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  1. Article ; Online: A

    Spinaci, Andrea / Lambertucci, Catia / Buccioni, Michela / Dal Ben, Diego / Graiff, Claudia / Barbalace, Maria Cristina / Hrelia, Silvana / Angeloni, Cristina / Tayebati, Seyed Khosrow / Ubaldi, Massimo / Masi, Alessio / Klotz, Karl-Norbert / Volpini, Rosaria / Marucci, Gabriella

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 8

    Abstract: ... The ... ...

    Abstract The A
    MeSH term(s) Adenosine A2 Receptor Antagonists/chemistry ; Adenosine A2 Receptor Antagonists/pharmacology ; Purinergic P1 Receptor Antagonists/pharmacology ; Purines/chemistry ; Receptor, Adenosine A2A/metabolism ; Structure-Activity Relationship
    Chemical Substances Adenosine A2 Receptor Antagonists ; Purinergic P1 Receptor Antagonists ; Purines ; Receptor, Adenosine A2A ; purine (W60KTZ3IZY)
    Language English
    Publishing date 2022-04-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27082386
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    Zs.MO 81: Show issues

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  2. Article: Role of Endothelial Cell Metabolism in Normal and Tumor Vasculature.

    D'Alessio, Alessio

    Cancers

    2023  Volume 15, Issue 7

    Abstract: Endothelial cells (ECs) form a simple squamous epithelium, the endothelium, which lines the lumen of all blood vessels and the heart [ ... ]. ...

    Abstract Endothelial cells (ECs) form a simple squamous epithelium, the endothelium, which lines the lumen of all blood vessels and the heart [...].
    Language English
    Publishing date 2023-03-23
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15071921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Unraveling the Cave: A Seventy-Year Journey into the Caveolar Network, Cellular Signaling, and Human Disease.

    D'Alessio, Alessio

    Cells

    2023  Volume 12, Issue 23

    Abstract: In the mid-1950s, a groundbreaking discovery revealed the fascinating presence of caveolae, referred to as flask-shaped invaginations of the plasma membrane, sparking renewed excitement in the field of cell biology. Caveolae are small, flask-shaped ... ...

    Abstract In the mid-1950s, a groundbreaking discovery revealed the fascinating presence of caveolae, referred to as flask-shaped invaginations of the plasma membrane, sparking renewed excitement in the field of cell biology. Caveolae are small, flask-shaped invaginations in the cell membrane that play crucial roles in diverse cellular processes, including endocytosis, lipid homeostasis, and signal transduction. The structural stability and functionality of these specialized membrane microdomains are attributed to the coordinated activity of scaffolding proteins, including caveolins and cavins. While caveolae and caveolins have been long appreciated for their integral roles in cellular physiology, the accumulating scientific evidence throughout the years reaffirms their association with a broad spectrum of human disorders. This review article aims to offer a thorough account of the historical advancements in caveolae research, spanning from their initial discovery to the recognition of caveolin family proteins and their intricate contributions to cellular functions. Furthermore, it will examine the consequences of a dysfunctional caveolar network in the development of human diseases.
    MeSH term(s) Humans ; Caveolae/metabolism ; Caveolins/metabolism ; Cell Membrane/metabolism ; Membrane Microdomains/metabolism ; Signal Transduction
    Chemical Substances Caveolins
    Language English
    Publishing date 2023-11-22
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12232680
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  4. Article ; Online: The long and winding road: Adjuvant therapy for early-stage hepatocellular carcinoma.

    D'Alessio, Antonio / Rimassa, Lorenza

    Med (New York, N.Y.)

    2024  Volume 5, Issue 1, Page(s) 7–9

    Abstract: Despite being the first positive phase 3 trial in the adjuvant setting for early-stage hepatocellular carcinoma, the IMbrave050 study raises a number of questions regarding patient selection, endpoint robustness, and the balance between efficacy and ... ...

    Abstract Despite being the first positive phase 3 trial in the adjuvant setting for early-stage hepatocellular carcinoma, the IMbrave050 study raises a number of questions regarding patient selection, endpoint robustness, and the balance between efficacy and acceptable toxicity.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/pathology ; Combined Modality Therapy ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Clinical Trials, Phase III as Topic
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ISSN 2666-6340
    ISSN (online) 2666-6340
    DOI 10.1016/j.medj.2023.11.004
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  5. Article ; Online: Personalized Screening in the Age of Acceleration.

    Morris, Elizabeth A / D'Alessio, Donna

    Journal of breast imaging

    2024  Volume 1, Issue 2, Page(s) 107–108

    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ISSN 2631-6129
    ISSN (online) 2631-6129
    DOI 10.1093/jbi/wbz011
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  6. Article ; Online: Synthesis, characterization, and environmental applications of graphene-coated sand: A review.

    Nusair, Abdulla / Alkhateb, Hunain / D'Alessio, Matteo

    The Science of the total environment

    2024  Volume 917, Page(s) 170107

    Abstract: Global water quality has deteriorated, leaving over 844 million individuals without access to clean drinking water. While sand filters (SF) offer a solution, their limited surface area and adsorption capacity for emerging contaminants remain a challenge. ...

