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  1. Article: Nonenzymatic enantioselective synthesis of all-carbon quaternary centers through desymmetrization.

    Petersen, Kimberly S

    Tetrahedron letters

    2016  Volume 56, Issue 47, Page(s) 6523–6535

    Abstract: The asymmetric desymmetrization ... ...

    Abstract The asymmetric desymmetrization of
    Language English
    Publishing date 2016-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2015.09.134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reimagining Incident Management Systems for Public Health Responses.

    Hawkins, Regina M / Ma, Kimberly Y / Pickett, Andrew D / Bakker, Gerrit / Kipp, Steven S / Mihalakos, Alysia / Petersen, Paul E

    Health security

    2023  Volume 21, Issue S1, Page(s) S95–S100

    MeSH term(s) Humans ; Public Health ; Risk Management
    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2823049-8
    ISSN 2326-5108 ; 2326-5094
    ISSN (online) 2326-5108
    ISSN 2326-5094
    DOI 10.1089/hs.2023.0037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Chiral Brønsted Acid Catalyzed Cascade Alcohol Deprotection and Enantioselective Cyclization.

    Frost, Joshua A / Korb, Sarah M / Green, Fiona E / Youngblood, Kala C / Petersen, Kimberly S

    ACS omega

    2023  Volume 9, Issue 2, Page(s) 2962–2969

    Abstract: The protection-deprotection sequence is vital to organic synthesis. Here, we describe a novel catalytic cascade where a chiral Brønsted acid selectively removes ether protecting groups and catalyzes intramolecular cyclization in one pot. We tested three ... ...

    Abstract The protection-deprotection sequence is vital to organic synthesis. Here, we describe a novel catalytic cascade where a chiral Brønsted acid selectively removes ether protecting groups and catalyzes intramolecular cyclization in one pot. We tested three model substrates from our previous work and investigated the rate of deprotection through gas chromatography (GC) studies. This work builds on our stereoselective synthesis of lactones by streamlining our synthesis. It also opens the door for additional investigations into other catalytic cascade reactions using chiral Brønsted acid catalysts.
    Language English
    Publishing date 2023-12-29
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c08869
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Chiral Brønsted Acid Catalyzed Kinetic Resolutions.

    Petersen, Kimberly S

    Asian journal of organic chemistry

    2016  Volume 5, Issue 3, Page(s) 308–320

    Abstract: The synthesis of enantioenriched small molecules is an ongoing goal of organic chemists. This focus review explores the use of kinetic resolutions catalyzed by chiral Brønsted acids. Methods include classic kinetic resolutions and dynamic kinetic ... ...

    Abstract The synthesis of enantioenriched small molecules is an ongoing goal of organic chemists. This focus review explores the use of kinetic resolutions catalyzed by chiral Brønsted acids. Methods include classic kinetic resolutions and dynamic kinetic resolutions. The small molecules obtained are potentially valuable intermediates in the synthesis of biologically important compounds.
    Language English
    Publishing date 2016-03-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2679333-7
    ISSN 2193-5815 ; 2193-5807
    ISSN (online) 2193-5815
    ISSN 2193-5807
    DOI 10.1002/ajoc.201600021
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  5. Article ; Online: Chiral Brønsted Acid Catalyzed Cascade Alcohol Deprotection and Enantioselective Cyclization

    Joshua A. Frost / Sarah M. Korb / Fiona E. Green / Kala C. Youngblood / Kimberly S. Petersen

    ACS Omega, Vol 9, Iss 2, Pp 2962-

    2023  Volume 2969

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Secondary breast angiosarcoma following accelerated partial breast irradiation with intracavitary multicatheter applicator brachytherapy.

    Rummel, Keaton A / Gao, Robert W / Francis, Leah N / Petersen, Ivy A / Mutter, Robert W / Corbin, Kimberly S

    Brachytherapy

    2023  Volume 22, Issue 4, Page(s) 487–490

    Abstract: Purpose: Secondary angiosarcoma of the breast is a rare complication of breast radiotherapy and is associated with a poor prognosis. There are many reported cases of secondary angiosarcoma following whole breast irradiation (WBI), however development of ...

    Abstract Purpose: Secondary angiosarcoma of the breast is a rare complication of breast radiotherapy and is associated with a poor prognosis. There are many reported cases of secondary angiosarcoma following whole breast irradiation (WBI), however development of secondary angiosarcoma following brachytherapy-based accelerated partial breast irradiation (APBI) is not as well characterized.
    Methods and materials: We reviewed and reported a case of a patient who developed secondary angiosarcoma of the breast following intracavitary multicatheter applicator brachytherapy APBI.
    Results: A 69-year-old female was originally diagnosed with T1N0M0 invasive ductal carcinoma of the left breast and treated with lumpectomy followed by adjuvant intracavitary multicatheter applicator brachytherapy APBI. Seven years following her treatment, she developed secondary angiosarcoma. However, the diagnosis of secondary angiosarcoma was delayed due to nonspecific imaging findings and a negative biopsy.
    Conclusions: Our case highlights the need for secondary angiosarcoma to be considered in the differential diagnosis when patients present with symptoms such as breast ecchymosis and skin thickening following WBI or APBI. Prompt diagnosis and referral to a high-volume sarcoma treatment center for multidisciplinary evaluation is vital.
    MeSH term(s) Female ; Humans ; Aged ; Hemangiosarcoma/etiology ; Brachytherapy/methods ; Breast Neoplasms/surgery ; Breast/pathology ; Mastectomy, Segmental
    Language English
    Publishing date 2023-05-20
    Publishing country United States
    Document type Review ; Case Reports
    ZDB-ID 2098608-7
    ISSN 1873-1449 ; 1538-4721
    ISSN (online) 1873-1449
    ISSN 1538-4721
    DOI 10.1016/j.brachy.2023.04.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Central subfield thickness predicts visual acuity outcomes in plaque-irradiated eyes with choroidal melanoma.

