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  1. Article ; Online: Prevalence of methamphetamine use among gay, bisexual and other men who have sex with men: A systematic review and meta-analysis.

    Lodge, William / Kelly, Patrick J A / Napoleon, Siena / Plezia, Samantha / Mimiaga, Matthew J / Biello, Katie B

    The International journal on drug policy

    2023  Volume 123, Page(s) 104271

    Abstract: Background: International efforts have reduced the availability of methamphetamine precursors, but its distribution and use continue to rise. Methamphetamine use can lead to short- and long-term adverse effects, including addiction, physical and ... ...

    Abstract Background: International efforts have reduced the availability of methamphetamine precursors, but its distribution and use continue to rise. Methamphetamine use can lead to short- and long-term adverse effects, including addiction, physical and psychosocial health problems, socioeconomic troubles, incarceration, overdose, and death. Gay, bisexual, and other men who have sex with men (MSM) have been shown to have an elevated prevalence of methamphetamine use.
    Methods: We conducted a systematic review and meta-analysis to estimate the prevalence of methamphetamine use among MSM. We searched electronic databases, such as PubMed, for peer-reviewed literature published between 2011 and 2022. Data on methamphetamine use were extracted, including study features, location, study design, sampling method, recruitment period, specific MSM subgroups, prevalence period, and demographics. Employing a random-effects model, we computed the pooled prevalence of methamphetamine use among MSM across two prevalence periods: recent use (i.e., one month, three months, six months, one year) and lifetime use.
    Results: The systematic review included 56 studies with a total of 25,953 MSM who use methamphetamine. Most studies were conducted in Europe, with the highest prevalence reported in the United Kingdom. The studies primarily used cross-sectional or cohort study designs with convenience sampling. The pooled prevalence rates across recent use (i.e., past month, past three months, past six months, and past year) was 15% (95% CI [11-19%]). Additionally, we pooled lifetime use, which was 23% (95% CI [9-38%]). High heterogeneity (I
    Conclusion: This systematic review and meta-analysis provide a pooled prevalence of methamphetamine use among MSM. The analysis accounts for study design, prevalence period, specific MSM subgroups, and geographical areas to estimate methamphetamine use in diverse settings and populations. The review highlights the need for targeted interventions and harm reduction strategies focused on prevention, education, healthcare access, and stakeholder collaboration to address the multifaceted challenges of methamphetamine use among MSM.
    MeSH term(s) Humans ; Male ; Cohort Studies ; Cross-Sectional Studies ; HIV Infections/epidemiology ; Homosexuality, Male/psychology ; Methamphetamine/adverse effects ; Prevalence ; Sexual and Gender Minorities ; Recreational Drug Use/legislation & jurisprudence
    Chemical Substances Methamphetamine (44RAL3456C)
    Language English
    Publishing date 2023-12-06
    Publishing country Netherlands
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2010000-0
    ISSN 1873-4758 ; 0955-3959
    ISSN (online) 1873-4758
    ISSN 0955-3959
    DOI 10.1016/j.drugpo.2023.104271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Exploring the Interactions between Obesity and Diabetes: Implications for Understanding Metabolic Dysregulation in a Saudi Arabian Adult Population.

    Ahmad, Muhammad Saeed / Minaee, Novia / Serrano-Contreras, Jose Ivan / Kaluarachchi, Manuja / Shen, Eric Yi-Liang / Boulange, Claire / Ahmad, Sultan / Phetcharaburanin, Jutarop / Holmes, Elaine / Wist, Julien / Albaloshi, Ahmed Hakem / Alaama, Tareef / Damanhouri, Zoheir Abdullah / Lodge, Samantha

    Journal of proteome research

    2024  Volume 23, Issue 2, Page(s) 809–821

    Abstract: The rising prevalence of obesity in Saudi Arabia is a major contributor to the nation's high levels of cardiometabolic diseases such as type 2 diabetes. To assess the impact of obesity on the diabetic metabolic phenotype presented in young Saudi Arabian ... ...

    Abstract The rising prevalence of obesity in Saudi Arabia is a major contributor to the nation's high levels of cardiometabolic diseases such as type 2 diabetes. To assess the impact of obesity on the diabetic metabolic phenotype presented in young Saudi Arabian adults, participants (
    MeSH term(s) Young Adult ; Humans ; Saudi Arabia/epidemiology ; Diabetes Mellitus, Type 2 ; Body Mass Index ; Obesity/complications ; Obesity/metabolism ; Lipoproteins
    Chemical Substances Lipoproteins
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2078618-9
    ISSN 1535-3907 ; 1535-3893
    ISSN (online) 1535-3907
    ISSN 1535-3893
    DOI 10.1021/acs.jproteome.3c00717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Stratification of Sepsis Patients on Admission into the Intensive Care Unit According to Differential Plasma Metabolic Phenotypes.

