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Article ; Online: Fibrinolytic Therapy to Reduce Microvascular Obstruction After Myocardial Infarction-Reply.

Berry, Colin / McCartney, Peter J / Maznyczka, Annette M

2019 Volume 321, Issue 20, Page(s) 2033–2034

MeSH term(s)	Humans ; Myocardial Infarction ; Thrombolytic Therapy
Language	English
Publishing date	2019-05-23
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2019.2784
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Article ; Online: Redefining successful primary PCI.

McCartney, Peter J / Berry, Colin

European heart journal. Cardiovascular Imaging

2018 Volume 20, Issue 2, Page(s) 133–135

MeSH term(s)	Coronary Occlusion ; Humans ; Percutaneous Coronary Intervention ; Prognosis ; ST Elevation Myocardial Infarction
Language	English
Publishing date	2018-12-10
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	2638345-7
ISSN	2047-2412 ; 2047-2404
ISSN (online)	2047-2412
ISSN	2047-2404
DOI	10.1093/ehjci/jey159
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Article ; Online: Femoral Vein Thrombus Diagnosed during Ultrasound-guided Femoral Nerve Catheter Placement.

Sullivan, Timothy R / Rose, Peter / McCartney, Colin J L

Anesthesiology

2019 Volume 131, Issue 2, Page(s) 400

MeSH term(s)	Catheterization, Central Venous ; Femoral Nerve ; Femoral Vein/diagnostic imaging ; Femoral Vein/pathology ; Humans ; Incidental Findings ; Ultrasonography, Interventional/methods ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/pathology
Language	English
Publishing date	2019-05-02
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	269-0
ISSN	1528-1175 ; 0003-3022
ISSN (online)	1528-1175
ISSN	0003-3022
DOI	10.1097/ALN.0000000000002754
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Article: Effects of Cannabidiol on Exercise Physiology and Bioenergetics: A Randomised Controlled Pilot Trial.

Sahinovic, Ayshe / Irwin, Christopher / Doohan, Peter T / Kevin, Richard C / Cox, Amanda J / Lau, Namson S / Desbrow, Ben / Johnson, Nathan A / Sabag, Angelo / Hislop, Matthew / Haber, Paul S / McGregor, Iain S / McCartney, Danielle

Sports medicine - open

2022 Volume 8, Issue 1, Page(s) 27

Abstract: Background: Cannabidiol (CBD) has demonstrated anti-inflammatory, analgesic, anxiolytic and neuroprotective effects that have the potential to benefit athletes. This pilot study investigated the effects of acute, oral CBD treatment on physiological and ... ...

Abstract	Background: Cannabidiol (CBD) has demonstrated anti-inflammatory, analgesic, anxiolytic and neuroprotective effects that have the potential to benefit athletes. This pilot study investigated the effects of acute, oral CBD treatment on physiological and psychological responses to aerobic exercise to determine its practical utility within the sporting context. Methods: On two occasions, nine endurance-trained males (mean ± SD V̇O Results: CBD appeared to increase V̇O Conclusion: CBD appears to alter some key physiological and psychological responses to aerobic exercise without impairing performance. Larger studies are required to confirm and better understand these preliminary findings. Trial Registration This investigation was approved by the Sydney Local Health District's Human Research Ethics Committee (2020/ETH00226) and registered with the Australia and New Zealand Clinical Trials Registry (ACTRN12620000941965).
Language	English
Publishing date	2022-03-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2809942-4
ISSN	2198-9761 ; 2199-1170
ISSN (online)	2198-9761
ISSN	2199-1170
DOI	10.1186/s40798-022-00417-y
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Article: Coronary perforation incidence, outcomes and temporal trends (COPIT): a systematic review and meta-analysis.

Mikhail, Philopatir / Howden, Nicklas / Monjur, Mohammad / Jeyaprakash, Prajith / Said, Christian / Bland, Adam / Collison, Damien / McCartney, Peter / Adamson, Carly / Morrow, Andrew / Carrick, David / McEntegart, Margaret / Ford, Thomas J

Open heart

2022 Volume 9, Issue 2

Abstract: Coronary perforation is a potentially life-threatening complication of percutaneous coronary intervention (PCI). We studied incidence, outcomes and temporal trends following PCI-related coronary artery perforation (CAP).: Methods: Prospective ... ...

