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Article ; Online: Heterologous synthesis of the complex homometallic cores of nitrogenase P- and M-clusters in

Quechol, Robert / Solomon, Joseph B / Liu, Yiling A / Lee, Chi Chung / Jasniewski, Andrew J / Górecki, Kamil / Oyala, Paul / Hedman, Britt / Hodgson, Keith O / Ribbe, Markus W / Hu, Yilin

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 44, Page(s) e2314788120

Abstract: Nitrogenase is an active target of heterologous expression because of its importance for areas related to agronomy, energy, and environment. One major hurdle for expressing an active Mo-nitrogenase ... ...

Abstract	Nitrogenase is an active target of heterologous expression because of its importance for areas related to agronomy, energy, and environment. One major hurdle for expressing an active Mo-nitrogenase in
MeSH term(s)	Nitrogenase/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Nitrogen Fixation/genetics ; Oxidoreductases/metabolism ; Azotobacter vinelandii ; Metalloproteins/metabolism ; Bacterial Proteins/metabolism
Chemical Substances	Nitrogenase (EC 1.18.6.1) ; Oxidoreductases (EC 1.-) ; Metalloproteins ; Bacterial Proteins
Language	English
Publishing date	2023-10-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2314788120
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Article ; Online: Correction: Lee, C.-P.; Chen, M.-R. Conquering the Nuclear Envelope Barriers by EBV Lytic Replication.

Lee, Chung-Pei / Chen, Mei-Ru

Viruses

2023 Volume 15, Issue 10

Abstract: In the original publication [ ... ]. ...

Abstract	In the original publication [...].
Language	English
Publishing date	2023-09-25
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15101991
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Article: Experimental and theoretical study of novel amino-functionalized P(V) coordination compounds suggested as inhibitor of M

Najarianzadeh, Mobina / Tarahhomi, Atekeh / Pishgo, Samaneh / van der Lee, Arie

Applied organometallic chemistry

2022 Volume 36, Issue 5, Page(s) e6636

Abstract: Amino-functionalized P(V) derivatives providing both ...

Abstract	Amino-functionalized P(V) derivatives providing both
Language	English
Publishing date	2022-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1480791-9
ISSN	1099-0739 ; 0268-2605
ISSN (online)	1099-0739
ISSN	0268-2605
DOI	10.1002/aoc.6636
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Article ; Online: The mitochondrial DNA variant m.9032T > C in MT-ATP6 encoding p.(Leu169Pro) causes a complex mitochondrial neurological syndrome.

Knight, Kaz M / Shelkowitz, Emily / Larson, Austin A / Mirsky, David M / Wang, Yue / Chen, Ting / Wong, Lee-Jun / Friederich, Marisa W / Van Hove, Johan L K

Mitochondrion

2020 Volume 55, Page(s) 8–13

Abstract: ... to the rarity, phenotypic diversity, and limited functional assessments. We describe a child with the m.9032T ... C variant in MT-ATP6 encoding p.(Leu169Pro), with primary presentation of microcephaly, ataxia ...

Abstract	Diagnosing complex V deficiencies caused by new variants in mitochondrial DNA is challenging due to the rarity, phenotypic diversity, and limited functional assessments. We describe a child with the m.9032T > C variant in MT-ATP6 encoding p.(Leu169Pro), with primary presentation of microcephaly, ataxia, hearing loss, and lactic acidosis. Functional studies reveal abnormal fragment F
MeSH term(s)	Amino Acid Substitution ; Brain/diagnostic imaging ; Child ; High-Throughput Nucleotide Sequencing ; Humans ; Male ; Mitochondrial Diseases/diagnostic imaging ; Mitochondrial Diseases/genetics ; Mitochondrial Proton-Translocating ATPases/genetics ; Polymorphism, Single Nucleotide ; Sequence Analysis, DNA/methods
Chemical Substances	MT-ATP6 protein, human ; Mitochondrial Proton-Translocating ATPases (EC 3.6.3.-)
Language	English
Publishing date	2020-09-12
Publishing country	Netherlands
Document type	Case Reports ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2056923-3
ISSN	1872-8278 ; 1567-7249
ISSN (online)	1872-8278
ISSN	1567-7249
DOI	10.1016/j.mito.2020.08.009
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Article: Preventive Effect of M. cochinchinensis on Melanogenesis via Tyrosinase Activity Inhibition and p-PKC Signaling in Melan-A Cell

Kim, Juyong / Hong, Sung-Chul / Lee, Eun Ha / Lee, Jae Wook / Yang, Seung-Hoon / Kim, Jin-Chul

Nutrients. 2021 Oct. 29, v. 13, no. 11

2021

Abstract: ... for their effects on tyrosinase activity and p-PKC signaling pathways by Western blotting. It was found that M ... involved with tyrosinase activity and p-PKC signaling. In this study, we used Momordica cochinchinensis ... of melanogenesis. M. cochinchinensis contains a high concentration of polyphenols, flavonoids, and ...