    Lodge, Samantha / Litton, Edward / Gray, Nicola / Ryan, Monique / Millet, Oscar / Fear, Mark / Raby, Edward / Currie, Andrew / Wood, Fiona / Holmes, Elaine / Wist, Julien / Nicholson, Jeremy K

    Journal of proteome research

    2024  Volume 23, Issue 4, Page(s) 1328–1340

    Abstract: Delayed diagnosis of patients with sepsis or septic shock is associated with increased mortality and morbidity. UPLC-MS and NMR spectroscopy were used to measure panels of lipoproteins, lipids, biogenic amines, amino acids, and tryptophan pathway ... ...

    Abstract Delayed diagnosis of patients with sepsis or septic shock is associated with increased mortality and morbidity. UPLC-MS and NMR spectroscopy were used to measure panels of lipoproteins, lipids, biogenic amines, amino acids, and tryptophan pathway metabolites in blood plasma samples collected from 152 patients within 48 h of admission into the Intensive Care Unit (ICU) where 62 patients had no sepsis, 71 patients had sepsis, and 19 patients had septic shock. Patients with sepsis or septic shock had higher concentrations of neopterin and lower levels of HDL cholesterol and phospholipid particles in comparison to nonsepsis patients. Septic shock could be differentiated from sepsis patients based on different concentrations of 10 lipids, including significantly lower concentrations of five phosphatidylcholine species, three cholesterol esters, one dihydroceramide, and one phosphatidylethanolamine. The Supramolecular Phospholipid Composite (SPC) was reduced in all ICU patients, while the composite markers of acute phase glycoproteins were increased in the sepsis and septic shock patients within 48 h admission into ICU. We show that the plasma metabolic phenotype obtained within 48 h of ICU admission is diagnostic for the presence of sepsis and that septic shock can be differentiated from sepsis based on the lipid profile.
    MeSH term(s) Humans ; Shock, Septic ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Sepsis/diagnosis ; Intensive Care Units ; Phenotype ; Phospholipids
    Chemical Substances Phospholipids
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2078618-9
    ISSN 1535-3907 ; 1535-3893
    ISSN (online) 1535-3907
    ISSN 1535-3893
    DOI 10.1021/acs.jproteome.3c00803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mood monitoring in bipolar disorder: Is it always helpful?

    Palmier-Claus, Jasper / Lobban, Fiona / Mansell, Warren / Jones, Steve / Tyler, Elizabeth / Lodge, Christopher / Bowe, Samantha / Dodd, Alyson / Wright, Kim

    Bipolar disorders

    2021  Volume 23, Issue 4, Page(s) 429–431

    MeSH term(s) Affect ; Bipolar Disorder/diagnosis ; Humans ; Mood Disorders/diagnosis
    Language English
    Publishing date 2021-02-19
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1472242-2
    ISSN 1399-5618 ; 1398-5647
    ISSN (online) 1399-5618
    ISSN 1398-5647
    DOI 10.1111/bdi.13057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Nonsevere Burn Induces a Prolonged Systemic Metabolic Phenotype Indicative of a Persistent Inflammatory Response Postinjury.

    Ryan, Monique J / Raby, Edward / Whiley, Luke / Masuda, Reika / Lodge, Samantha / Nitschke, Philipp / Maker, Garth L / Wist, Julien / Holmes, Elaine / Wood, Fiona M / Nicholson, Jeremy K / Fear, Mark W / Gray, Nicola

    Journal of proteome research

    2023  

    Abstract: Globally, burns are a significant cause of injury that can cause substantial acute trauma as well as lead to increased incidence of chronic comorbidity and disease. To date, research has primarily focused on the systemic response to severe injury, with ... ...

    Abstract Globally, burns are a significant cause of injury that can cause substantial acute trauma as well as lead to increased incidence of chronic comorbidity and disease. To date, research has primarily focused on the systemic response to severe injury, with little in the literature reported on the impact of nonsevere injuries (<15% total burn surface area; TBSA). To elucidate the metabolic consequences of a nonsevere burn injury, longitudinal plasma was collected from adults (
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2078618-9
    ISSN 1535-3907 ; 1535-3893
    ISSN (online) 1535-3907
    ISSN 1535-3893
    DOI 10.1021/acs.jproteome.3c00516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

    Barbosa, Jérémy A Ferreira / Sparapani, Samantha / Boulais, Jonathan / Lodge, Robert / Cohen, Éric A

    Journal of virology

    2021  Volume 95, Issue 15, Page(s) e0097120

    Abstract: HIV-1 encodes several accessory proteins-Nef, Vif, Vpr, and Vpu-whose functions are to modulate the cellular environment to favor immune evasion and viral replication. While Vpr was shown to mediate a ... ...

