tye, Karen / Goodman, Chelain R

    International journal of radiation oncology, biology, physics

    2021  Volume 109, Issue 3, Page(s) 835–836

    Language English
    Publishing date 2021-01-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2020.10.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Modernization of Board Certification in Radiation Oncology: Opportunities Following COVID-19.

    Goodman, Chelain R / Campbell, Shauna R / Jeans, Elizabeth B / Agarwal, Ankit / Tye, Karen / Kahn, Jenna M

    International journal of radiation oncology, biology, physics

    2020  Volume 108, Issue 2, Page(s) 458–461

    MeSH term(s) Betacoronavirus ; COVID-19 ; Certification ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Quality Assurance, Health Care ; Radiation Oncology/education ; SARS-CoV-2 ; Social Change ; Specialty Boards ; User-Computer Interface
    Keywords covid19
    Language English
    Publishing date 2020-09-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2020.06.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A Radiomics-Based Classifier for the Progression of Oropharyngeal Cancer Treated with Definitive Radiotherapy.

    Garcia, Darwin A / Jeans, Elizabeth B / Morris, Lindsay K / Shiraishi, Satomi / Laughlin, Brady S / Rong, Yi / Rwigema, Jean-Claude M / Foote, Robert L / Herman, Michael G / Qian, Jing

    Cancers

    2023  Volume 15, Issue 14

    Abstract: In this study, we investigated whether radiomics features from pre-treatment positron emission tomography (PET) images could be used to predict disease progression in patients with HPV-positive oropharyngeal cancer treated with definitive proton or x-ray ...

    Abstract In this study, we investigated whether radiomics features from pre-treatment positron emission tomography (PET) images could be used to predict disease progression in patients with HPV-positive oropharyngeal cancer treated with definitive proton or x-ray radiotherapy. Machine learning models were built using a dataset from Mayo Clinic, Rochester, Minnesota (n = 72) and tested on a dataset from Mayo Clinic, Phoenix, Arizona (n = 22). A total of 71 clinical and radiomics features were considered. The Mann-Whitney U test was used to identify the top 2 clinical and top 20 radiomics features that were significantly different between progression and progression-free patients. Two dimensionality reduction methods were used to define two feature sets (manually filtered or machine-driven). A forward feature selection scheme was conducted on each feature set to build models of increased complexity (number of input features from 1 to 6) and evaluate model robustness and overfitting. The machine-driven features had superior performance and were less prone to overfitting compared to the manually filtered features. The four-variable Gaussian Naïve Bayes model using the 'Radiation Type' clinical feature and three machine-driven features achieved a training accuracy of 79% and testing accuracy of 77%. These results demonstrate that radiomics features can provide risk stratification beyond HPV-status to formulate individualized treatment and follow-up strategies.
    Language English
    Publishing date 2023-07-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15143715
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Lymphoedema after head and neck cancer treatment: an overview for clinical practice.

    Jeans, Claire / Brown, Bena / Ward, Elizabeth C / Vertigan, Anne E

    British journal of community nursing

    2021  Volume 26, Issue Sup4, Page(s) S24–S29

    Abstract: Lymphoedema is a disorder of the lymphatic system that presents as an atypical swelling and accumulation of protein-rich fluid within the interstitial spaces. Head and neck lymphoedema (HNL) is highly prevalent in patients who have been treated for head ... ...

    Abstract Lymphoedema is a disorder of the lymphatic system that presents as an atypical swelling and accumulation of protein-rich fluid within the interstitial spaces. Head and neck lymphoedema (HNL) is highly prevalent in patients who have been treated for head and neck cancer (HNC) and may manifest externally on the face and neck; internally within the oral cavity, pharynx or larynx; or as a combination of both. HNL is known to contribute to a wide range of physical, functional and psychological issues, and presents several unique challenges in terms of its management. This review article provides an overview of HNL for clinicians and aims to improve awareness of this condition and the impact it has on patients.
    MeSH term(s) Head and Neck Neoplasms/complications ; Head and Neck Neoplasms/therapy ; Humans ; Lymphedema/etiology
    Language English
    Publishing date 2021-04-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2146386-4
    ISSN 1462-4753
    ISSN 1462-4753
    DOI 10.12968/bjcn.2021.26.Sup4.S24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Radiation Oncology Initial Certification Qualification Examinations: The Resident Experience in 2019.

    Campbell, Shauna R / Jeans, Elizabeth B / Albert, Ashley / Agarwal, Ankit / Tye, Karen / Goodman, Chelain R

    Practical radiation oncology

    2020  Volume 11, Issue 1, Page(s) 5–12

    Abstract: Purpose: To characterize the resident experience preparing for the 2019 American Board of Radiology initial certification (IC) qualifying examinations in radiation oncology.: Methods and materials: The Association of Residents in Radiation Oncology ... ...

