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  1. Article ; Online: Comparative effectiveness of Cangrelor in patients with acute coronary syndrome undergoing percutaneous coronary intervention: an observational investigation from the M.O.Ca. registry.

    Pepe, Martino / Carulli, Eugenio / Larosa, Claudio / Napoli, Gianluigi / Nestola, Palma Luisa / Carella, Maria Cristina / Giordano, Salvatore / Tritto, Rocco / Bartolomucci, Francesco / Cirillo, Plinio / Zoccai, Giuseppe Biondi / Giordano, Arturo / Ciccone, Marco Matteo

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 10685

    Abstract: Cangrelor, the first intravenous ... ...

    Abstract Cangrelor, the first intravenous P2Y
    MeSH term(s) Humans ; Acute Coronary Syndrome/surgery ; Retrospective Studies ; Percutaneous Coronary Intervention ; Registries
    Chemical Substances cangrelor (6AQ1Y404U7)
    Language English
    Publishing date 2023-07-01
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-37084-2
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  2. Article ; Online: Pathology, epidemiology, and phylogeny of mussel egg disease due to the microsporidian Steinhausia mytilovum (Field, 1924) in the Mediterranean mussel (Mytilus galloprovincialis).

    Carella, Francesca / De Vico, Gionata

    Journal of invertebrate pathology

    2023  Volume 198, Page(s) 107927

    Abstract: ... beds and farms along coast of southern Italy. A survey of M. galloprovincialis was conducted in 13 ... microsporidian. The constant presence, prevalence, and severity of S. mytilovum in coastline populations of M ...

    Abstract Microsporidia are well known fungal pathogens of aquatic animals. However, the taxonomy of microsporidia is generally poorly resolved, which has consequently constrained our understanding of their pathology and epidemiology in marine animals. To date, microsporidia have been reported in both bivalves and gastropods, and microsporidia from mollusks have been classified in different genera. Despite ongoing work to better describe these genera, including detailed microscopic and ultrastructural images, so far we lack information on microsporidian phylogeny and pathogenicity of species within these genera. Here we investigate the microsporidian parasite Steinhausia mytilovum associated with the mussel, Mytilus galloprovincialis, in natural beds and farms along coast of southern Italy. A survey of M. galloprovincialis was conducted in 13 mussel farms and one natural bed between 2009 and 2020. We found the presence of S. mytilovum in 10 of the investigated farms, with a prevalence ranging between 14 and 100% of female mussels, depending on the population and season in which they were sampled. The parasite developed in the oocytes within a sporophorous vesicle (SV) where it produced 1-3 spores per cell, both in the cytoplasm and in the nucleus. Stenhausia mytilovum elicited an infiltrative (24.8%) or a strong capsular inflammatory response (43.4%) at gonadal follicles and surrounding vesicular connective tissue, in some cases accompanied by gonadal atresia (24.8%), leading to loss of gonadal architecture. In 7% of cases no reaction was observed. Ultrastructural observations revealed a mitochondrial re-organization to interact with all the phases of parasite development; the mitochondria were arranged outside the parasitophorous vesicle (PV) or directly interacting with the spore inside vesicle. There are five taxonomic clades of microsporidians as identified by SSU ribosomal gene sequence data. Maximum likelihood analysis assigned S. mytilovum within the Clade IV, defined as the Class Terresporidia, with closest genetic relationship (83.6% identity) to an undetermined invertebrate ovarian microsporidian. The constant presence, prevalence, and severity of S. mytilovum in coastline populations of M. galloprovincialis populations in southern Italy may indirectly reflect immunocompetence at both individual and population levels.
    MeSH term(s) Female ; Animals ; Mytilus/microbiology ; Microsporidia/genetics ; Phylogeny ; Italy ; Seafood
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390885-9
    ISSN 1096-0805 ; 0022-2011
    ISSN (online) 1096-0805
    ISSN 0022-2011
    DOI 10.1016/j.jip.2023.107927
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    Zs.B 958: Show issues Location:
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  3. Book ; Conference proceedings: Proceedings from Leukemia 2012

    Carella, Angelo M.

