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Article: Immunoglobulin G4-related Disease and Pancreatic Malignancy: An Association or Two Independent Processes?

Tocut, Milena / Davidson, Tima / Leibu, Rebecca / Amital, Howard / Shoenfeld, Yehuda / Shovman, Ora

The Israel Medical Association journal : IMAJ

2021 Volume 23, Issue 11, Page(s) 748–750

MeSH term(s)	Adenocarcinoma/complications ; Adenocarcinoma/diagnosis ; Aged ; Humans ; Immunoglobulin G4-Related Disease/complications ; Immunoglobulin G4-Related Disease/diagnosis ; Male ; Pancreatic Neoplasms/complications ; Pancreatic Neoplasms/diagnosis
Language	English
Publishing date	2021-11-23
Publishing country	Israel
Document type	Case Reports ; Journal Article
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Article ; Online: Bilateral hearing loss preceding rhomboencephalitis - a hint for Kelch-like 11 syndrome.

Krivitski, David / Alcalay, Yifat / Peer, Michael / Paran, Yael / Eisenstein, Orna / Davidson, Tima / Gadoth, Avi

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2022

Abstract: Background: Paraneoplastic neurological syndromes have diverse clinical presentations and offer an opportunity for early diagnosis of malignancy and treatment. Recently, a new paraneoplastic syndrome associated with seminoma was described, consisting of ...

Abstract	Background: Paraneoplastic neurological syndromes have diverse clinical presentations and offer an opportunity for early diagnosis of malignancy and treatment. Recently, a new paraneoplastic syndrome associated with seminoma was described, consisting of rhombencephalitis with antibodies targeting the Kelch-like protein 11 (KLHL11). Questions were raised as to the spectrum of clinical symptoms and strength of association to seminoma. Methods: We present a 45-year-old man with bilateral sensorineural hearing loss, vertigo, and progressive ataxia. An extensive diagnostic workup led to the diagnosis of anti-KLHL11 paraneoplastic syndrome based on an immunofluorescence assay showing a typical pattern and a confirmatory serological assay. As a result, the patient underwent a meticulous search for an underlying seminoma. Results: Although initially, all images were interpreted as negative, a revision of the positron emission tomography-CT (PET-CT) examination identified a small mediastinal suspicious mass. The mass was resected, and pathological examination confirmed it to be an extra-testicular seminoma. Conclusions: Patients presenting with progressive sensorineural hearing loss, vertigo, and ataxia should be evaluated for KLHL11 paraneoplastic syndrome. Furthermore, we support a strong association between anti-KLH11 rhombencephalitis and an underlying seminoma and recommend a thorough search for an undiagnosed germ cell tumor in these patients.
Language	English
Publishing date	2022-09-16
Publishing country	Italy
Document type	Letter
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-022-06369-1
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Article ; Online: Effectiveness and safety of immune checkpoint inhibitors in combination with palliative radiotherapy in advanced melanoma: A systematic review.

Ben Shimol, Jennifer / Guzman-Prado, Yuli / Karlinskaya, Maria / Davidson, Tima

Critical reviews in oncology/hematology

2021 Volume 167, Page(s) 103499

Abstract: Background: Radiotherapy is frequently added to immune checkpoint inhibitors (ICI) when treating melanoma. We sought to describe the efficacy of combination ICI and palliative radiotherapy (pRT) and assess safety, focusing on immune related adverse ... ...

