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  1. Article: Tuberculosis in the European Region.

    Mencarini, Jessica / Spinicci, Michele / Zammarchi, Lorenzo / Bartoloni, Alessandro

    Current tropical medicine reports

    2023  , Page(s) 1–6

    Abstract: Purpose of review: Tuberculosis (TB) remains a major public health concern worldwide. The COVID-19 pandemic and migration flow due to socioeconomic conditions, climate change, and geopolitical issues, such as the war, are important drivers influencing ... ...

    Abstract Purpose of review: Tuberculosis (TB) remains a major public health concern worldwide. The COVID-19 pandemic and migration flow due to socioeconomic conditions, climate change, and geopolitical issues, such as the war, are important drivers influencing TB epidemiology in Europe. This article aims to review the data about TB in this area and the new findings about treatment and prevention strategies.
    Recent findings: During the COVID-19 pandemic, access to health facilities and retention in care were difficult for TB patients, with consequences on TB diagnosis and TB incidence. The ongoing conflict in Europe, in areas with high prevalence of TB and MDR-TB, has reduced the access to health services and the availability of anti-TB drugs and increased the migration of refugees. New data on short treatment regimens could change the length of therapy and adverse events.
    Summary: TB control programs are facing emerging challenges that could change TB incidence in the near future. Novel antibiotic strategies and improved preventive policies could offer new opportunities to reduce the TB impact on public health.
    Language English
    Publishing date 2023-05-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2196-3045
    ISSN 2196-3045
    DOI 10.1007/s40475-023-00287-8
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  2. Article ; Online: Septic arthritis in the antimicrobial stewardship era.

    Spinicci, Michele / Corti, Giampaolo

    Internal and emergency medicine

    2020  Volume 15, Issue 4, Page(s) 567–569

    MeSH term(s) Adult ; Anti-Bacterial Agents ; Antimicrobial Stewardship ; Arthritis, Infectious ; Bacteria ; Drug Resistance, Bacterial ; Humans ; Retrospective Studies
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-03-31
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-020-02302-6
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  3. Article ; Online: Seroconversion following empiric praziquantel treatment as confirmatory diagnostic tool for chronic schistosomiasis.

    Marangoni, Davide / Manciulli, Tommaso / Barbiero, Anna / Mantella, Antonia / Spinicci, Michele / Bartoloni, Alessandro / Zammarchi, Lorenzo

    Journal of travel medicine

    2023  Volume 30, Issue 7

    Abstract: We report on six patients with suspected chronic schistosomiasis and negative microbiological findings at baseline. All patients were treated empirically with praziquantel and all seroconverted 20 days to two months after treatment. We suggest that ... ...

    Abstract We report on six patients with suspected chronic schistosomiasis and negative microbiological findings at baseline. All patients were treated empirically with praziquantel and all seroconverted 20 days to two months after treatment. We suggest that seroconversion after praziquantel treatment may be used as a confirmatory diagnostic tool for chronic schistosomiasis.
    MeSH term(s) Humans ; Praziquantel/adverse effects ; Seroconversion ; Schistosomiasis/diagnosis ; Schistosomiasis/drug therapy
    Chemical Substances Praziquantel (6490C9U457)
    Language English
    Publishing date 2023-07-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/taad091
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  4. Article: Letter to the Editor Regarding Management of Adult Patients with COVID-19 Outside Intensive Care Units: Guidelines from the Italian Society of Anti-Infective Therapy (SITA) and the Italian Society of Pulmonology (SIP).

    Manciulli, Tommaso / Spinicci, Michele / Bartoloni, Alessandro / Zammarchi, Lorenzo

    Infectious diseases and therapy

    2021  Volume 11, Issue 1, Page(s) 629–633

    Abstract: Recently, the Italian Society of Anti-Infective Therapy (SITA) and the Italian Society of Pulmonology (SIP) published guidelines on the management of inpatients with COVID-19. The guidelines do not recommend the use of monoclonal antibodies (mAbs) in ... ...