    International Conference "Leukemia 2012", 19 - 20 April 2012, Milan

    (Leukemia : Supplements ; 1,2)

    2012  

    Event/congress International Conference Leukemia 2012 (2012, Mailand)
    Author's details chairmen: Angelo M. Carella
    Series title Leukemia : Supplements ; 1,2
    Leukemia
    Leukemia ; Supplements
    Collection Leukemia
    Leukemia ; Supplements
    Language English
    Size S55 S.
    Publisher Nature Publ. Group
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT017410884
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 2295 -Suppl.1,2- not available for loan Zeitschriften-Lesesaal

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  4. Article ; Online: Pathology, epidemiology, and phylogeny of mussel egg disease due to the microsporidian Steinhausia mytilovum (Field, 1924) in the Mediterranean mussel (Mytilus galloprovincialis)

    Carella, Francesca / De Vico, Gionata

    Journal of Invertebrate Pathology. 2023 June, v. 198 p.107927-

    2023  

    Abstract: ... beds and farms along coast of southern Italy. A survey of M. galloprovincialis was conducted in 13 ... microsporidian. The constant presence, prevalence, and severity of S. mytilovum in coastline populations of M ...

    Abstract Microsporidia are well known fungal pathogens of aquatic animals. However, the taxonomy of microsporidia is generally poorly resolved, which has consequently constrained our understanding of their pathology and epidemiology in marine animals. To date, microsporidia have been reported in both bivalves and gastropods, and microsporidia from mollusks have been classified in different genera. Despite ongoing work to better describe these genera, including detailed microscopic and ultrastructural images, so far we lack information on microsporidian phylogeny and pathogenicity of species within these genera. Here we investigate the microsporidian parasite Steinhausia mytilovum associated with the mussel, Mytilus galloprovincialis, in natural beds and farms along coast of southern Italy. A survey of M. galloprovincialis was conducted in 13 mussel farms and one natural bed between 2009 and 2020. We found the presence of S. mytilovum in 10 of the investigated farms, with a prevalence ranging between 14 and 100% of female mussels, depending on the population and season in which they were sampled. The parasite developed in the oocytes within a sporophorous vesicle (SV) where it produced 1–3 spores per cell, both in the cytoplasm and in the nucleus. Stenhausia mytilovum elicited an infiltrative (24.8%) or a strong capsular inflammatory response (43.4%) at gonadal follicles and surrounding vesicular connective tissue, in some cases accompanied by gonadal atresia (24.8%), leading to loss of gonadal architecture. In 7% of cases no reaction was observed. Ultrastructural observations revealed a mitochondrial re-organization to interact with all the phases of parasite development; the mitochondria were arranged outside the parasitophorous vesicle (PV) or directly interacting with the spore inside vesicle. There are five taxonomic clades of microsporidians as identified by SSU ribosomal gene sequence data. Maximum likelihood analysis assigned S. mytilovum within the Clade IV, defined as the Class Terresporidia, with closest genetic relationship (83.6% identity) to an undetermined invertebrate ovarian microsporidian. The constant presence, prevalence, and severity of S. mytilovum in coastline populations of M. galloprovincialis populations in southern Italy may indirectly reflect immunocompetence at both individual and population levels.
    Keywords Microsporidia ; Mytilus galloprovincialis ; abnormal development ; coasts ; eggs ; females ; fungi ; genetic relationships ; gonads ; immunocompetence ; inflammation ; mitochondria ; mussels ; nucleotide sequences ; oocytes ; parasites ; pathogenicity ; phylogeny ; probability analysis ; spores ; surveys ; taxonomy ; Italy ; Bivalve disease ; Marine microsporidia ; Mussel egg disease
    Language English
    Dates of publication 2023-06
    Publishing place Elsevier Inc.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 390885-9
    ISSN 1096-0805 ; 0022-2011
    ISSN (online) 1096-0805
    ISSN 0022-2011
    DOI 10.1016/j.jip.2023.107927
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 958: Show issues Location:
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  5. Book: Progress in autologous stem cell transplantation

    Carella, Angelo M.

    10 tables

    (Acta haematologica ; 114,4)

    2005  

    Author's details guest ed. Angelo M. Carella
    Series title Acta haematologica ; 114,4
    Collection
    Language English
    Size S. 187 - 263
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT015316599
    ISBN 3805580487 ; 9783805580489
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ud II Zs 145 -114- verfügbar in Königswinter Königswinter

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  6. Article ; Online: Effect of virtual reality hypnosis on intraoperative sedation needs and functional recovery in knee arthroplasty: a prospective randomized clinical trial.

    Carella, Michele / Beck, Florian / Quoilin, Caroline / Azongmo, Murielle M / Loheac, Adrien / Bonhomme, Vincent L / Vanhaudenhuyse, Audrey

    Regional anesthesia and pain medicine

    2024  

    Abstract: Background and objectives: Perioperative psychological stress and pharmacological anxiolysis can negatively affect the quality of recovery after total knee arthroplasty. We aimed to assess whether hypnosis combined with virtual reality could reduce ... ...

