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  1. Article: Training in Radiation and Clinical Oncology in Europe.

    Lara, Pedro C / Benstead, Kim / Erikssen, Jesper Grau

    Journal of medical education and curricular development

    2023  Volume 10, Page(s) 23821205231197982

    Abstract: The European population is strongly affected by cancer. Radiotherapy is roughly used in 50% of cancer patients in European countries. The increased cancer burden demands a new generation of radiation/clinical oncologist (RO/CO) that, besides a strong ... ...

    Abstract The European population is strongly affected by cancer. Radiotherapy is roughly used in 50% of cancer patients in European countries. The increased cancer burden demands a new generation of radiation/clinical oncologist (RO/CO) that, besides a strong evidence-based oncological knowledge, will be ready for leadership in cancer care. The mutual recognition of professional qualifications of Radiation/Clinical Oncology in the EU needs training harmonization. The European Society of Radiotherapy and Oncology (ESTRO) and the European Union for Medical Specialties (UEMS) made important efforts toward a European Common Curriculum for RO/CO leadership in cancer care. If qualifications are mutually recognized, the training supporting these qualifications should be also harmonized. Since 1991, ESTRO produced several editions of the Core Curriculum in Radiation Oncology (1991, 2004, 2012, 2019). These Core Curricula were endorsed as European Training Requirements by the UEMS in 2004, 2013, and 2019. A core curriculum for clinical oncology was also produced to provide this harmonization tool to countries where radiation oncology is practiced inside the broader specialty of clinical oncology. New initiatives are in place to continuously adapt the training programs to the rapidly evolving cancer care organization.
    Language English
    Publishing date 2023-09-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2798123-X
    ISSN 2382-1205
    ISSN 2382-1205
    DOI 10.1177/23821205231197982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Combined Ultrahypofractionated Whole-Breast Irradiation and IORT-Boost: A Safety and Feasibility Analysis.

    Burgos-Burgos, Javier / Vega, Víctor / Macias-Verde, David / Gómez, Virginia / Vicente, Elena / Murias, Carmen / Santana, Carlos / Lara, Pedro C

    Cancers

    2024  Volume 16, Issue 6

    Abstract: Background: The current standard of local treatment for patients with localized breast cancer (BC) includes whole breast irradiation (WBI) after breast-conserving surgery (BCS). Ultrahypofractionated WBI schemes (1-week treatment) were shown not to be ... ...

    Abstract Background: The current standard of local treatment for patients with localized breast cancer (BC) includes whole breast irradiation (WBI) after breast-conserving surgery (BCS). Ultrahypofractionated WBI schemes (1-week treatment) were shown not to be inferior to the standard WBI. Tumor bed boost using photon intraoperative radiotherapy (IORT) is safe and feasible in combination with standard WBI. The aim of the present study is to assess, for the first time, the feasibility and safety of combining photon IORT with ultrahypofractionated WBI.
    Methods: Patients diagnosed with low-risk early BC candidates for BCS were included in this prospective study. IORT was administered at a dose of 20 Gy to the surface's applicator, and WBI was administered 3-5 weeks after surgery at a total dose of 26 Gy in five consecutive days.
    Results: From July 2020 to December 2022, seventy-two patients diagnosed with low-risk early BC and treated in our institution were included in this prospective study. All patients completed the proposed treatment, and no severe acute or late grade 3 toxicity was observed 3 and 12 months after WBI, respectively.
    Conclusions: Our results confirm for the first time that the combination of ultrafractionation WBI and photon-IORT after BCS is a feasible and safe option in patients with early BC.
    Language English
    Publishing date 2024-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16061105
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  3. Article ; Online: Pretreatment inflammatory indices predict Bevacizumab response in recurrent Glioma.

    Martínez-González, Alicia / Cabrera, Raquel / Lloret, Marta / Lara, Pedro C

    Cancer drug resistance (Alhambra, Calif.)

    2020  Volume 3, Issue 3, Page(s) 623–635

    Abstract: ... ...