    Abstract HIV-1 encodes several accessory proteins-Nef, Vif, Vpr, and Vpu-whose functions are to modulate the cellular environment to favor immune evasion and viral replication. While Vpr was shown to mediate a G
    MeSH term(s) Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome/metabolism ; CD4-Positive T-Lymphocytes/virology ; Cell Line, Tumor ; G2 Phase Cell Cycle Checkpoints/genetics ; HEK293 Cells ; HIV Infections/pathology ; HIV-1/growth & development ; HIV-1/metabolism ; HeLa Cells ; Humans ; Macrophages/virology ; Protein Serine-Threonine Kinases/genetics ; RNA Interference ; RNA, Small Interfering/genetics ; Tandem Mass Spectrometry ; Ubiquitin-Protein Ligases/genetics ; Virus Replication/genetics ; vpr Gene Products, Human Immunodeficiency Virus/genetics ; vpr Gene Products, Human Immunodeficiency Virus/metabolism
    Chemical Substances ANAPC1 protein, human ; Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome ; RNA, Small Interfering ; vpr Gene Products, Human Immunodeficiency Virus ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; DCAF1 protein, human (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2021-07-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.00971-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Designing a Library of Lived Experience for Mental Health: integrated realist synthesis and experience-based co-design study in UK mental health services.

    Marshall, Paul / Barbrook, John / Collins, Grace / Foster, Sheena / Glossop, Zoe / Inkster, Clare / Jebb, Paul / Johnston, Rose / Jones, Steven H / Khan, Hameed / Lodge, Christopher / Machin, Karen / Michalak, Erin / Powell, Sarah / Russell, Samantha / Rycroft-Malone, Jo / Slade, Mike / Whittaker, Lesley / Lobban, Fiona

    BMJ open

    2024  Volume 14, Issue 1, Page(s) e081188

    Abstract: Objective: Living Library events involve people being trained as living 'Books', who then discuss aspects of their personal experiences in direct conversation with attendees, referred to as 'Readers'. This study sought to generate a realist programme ... ...

    Abstract Objective: Living Library events involve people being trained as living 'Books', who then discuss aspects of their personal experiences in direct conversation with attendees, referred to as 'Readers'. This study sought to generate a realist programme theory and a theory-informed implementation guide for a Library of Lived Experience for Mental Health (LoLEM).
    Design: Integrated realist synthesis and experience-based co-design.
    Setting: Ten online workshops with participants based in the North of England.
    Participants: Thirty-one participants with a combination of personal experience of using mental health services, caring for someone with mental health difficulties and/or working in mental health support roles.
    Results: Database searches identified 30 published and grey literature evidence sources which were integrated with data from 10 online co-design workshops conducted over 12 months. The analysis generated a programme theory comprising five context-mechanism-outcome (CMO) configurations. Findings highlight how establishing psychological safety is foundational to productive Living Library events (CMO 1). For Readers, direct conversations humanise others' experiences (CMO 2) and provide the opportunity to flexibly explore new ways of living (CMO 3). Through participation in a Living Library, Books may experience personal empowerment (CMO 4), while the process of self-authoring and co-editing their story (CMO 5) can contribute to personal development. This programme theory informed the co-design of an implementation guide highlighting the importance of tailoring event design and participant support to the contexts in which LoLEM events are held.
    Conclusions: The LoLEM has appeal across stakeholder groups and can be applied flexibly in a range of mental health-related settings. Implementation and evaluation are required to better understand the positive and negative impacts on Books and Readers.
    Trial registration number: PROSPERO CRD42022312789.
    MeSH term(s) Humans ; Mental Health ; Mental Health Services ; Empowerment ; England ; Qualitative Research
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-081188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Gut microbiota and metabolomics profiles in patients with chronic stable angina and acute coronary syndrome.

    Ahmad, Adilah F / Caparrós-Martin, Jose A / Gray, Nicola / Lodge, Samantha / Wist, Julien / Lee, Silvia / O'Gara, Fergal / Dwivedi, Girish / Ward, Natalie C

    Physiological genomics

    2023  Volume 56, Issue 1, Page(s) 48–64

    Abstract: Cardiovascular disease (CVD) is the leading cause of death worldwide. The gut microbiota and its associated metabolites may be involved in the development and progression of CVD, although the mechanisms and impact on clinical outcomes are not fully ... ...