    Abstract Background and objectives: Perioperative psychological stress and pharmacological anxiolysis can negatively affect the quality of recovery after total knee arthroplasty. We aimed to assess whether hypnosis combined with virtual reality could reduce intraoperative pharmacological sedation and improve quality of recovery after total knee arthroplasty surgery.
    Methods: In this prospective randomized clinical trial, 60 patients scheduled for total knee arthroplasty with spinal anesthesia were randomly divided into 2 groups of 30 patients each. Intraoperatively, intermittent boluses of midazolam 1 mg were administered at 5 min intervals at the patient's request, with a maximum driven by the clinical assessment of sedation depth. During surgery, patients received standard care (group control) or virtual reality hypnosis (group VRH). An unblinded observer recorded the total dose of midazolam administered during surgery, and changes in the Quality-of-Recovery 15-item score, comfort, fatigue, pain and anxiety before and 1, 3 and 7 days after surgery.
    Results: Patients in the VRH group required a lower dose of midazolam (mg; median (range)) intraoperatively (group VRH: 0 (0-4) and group control: 2 (0-9), p<0.001). Quality-of-Recovery 15-item, anxiety, and pain were similar between groups.
    Conclusions: In total knee arthroplasty with spinal anesthesia, VRH reduces the requirement for intraoperative pharmacological sedation, without a change in the quality of recovery.
    Trial registration number: NCT05707234.
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1425299-5
    ISSN 1532-8651 ; 1098-7339 ; 0146-521X
    ISSN (online) 1532-8651
    ISSN 1098-7339 ; 0146-521X
    DOI 10.1136/rapm-2023-105261
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  7. Article ; Online: Insights into the phototautomerism of free-base 5, 10, 15, 20-tetrakis(4-sulfonatophenyl) porphyrin.

    Ciuti, Susanna / Carella, Angelo / Lucotti, Andrea / Tommasini, Matteo / Barbon, Antonio / Di Valentin, Marilena

    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

    2023  Volume 22, Issue 8, Page(s) 1825–1838

    Abstract: Phototautomerism in the excited states of free-base 5, 10, 15, 20-tetrakis(4-sulfonatophenyl) porphyrin ( ... ...

    Abstract Phototautomerism in the excited states of free-base 5, 10, 15, 20-tetrakis(4-sulfonatophenyl) porphyrin (H
    Language English
    Publishing date 2023-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2072584-X
    ISSN 1474-9092 ; 1474-905X
    ISSN (online) 1474-9092
    ISSN 1474-905X
    DOI 10.1007/s43630-023-00413-5
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  8. Article ; Online: The N-terminal domains of NLR immune receptors exhibit structural and functional similarities across divergent plant lineages.

    Chia, Khong-Sam / Kourelis, Jiorgos / Teulet, Albin / Vickers, Martin / Sakai, Toshiyuki / Walker, Joseph F / Schornack, Sebastian / Kamoun, Sophien / Carella, Philip

    The Plant cell

    2024  

    Abstract: Nucleotide-binding domain and leucine-rich repeat (NLR) proteins are a prominent class of intracellular immune receptors in plants. However, our understanding of plant NLR structure and function is limited to the evolutionarily young flowering plant ... ...

    Abstract Nucleotide-binding domain and leucine-rich repeat (NLR) proteins are a prominent class of intracellular immune receptors in plants. However, our understanding of plant NLR structure and function is limited to the evolutionarily young flowering plant clade. Here, we describe an extended spectrum of NLR diversity across divergent plant lineages and demonstrate the structural and functional similarities of N-terminal domains that trigger immune responses. We show that the broadly distributed coiled-coil (CC) and toll/interleukin-1 receptor (TIR) domain families of non-flowering plants retain immune-related functions through trans-lineage activation of cell death in the angiosperm Nicotiana benthamiana. We further examined a CC subfamily specific to non-flowering lineages and uncovered an essential N-terminal MAEPL motif that is functionally comparable to motifs in resistosome-forming CC-NLRs. Consistent with a conserved role in immunity, the ectopic activation of CCMAEPL in the non-flowering liverwort Marchantia polymorpha led to profound growth inhibition, defense gene activation, and signatures of cell death. Moreover, comparative transcriptomic analyses of CCMAEPL activity delineated a common CC-mediated immune program shared across evolutionarily divergent non-flowering and flowering plants. Collectively, our findings highlight the ancestral nature of NLR-mediated immunity during plant evolution that dates its origin to at least ∼500 million years ago.
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 623171-8
    ISSN 1532-298X ; 1040-4651
    ISSN (online) 1532-298X
    ISSN 1040-4651
    DOI 10.1093/plcell/koae113
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  9. Article ; Online: Comparison between supra-inguinal fascia iliaca and pericapsular nerve group blocks on postoperative pain and functional recovery after total hip arthroplasty: A noninferiority randomised clinical trial.