    Abstract Aim
    Language English
    Publishing date 2020-08-07
    Publishing country United States
    Document type Journal Article
    ISSN 2578-532X
    ISSN (online) 2578-532X
    DOI 10.20517/cdr.2020.33
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  4. Article: Ten-Year Results of Accelerated Partial-Breast Irradiation with Interstitial Multicatheter Brachytherapy after Breast-Conserving Surgery for Low-Risk Early Breast Cancer.

    Rodríguez-Ibarria, Nieves G / Pinar, Beatriz / García, Laura / Cabezón, Auxiliadora / Rey-Baltar, Dolores / Rodríguez-Melcón, Juan Ignacio / Lloret, Marta / Lara, Pedro C

    Cancers

    2024  Volume 16, Issue 6

    Abstract: Patients with an early carcinoma of the breast are commonly treated by breast-conserving surgery (BCS) and postoperative radiotherapy. Partial-breast irradiation has gained acceptance in the last few years. Between December 2008 and December 2017, 182 ... ...

    Abstract Patients with an early carcinoma of the breast are commonly treated by breast-conserving surgery (BCS) and postoperative radiotherapy. Partial-breast irradiation has gained acceptance in the last few years. Between December 2008 and December 2017, 182 low-risk breast cancer patients treated by BCS in the four university hospitals of the province of Las Palmas and treated with APBI using interstitial multicatheter brachytherapy were included in this study. After a mean follow-up for survivors of 10 years, the treatment was shown to be safe, as no severe acute/late toxicity (grade ≥ 3) was observed. The 10-year IBTR was 1.7% (95%CI: 0.7-2.7%), and the cause-specific survival was 94.9% (95%CI: 93.2-96.6%). We suggest that multicatheter brachytherapy after BCS is safe and effective in early breast cancer patients.
    Language English
    Publishing date 2024-03-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16061138
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  5. Article ; Online: An Experimental Review on Deep Learning Architectures for Time Series Forecasting.

    Lara-Benítez, Pedro / Carranza-García, Manuel / Riquelme, José C

    International journal of neural systems

    2021  Volume 31, Issue 3, Page(s) 2130001

    Abstract: In recent years, deep learning techniques have outperformed traditional models in many machine learning tasks. Deep neural networks have successfully been applied to address time series forecasting problems, which is a very important topic in data mining. ...

    Abstract In recent years, deep learning techniques have outperformed traditional models in many machine learning tasks. Deep neural networks have successfully been applied to address time series forecasting problems, which is a very important topic in data mining. They have proved to be an effective solution given their capacity to automatically learn the temporal dependencies present in time series. However, selecting the most convenient type of deep neural network and its parametrization is a complex task that requires considerable expertise. Therefore, there is a need for deeper studies on the suitability of all existing architectures for different forecasting tasks. In this work, we face two main challenges: a comprehensive review of the latest works using deep learning for time series forecasting and an experimental study comparing the performance of the most popular architectures. The comparison involves a thorough analysis of seven types of deep learning models in terms of accuracy and efficiency. We evaluate the rankings and distribution of results obtained with the proposed models under many different architecture configurations and training hyperparameters. The datasets used comprise more than 50,000 time series divided into 12 different forecasting problems. By training more than 38,000 models on these data, we provide the most extensive deep learning study for time series forecasting. Among all studied models, the results show that long short-term memory (LSTM) and convolutional networks (CNN) are the best alternatives, with LSTMs obtaining the most accurate forecasts. CNNs achieve comparable performance with less variability of results under different parameter configurations, while also being more efficient.
    MeSH term(s) Deep Learning ; Forecasting ; Machine Learning ; Memory, Long-Term ; Neural Networks, Computer
    Language English
    Publishing date 2021-02-16
    Publishing country Singapore
    Document type Journal Article ; Review
    ISSN 1793-6462
    ISSN (online) 1793-6462
    DOI 10.1142/S0129065721300011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Low dose lung radiotherapy for COVID-19 pneumonia. The rationale for a cost-effective anti-inflammatory treatment.