Abstract	Background: Radiotherapy is frequently added to immune checkpoint inhibitors (ICI) when treating melanoma. We sought to describe the efficacy of combination ICI and palliative radiotherapy (pRT) and assess safety, focusing on immune related adverse events (irAE). Methods: A systematic search for studies investigating the combination of pRT and ICI was conducted. Results: Five hundred-two articles were identified; nine met inclusion criteria. Improvements in objective response rate (p = 0.02), complete response (p = 0.04), and one-year local control (p < 0.005) were demonstrated when pRT was added to ICI. While some studies revealed improved overall and progression free survival, findings were mixed. No significant increases in adverse events or irAE were seen with the combined treatment compared with ICI alone. Conclusion: The included studies revealed that the addition of pRT to ICI is effective and safe in patients with advanced melanoma. Measures of survival varied. More studies are warranted to identify optimal conditions for combination treatment.
MeSH term(s)	Combined Modality Therapy ; Humans ; Immune Checkpoint Inhibitors ; Melanoma/drug therapy ; Progression-Free Survival
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2021-10-20
Publishing country	Netherlands
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	605680-5
ISSN	1879-0461 ; 0737-9587 ; 1040-8428
ISSN (online)	1879-0461
ISSN	0737-9587 ; 1040-8428
DOI	10.1016/j.critrevonc.2021.103499
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Article: Brain 18F-FDG-PET: Utility in the Diagnosis of Dementia and Epilepsy.

Lotan, Eyal / Friedman, Kent P / Davidson, Tima / Shepherd, Timothy M

The Israel Medical Association journal : IMAJ

2020 Volume 22, Issue 3, Page(s) 178–184

Abstract: Background: The authors reviewed the two most common current uses of brain 18F-labeled fluoro-2-deoxyglucose positron emission tomography (FDG-PET) at a large academic medical center. For epilepsy patients considering surgical management, FDG-PET can ... ...

Abstract	Background: The authors reviewed the two most common current uses of brain 18F-labeled fluoro-2-deoxyglucose positron emission tomography (FDG-PET) at a large academic medical center. For epilepsy patients considering surgical management, FDG-PET can help localize epileptogenic lesions, discriminate between multiple or discordant EEG or MRI findings, and predict prognosis for post-surgical seizure control. In elderly patients with cognitive impairment, FDG-PET often demonstrates lobar-specific patterns of hypometabolism that suggest particular underlying neurodegenerative pathologies, such as Alzheimer's disease. FDG-PET of the brain can be a key diagnostic modality and contribute to improved patient care.
MeSH term(s)	Brain/diagnostic imaging ; Brain/pathology ; Dementia/diagnostic imaging ; Dementia/pathology ; Epilepsy/diagnostic imaging ; Epilepsy/pathology ; Fluorodeoxyglucose F18 ; Humans ; Positron-Emission Tomography/methods
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2020-03-09
Publishing country	Israel
Document type	Journal Article ; Review
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Article ; Online: Early prediction of urinary retention following radical hysterectomy by 18F-FDG PET/CT imaging.

Davidson, Tima / Yakobi, Yonatan / Nayruz, Knaana / Levin, Gabriel / Korach, Jacob / Perri, Tamar

Minerva obstetrics and gynecology

2021 Volume 75, Issue 3, Page(s) 243–250

Abstract: Background: Radical hysterectomy for early cervical cancer is associated with postoperative bladder dysfunction. Postoperative imaging by : Methods: Women who underwent radical hysterectomy for cervical cancer between July 2010 and January 2019 were ... ...

Abstract	Background: Radical hysterectomy for early cervical cancer is associated with postoperative bladder dysfunction. Postoperative imaging by Methods: Women who underwent radical hysterectomy for cervical cancer between July 2010 and January 2019 were included in the study. Multi-Modality Tumor Tracking Results: Overall, 64 patients were included. Among those, in 24 (38%) the bladder volume reached ≥150 cm Conclusions: Measuring bladder volume on postoperative
MeSH term(s)	Female ; Humans ; Male ; Fluorodeoxyglucose F18 ; Hysterectomy/adverse effects ; Positron Emission Tomography Computed Tomography/adverse effects ; Positron Emission Tomography Computed Tomography/methods ; Urinary Retention/diagnostic imaging ; Urinary Retention/etiology ; Uterine Cervical Neoplasms/diagnostic imaging ; Uterine Cervical Neoplasms/surgery ; Uterine Cervical Neoplasms/complications ; Postoperative Complications
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2021-12-14
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062815-5
ISSN	2724-6450
ISSN (online)	2724-6450
DOI	10.23736/S2724-606X.21.05008-9
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Article ; Online: The utility of PET/CT in large vessel vasculitis.