Abstract	Coronary perforation is a potentially life-threatening complication of percutaneous coronary intervention (PCI). We studied incidence, outcomes and temporal trends following PCI-related coronary artery perforation (CAP). Methods: Prospective systematic review and meta-analysis including meta-regression using MEDLINE and EMBASE to November 2020. We included 'all-comer' PCI cohorts including large PCI registries and randomised controlled trials and excluding registries or trials limited to PCI in high-risk populations such as chronic total occlusion PCI or cohorts treated only with atheroablative devices. Regression analysis and corresponding correlation coefficients were performed comparing perforation incidence, mortality rate, tamponade rate and the rate of Ellis III perforations against the midpoint (year) of data collection to determine if a significant temporal relationship was present. Results: 3997 studies were screened for inclusion. 67 studies met eligibility criteria with a total of 5 568 191 PCIs included over a 38-year period (1982-2020). The overall pooled incidence of perforation was 0.39% (95% CI 0.34% to 0.45%) and remained similar throughout the study period. Around 1 in 5 coronary perforations led to tamponade (21.1%). Ellis III perforations are increasing in frequency and account for 43% of all perforations. Perforation mortality has trended lower over the years (7.5%; 95% CI 6.7% to 8.4%). Perforation risk factors derived using meta-regression were female sex, hypertension, chronic kidney disease and previous coronary bypass grafting. Coronary perforation was most frequently caused by distal wire exit (37%) followed by balloon dilation catheters (28%). Covered stents were used to treat 25% of perforations, with emergency cardiac surgery needed in 17%. Conclusion: Coronary perforation complicates approximately 1 in 250 PCIs. Ellis III perforations are increasing in incidence although it is unclear whether this is due to reporting bias. Despite this, the overall perforation mortality rate (7.5%) has trended lower in recent years. Limitations of our findings include bias that may be introduced through analysis of multidesign studies and registries without pre-specified standardised perforation reporting CMore research into coronary perforation management including the optimal use of covered stents seems warranted. Prospero registration number: CRD42020207881.
MeSH term(s)	Female ; Humans ; Male ; Percutaneous Coronary Intervention/adverse effects ; Incidence ; Prospective Studies ; Heart Injuries/epidemiology ; Heart Injuries/therapy ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery
Language	English
Publishing date	2022-10-21
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2747269-3
ISSN	2053-3624
ISSN	2053-3624
DOI	10.1136/openhrt-2022-002076
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Article ; Online: FRET-Based Assays to Determine Calpain Activity.

McCartney, Christian-Scott E / Davies, Peter L

Methods in molecular biology (Clifton, N.J.)

2019 Volume 1915, Page(s) 39–55

Abstract: Calpains are signaling proteases that have relatively little sequence specificity but some preferences for certain residues on either side of the scissile bond. As with most proteases, they mainly cut unstructured or extended regions of their target ... ...

Abstract	Calpains are signaling proteases that have relatively little sequence specificity but some preferences for certain residues on either side of the scissile bond. As with most proteases, they mainly cut unstructured or extended regions of their target proteins. The tendency for concentrated calpain to rapidly autoproteolyze when activated by calcium complicates the kinetic assessment of calpain activity. As calpain autoproteolyzes, the amount of fully active enzyme continuously decreases until all of the calpain molecules have been cut and their activity reduced to a tiny fraction of the starting rate. To accurately measure calpain kinetics, only the initial rate of substrate hydrolysis, where autoproteolysis is minimal, can be used. To accomplish this, a method for rapid, quantifiable determination of substrate cleavage is required. Many of the existing assays are lacking in their sensitivity to accurately quantify calpain activity within this timeframe. However, the FRET peptide substrates developed by Cuerrier et al. have been shown to have sufficiently high affinity between substrate and enzyme to accurately measure the initial enzyme reaction velocity at substrate concentrations above the K
MeSH term(s)	Amino Acid Sequence/genetics ; Biological Assay/methods ; Calcium/chemistry ; Calpain/chemistry ; Calpain/genetics ; Calpain/isolation & purification ; Fluorescence Resonance Energy Transfer/methods ; Hydrolysis ; Kinetics ; Peptides/chemistry ; Proteolysis ; Substrate Specificity
Chemical Substances	Peptides ; Calpain (EC 3.4.22.-) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2019-01-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-8988-1_4
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Article ; Online: Bacterial Expression and Purification of Calpains.