    Shah, Saumya M / Tanke, Laurel B / Deufel, Christopher L / Petersen, Ivy A / Corbin, Kimberly S / Hodge, David O / Olsen, Timothy W / Dalvin, Lauren A

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2023  Volume 262, Issue 4, Page(s) 1305–1320

    Abstract: Objective: To determine the association between pre-operative central subfield thickness (CST) and post-radiotherapy visual acuity (VA), cystoid macular edema (CME), and intravitreal anti-vascular endothelial growth factor (VEGF) requirement.: Design!# ...

    Abstract Objective: To determine the association between pre-operative central subfield thickness (CST) and post-radiotherapy visual acuity (VA), cystoid macular edema (CME), and intravitreal anti-vascular endothelial growth factor (VEGF) requirement.
    Design: Single-center retrospective study.
    Participants: Patients with plaque-irradiated extramacular choroidal melanoma treated between 11/11/2011 and 4/30/2021. Pre-operative CST difference between the affected and unaffected eye was used. Kaplan-Meier analysis and hazard ratios were calculated.
    Results: Of 85 patients, pre-operative CST was greater in the melanoma-affected eye (vs. fellow eye) by mean of 20.4 μm (median 14.0, range - 60.0-182.0). Greater CST at presentation (vs. fellow eye) was associated with larger tumor diameter (p = 0.02), greater tumor thickness (p < 0.001), and more frequent tumor-related Bruch's membrane rupture (p = 0.006). On univariate analysis of outcome data, greater CST at presentation (vs. fellow eye) was associated with higher 5-year risk (1.09 [1.02-1.17], p = 0.02) of VA 20/200 or worse and increased (1.10 [1.01-1.20], p = 0.03) likelihood for anti-VEGF injections after plaque irradiation. There was no significant association with CME. The association between CST and VA outcome remained significant on multivariate analysis accounting for impact of tumor thickness and radiation dose to optic disc, while tumor distance to fovea was the only significant factor on multivariate analysis for anti-VEGF injections.
    Conclusion: Greater CST at presentation (vs. fellow eye) was associated with worse VA outcome following plaque radiotherapy for choroidal melanoma. Large-sized tumors may contribute to a higher intraocular VEGF burden, potentially leading to greater preoperative CST, which correlates with poor VA outcome post-plaque radiotherapy.
    MeSH term(s) Humans ; Retrospective Studies ; Vascular Endothelial Growth Factor A ; Melanoma/diagnosis ; Melanoma/radiotherapy ; Macular Edema/drug therapy ; Choroid Neoplasms/diagnosis ; Choroid Neoplasms/radiotherapy ; Visual Acuity ; Intravitreal Injections ; Angiogenesis Inhibitors ; Tomography, Optical Coherence ; Uveal Neoplasms
    Chemical Substances Vascular Endothelial Growth Factor A ; Angiogenesis Inhibitors
    Language English
    Publishing date 2023-11-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-023-06313-9
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  8. Article: Nonenzymatic enantioselective synthesis of all-carbon quaternary centers through desymmetrization

    Petersen, Kimberly S

    Tetrahedron letters. 2015 Nov. 25, v. 56

    2015  

    Abstract: The asymmetric desymmetrization of meso or prochiral compounds containing an all-carbon quaternary center is an attractive alternative to classical synthetic approaches aimed at the asymmetric formation of a new C–C bond. This review focuses on ... ...

    Abstract The asymmetric desymmetrization of meso or prochiral compounds containing an all-carbon quaternary center is an attractive alternative to classical synthetic approaches aimed at the asymmetric formation of a new C–C bond. This review focuses on nonenzymatic desymmetrizations that utilize transition metal catalysts or organocatalysts to distinguish between enantiotopic groups to generate enantioenriched compounds containing all-carbon quaternary stereocenters.
    Keywords catalysts ; chemical bonding ; chemical reactions ; enantiomers ; organic compounds ; synthesis
    Language English
    Dates of publication 2015-1125
    Size p. 6523-6535.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2015.09.134
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2837: Show issues Location:
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  9. Article: Stereoselective Desymmetrizations of Dinitriles to Synthesize Lactones.

    Kelley, Amber M / Frost, Joshua A / Baber, Tylisha M / Youngblood, Kala C / Michishita, Emiri / Bain, Schuyler A / Lykins, T Caleb / Petersen, Kimberly S

    Tetrahedron letters

    2021  Volume 88

    Abstract: Nitriles are important organic functional groups, allowing for installation of nitrogen in organic synthesis. The Pinner reaction transforms nitriles into esters via the imidate group, but in general has previously necessitated harsh acid conditions. ... ...

    Abstract Nitriles are important organic functional groups, allowing for installation of nitrogen in organic synthesis. The Pinner reaction transforms nitriles into esters via the imidate group, but in general has previously necessitated harsh acid conditions. This work builds on the utility of the Pinner reaction through a stereoselective desymmetrization of dinitriles to form γ- and δ-lactones in good yields and diastereoselectivites.
    Language English
    Publishing date 2021-12-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2021.153573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Enantioselective Synthesis of α,α-Disubstituted Lactones via a Chiral Brønsted Acid Catalyzed Intramolecular Cyclization.

    Wilent, Jennifer E / Qabaja, Ghassan / Petersen, Kimberly S

    Organic syntheses; an annual publication of satisfactory methods for the preparation of organic chemicals

    2016  Volume 93, Page(s) 75–87

    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2247669-6
    ISSN 0078-6209
    ISSN 0078-6209
    DOI 10.15227/orgsyn.093.0075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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