Ben Shimol, Jennifer / Amital, Howard / Lidar, Merav / Domachevsky, Liran / Shoenfeld, Yehuda / Davidson, Tima

Scientific reports

2020 Volume 10, Issue 1, Page(s) 17709

Abstract: ... ...

Abstract	18
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Female ; Fluorodeoxyglucose F18/administration & dosage ; Humans ; Male ; Middle Aged ; Monitoring, Physiologic/methods ; Positron Emission Tomography Computed Tomography/methods ; Retrospective Studies ; Vasculitis/complications ; Vasculitis/diagnostic imaging ; Vasculitis/physiopathology ; Young Adult
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2020-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-73818-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Reply to Veerman et al. Comment on "Rosenzweig et al. Very Low Prostate PET/CT PSMA Uptake May Be Misleading in Staging Radical Prostatectomy Candidates.

Rosenzweig, Barak / Haramaty, Rennen / Davidson, Tima / Lazarovich, Alon / Shvero, Asaf / Haifler, Miki / Gal, Jonathan / Golan, Shay / Shpitzer, Sagi / Hoffman, Azik / Nativ, Omri / Freifeld, Yuval / Zreik, Rani / Dotan, Zohar A

Journal of personalized medicine

2022 Volume 12, Issue 6

Abstract: We thank the commenters for their important insights [ ... ]. ...

Abstract	We thank the commenters for their important insights [...].
Language	English
Publishing date	2022-05-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12060861
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Article ; Online: The usefulness of [18F]FDG-PET/CT in detecting and managing cancers with unknown primary site depends on histological subtype.

Nissan, Ella / Amit, Uri / Baron, Leo / Zabatani, Amit / Urban, Damien / Barshack, Iris / Davidson, Tima

Scientific reports

2021 Volume 11, Issue 1, Page(s) 17732

Abstract: We assessed the role of [18F]FDG-PET/CT in identifying and managing cancer of unknown primary site (CUP syndrome). We reviewed [18F]FDG-PET/CT scans of individuals with CUP syndrome recorded in clinical referral letters from 2012 to 2019. We evaluated ... ...

Abstract	We assessed the role of [18F]FDG-PET/CT in identifying and managing cancer of unknown primary site (CUP syndrome). We reviewed [18F]FDG-PET/CT scans of individuals with CUP syndrome recorded in clinical referral letters from 2012 to 2019. We evaluated the identification of primary tumor (PT) by [18F]FDG-PET/CT, according to histological subtype, and the impact on clinical management. The median age was 65 years, 36/64 males (56%). PTs were detected in 28/64 (44%) patients. Detection was significantly lower in patients with squamous cell carcinoma (SCC) than with other histologies combined, p = 0.034. Mean age, mean SUVmax (10.6 ± 6.0) and organ involvement were similar between patients with and without discovered PTs; and between patients with SCC and with other histologies combined. However, those with SCC were less likely than the others to present with multi-lesion involvement, p < 0.001. [18F]FDG-PET/CT interpretations apparently affected treatment of 8/28 (29%) patients with PT detected, and in none of the 35 whose PT was not discovered, p < 0.001. [18F]FDG-PET/CT appeared helpful in detecting PT in almost half the patients with CUP syndrome; the lowest rate was for patients with SCC pathology. PET/CT showed limited overall value in guiding clinical management, however benefited those with discovered PT.
MeSH term(s)	Adenocarcinoma/diagnostic imaging ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Neuroendocrine/diagnostic imaging ; Carcinoma, Squamous Cell/diagnostic imaging ; Female ; Fluorodeoxyglucose F18 ; Humans ; Male ; Middle Aged ; Neoplasms, Unknown Primary/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; Young Adult
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2021-09-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-96451-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The usefulness of [18F]FDG-PET/CT in detecting and managing cancers with unknown primary site depends on histological subtype

Ella Nissan / Uri Amit / Leo Baron / Amit Zabatani / Damien Urban / Iris Barshack / Tima Davidson

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 8

Abstract: Abstract We assessed the role of [18F]FDG-PET/CT in identifying and managing cancer of unknown primary site (CUP syndrome). We reviewed [18F]FDG-PET/CT scans of individuals with CUP syndrome recorded in clinical referral letters from 2012 to 2019. We ... ...