    Abstract Purpose: To characterize the resident experience preparing for the 2019 American Board of Radiology initial certification (IC) qualifying examinations in radiation oncology.
    Methods and materials: The Association of Residents in Radiation Oncology distributed a survey to 360 radiation oncology residents from the 2019 and 2020 graduating classes covering topics pertinent to preparation for the medical physics (MP), radiation and cancer biology (RCB), and clinical radiation oncology (CRO) qualifying examinations.
    Results: The response rate was 58% (n = 210). In the 12 weeks before the MP and RCB examinations, first-time examinees studied a median of 160 hours (interquartile range, 96 to 270). Residents reported a "moderate" or "significant" negative effect on research productivity (3 [2-4]), mental health (3 [2-4]), clinical development (3 [2-4]), and family life (3 [2-4]). Half of surveyed residents (52%, n = 110) used a protected research or elective block to study while an additional 21% (n = 45) used a median of 5 (3-20) vacation days. Residents overall "agreed" (4 [2-4]) that their program's physics course was "important" for their preparation but were "neutral" (3 [2-4]) regarding the value of their program's radiobiology course. Question-based educational resources were most frequently rated as "important" study resources. Respondents "strongly" endorsed the development of a consensus radiation oncology curriculum (5 [4-5]) and "agreed" (4 [3-4]) that consolidation of the MP, RCB, and CRO qualifying examinations into a single written examination would be preferred.
    Conclusions: Radiation oncology residents dedicate substantial time preparing for the IC examinations at the expense of training- and health-related outcomes. Residents report a wide range in quality of internal program didactic courses in physics and radiobiology, endorse development of a consensus radiation oncology curriculum, and prefer consolidation of the three qualifying examinations into a single written IC examination. We caution the high pass rates seen on the 2019 examinations do not obviate the need for ongoing improvement in radiation oncology graduate medical education and the board certification process.
    MeSH term(s) Certification ; Curriculum ; Education, Medical, Graduate ; Educational Measurement ; Humans ; Internship and Residency ; Radiation Oncology/education ; United States
    Language English
    Publishing date 2020-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2655748-4
    ISSN 1879-8519 ; 1879-8500
    ISSN (online) 1879-8519
    ISSN 1879-8500
    DOI 10.1016/j.prro.2020.04.010
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  8. Article ; Online: Adjuvant brachytherapy for FIGO stage I serous or clear cell endometrial cancer.

    Jeans, Elizabeth B / Breen, William G / Mullikin, Trey C / Looker, Brittany A / Mariani, Andrea / Keeney, Gary L / Haddock, Michael G / Petersen, Ivy A

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2021  Volume 31, Issue 6, Page(s) 859–867

    Abstract: Objectives: Optimal adjuvant treatment for early-stage clear cell and serous endometrial cancer remains unclear. We report outcomes for women with surgically staged International Federation of Gynecology and Obstetrics (FIGO) stage I clear cell, serous, ...

    Abstract Objectives: Optimal adjuvant treatment for early-stage clear cell and serous endometrial cancer remains unclear. We report outcomes for women with surgically staged International Federation of Gynecology and Obstetrics (FIGO) stage I clear cell, serous, and mixed endometrial cancers following adjuvant vaginal cuff brachytherapy with or without chemotherapy.
    Methods: From April 1998 to January 2020, women with FIGO stage IA-IB clear cell, serous, and mixed endometrial cancer underwent surgery and adjuvant vaginal cuff brachytherapy. Seventy-six patients received chemotherapy. High-dose rate vaginal cuff brachytherapy was planned to a total dose of 21 gray in three fractions using a multichannel vaginal cylinder. The primary objective was to determine the effectiveness of adjuvant vaginal cuff brachytherapy and to identify surgicopathological risk factors that could portend towards worse oncological outcomes.
    Results: A total of 182 patients were included in the analysis. Median follow-up was 5.3 years (2.3-12.2). Ten-year survival was 73.3%. Five-year cumulative incidence (CI) of vaginal, pelvic, and para-aortic relapse was 1.4%, 2.1%, and 0.9%, respectively. Five-year locoregional failure, any recurrence, peritoneal relapse, and other distant recurrence was 4.4%, 11.6%, 5.3%, and 6.7%, respectively. On univariate analysis, locoregional failure was worse for larger tumors (per 1 cm) (HR 1.9, 95% CI 1.2 to 3.0, p≤0.01). Any recurrence was worse for tumors of at least 3.5 cm (HR 3.8, 95% CI 1.3 to 11.7, p=0.02) and patients with positive/suspicious cytology (HR 4.4, 95% CI 1.5 to 12.4, p≤0.01). Ten-year survival for tumors of at least 3.5 cm was 56.9% versus 86.6% for those with smaller tumors (HR 2.9, 95% CI 1.4 to 5.8, p≤0.01). Ten-year survival for positive/suspicious cytology was 50.9% versus 77.4% (HR 2.2, 95% CI 0.9 to 5.4, p=0.09). Multivariate modeling demonstrated worse locoregional failure, any recurrence, and survival with larger tumors, as well as any recurrence with positive/suspicious cytology. Subgroup analysis demonstrated improved outcomes with the use of adjuvant chemotherapy in patients with large tumors or positive/suspicious cytology.
    Conclusion: Adjuvant vaginal cuff brachytherapy alone without chemotherapy is an appropriate treatment for women with negative peritoneal cytology and small, early-stage clear cell, serous, and mixed endometrial cancer. Larger tumors or positive/suspicious cytology are at increased risk for relapse and worse survival, and should be considered for additional upfront adjuvant treatments, such as platinum-based chemotherapy.
    MeSH term(s) Adenocarcinoma, Clear Cell/drug therapy ; Adult ; Aged ; Aged, 80 and over ; Brachytherapy/methods ; Endometrial Neoplasms/drug therapy ; Female ; Humans ; Middle Aged ; Neoplasm Staging ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2021-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2020-002217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Opportunities to Improve Radiation Oncology Medical Education in the Post-Pandemic Era.

