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Article: A Patient With Pancoast Tumor Presenting With Cervical Radiculopathy: A Case Report.

Berntheizel, Emma K / Tollefson, Lauren J / Fischer, Charles P / Stefanowicz, Eric T

2023 Volume 22, Issue 4, Page(s) 328–333

Abstract: Objective: The purpose of this report was to describe a patient with a Pancoast tumor who presented for chiropractic care with neck and arm pain.: Clinical features: A 52-year-old male patient with right-sided cervicothoracic pain and numbness in the ...

Abstract	Objective: The purpose of this report was to describe a patient with a Pancoast tumor who presented for chiropractic care with neck and arm pain. Clinical features: A 52-year-old male patient with right-sided cervicothoracic pain and numbness in the right upper extremity presented to a chiropractic office for care. The patient reported an occupational history of repetitive lifting motions and overuse injuries. The patient denied history of smoking at the time of presentation. Intervention and outcome: Radiographic imaging revealed tracheal deviation. A chest computed tomography image demonstrated a large lesion in the apex of the right lung, suggestive of bronchogenic carcinoma. The patient was referred to an oncology clinic, where he admitted to having a 20-year history of smoking. The diagnosis of adenocarcinoma was made via biopsy, and the oncologist's evaluation confirmed the cancer to be stage IIIC. The patient received palliative care treatments, as the advanced state of his condition determined that he was not a candidate for surgical intervention. Conclusion: Chiropractors and other first-contact health care providers must keep in mind unusual presentations masquerading as common conditions. This case demonstrates the importance of including apical lung tumors in the differential diagnosis of unilateral arm and neck pain and neurologic deficits of the upper extremity. This case demonstrates the importance of thorough follow-up on images ordered, including the ordering clinicians viewing the images themselves.
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Case Reports
ZDB-ID	2365038-2
ISSN	1556-3715 ; 1556-3707
ISSN (online)	1556-3715
ISSN	1556-3707
DOI	10.1016/j.jcm.2023.07.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dopamine‑iron homeostasis interaction rescues mitochondrial fitness in Parkinson's disease.

Buoso, Chiara / Seifert, Markus / Lang, Martin / Griffith, Corey M / Andújar, Begoña Talavera / Rueda, Maria Paulina Castelo / Fischer, Christine / Doerrier, Carolina / Talasz, Heribert / Zanon, Alessandra / Pramstaller, Peter P / Schymanski, Emma L / Pichler, Irene / Weiss, Guenter

Neurobiology of disease

2024 , Page(s) 106506

Abstract: Imbalances of iron and dopamine metabolism along with mitochondrial dysfunction have been linked to the pathogenesis of Parkinson's disease (PD). We have previously suggested a direct link between iron homeostasis and dopamine metabolism, as dopamine can ...

Abstract	Imbalances of iron and dopamine metabolism along with mitochondrial dysfunction have been linked to the pathogenesis of Parkinson's disease (PD). We have previously suggested a direct link between iron homeostasis and dopamine metabolism, as dopamine can increase cellular uptake of iron into macrophages thereby promoting oxidative stress responses. In this study, we investigated the interplay between iron, dopamine, and mitochondrial activity in neuroblastoma SH-SY5Y cells and human induced pluripotent stem cell (hiPSC)-derived dopaminergic neurons differentiated from a healthy control and a PD patient with a mutation in the α-synuclein (SNCA) gene. In SH-SY5Y cells, dopamine treatment resulted in increased expression of the transmembrane iron transporters transferrin receptor 1 (TFR1), ferroportin (FPN), and mitoferrin2 (MFRN2) and intracellular iron accumulation, suggesting that dopamine may promote iron uptake. Furthermore, dopamine supplementation led to reduced mitochondrial fitness including decreased mitochondrial respiration, increased cytochrome c control efficiency, reduced mtDNA copy number and citrate synthase activity, increased oxidative stress and impaired aconitase activity. In dopaminergic neurons derived from a healthy control individual, dopamine showed comparable effects as observed in SH-SY5Y cells. The hiPSC-derived PD neurons harboring an endogenous SNCA mutation demonstrated altered mitochondrial iron homeostasis, reduced mitochondrial capacity along with increased oxidative stress and alterations of tricarboxylic acid cycle linked metabolic pathways compared with control neurons. Importantly, dopamine treatment of PD neurons promoted a rescue effect by increasing mitochondrial respiration, activating antioxidant stress response, and normalizing altered metabolite levels linked to mitochondrial function. These observations provide evidence that dopamine affects iron homeostasis, intracellular stress responses and mitochondrial function in healthy cells, while dopamine supplementation can restore the disturbed regulatory network in PD cells.
Language	English
Publishing date	2024-04-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1211786-9
ISSN	1095-953X ; 0969-9961
ISSN (online)	1095-953X
ISSN	0969-9961
DOI	10.1016/j.nbd.2024.106506
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Article ; Online: Comparisons of Intracranial Volume and Cephalic Index After Correction of Sagittal Craniosynostosis With Either Two or Three Springs.

