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  1. Article ; Online: Effects of Vitamin E Supplementation on Antioxidant, Inflammatory Biomarker, and Cell Viability of Peripheral Blood Mononuclear Cells from Japanese Black Calves with or without Lipopolysaccharide Stimulation.

    Otomaru, Konosuke / Miyahara, Takuro / Saita, Hiroto / Maeda, Yosuke

    Journal of nutritional science and vitaminology

    2022  Volume 68, Issue 5, Page(s) 470–474

    Abstract: The purpose of this study was to determine the effects of vitamin E supplementation on antioxidant, inflammatory status, and cell viability of peripheral blood mononuclear cells. Eighteen clinically healthy Japanese Black calves were used in this study. ... ...

    Abstract The purpose of this study was to determine the effects of vitamin E supplementation on antioxidant, inflammatory status, and cell viability of peripheral blood mononuclear cells. Eighteen clinically healthy Japanese Black calves were used in this study. The peripheral blood mononuclear cells (PBMCs) were isolated from their venous blood. PBMCs were cultured with vitamin E (vitamin E group) or without vitamin E (control group), and stimulated with or without lipopolysaccharide (LPS). As a result, the total antioxidant capacities, which are the reducing power of components from Fe
    MeSH term(s) Cattle ; Animals ; Lipopolysaccharides ; Leukocytes, Mononuclear ; Antioxidants/pharmacology ; Cell Survival ; Tumor Necrosis Factor-alpha/pharmacology ; Vitamin E/pharmacology ; Biomarkers ; Dietary Supplements
    Chemical Substances Lipopolysaccharides ; Antioxidants ; Tumor Necrosis Factor-alpha ; Vitamin E (1406-18-4) ; Biomarkers
    Language English
    Publishing date 2022-10-30
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 191366-9
    ISSN 1881-7742 ; 0301-4800
    ISSN (online) 1881-7742
    ISSN 0301-4800
    DOI 10.3177/jnsv.68.470
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 596: Show issues Location:
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  2. Article: Clinical Outcomes in Elderly Patients with Chronic Subdural Hematoma: Validation of Irrigation Assignment Based on Hematoma Characteristics.

    Maeda, Takuma / Kikkawa, Yuichiro / Ehara, Takuro / Tsuchiya, Ryosuke / Tabata, Shinya / Onodera, Koki / Kimura, Tatsuki / Take, Yushiro / Suzuki, Kaima / Kurita, Hiroki

    Life (Basel, Switzerland)

    2024  Volume 14, Issue 4

    Abstract: The number of elderly patients with chronic subdural hematomas (CSDH) is increasing worldwide; however, there is limited data regarding the clinical outcomes in this population. Our therapeutic method using burr hole evacuation for CSDH is based on the ... ...

    Abstract The number of elderly patients with chronic subdural hematomas (CSDH) is increasing worldwide; however, there is limited data regarding the clinical outcomes in this population. Our therapeutic method using burr hole evacuation for CSDH is based on the hematoma characteristics, using simple drainage for single-layer lesions and drainage with irrigation for multiple-layer lesions. This study aimed to compare the postoperative outcomes of elderly and younger patients, identify the predictors of outcomes in elderly patients, and verify the validity of our therapeutic methods. In total, we included 214 patients who underwent burr hole evacuation between April 2018 and March 2022. Baseline characteristics, hematoma characteristics, recurrence, and clinical outcomes were compared between the elderly and younger patients. Overall, 96 elderly patients (44.9%) were included in the study, and more elderly patients underwent antithrombotic therapy than younger patients (33.3% vs. 19.5%,
    Language English
    Publishing date 2024-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14040518
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  3. Article ; Online: Onasemnogene Abeparvovec Treatment after Nusinersen in an Infant with Spinal Muscular Atrophy Type 1.

    Nanri, Daiki / Yuge, Kotaro / Goto, Kohei / Kimura, Takuro / Yae, Yukako / Mizuochi, Tatsuki / Sato, Ryosuke / Itonaga, Tomoyo / Maeda, Tomoki / Yamashita, Yushiro

    The Kurume medical journal

    2024  

    Abstract: Background: Until recently, the treatment of spinal muscular atrophy (SMA) was limited to symptomatic treatment with no cure. Three innovative drugs, nusinersen, onasemnogene abeparvovec (OA), and risdiplam have been developed to treat SMA. Although the ...