McCartney, Christian-Scott E / Davies, Peter L

Methods in molecular biology (Clifton, N.J.)

2019 Volume 1915, Page(s) 13–27

Abstract: The production of recombinant proteins has been a cornerstone of the study of protein structure and function. As an example, the expression and purification of recombinant rat calpain-2 in bacteria was essential for solving the first crystal structures ... ...

Abstract	The production of recombinant proteins has been a cornerstone of the study of protein structure and function. As an example, the expression and purification of recombinant rat calpain-2 in bacteria was essential for solving the first crystal structures of the calpains in both calcium-free and calcium-bound forms. Here we describe the production and purification of recombinant rat calpain-2 from Escherichia coli using anion-exchange, affinity, and size-exclusion chromatographies. The heterodimeric enzyme is produced from a stable two-plasmid system. The order in which the protocol is carried out has been optimized to reduce unnecessary concentration and dialysis steps. The typical yield of this multi-domain enzyme from 4 L of E. coli culture is about 20 mg. The production of whole structures for the other calpain family members has been fraught with difficulty. To circumvent this roadblock, a certain amount of structure-function information can be gleaned about these other calpain isoforms by expressing just their protease core. These "mini-calpains" have been useful for X-ray co-crystallography with calpain inhibitors.Here we also present a variation of the whole enzyme production and purification protocol optimized for the expression and purification of the calpain-1 and calpain-3 protease cores (mini-calpains).
MeSH term(s)	Animals ; Calcium/chemistry ; Calpain/biosynthesis ; Calpain/chemistry ; Calpain/genetics ; Calpain/isolation & purification ; Chromatography, Gel/methods ; Crystallography, X-Ray ; Escherichia coli/genetics ; Gene Expression/genetics ; Molecular Biology/methods ; Rats ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics
Chemical Substances	Recombinant Proteins ; Calpain (EC 3.4.22.-) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2019-01-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-8988-1_2
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Article ; Online: Coronary Artery Perforations: Glasgow Natural History Study of Covered Stent Coronary Interventions (GNOCCI) Study.

Ford, Thomas J / Adamson, Carly / Morrow, Andrew J / Rocchiccioli, Paul / Collison, Damien / McCartney, Peter J / Shaukat, Aadil / Lindsay, Mitchell / Good, Richard / Watkins, Stuart / Eteiba, Hany / Robertson, Keith / Berry, Colin / Oldroyd, Keith G / McEntegart, Margaret

Journal of the American Heart Association

2022 Volume 11, Issue 19, Page(s) e024492

Abstract: Background The objective of the GNOCCI (Glasgow Natural History Study of Covered Stent Coronary Interventions) Study was to report the incidence and outcomes of coronary artery perforations over an 18-year period at a single, high-volume percutaneous ... ...

Abstract	Background The objective of the GNOCCI (Glasgow Natural History Study of Covered Stent Coronary Interventions) Study was to report the incidence and outcomes of coronary artery perforations over an 18-year period at a single, high-volume percutaneous coronary intervention center. We considered both the temporal trends and long-term outcomes of covered stent deployment. Methods and Results We evaluated procedural and long-term clinical outcomes following coronary perforation in a cohort of 43,343 consecutive percutaneous coronary intervention procedures. Procedural major adverse cardiac events were defined as a composite of death, myocardial infarction, stroke, target vessel revascularization, or cardiac surgery within 24 hours. A total of 161 (0.37%) procedures were complicated by coronary perforation of which 57 (35%) were Ellis grade III. Incidence increased with time over the study period (
MeSH term(s)	Coronary Artery Disease/complications ; Coronary Artery Disease/surgery ; Heart Injuries ; Humans ; Percutaneous Coronary Intervention ; Prosthesis Design ; Risk Factors ; Stents/adverse effects ; Thrombosis/etiology ; Treatment Outcome ; Vascular System Injuries/etiology
Language	English
Publishing date	2022-09-21
Publishing country	England
Document type	Clinical Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.121.024492
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Article ; Online: Correction: Epigenetic scores for the circulating proteome as tools for disease prediction.