Fischer, Sara / Maltese, Giovanni / Tarnow, Peter / Wikberg, Emma / Søfteland, Madiha Bhatti / Kölby, Lars

The Journal of craniofacial surgery

2021 Volume 32, Issue 8, Page(s) 2636–2640

Abstract: ... in the three-spring group (P value = 0.559), and the relative increase in CI was 3.6 ± 3.3% in the two-spring ... group as compared with 6.0 ± 5.0% in the three-spring group (P = 0.004). These findings demonstrated ...

Abstract	Abstract: In this retrospective study, the authors determined changes in intracranial volume (ICV) and cephalic index (CI) in patients with sagittal craniosynostosis and operated with craniotomy combined with either 2 or 3 springs. The authors included patients (n = 112) with complete follow-up that had undergone surgical correction for isolated sagittal craniosynostosis with craniotomy combined with springs between 2008 and 2017. All patients underwent computed tomography examination preoperative, at the time of spring extraction, and at 3 years of age. Intracranial volume was measured using a semiautomatic MATLAB program, and CI was calculated as the width/length of the skull. The authors found that craniotomy combined with 2 springs increased the ICV from a preoperative value of 792 ± 113 mL (mean ± standard deviation) to 1298 ± 181 mL at 3 years of age and increased the CI from 72.1 ± 4.1 to 74.6 ± 4.3, whereas craniotomy combined with 3 springs increased the ICV from 779 ± 128 mL to 1283 ± 136 mL and the CI from 70.7 ± 4.3 to 74.8 ± 3.7. The relative increase in ICV was 65 ± 21% in the two-spring group and 68 ± 34% in the three-spring group (P value = 0.559), and the relative increase in CI was 3.6 ± 3.3% in the two-spring group as compared with 6.0 ± 5.0% in the three-spring group (P = 0.004). These findings demonstrated that use of 3 springs resulted in additional absolute and relative CI-specific effects as compared with 2 springs during the time when the springs were in place, with this effect maintained at 3 years of age.
MeSH term(s)	Craniosynostoses/diagnostic imaging ; Craniosynostoses/surgery ; Craniotomy ; Humans ; Infant ; Reconstructive Surgical Procedures ; Retrospective Studies ; Skull/diagnostic imaging ; Skull/surgery
Language	English
Publishing date	2021-07-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000007870
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Zs.A 3761: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 175: Show issues

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Article ; Online: Low-cost measurement of face mask efficacy for filtering expelled droplets during speech.

Fischer, Emma P / Fischer, Martin C / Grass, David / Henrion, Isaac / Warren, Warren S / Westman, Eric

Science advances

2020 Volume 6, Issue 36

Abstract: Mandates for mask use in public during the recent coronavirus disease 2019 (COVID-19) pandemic, worsened by global shortage of commercial supplies, have led to widespread use of homemade masks and mask alternatives. It is assumed that wearing such masks ... ...

Abstract	Mandates for mask use in public during the recent coronavirus disease 2019 (COVID-19) pandemic, worsened by global shortage of commercial supplies, have led to widespread use of homemade masks and mask alternatives. It is assumed that wearing such masks reduces the likelihood for an infected person to spread the disease, but many of these mask designs have not been tested in practice. We have demonstrated a simple optical measurement method to evaluate the efficacy of masks to reduce the transmission of respiratory droplets during regular speech. In proof-of-principle studies, we compared a variety of commonly available mask types and observed that some mask types approach the performance of standard surgical masks, while some mask alternatives, such as neck gaiters or bandanas, offer very little protection. Our measurement setup is inexpensive and can be built and operated by nonexperts, allowing for rapid evaluation of mask performance during speech, sneezing, or coughing.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/prevention & control ; Filtration/statistics & numerical data ; Humans ; Masks/statistics & numerical data ; Optical Imaging ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Respiration ; SARS-CoV-2 ; Speech
Keywords	covid19
Language	English
Publishing date	2020-09-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abd3083
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Article ; Online: Fate of Environmental Proteins (eProteins) from Genetically Engineered Crops in Streams is Controlled by Water pH and Ecosystem Metabolism.

Brandão-Dias, Pedro F P / Rosi, Emma J / Shogren, Arial J / Tank, Jennifer L / Fischer, David T / Egan, Scott P

Environmental science & technology

2021 Volume 55, Issue 8, Page(s) 4688–4697

Abstract: Environmental proteins (eProteins), such as Cry proteins associated with genetically engineered (GE) organisms, are present in ecosystems worldwide, but only rarely reach concentrations with detectable ecosystem-level impacts. Despite their ubiquity, the ...