    Abstract Background: Until recently, the treatment of spinal muscular atrophy (SMA) was limited to symptomatic treatment with no cure. Three innovative drugs, nusinersen, onasemnogene abeparvovec (OA), and risdiplam have been developed to treat SMA. Although the clinical trials for these drugs have demonstrated their efficacy, there is limited information on real world treatment strategies. In this study, we present a case of a male infant with SMA type 1 who underwent OA treatment after nusinersen treatment.
    Case presentation: At 4 months of age, the patient was diagnosed with SMA type 1. At 6 months of age, nusinersen treatment was initiated. His motor function improved, but the effect was limited; therefore, his parents requested gene replacement therapy. During the preparation for OA treatment, anti-adeno-associated virus 9 (AAV9) antibody tests repeatedly showed non-specific reactions, which delayed initiation of treatment. The patient was put on ventilator management after he caught a common cold. During this management, the anti-AAV9 antibody test results were negative. Furthermore, the patient showed increased transaminase levels just before OA treatment; however, since these gradually decreased without signs of liver failure, we started OA treatment at 13 months of age. Four months later, the patient began to sit without support and was weaned from non-invasive positive pressure ventilation, although nasogastric tube feeding remained partially necessary.
    Conclusion: We believe that the management of unstable SMA type 1 symptoms, anti-AAV9 antibody testing, and changes in transaminase levels will be helpful for other patients with SMA who require treatment.
    Language English
    Publishing date 2024-01-16
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 603905-4
    ISSN 1881-2090 ; 0023-5679
    ISSN (online) 1881-2090
    ISSN 0023-5679
    DOI 10.2739/kurumemedj.MS6934008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 704: Show issues Location:
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  4. Article ; Online: Response to: 'Comment on 'Metagenome-wide association study of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population' by Kishikawa

    Kishikawa, Toshihiro / Maeda, Yuichi / Nii, Takuro / Okada, Yukinori

    Annals of the rheumatic diseases

    2020  Volume 81, Issue 5, Page(s) e72

    MeSH term(s) Arthritis, Rheumatoid/genetics ; Gastrointestinal Microbiome/physiology ; Humans ; Japan/epidemiology ; Metagenome ; Metagenomics
    Language English
    Publishing date 2020-05-29
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2020-217897
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  5. Article ; Online: Response to: 'Can sexual dimorphism in rheumatoid arthritis be attributed to the different abundance of

    Kishikawa, Toshihiro / Maeda, Yuichi / Nii, Takuro / Okada, Yukinori

    Annals of the rheumatic diseases

    2020  Volume 81, Issue 3, Page(s) e37

    MeSH term(s) Arthritis, Rheumatoid ; Gardnerella ; Humans ; Sex Characteristics
    Language English
    Publishing date 2020-03-25
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2020-217264
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  6. Article: [THE IMMUNE RESPONSE TO PREVOTELLA BACTERIA IN AUTOIMMUNE DISEASES].

    Nii, Takuro / Maeda, Yuichi / Takeda, Kiyoshi

    Arerugi = [Allergy

    2018  Volume 67, Issue 1, Page(s) 24–27

    MeSH term(s) Autoimmune Diseases ; Humans ; Prevotella
    Language Japanese
    Publishing date 2018-02-16
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 974201-3
    ISSN 0021-4884
    ISSN 0021-4884
    DOI 10.15036/arerugi.67.24
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    Zs.A 245: Show issues Location:
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  7. Article: [Acute myeloid leukemia with type I CBFB::MYH11 fusion gene not detected by screening test for leukemia-related chimeric genes].

    Utsumi, Sae / Shima, Takahiro / Kubara, Chiaki / Semba, Yuichiro / Hayashi, Masayasu / Takigawa, Ken / Yoshino, Teruhiko / Minami, Mariko / Matsuo, Yayoi / Kuriyama, Takuro / Akashi, Koichi / Maeda, Takahiro / Taniguchi, Shuichi / Eto, Tetsuya

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2024  Volume 64, Issue 12, Page(s) 1503–1507

    Abstract: A 27-year-old woman with pancytopenia was admitted to our hospital. Bone marrow aspiration revealed 52.2% myeloperoxidase-positive myeloblasts, leading to a diagnosis of acute myeloid leukemia. While a screening test for chimeric genes related to ... ...