    Abstract Recently, the Italian Society of Anti-Infective Therapy (SITA) and the Italian Society of Pulmonology (SIP) published guidelines on the management of inpatients with COVID-19. The guidelines do not recommend the use of monoclonal antibodies (mAbs) in inpatients, pending results from clinical trials. However, recently the Italian Drug Agency (AIFA) has allowed for the use of casirivimab/imdevimab at higher doses in hospitalized seronegative patients with COVID-19. Furthermore, several other therapeutic options based on mAbs are about to become available for outpatients. Here we provide a brief summary of the future possibilities and summarize existing data.
    Language English
    Publishing date 2021-12-10
    Publishing country New Zealand
    Document type Letter
    ZDB-ID 2701611-0
    ISSN 2193-6382 ; 2193-8229
    ISSN (online) 2193-6382
    ISSN 2193-8229
    DOI 10.1007/s40121-021-00565-w
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  5. Article ; Online: "COVID-19: diagnosis, management and prognosis": a new topical collection of Internal and Emergency Medicine.

    Polosa, Riccardo / Spinicci, Michele / Prisco, Domenico

    Internal and emergency medicine

    2020  Volume 15, Issue 5, Page(s) 747–750

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Prognosis ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-30
    Publishing country Italy
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-020-02461-6
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  6. Article ; Online: Steroid modified tinea.

    Spinicci, Michele / Rinaldi, Francesca / Zammarchi, Lorenzo / Bartoloni, Alessandro

    Internal and emergency medicine

    2020  Volume 15, Issue 6, Page(s) 1107–1108

    MeSH term(s) Humans ; Male ; Miconazole/adverse effects ; Miconazole/therapeutic use ; Middle Aged ; Pregnadienetriols/adverse effects ; Pregnadienetriols/therapeutic use ; Pruritus/etiology ; Tinea Pedis/etiology ; Trichophyton/drug effects ; Trichophyton/pathogenicity
    Chemical Substances Pregnadienetriols ; Miconazole (7NNO0D7S5M) ; fluprednidene acetate (GE65DV564S)
    Language English
    Publishing date 2020-03-21
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-020-02311-5
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  7. Article ; Online: High-dose steroids for the treatment of severe COVID-19.

    Piccica, Matteo / Lagi, Filippo / Trotta, Michele / Spinicci, Michele / Zammarchi, Lorenzo / Bartoloni, Alessandro

    Internal and emergency medicine

    2021  Volume 16, Issue 5, Page(s) 1395–1399

    MeSH term(s) Aged ; Aged, 80 and over ; COVID-19/drug therapy ; Female ; Glucocorticoids/administration & dosage ; Glucocorticoids/therapeutic use ; Humans ; Italy ; Male ; Methylprednisolone/administration & dosage ; Methylprednisolone/therapeutic use ; Middle Aged ; Patient Acuity
    Chemical Substances Glucocorticoids ; Methylprednisolone (X4W7ZR7023)
    Language English
    Publishing date 2021-04-15
    Publishing country Italy
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-021-02707-x
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  8. Article ; Online: A calcified intestinal worm or Salgari's syndrome?

    Zammarchi, Lorenzo / Viligiardi, Riccardo / Modi, Giulia / Spinicci, Michele / Bartoloni, Alessandro

    Journal of travel medicine

    2020  Volume 28, Issue 1

    MeSH term(s) Helminthiasis ; Humans ; Intestinal Diseases, Parasitic
    Language English
    Publishing date 2020-11-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/taaa208
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    Zs.A 4120: Show issues Location:
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  9. Article ; Online: Scalp eschar and neck lymph adenopathy after a tick bite (SENLAT) in Tuscany, Italy (2015-2022).

    Barbiero, Anna / Manciulli, Tommaso / Spinicci, Michele / Vellere, Iacopo / Colao, Maria Grazia / Rossolini, Gian Maria / Bartoloni, Alessandro / Raoult, Didier / Zammarchi, Lorenzo

    Infection

    2023  Volume 51, Issue 6, Page(s) 1847–1854

    Abstract: Introduction: The Scalp Eschar and Neck Lymph Adenopathy After a Tick Bite (SENLAT) syndrome is frequently caused by Rickettsia slovaca and Rickettsia raoultii. Only six microbiologically confirmed SENLAT cases have been reported in Italy between 1996 ... ...