Abstract	Environmental proteins (eProteins), such as Cry proteins associated with genetically engineered (GE) organisms, are present in ecosystems worldwide, but only rarely reach concentrations with detectable ecosystem-level impacts. Despite their ubiquity, the degradation and fate of Cry and other eProteins are mostly unknown. Here, we report the results of an experiment where we added Cry proteins leached from GE Bt maize to a suite of 19 recirculating experimental streams. We found that Cry exhibited a biphasic degradation with an initial phase of rapid and variable degradation within 1 h, followed by a slow and steady phase of degradation with traces of protein persisting after 48 h. The initial degradation was correlated with heterotrophic respiration and water column dissolved oxygen, confirming a previously documented association with stream metabolism. However, protein degradation persisted even with no biofilm and was faster at a more acidic pH, suggesting that water chemistry is also a critical factor in both degradation and subsequent detection. We suggest that Cry, as well as other eProteins, will have a rapid degradation caused by denaturation of proteins and pH changes, which confirms that the detection of Cry proteins in natural streams must be the result of steady and consistent leaching into the environment.
MeSH term(s)	Bacillus thuringiensis Toxins ; Bacterial Proteins/genetics ; Ecosystem ; Endotoxins ; Hydrogen-Ion Concentration ; Plants, Genetically Modified ; Rivers ; Water/chemistry ; Zea mays
Chemical Substances	Bacillus thuringiensis Toxins ; Bacterial Proteins ; Endotoxins ; Water (059QF0KO0R)
Language	English
Publishing date	2021-03-23
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.0c05731
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Article: Disparities in Research during Plastic Surgery Training: How Can We Level the Playing Field?

Murphy, Alexander I / Mellia, Joseph A / Iaconetti, Emma K / Asadourian, Paul A / Diatta, Fortunay / Klifto, Kevin M / Morris, Martin P / Broach, Robyn B / Fischer, John P / Butler, Paris D

Plastic and reconstructive surgery. Global open

2022 Volume 10, Issue 5, Page(s) e4301

Abstract: Background: Lack of female and ethnically underrepresented in medicine (UIM) surgeons remains concerning in academic plastic surgery. One barrier to inclusion may be unequal opportunity to publish research. This study evaluates the extent of this ... ...

Abstract	Background: Lack of female and ethnically underrepresented in medicine (UIM) surgeons remains concerning in academic plastic surgery. One barrier to inclusion may be unequal opportunity to publish research. This study evaluates the extent of this challenge for plastic surgery trainees and identifies potential solutions. Methods: Data were collected on academic plastic surgeons' research productivity during training. Bivariate analysis compared publication measures between genders and race/ethnicities at different training stages (pre-residency/residency/clinical fellowship). Multivariate analysis determined training experiences independently associated with increased research productivity. Results: Overall, women had fewer total publications than men during training (8.89 versus 12.46, Conclusions: Less research productivity for female plastic surgery trainees may reflect a disparity in opportunity to publish. Fewer middle-author publications could indicate challenges with network-building in a predominately male field. Despite comparable research productivity during training relative to non- UIM individuals, UIM individuals remain underrepresented in academic plastic surgery. Creating research fellowships for targeting underrepresented groups could help overcome these challenges.
Language	English
Publishing date	2022-05-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2851682-5
ISSN	2169-7574 ; 2169-7574
ISSN (online)	2169-7574
ISSN	2169-7574
DOI	10.1097/GOX.0000000000004301
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Zs.A 7091: Show issues

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Article ; Online: Diabetes Rescue, Engagement and Management (D-REM)

Michelle A Lampman / Emma Behnken / Rozalina G McCoy / Lucas A Myers / Michael B Juntunen / Chad P Liedl / Peter N Carlson / Zachary R Stickler / Jill A Ryan Schultz / Angela K Meilander / M Carson Rogerson / Karen M Fischer

BMJ Open, Vol 12, Iss

rationale and design of a pragmatic clinical trial of a community paramedicine programme to improve diabetes care

2022 Volume 4

Keywords	Medicine ; R
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Low-cost measurement of face mask efficacy for filtering expelled droplets during speech

Fischer, Emma P / Fischer, Martin C / Grass, David / Henrion, Isaac / Warren, Warren S / Westman, Eric