Gadd, Danni A / Hillary, Robert F / McCartney, Daniel L / Zaghlool, Shaza B / Stevenson, Anna J / Cheng, Yipeng / Fawns-Ritchie, Chloe / Nangle, Cliff / Campbell, Archie / Flaig, Robin / Harris, Sarah E / Walker, Rosie M / Shi, Liu / Tucker-Drob, Elliot M / Gieger, Christian / Peters, Annette / Waldenberger, Melanie / Graumann, Johannes / McRae, Allan F /

Deary, Ian J / Porteous, David J / Hayward, Caroline / Visscher, Peter M / Cox, Simon R / Evans, Kathryn L / McIntosh, Andrew M / Suhre, Karsten / Marioni, Riccardo E

eLife

2023 Volume 12

Language	English
Publishing date	2023-11-20
Publishing country	England
Document type	Published Erratum
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.94481
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Article ; Online: Creating and Validating a DNA Methylation-Based Proxy for Interleukin-6.

Stevenson, Anna J / Gadd, Danni A / Hillary, Robert F / McCartney, Daniel L / Campbell, Archie / Walker, Rosie M / Evans, Kathryn L / Harris, Sarah E / Spires-Jones, Tara L / McRae, Allan F / Visscher, Peter M / McIntosh, Andrew M / Deary, Ian J / Marioni, Riccardo E

The journals of gerontology. Series A, Biological sciences and medical sciences

2022 Volume 76, Issue 12, Page(s) 2284–2292

Abstract: Background: Studies evaluating the relationship between chronic inflammation and cognitive functioning have produced heterogeneous results. A potential reason for this is the variability of inflammatory mediators which could lead to misclassifications ... ...

Abstract	Background: Studies evaluating the relationship between chronic inflammation and cognitive functioning have produced heterogeneous results. A potential reason for this is the variability of inflammatory mediators which could lead to misclassifications of individuals' persisting levels of inflammation. DNA methylation (DNAm) has shown utility in indexing environmental exposures and could be leveraged to provide proxy signatures of chronic inflammation. Method: We conducted an elastic net regression of interleukin-6 (IL-6) in a cohort of 875 older adults (Lothian Birth Cohort 1936; mean age: 70 years) to develop a DNAm-based predictor. The predictor was tested in an independent cohort (Generation Scotland; N = 7028 [417 with measured IL-6], mean age: 51 years). Results: A weighted score from 35 CpG sites optimally predicted IL-6 in the independent test set (Generation Scotland; R2 = 4.4%, p = 2.1 × 10-5). In the independent test cohort, both measured IL-6 and the DNAm proxy increased with age (serum IL-6: n = 417, β = 0.02, SE = 0.004, p = 1.3 × 10-7; DNAm IL-6 score: N = 7028, β = 0.02, SE = 0.0009, p < 2 × 10-16). Serum IL-6 did not associate with cognitive ability (n = 417, β = -0.06, SE = 0.05, p = .19); however, an inverse association was identified between the DNAm score and cognitive functioning (N = 7028, β = -0.16, SE = 0.02, pFDR < 2 × 10-16). Conclusions: These results suggest methylation-based predictors can be used as proxies for inflammatory markers, potentially allowing for further insight into the relationship between inflammation and pertinent health outcomes.
MeSH term(s)	Aged ; Cognition ; Cohort Studies ; DNA Methylation ; Epigenesis, Genetic ; Humans ; Inflammation/genetics ; Interleukin-6/genetics ; Middle Aged
Chemical Substances	Interleukin-6
Language	English
Publishing date	2022-03-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/glab046
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