    Abstract Global water quality has deteriorated, leaving over 844 million individuals without access to clean drinking water. While sand filters (SF) offer a solution, their limited surface area and adsorption capacity for emerging contaminants remain a challenge. This has prompted the development of new materials such as graphene-coated sand (GCS) to enhance the sand's adsorptive properties. Notably, GCS also possesses inherent anti-bacterial properties and can function as a photocatalyst when exposed to UV and visible light, offering enhanced water purification. This manuscript 1) reviews the synthesis of GCS, detailing the characterization techniques employed to understand its structure, composition, and multifunctional properties and 2) highlights the superior efficacy of GCS in removing contaminants, including metals (>95 % removal of Cd
    MeSH term(s) Humans ; Graphite/chemistry ; Drinking Water ; Metals ; Water Purification/methods ; Adsorption ; Water Pollutants, Chemical/chemistry
    Chemical Substances Graphite (7782-42-5) ; Drinking Water ; Metals ; Water Pollutants, Chemical
    Language English
    Publishing date 2024-01-15
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.170107
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    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Diabetes and Immune Checkpoint Inhibitors-Response.

    Cortellini, Alessio / D'Alessio, Antonio / Pinato, David J

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2023  Volume 29, Issue 19, Page(s) 4017–4018

    MeSH term(s) Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Neoplasms/drug therapy ; Antibodies, Monoclonal/therapeutic use ; Diabetes Mellitus ; Immunotherapy
    Chemical Substances Immune Checkpoint Inhibitors ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-10-01
    Publishing country United States
    Document type Research Support, Non-U.S. Gov't ; Letter ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-23-2097
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    Zs.A 4223: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Immunotherapy at all stages of hepatocellular carcinoma.

    Pinato, David J / Fulgenzi, Claudia A M / D'Alessio, Antonio

    Nature medicine

    2024  Volume 30, Issue 3, Page(s) 640–641

    MeSH term(s) Humans ; Carcinoma, Hepatocellular/therapy ; Liver Neoplasms/therapy ; Liver Neoplasms/pathology ; Immunotherapy
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-024-02828-8
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    Zs.A 4212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MG 39: Show issues

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  9. Article ; Online: Network meta-analysis: A map to navigate the maze of treatment for advanced hepatocellular carcinoma.

    D'Alessio, Antonio / Cammarota, Antonella / Rimassa, Lorenza

    European journal of internal medicine

    2023  Volume 111, Page(s) 32–34

    MeSH term(s) Humans ; Carcinoma, Hepatocellular/surgery ; Liver Neoplasms/surgery ; Immune Checkpoint Inhibitors/therapeutic use ; Chemoembolization, Therapeutic
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2023-02-23
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.02.015
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    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Assessment of the incretin effect in healthy subjects: concordance between clamp and OGTT methods.

    Aulinger, Benedikt A / D'Alessio, David A

    American journal of physiology. Endocrinology and metabolism

    2023  Volume 325, Issue 4, Page(s) E412–E420

    Abstract: The incretin effect describes the insulin response to nutrient ingestion that exceeds the response to glycemia per se. It is mediated by gastrointestinal factors and is necessary to maintain postprandial glucose homeostasis. The incretin effect results ... ...

    Abstract The incretin effect describes the insulin response to nutrient ingestion that exceeds the response to glycemia per se. It is mediated by gastrointestinal factors and is necessary to maintain postprandial glucose homeostasis. The incretin effect results in a more than twofold increase of the insulin response to a meal in healthy people and two different techniques have been used in the past to measure its magnitude. Most studies employ an OGTT on 1 day, followed by a matching glucose infusion on a separate day. Another study design employs a hyperglycemic glucose clamp that is maintained after oral ingestion of glucose. Both protocols allow quantification of the incretin effect by comparing the insulin response to an identical glycemic stimulus. Here we performed a within-subject comparison of both techniques to quantify the incretin effect and suggest different calculation methods to interpret the results derived from the clamp experiment in a cohort of healthy young adults (
    MeSH term(s) Young Adult ; Humans ; Adult ; Incretins ; Glucose Tolerance Test ; Blood Glucose ; Healthy Volunteers ; C-Peptide ; Glucagon-Like Peptide 1 ; Insulin ; Glucose ; Gastric Inhibitory Polypeptide/physiology
    Chemical Substances Incretins ; Blood Glucose ; C-Peptide ; Glucagon-Like Peptide 1 (89750-14-1) ; Insulin ; Glucose (IY9XDZ35W2) ; Gastric Inhibitory Polypeptide (59392-49-3)
    Language English
    Publishing date 2023-09-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 603841-4
    ISSN 1522-1555 ; 0193-1849
    ISSN (online) 1522-1555
    ISSN 0193-1849
    DOI 10.1152/ajpendo.00104.2022
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    Uc I Zs.89: Show issues Location:
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