    Abstract Cardiovascular disease (CVD) is the leading cause of death worldwide. The gut microbiota and its associated metabolites may be involved in the development and progression of CVD, although the mechanisms and impact on clinical outcomes are not fully understood. This study investigated the gut microbiome profile and associated metabolites in patients with chronic stable angina (CSA) and acute coronary syndrome (ACS) compared with healthy controls. Bacterial alpha diversity in stool from patients with ACS or CSA was comparable to healthy controls at both baseline and follow-up visits. Differential abundance analysis identified operational taxonomic units (OTUs) assigned to commensal taxa differentiating patients with ACS from healthy controls at both baseline and follow-up. Patients with CSA and ACS had significantly higher levels of trimethylamine
    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Acute Coronary Syndrome ; Angina, Stable ; Lipopolysaccharide Receptors ; Metabolomics ; Bacteria
    Chemical Substances Lipopolysaccharide Receptors
    Language English
    Publishing date 2023-10-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2038823-8
    ISSN 1531-2267 ; 1094-8341
    ISSN (online) 1531-2267
    ISSN 1094-8341
    DOI 10.1152/physiolgenomics.00072.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Insights into the associations between the gut microbiome, its metabolites, and heart failure.

    Ahmad, Adilah F / Caparrós-Martin, Jose A / Gray, Nicola / Lodge, Samantha / Wist, Julien / Lee, Silvia / O'Gara, Fergal / Shah, Amit / Ward, Natalie C / Dwivedi, Girish

    American journal of physiology. Heart and circulatory physiology

    2023  Volume 325, Issue 6, Page(s) H1325–H1336

    Abstract: Heart failure (HF) is the end stage of most cardiovascular diseases and remains a significant health problem globally. We aimed to assess whether patients with left ventricular ejection fraction ≤45% had alterations in both the gut microbiome profile and ...

    Abstract Heart failure (HF) is the end stage of most cardiovascular diseases and remains a significant health problem globally. We aimed to assess whether patients with left ventricular ejection fraction ≤45% had alterations in both the gut microbiome profile and production of associated metabolites when compared with a healthy cohort. We also examined the associated inflammatory, metabolomic, and lipidomic profiles of patients with HF. This single center, observational study, recruited 73 patients with HF and 59 healthy volunteers. Blood and stool samples were collected at baseline and 6-mo follow-up, along with anthropometric and clinical data. When compared with healthy controls, patients with HF had reduced gut bacterial alpha diversity at follow-up (
    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Stroke Volume ; Ventricular Function, Left ; Heart Failure ; Microbiota
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00436.2023
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  10. Article: Altered dietary behaviour during pregnancy impacts systemic metabolic phenotypes.

    Rowley, Charlotte E / Lodge, Samantha / Egan, Siobhon / Itsiopoulos, Catherine / Christophersen, Claus T / Silva, Desiree / Kicic-Starcevich, Elizabeth / O'Sullivan, Therese A / Wist, Julien / Nicholson, Jeremy / Frost, Gary / Holmes, Elaine / D'Vaz, Nina

    Frontiers in nutrition

    2023  Volume 10, Page(s) 1230480

    Abstract: Rationale: Evidence suggests consumption of a Mediterranean diet (MD) can positively impact both maternal and offspring health, potentially mediated by a beneficial effect on inflammatory pathways. We aimed to apply metabolic profiling of serum and ... ...

    Abstract Rationale: Evidence suggests consumption of a Mediterranean diet (MD) can positively impact both maternal and offspring health, potentially mediated by a beneficial effect on inflammatory pathways. We aimed to apply metabolic profiling of serum and urine samples to assess differences between women who were stratified into high and low alignment to a MD throughout pregnancy and investigate the relationship of the diet to inflammatory markers.
    Methods: From the ORIGINS cohort, 51 pregnant women were stratified for persistent high and low alignment to a MD, based on validated MD questionnaires.
    Results: There were clear differences in both the food choice and metabolic profiles of women who self-reported concordance to a high (HMDA) and low (LMDA) Mediterranean diet, indicating that alignment with the MD was associated with a specific metabolic phenotype during pregnancy. Reduced meat intake and higher vegetable intake in the HMDA group was supported by increased levels of urinary hippurate (
    Conclusion: Metabolic phenotypes of pregnant women who had a high alignment with the MD were significantly different from pregnant women who had a poor alignment with the MD. The metabolite profiles aligned with reported food intake. Differences were most significant biomarkers of systemic inflammation and selected gut-microbial metabolites. This research expands our understanding of the mechanisms driving health outcomes during the perinatal period and provides additional biomarkers for investigation in pregnant women to assess potential health risks.
    Language English
    Publishing date 2023-12-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1230480
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