    Abstract A 27-year-old woman with pancytopenia was admitted to our hospital. Bone marrow aspiration revealed 52.2% myeloperoxidase-positive myeloblasts, leading to a diagnosis of acute myeloid leukemia. While a screening test for chimeric genes related to leukemia initially yielded negative results, including for the CBFB::MYH11 fusion gene, G-banded karyotyping uncovered the presence of inv (16)(p13.1q22). Further investigation by fluorescence in situ hybridization (FISH) confirmed the split signals for CBFB. A second screening test for leukemia-related chimeric genes with different PCR primers revealed the elusive CBFB::MYH11 fusion gene. Subsequently, the type I CBFB::MYH11 fusion gene was identified through exhaustive exploration using RNA sequencing for fusion gene discovery. This exceptional case highlights the existence of a distinctive subtype of CBFB::MYH11 that may yield false-negative results in conventional chimeric fusion screening, thus emphasizing the indispensable utility of PCR primer modification, FISH, and RNA sequencing in the investigative process.
    MeSH term(s) Female ; Humans ; Adult ; In Situ Hybridization, Fluorescence ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/genetics ; Karyotyping ; Oncogene Proteins, Fusion/genetics ; Core Binding Factor beta Subunit/genetics ; Myosin Heavy Chains/genetics
    Chemical Substances Oncogene Proteins, Fusion ; CBFB protein, human ; Core Binding Factor beta Subunit ; MYH11 protein, human ; Myosin Heavy Chains (EC 3.6.4.1)
    Language Japanese
    Publishing date 2024-01-12
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
    DOI 10.11406/rinketsu.64.1503
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    Zs.MO 535: Show issues

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  8. Article: Authors' reply.

    Wakahara, Tomoyuki / Ueno, Nozomi / Maeda, Tetsuo / Kanemitsu, Kiyonori / Yoshikawa, Takuro / Tsuchida, Shinobu / Toyokawa, Akihiro

    Annals of gastroenterology

    2019  Volume 32, Issue 2, Page(s) 215–216

    Language English
    Publishing date 2019-01-17
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2032850-3
    ISSN 1108-7471
    ISSN 1108-7471
    DOI 10.20524/aog.2019.0354
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  9. Article ; Online: Prevalence of chromosome 8p11.2 translocations and correlation with myeloid and lymphoid neoplasms associated with FGFR1 abnormalities in a consecutive cohort from nine institutions in Japan.

    Usuki, Kensuke / Kameda, Takuro / Kawano, Noriaki / Ito, Tomoki / Hashimoto, Yoshinori / Shide, Kotaro / Kawano, Hiroshi / Sekine, Masaaki / Toyama, Takanori / Iizuka, Hiromitsu / Sato, Seiichi / Takeuchi, Masanori / Ishizaki, Junzo / Maeda, Kouichi / Nakai, Michikazu / Yamashita, Kiyoshi / Kubuki, Yoko / Shimoda, Kazuya

    International journal of hematology

    2024  

    Abstract: Myeloid and lymphoid neoplasms associated with FGFR1 abnormalities (MLN-FGFR1 abnormalities) are rare hematologic malignancies associated with chromosome 8p11.2 abnormalities. Translocations of 8p11.2 were detected in 10 of 17,039 (0.06%) unique patient ... ...

    Abstract Myeloid and lymphoid neoplasms associated with FGFR1 abnormalities (MLN-FGFR1 abnormalities) are rare hematologic malignancies associated with chromosome 8p11.2 abnormalities. Translocations of 8p11.2 were detected in 10 of 17,039 (0.06%) unique patient cytogenetic studies performed at nine institutions in Japan. No inversions or insertions of 8p11.2 were detected. Among the 10 patients with 8p11.2 translocations, three patients were diagnosed with MLN-FGFR1 abnormalities, which were confirmed by FISH analysis. Peripheral blood eosinophilia was observed in all three patients, and all progressed to AML or T-lymphoblastic lymphoma/leukemia. The prevalence of 8p11.2 translocations in clinical practice and the proportion of MLN-FGFR1 abnormalities in patients with 8p11.2 translocations in Japan were consistent with those in previous reports from Western countries.
    Language English
    Publishing date 2024-03-08
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1076875-0
    ISSN 1865-3774 ; 0917-1258 ; 0925-5710
    ISSN (online) 1865-3774
    ISSN 0917-1258 ; 0925-5710
    DOI 10.1007/s12185-024-03740-0
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  10. Article: Alkyl gallates inhibit serine

    Toyomoto, Touya / Ono, Katsuhiko / Shiba, Tomoo / Momitani, Kenta / Zhang, Tianli / Tsutsuki, Hiroyasu / Ishikawa, Takeshi / Hoso, Kanae / Hamada, Koma / Rahman, Azizur / Wen, Liping / Maeda, Yosuke / Yamamoto, Keiichi / Matsuoka, Masao / Hanaoka, Kenjiro / Niidome, Takuro / Akaike, Takaaki / Sawa, Tomohiro

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1276447

    Abstract: A principal concept in developing antibacterial agents with selective toxicity is blocking metabolic pathways that are critical for bacterial growth but that mammalian cells lack. ... ...

    Abstract A principal concept in developing antibacterial agents with selective toxicity is blocking metabolic pathways that are critical for bacterial growth but that mammalian cells lack. Serine
    Language English
    Publishing date 2023-10-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1276447
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