    Abstract Introduction: The Scalp Eschar and Neck Lymph Adenopathy After a Tick Bite (SENLAT) syndrome is frequently caused by Rickettsia slovaca and Rickettsia raoultii. Only six microbiologically confirmed SENLAT cases have been reported in Italy between 1996 and 2021. We report ten cases of SENLAT seen between 2015 and 2022 in a tertiary care center in Tuscany, Italy.
    Cases presentation: All patients were women; most common symptoms were scalp eschar on the site of tick bite (100%) and cervical lymphadenopathy (90%). No microbiological identification was obtained. Persistent alopecia, for several months to years, was observed in four patients. The known difficulty of microbiological diagnosis in SENLAT was worsened, in our cases, by factors as the absence of ticks available for identification and microbiological study, and antibiotic treatment administration previous to microbiological tests.
    Conclusion: The report highlights the presence of SENLAT in Italy, aiming to raise the awareness toward the emergence of this clinical entity.
    MeSH term(s) Humans ; Female ; Male ; Tick Bites/complications ; Scalp ; Rickettsia Infections/diagnosis ; Rickettsia Infections/drug therapy ; Rickettsia Infections/epidemiology ; Lymphadenopathy/microbiology ; Anti-Bacterial Agents/therapeutic use ; Italy/epidemiology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-08-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-023-02079-8
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    Zs.A 881: Show issues Location:
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    Zs.MO 528: Show issues

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  10. Article ; Online: Treatment with anti-SARS-CoV-2 monoclonal antibodies in pregnant and postpartum women: first experiences in Florence, Italy.

    Manciulli, Tommaso / Modi, Giulia / Campolmi, Irene / Borchi, Beatrice / Trotta, Michele / Spinicci, Michele / Lagi, Filippo / Bartoloni, Alessandro / Zammarchi, Lorenzo

    Infection

    2022  Volume 50, Issue 5, Page(s) 1139–1145

    Abstract: Purpose: Pregnant and postpartum women are at increased risk of developing severe COVID-19. Monoclonal antibodies (mAbs) are now widely used in high-income countries to treat mild to moderate COVID-19 outpatients at risk for developing severe disease. ... ...

    Abstract Purpose: Pregnant and postpartum women are at increased risk of developing severe COVID-19. Monoclonal antibodies (mAbs) are now widely used in high-income countries to treat mild to moderate COVID-19 outpatients at risk for developing severe disease. Very few data are available on the use of mAbs in special populations, including pregnant and postpartum women. Here we present our early experience with mAbs in these two populations.
    Methods: Electronic records of pregnant and postpartum women treated with mAbs at Careggi University Hospital, Florence, were retrieved. Relevant data were extracted (age, presence of risk factors for COVID-19, oxygen support, mAb type, gestational age, and pregnancy status). When available, outcomes at 28 days after administration were also included.
    Results: From March 1st to September 30th 2021, eight pregnant and two postpartum women have been treated with mAbs at our center. The median age was 31 years (IQR 30-33.5, range 29-38), median gestational age was 24 weeks. Seven patients had additional risk factors. According to the Italian disposition, all patients received casirivimab/imdevimab, with five receiving a 2.4 mg dose and five receiving a 8 g dose. Eight patients improved. One developed myocarditis, considered a COVID-19 complication. Another required a transient increase of low flow oxygen support before improving and being discharged. At a 28 days follow-up, all patients were clinically recovered. We did not observe mAbs related adverse events.
    Conclusion: Although preliminary data should be interpreted with caution, it is remarkable how mAbs were well tolerated by pregnant women with COVID-19. Further data on mAbs in this special population should be collected but the use of mAbs in pregnant and postpartum patients should be considered. Even thus oral antivirals are becoming available, they are not recommended in pregnant and postpartum women. This population may specifically benefit from treatment with last generation mAbs.
    MeSH term(s) Adult ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized ; Antibodies, Viral ; Antiviral Agents ; COVID-19/drug therapy ; Female ; Humans ; Infant ; Oxygen ; Postpartum Period ; Pregnancy
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antibodies, Viral ; Antiviral Agents ; imdevimab (2Z3DQD2JHM) ; casirivimab (J0FI6WE1QN) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2022-03-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-022-01777-z
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