    Lara, Pedro C / Burgos, Javier / Macias, David

    Clinical and translational radiation oncology

    2020  Volume 23, Page(s) 27–29

    Abstract: The COVID-19 pandemia is affecting people worldwide. Most of the patients suffered of a respiratory disease that will progress to an acute respiratory distress syndrome (ARDS). SARS-CoV-2 pneumonia severely ill patients, develop a systemic inflammatory ... ...

    Abstract The COVID-19 pandemia is affecting people worldwide. Most of the patients suffered of a respiratory disease that will progress to an acute respiratory distress syndrome (ARDS). SARS-CoV-2 pneumonia severely ill patients, develop a systemic inflammatory response with a Cytokine Release Syndrome (CRS), that is characterized by a sudden increase in several pro-inflammatory cytokines, mainly IL-1, IL-6 and TNF-alfa by activated macrophages (M1 phenotype). Blocking IL-6 with tocilizumab and using respirator equipment seems to be a very important issue in this (SARS-CoV-2) pneumonia, but not all patients are referred to such treatments. Low dose radiotherapy (0,5 Gy), is an evidence-based anti-inflammatory treatment, that could modify the immune landscape in the lung affected of SARS-CoV-2 pneumonia, through macrophages polarization to alternatively activated Macrophages (M2 phenotype). Radiation-induced cancer risk could be assumed due to the very low dose used, the advanced age of the patients and the life-threatening condition of SARS-Cov2 pneumonia. LDRT is a cost-effective non-toxic treatment already available in most general hospitals. This fact allows that it would be used for the large number of patients that will suffer this disease, and that would not receive specific anti-IL-6 treatments in ICUs in low and middle income countries.
    Keywords covid19
    Language English
    Publishing date 2020-04-25
    Publishing country Ireland
    Document type Journal Article
    ISSN 2405-6308
    ISSN (online) 2405-6308
    DOI 10.1016/j.ctro.2020.04.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Expansion of the cytochrome C oxidase subunit I database and description of four new lobose testate amoebae species (Amoebozoa; Arcellinida).

    Ribeiro, Giulia M / Useros, Fernando / Dumack, Kenneth / González-Miguéns, Rubén / Siemensma, Ferry / Porfírio-Sousa, Alfredo L / Soler-Zamora, Carmen / Pedro Barbosa Alcino, João / Lahr, Daniel J G / Lara, Enrique

    European journal of protistology

    2023  Volume 91, Page(s) 126013

    Abstract: Arcellinida is ascending in importance in protistology, but description of their diversity still presents multiple challenges. Furthermore, applicable tools for surveillance of these organisms are still in developing stages. Importantly, a good database ... ...

    Abstract Arcellinida is ascending in importance in protistology, but description of their diversity still presents multiple challenges. Furthermore, applicable tools for surveillance of these organisms are still in developing stages. Importantly, a good database that sets a correspondence between molecular barcodes and species morphology is lacking. Cytochrome oxidase (COI) has been suggested as the most relevant marker for species discrimination in Arcellinida. However, some major groups of Arcellinida are still lacking a COI sequence. Here we expand the database of COI marker sequences for Arcellinids, using single-cell PCR, transcriptomics, and database scavenging. In the present work, we added 24 new Arcellinida COI sequences to the database, covering all unsampled infra- and suborders. Additionally, we added six new SSUrRNA sequences and described four new species using morphological, morphometrical, and molecular evidence: Heleopera steppica, Centropyxis blatta, Arcella uspiensis, and Cylindrifflugia periurbana. This new database will provide a new starting point to address new research questions from shell evolution, biogeography, and systematics of arcellinids.
    MeSH term(s) Amoeba ; Electron Transport Complex IV/genetics ; Phylogeny ; Amoebozoa ; Lobosea
    Chemical Substances Electron Transport Complex IV (EC 1.9.3.1)
    Language English
    Publishing date 2023-08-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2047872-0
    ISSN 1618-0429 ; 0932-4739
    ISSN (online) 1618-0429
    ISSN 0932-4739
    DOI 10.1016/j.ejop.2023.126013
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  8. Article ; Online: Low dose lung radiotherapy for COVID-19 pneumonia. The rationale for a cost-effective anti-inflammatory treatment