Abstract	Abstract We assessed the role of [18F]FDG-PET/CT in identifying and managing cancer of unknown primary site (CUP syndrome). We reviewed [18F]FDG-PET/CT scans of individuals with CUP syndrome recorded in clinical referral letters from 2012 to 2019. We evaluated the identification of primary tumor (PT) by [18F]FDG-PET/CT, according to histological subtype, and the impact on clinical management. The median age was 65 years, 36/64 males (56%). PTs were detected in 28/64 (44%) patients. Detection was significantly lower in patients with squamous cell carcinoma (SCC) than with other histologies combined, p = 0.034. Mean age, mean SUVmax (10.6 ± 6.0) and organ involvement were similar between patients with and without discovered PTs; and between patients with SCC and with other histologies combined. However, those with SCC were less likely than the others to present with multi-lesion involvement, p < 0.001. [18F]FDG-PET/CT interpretations apparently affected treatment of 8/28 (29%) patients with PT detected, and in none of the 35 whose PT was not discovered, p < 0.001. [18F]FDG-PET/CT appeared helpful in detecting PT in almost half the patients with CUP syndrome; the lowest rate was for patients with SCC pathology. PET/CT showed limited overall value in guiding clinical management, however benefited those with discovered PT.
Keywords	Medicine ; R ; Science ; Q
Subject code	610 ; 616
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Response to Anti-PD1/L1 Antibodies in Advanced Urothelial Cancer in the 'Real-Life' Setting.

Gadot, Moran / Arad, Ido / Atenafu, Eshetu G / Levartovsky, Meital / Portnoy, Orith / Davidson, Tima / Schor-Bardach, Rachel / Berger, Raanan / Leibowitz, Raya

Pharmaceuticals (Basel, Switzerland)

2022 Volume 15, Issue 9

Abstract: Immune checkpoint inhibitors (ICIs) are now the standard of care for metastatic urothelial carcinoma (mUC) patients. Our aim was to describe the activity of ICIs in mUC and find the clinical parameters associated with response. This is a retrospective, ... ...

Abstract	Immune checkpoint inhibitors (ICIs) are now the standard of care for metastatic urothelial carcinoma (mUC) patients. Our aim was to describe the activity of ICIs in mUC and find the clinical parameters associated with response. This is a retrospective, single-center chart review of mUC patients receiving ICIs. The overall survival (OS) was plotted using the Kaplan-Meier method and was compared using a log-rank test. Associations between the variables and responses were analyzed by univariate and multivariable analyses, using either logistic regression or a Chi-square/Fisher's exact test. Ninety-four patients received ICIs, 85% of which were in the second line or beyond; the median age was 71.8 years, and 82% were men. Six (6.4%), 11 (11.7%), 7 (7.4%) and 70 (74.5%) patients achieved a complete response (CR), partial response (PR), mixed response/stable disease (M/SD) or progressive disease (PD), respectively. The median overall survival was 3.2 months for the entire cohort and was significantly different according to the response pattern-not reached, 32.3, 6.4 and 2.0 months for CR, PR, M/SD and PD, respectively. The response was not significantly associated with the line of treatment. 'Site of metastasis' was associated with the response, and the absolute neutrophil count was borderline associated with the response. In summary, we found a substantial variance in the potential benefit from ICIs in mUC, emphasizing the need for predictive biomarkers and frequent monitoring of mUC patients receiving ICIs.
Language	English
Publishing date	2022-09-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph15091154
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