Abstract	Whitening research is of particular interest in the cosmetics market. The main focus of whitening research is on melanogenesis inhibition through tyrosinase activity. The mechanism of melanogenesis is involved with tyrosinase activity and p-PKC signaling. In this study, we used Momordica cochinchinensis (Lour.) spreng, a tropical fruit found throughout Southeast Asia, to investigate the inhibitory effect of melanogenesis. M. cochinchinensis contains a high concentration of polyphenols, flavonoids, and unsaturated fatty acids, which might be related to antioxidant activity. This study aimed to determine whether M. cochinchinensis extracts inhibit melanin synthesis in melan-A cells by inhibiting tyrosinase activity and p-PKC signaling. M. cochinchinensis was divided into pulp and aril and extracted under various conditions, and it was confirmed that all pulp and aril extracts have high contents of both phenols and flavonoids. Melan-A cells were treated with PMA for three days to induce melanin synthesis. After PMA treatment, M. cochinchinensis extracts were added to cultured media in a dose-dependent manner. Melanin contents and MTS were used to determine the amount of melanin in live cells. M. cochinchinensis extracts were evaluated for their effects on tyrosinase activity and p-PKC signaling pathways by Western blotting. It was found that M. cochinchinensis extract treatment decreased the amount of melanin and suppressed p-PKC expression. Additionally, tyrosinase activity was reduced after M. cochinchinensis extract treatment in a dose-dependent manner. Therefore, it was concluded that M. cochinchinensis could be used in antimelanogenesis and functional cosmetic materials to improve whitening.
Keywords	Momordica cochinchinensis ; antioxidant activity ; aril ; cosmetics ; dose response ; flavonoids ; fruits ; markets ; melanin ; melanogenesis ; polyphenols ; pulp ; South East Asia
Language	English
Dates of publication	2021-1029
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13113894
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The splicing factor 1–FLOWERING LOCUS M module spatially regulates temperature-dependent flowering by modulating FLOWERING LOCUS T and LEAFY expression [Correction: Dec. 2022, 41(12), p. 2423]

Lee, Keh Chien / Lee, Hee Tae / Jeong, Hwa Hyun / Park, Jae-Hyeok / Kim, Young-Cheon / Lee, Jeong Hwan / Kim, Jeong-Kook

Plant Cell Rep. 2022 July, v. 41, no. 7, p. 1603-1612

2022 , Page(s) 1603–1612

Abstract: ... factor 1 (AtSF1) and FLOWERING LOCUS M (FLM) pre-mRNA introns controls the differential production of FLM ...

Abstract	KEY MESSAGE: The AtSF1-FLM module spatially controls temperature-dependent flowering by negatively regulating the expression of FT and LFY in the leaf and shoot apex, respectively. Alternative splicing mediated by various splicing factors is important for the regulation of plant growth and development. Our recent reports have shown that a temperature-dependent interaction between Arabidopsis thaliana splicing factor 1 (AtSF1) and FLOWERING LOCUS M (FLM) pre-mRNA introns controls the differential production of FLM-β transcripts at different temperatures, eventually resulting in temperature-responsive flowering. However, the molecular and genetic interactions between the AtSF1-FLM module and floral activator genes remain unknown. Here, we aimed to identify the interactions among AtSF1, FLM, FLOWERING LOCUS T (FT), and LEAFY (LFY) by performing molecular and genetic analyses. FT and TWIN SISTER OF FT (TSF) expression in atsf1-2 mutants significantly increased in the morning and middle of the night at 16 and 23 °C, respectively, under long-day conditions. In addition, ft mutation suppressed the early flowering of atsf1-2 and atsf1-2 flm-3 mutants and masked the temperature response of atsf1-2 flm-3 mutants, suggesting that FT is a downstream target gene of the AtSF1-FLM module. LFY expression significantly increased in the diurnal samples of atsf1-2 mutants and in the shoot apex regions of atsf1-2 ft-10 mutants at different temperatures. The chromatin immunoprecipitation (ChIP) assay revealed that FLM directly binds to the genomic regions of LFY but not of APETALA1 (AP1). Moreover, lfy mutation suppressed the early flowering of flm-3 mutants, suggesting that LFY is another target of the AtSF1-FLM module. Our results reveal that the AtSF1-FLM module spatially modulates temperature-dependent flowering by regulating FT and LFY expressions.
Keywords	Arabidopsis thaliana ; chromatin immunoprecipitation ; genomics ; growth and development ; introns ; leaves ; loci ; mutation ; plant growth ; temperature
Language	English
Dates of publication	2022-07
Size	p. 1603-1612
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	8397-5
ISSN	1432-203X ; 0721-085X ; 0721-7714
ISSN (online)	1432-203X
ISSN	0721-085X ; 0721-7714
DOI	10.1007/s00299-022-02881-y
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Article: Measurements of the proton elastic-form-factor ratio mu pG p E/G p M at low momentum transfer.