    Lara, Pedro C. / Burgos, Javier / Macias, David

    Clinical and Translational Radiation Oncology

    2020  Volume 23, Page(s) 27–29

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2405-6308
    DOI 10.1016/j.ctro.2020.04.006
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Low dose lung radiotherapy for COVID-19 pneumonia. The rationale for a cost-effective anti-inflammatory treatment

    Pedro C. Lara / Javier Burgos / David Macias

    Clinical and Translational Radiation Oncology, Vol 23, Iss , Pp 27-

    2020  Volume 29

    Abstract: The COVID-19 pandemia is affecting people worldwide. Most of the patients suffered of a respiratory disease that will progress to an acute respiratory distress syndrome (ARDS). SARS-CoV-2 pneumonia severely ill patients, develop a systemic inflammatory ... ...

    Abstract The COVID-19 pandemia is affecting people worldwide. Most of the patients suffered of a respiratory disease that will progress to an acute respiratory distress syndrome (ARDS). SARS-CoV-2 pneumonia severely ill patients, develop a systemic inflammatory response with a Cytokine Release Syndrome (CRS), that is characterized by a sudden increase in several pro-inflammatory cytokines, mainly IL-1, IL-6 and TNF-alfa by activated macrophages (M1 phenotype). Blocking IL-6 with tocilizumab and using respirator equipment seems to be a very important issue in this (SARS-CoV-2) pneumonia, but not all patients are referred to such treatments.Low dose radiotherapy (0,5 Gy), is an evidence-based anti-inflammatory treatment, that could modify the immune landscape in the lung affected of SARS-CoV-2 pneumonia, through macrophages polarization to alternatively activated Macrophages (M2 phenotype). Radiation-induced cancer risk could be assumed due to the very low dose used, the advanced age of the patients and the life-threatening condition of SARS-Cov2 pneumonia.LDRT is a cost-effective non-toxic treatment already available in most general hospitals. This fact allows that it would be used for the large number of patients that will suffer this disease, and that would not receive specific anti-IL-6 treatments in ICUs in low and middle income countries.
    Keywords COVID-19 pneumonia ; Low dose radiotherapy ; Lung ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Critical Velocity, Maximal Lactate Steady State, and Muscle MCT1 and MCT4 after Exhaustive Running in Mice.

    Orsi, Juan B / Araujo, Lara S / Scariot, Pedro P M / Polisel, Emanuel E C / Cardoso, Luisa O / Gobatto, Claudio A / Manchado-Gobatto, Fúlvia B

    International journal of molecular sciences

    2023  Volume 24, Issue 21

    Abstract: ... into two groups (exercised-E and control-C). Group E was submitted to a CV protocol (4 days), using linear ( ...

    Abstract Although the critical velocity (CV) protocol has been used to determine the aerobic capacity in rodents, there is a lack of studies that compare CV with maximal lactate steady state intensity (iMLSS) in mice. As a consequence, their physiological and molecular responses after exercise until exhaustion at CV intensity remain unclear. Thus, we aimed to compare and correlate CV with iMLSS in running mice, following different mathematical models for CV estimation. We also evaluated their physiological responses and muscle MCT1 and MCT4 after running until exhaustion at CV. Thirty C57BL/6J mice were divided into two groups (exercised-E and control-C). Group E was submitted to a CV protocol (4 days), using linear (
    MeSH term(s) Mice ; Animals ; Lactic Acid ; Mice, Inbred C57BL ; Muscle, Skeletal/physiology ; Symporters ; Liver ; Monocarboxylic Acid Transporters
    Chemical Substances Lactic Acid (33X04XA5AT) ; Symporters ; Monocarboxylic Acid Transporters
    Language English
    Publishing date 2023-10-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242115753
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