    Carella, Michele / Beck, Florian / Piette, Nicolas / Denys, Sébastien / Lecoq, Jean-Pierre / Bonhomme, Vincent L

    European journal of anaesthesiology

    2023  Volume 40, Issue 9, Page(s) 660–671

    Abstract: ... at fixed time points: 1 and 6 h after surgery, on day-1 and day-2 at 8 a.m.,1 p.m. and 6 p.m. On day-1 and ...

    Abstract Background: Pain after a posterolateral approach for total hip arthroplasty (THA) may affect early functional recovery. Supra-inguinal fascia iliaca (SFIB) and pericapsular nerve group (PENG) blocks have been proposed as promising analgesia techniques.
    Objectives: This trial was conducted to compare a PENG with a SFIB for controlling postoperative pain and for providing functional recovery.
    Design: Noninferiority monocentric randomised controlled study.
    Setting: One hundred and two patients scheduled for a total hip arthroplasty via the posterolateral approach under spinal anaesthesia were prospectively allocated to two groups. Data acquisition occurred between October 2021 and July 2022 at the University Hospital of Liege.
    Patients: One hundred and two patients completed the trial.
    Interventions: Group SFIB received supra-inguinal fascia iliaca block (SFIB) (40 ml ropivacaine 0.375%), whereas group PENG received a PENG block (20 ml ropivacaine 0.75%).
    Main outcome measures: Rest and mobilisation pain on a 0 to 10 numeric rating scale at fixed time points: 1 and 6 h after surgery, on day-1 and day-2 at 8 a.m.,1 p.m. and 6 p.m. On day-1 and day-2, evolution of quality-of-recovery-15 score was assessed, and timed-up-and-go, 2 and 6 min-walking tests. The noninferiority margin was set as 1 numeric rating scale point 6 h after surgery.
    Results: Six hours after surgery, pain scores in group PENG were noninferior to those of group SFIB, with a difference between medians at 0 (95% CI -0.93 to 0.93). There were no significant differences between the groups regarding rest and dynamic pain trajectories during the first 48 postoperative hours, with no significant effects of group (rest P  = 0.800; dynamic P  = 0.708) or interaction between group and time (rest P  = 0.803; dynamic P  = 0.187). Similarly, no significant differences were observed regarding motor and functional recovery as assessed by timed-up-and-go ( P  = 0.197), 2 min ( P  = 0.364), and 6 min walking ( P  = 0.347) tests and quality-of-recovery-15 ( P  = 0.417) score.
    Conclusion: Following a total hip arthroplasty via the posterolateral approach, a PENG block is noninferior to SFIB regarding postoperative pain control 6 h after surgery, and functional recovery.
    Trial registration: European Clinical Trial Register under EudraCT-number 2020-005126-28 ( https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-005126-28/BE ).
    MeSH term(s) Humans ; Ropivacaine ; Arthroplasty, Replacement, Hip/adverse effects ; Femoral Nerve ; Pain, Postoperative/diagnosis ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control ; Fascia
    Chemical Substances Ropivacaine (7IO5LYA57N)
    Language English
    Publishing date 2023-06-30
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 605770-6
    ISSN 1365-2346 ; 0265-0215
    ISSN (online) 1365-2346
    ISSN 0265-0215
    DOI 10.1097/EJA.0000000000001875
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1955: Show issues Location:
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  10. Article ; Online: Clinical outcome after failure of hypomethylating therapy for myelodysplastic syndromes.

    Carella, Angelo M

    European journal of haematology

    2015  Volume 94, Issue 6, Page(s) 463

    MeSH term(s) Antimetabolites, Antineoplastic/therapeutic use ; Azacitidine/analogs & derivatives ; Azacitidine/therapeutic use ; DNA Modification Methylases/antagonists & inhibitors ; Female ; Humans ; Male ; Myelodysplastic Syndromes/mortality ; Myelodysplastic Syndromes/therapy
    Chemical Substances Antimetabolites, Antineoplastic ; DNA Modification Methylases (EC 2.1.1.-) ; Azacitidine (M801H13NRU)
    Language English
    Publishing date 2015-06
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 392482-8
    ISSN 1600-0609 ; 0902-4441
    ISSN (online) 1600-0609
    ISSN 0902-4441
    DOI 10.1111/ejh.12521
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