Ron, G / Glister, J / Lee, B / Allada, K / Armstrong, W / Arrington, J / Beck, A / Benmokhtar, F / Berman, B L / Boeglin, W / Brash, E / Camsonne, A / Calarco, J / Chen, J P / Choi, Seonho / Chudakov, E / Coman, L / Craver, B / Cusanno, F /

Dumas, J / Dutta, C / Feuerbach, R / Freyberger, A / Frullani, S / Garibaldi, F / Gilman, R / Hansen, O / Higinbotham, D W / Holmstrom, T / Hyde, C E / Ibrahim, H / Ilieva, Y / de Jager, C W / Jiang, X / Jones, M K / Kang, H / Kelleher, A / Khrosinkova, E / Kuchina, E / Kumbartzki, G / LeRose, J J / Lindgren, R / Markowitz, P / May-Tal Beck, S / McCullough, E / Meekins, D / Meziane, M / Meziani, Z-E / Michaels, R / Moffit, B / Norum, B E / Oh, Y / Olson, M / Paolone, M / Paschke, K / Perdrisat, C F / Piasetzky, E / Potokar, M / Pomatsalyuk, R / Pomerantz, I / Puckett, A / Punjabi, V / Qian, X / Qiang, Y / Ransome, R / Reyhan, M / Roche, J / Rousseau, Y / Saha, A / Sarty, A J / Sawatzky, B / Schulte, E / Shabestari, M / Shahinyan, A / Shneor, R / Sirca, S / Slifer, K / Solvignon, P / Song, J / Sparks, R / Subedi, R / Strauch, S / Urciuoli, G M / Wang, K / Wojtsekhowski, B / Yan, X / Yao, H / Zhan, X / Zhu, X

Physical review letters

2007 Volume 99, Issue 20, Page(s) 202002

Abstract: High-precision measurements of the proton elastic form-factor ratio, mu pG p E/G p M, have been ... measurement, one finds that in this Q2 range the deviation from unity is primarily due to G p E being smaller ...

Abstract	High-precision measurements of the proton elastic form-factor ratio, mu pG p E/G p M, have been made at four-momentum transfer, Q2, values between 0.2 and 0.5 GeV2. The new data, while consistent with previous results, clearly show a ratio less than unity and significant differences from the central values of several recent phenomenological fits. By combining the new form-factor ratio data with an existing cross-section measurement, one finds that in this Q2 range the deviation from unity is primarily due to G p E being smaller than expected.
Language	English
Publishing date	2007-11-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.99.202002
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Article ; Online: Response to: Esophageal atresia and tracheoesophageal fistula associated with tetralogy of Fallot: a review of mortality. KM O'Shea, ML Griffiths, KL King, P Losty, M Jones, J Minford, F Murphy. Pediatr Surg Int. 2020 Oct; 36(10):1243-1247.

Pardy, Caroline / Lee, Geraint / Bell, Aaron / Yardley, Iain

Pediatric surgery international

2021 Volume 37, Issue 4, Page(s) 519–521

MeSH term(s)	Abnormalities, Multiple ; Esophageal Atresia/complications ; Humans ; Tetralogy of Fallot/surgery ; Tracheoesophageal Fistula
Language	English
Publishing date	2021-01-01
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	632773-4
ISSN	1437-9813 ; 0179-0358
ISSN (online)	1437-9813
ISSN	0179-0358
DOI	10.1007/s00383-020-04811-z
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Article ; Online: n- and p-Type doping phenomenon by artificial DNA and M-DNA on two-dimensional transition metal dichalcogenides.

Park, Hyung-Youl / Dugasani, Sreekantha Reddy / Kang, Dong-Ho / Jeon, Jeaho / Jang, Sung Kyu / Lee, Sungjoo / Roh, Yonghan / Park, Sung Ha / Park, Jin-Hong

ACS nano

2014 Volume 8, Issue 11, Page(s) 11603–11613

Abstract: ... uniform across the TMD area. p-Doping which is uniformly achieved by M-DNA occurs between 2.3 × 10(10) and ... WSe2, which represent n- and p-channel materials, respectively) using DNA and slightly modified DNA ... by metal ions (Zn(2+), Ni(2+), Co(2+), and Cu(2+)), named as M-DNA. This study is an example ...