    Dooley, Sarah / Sim, Austin J / Campbell, Shauna R / Jeans, Elizabeth B / Anderson, Justin D / Tye, Karen / Goodman, Chelain R

    International journal of radiation oncology, biology, physics

    2020  Volume 108, Issue 2, Page(s) 455–457

    MeSH term(s) COVID-19/epidemiology ; Career Choice ; Education, Distance ; Education, Medical ; Employment/statistics & numerical data ; Humans ; Interviews as Topic ; Job Application ; Pandemics ; Personnel Selection/methods ; Radiation Oncology/education ; United States
    Keywords covid19
    Language English
    Publishing date 2020-09-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2020.06.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Development of a United States Radiation Oncology Curricular Framework: A Stakeholder Delphi Consensus.

    Jeans, Elizabeth B / Brower, Jeffrey V / Burmeister, Jay W / Deville, Curtiland / Fields, Emma / Kavanagh, Brian D / Suh, John H / Tekian, Ara / Vapiwala, Neha / Zeman, Elaine M / Golden, Daniel W

    International journal of radiation oncology, biology, physics

    2022  Volume 115, Issue 5, Page(s) 1030–1040

    Abstract: Purpose: A United States (US) radiation oncology curriculum, developed using best practices for curriculum inquiry, is needed to guide residency education and qualifying examinations. Competency-based training, including entrustable professional ... ...

    Abstract Purpose: A United States (US) radiation oncology curriculum, developed using best practices for curriculum inquiry, is needed to guide residency education and qualifying examinations. Competency-based training, including entrustable professional activities (EPAs), provides an outcomes-based approach to modern graduate medical education. This study aimed to define US radiation oncology EPAs and curricular content domains using a deliberative process with input from multiple stakeholder groups.
    Methods and materials: The Radiation Oncology Education Collaborative Study Group Core Curriculum Project Leadership Committee developed initial content domains and EPAs. Following recruitment of stakeholders, a Delphi process was used to achieve consensus. In the first round, content domains and EPAs were reviewed for inclusion and exclusion, clarity, time allocation (content domains), and level of training (EPAs). Participants submitted additional content domains and EPAs for consideration. Any content domains or EPAs 1 standard deviation below the median for inclusion and exclusion underwent Leadership Committee review. All participants completing the first Delphi round were invited to the second round. Percent curriculum time allocated for content domains and a single subdomain were finalized. New EPAs or EPAs undergoing major revisions were reviewed.
    Results: A total of 186 participants representing diverse stakeholder groups participated. One hundred fourteen completed the first Delphi round (61.3%). Of 114 invited, 77 participants completed the second round of the Delphi process (67.5%). Overall, 6 of 9 content domains met consensus, 1 content domain was removed, and 2 content domains were combined. Four subdomains of a single content domain were reviewed and met consensus. Consensus on percent time allocated per content domain and subdomain was reached. Of 55 initial EPAs, 52 final EPAs met consensus.
    Conclusions: Deliberative curriculum inquiry was successfully used to develop a consensus on US radiation oncology content domains and EPAs. These data can guide the allocation of educational time in training programs, help inform weighting for qualifying examinations, and help guide clinical training and resident assessment.
    MeSH term(s) Humans ; United States ; Radiation Oncology ; Consensus ; Delphi Technique ; Clinical Competence ; Curriculum ; Internship and Residency
    Language English
    Publishing date 2022-12-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2022.12.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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