Sci. Adv

Abstract	Mandates for mask use in public during the recent coronavirus disease 2019 (COVID-19) pandemic, worsened by global shortage of commercial supplies, have led to widespread use of homemade masks and mask alternatives. It is assumed that wearing such masks reduces the likelihood for an infected person to spread the disease, but many of these mask designs have not been tested in practice. We have demonstrated a simple optical measurement method to evaluate the efficacy of masks to reduce the transmission of respiratory droplets during regular speech. In proof-of-principle studies, we compared a variety of commonly available mask types and observed that some mask types approach the performance of standard surgical masks, while some mask alternatives, such as neck gaiters or bandanas, offer very little protection. Our measurement setup is inexpensive and can be built and operated by nonexperts, allowing for rapid evaluation of mask performance during speech, sneezing, or coughing.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #760209
Database	COVID19

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Article ; Online: Low-cost measurement of face mask efficacy for filtering expelled droplets during speech

Fischer, Emma P. / Fischer, Martin C. / Grass, David / Henrion, Isaac / Warren, Warren S. / Westman, Eric

Science Advances

2020 Volume 6, Issue 36, Page(s) eabd3083

Abstract	Mandates for mask use in public during the recent coronavirus disease 2019 (COVID-19) pandemic, worsened by global shortage of commercial supplies, have led to widespread use of homemade masks and mask alternatives. It is assumed that wearing such masks reduces the likelihood for an infected person to spread the disease, but many of these mask designs have not been tested in practice. We have demonstrated a simple optical measurement method to evaluate the efficacy of masks to reduce the transmission of respiratory droplets during regular speech. In proof-of-principle studies, we compared a variety of commonly available mask types and observed that some mask types approach the performance of standard surgical masks, while some mask alternatives, such as neck gaiters or bandanas, offer very little protection. Our measurement setup is inexpensive and can be built and operated by nonexperts, allowing for rapid evaluation of mask performance during speech, sneezing, or coughing.
Keywords	covid19
Language	English
Publisher	American Association for the Advancement of Science (AAAS)
Publishing country	us
Document type	Article ; Online
ZDB-ID	2810933-8
ISSN	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abd3083
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Diabetes Rescue, Engagement and Management (D-REM): rationale and design of a pragmatic clinical trial of a community paramedicine programme to improve diabetes care.

Juntunen, Michael B / Liedl, Chad P / Carlson, Peter N / Myers, Lucas A / Stickler, Zachary R / Ryan Schultz, Jill A / Meilander, Angela K / Behnken, Emma / Lampman, Michelle A / Rogerson, M Carson / Fischer, Karen M / McCoy, Rozalina G

BMJ open

2022 Volume 12, Issue 4, Page(s) e057224

Abstract: Introduction: Diabetes is one of the most common serious chronic health conditions in the USA. People living with diabetes face multiple barriers to optimal diabetes care, including gaps in access to medical care and self-management education, diabetes ... ...

Abstract	Introduction: Diabetes is one of the most common serious chronic health conditions in the USA. People living with diabetes face multiple barriers to optimal diabetes care, including gaps in access to medical care and self-management education, diabetes distress, and high burden of treatment. Community paramedics (CPs) are uniquely positioned to support multidisciplinary care for patients with diabetes by delivering focused diabetes self-management education and support and bridging the gaps between patients and the clinical and community resources they need to live well with their disease. Methods and analysis: We will conduct a pragmatic single-arm prospective trial of a CP-led Diabetes Rescue, Engagement and Management (D-REM) programme that seeks to reduce diabetes distress. We will enrol 70 adults (≥18 years) with diabetes who have haemoglobin A1c (HbA1c)≥9.0%, experienced an emergency department (ED) visit or hospitalisation for any cause within the prior 6 months, and reside in areas with available CP support in Southeast Minnesota (Olmsted, Freeborn and Mower counties) and Northwest Wisconsin (Barron, Rusk and Dunn counties). Participants will be identified using Mayo Clinic electronic health records, contacted for consent and enrolled into the D-REM programme. Visit frequency will be individualised for each patient, but will be an average of four CP visits over the course of approximately 1 month. Outcomes will be change in diabetes distress (primary outcome), confidence in diabetes self-management, health-related quality of life, self-reported hypoglycaemia and hyperglycaemia, HbA1c, ED visits and hospitalisations. Outcomes will be assessed on enrolment, programme completion and 3 months after programme completion. Ethics and dissemination: The study was approved by Mayo Clinic Institutional Review Board. Findings will be disseminated through peer-reviewed publications and presentations. If demonstrated to be successful, this model of care can be implemented across diverse settings and populations to support patients living with diabetes. Trial registration number: NCT04385758.
MeSH term(s)	Adult ; Diabetes Mellitus/therapy ; Glycated Hemoglobin A ; Humans ; Pragmatic Clinical Trials as Topic ; Prospective Studies ; Quality of Life ; Self-Management
Chemical Substances	Glycated Hemoglobin A
Language	English
Publishing date	2022-04-21
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-057224
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