Abstract	Deoxyribonucleic acid (DNA) and two-dimensional (2D) transition metal dichalcogenide (TMD) nanotechnology holds great potential for the development of extremely small devices with increasingly complex functionality. However, most current research related to DNA is limited to crystal growth and synthesis. In addition, since controllable doping methods like ion implantation can cause fatal crystal damage to 2D TMD materials, it is very hard to achieve a low-level doping concentration (nondegenerate regime) on TMD in the present state of technology. Here, we report a nondegenerate doping phenomenon for TMD materials (MoS2 and WSe2, which represent n- and p-channel materials, respectively) using DNA and slightly modified DNA by metal ions (Zn(2+), Ni(2+), Co(2+), and Cu(2+)), named as M-DNA. This study is an example of interdisciplinary convergence research between DNA nanotechnology and TMD-based 2D device technology. The phosphate backbone (PO4(-)) in DNA attracts and holds hole carriers in the TMD region, n-doping the TMD films. Conversely, M-DNA nanostructures, which are functionalized by intercalating metal ions, have positive dipole moments and consequently reduce the electron carrier density of TMD materials, resulting in p-doping phenomenon. N-doping by DNA occurs at ∼6.4 × 10(10) cm(-2) on MoS2 and ∼7.3 × 10(9) cm(-2) on WSe2, which is uniform across the TMD area. p-Doping which is uniformly achieved by M-DNA occurs between 2.3 × 10(10) and 5.5 × 10(10) cm(-2) on MoS2 and between 2.4 × 10(10) and 5.0 × 10(10) cm(-2) on WSe2. These doping levels are in the nondegenerate regime, allowing for the proper design of performance parameters of TMD-based electronic and optoelectronic devices (VTH, on-/off-currents, field-effect mobility, photoresponsivity, and detectivity). In addition, by controlling the metal ions used, the p-doping level of TMD materials, which also influences their performance parameters, can be controlled. This interdisciplinary convergence research will allow for the successful integration of future layered semiconductor devices requiring extremely small and very complicated structures.
MeSH term(s)	Chalcogens/chemistry ; DNA/chemistry ; Microscopy, Atomic Force ; Nanostructures ; Spectrum Analysis, Raman ; Transition Elements/chemistry
Chemical Substances	Chalcogens ; Transition Elements ; DNA (9007-49-2)
Language	English
Publishing date	2014-11-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/nn5048712
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Article ; Online: Commentary on: "Comprehensive transcriptional analysis of early-stage urothelial carcinoma." Hedegaard J, Lamy P, Nordentoft I, Algaba F, Høyer S, Ulhøi BP, Vang S, Reinert T, Hermann GG, Mogensen K, Thomsen MB, Nielsen MM, Marquez M, Segersten U, Aine M, Höglund M, Birkenkamp-Demtröder K, Fristrup N, Borre M, Hartmann A, Stöhr R, Wach S, Keck B, Seitz AK, Nawroth R, Maurer T, Tulic C, Simic T, Junker K, Horstmann M, Harving N, Petersen AC, Calle ML, Steyerberg EW, Beukers W, van Kessel KE, Jensen JB, Pedersen JS, Malmström PU, Malats N, Real FX, Zwarthoff EC, Ørntoft TF, Dyrskjøt L. Cancer Cell. 2016 Jul 11;30(1):27-42.

Lee, Byron H

Urologic oncology

2017 Volume 35, Issue 9, Page(s) 576–577

Abstract: Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease with widely different outcomes. We performed a comprehensive transcriptional analysis of 460 early-stage urothelial carcinomas and showed that NMIBC can be subgrouped into 3 major ... ...

Abstract	Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease with widely different outcomes. We performed a comprehensive transcriptional analysis of 460 early-stage urothelial carcinomas and showed that NMIBC can be subgrouped into 3 major classes with basal- and luminal-like characteristics and different clinical outcomes. Large differences in biological processes such as the cell cycle, epithelial-mesenchymal transition, and differentiation were observed. Analysis of transcript variants revealed frequent mutations in genes encoding proteins involved in chromatin organization and cytoskeletal functions. Furthermore, mutations in well-known cancer driver genes (e.g., TP53 and ERBB2) were primarily found in high-risk tumors, together with APOBEC-related mutational signatures. The identification of subclasses in NMIBC may offer better prognostication and treatment selection based on subclass assignment.
MeSH term(s)	Humans ; Neoplasm Staging ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/metabolism ; Urinary Bladder Neoplasms/pathology
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1336505-8
ISSN	1873-2496 ; 1078-1439
ISSN (online)	1873-2496
ISSN	1078-1439
DOI	10.1016/j.urolonc.2017.07.020
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