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  1. Article: Asymmetric Graves' Orbitopathy.

    Panagiotou, Grigorios / Perros, Petros

    Frontiers in endocrinology

    2020  Volume 11, Page(s) 611845

    Abstract: Graves' Orbitopathy (GO) is an autoimmune orbital disorder usually presenting as a sequala of autoimmune thyroid disease. The presence of GO is associated with increased psychological burden and, in severe cases may cause blindness. While most patients ... ...

    Abstract Graves' Orbitopathy (GO) is an autoimmune orbital disorder usually presenting as a sequala of autoimmune thyroid disease. The presence of GO is associated with increased psychological burden and, in severe cases may cause blindness. While most patients with GO present with bilateral disease, asymmetric or unilateral GO may affect a significant proportion of patients diagnosed with GO. Older age, male sex, active and severe disease correlate with asymmetric disease. However, the exact mechanisms causing asymmetry remain elusive. Herein, we review the literature on asymmetric GO and highlight its differences compared with bilateral GO.
    MeSH term(s) Age Factors ; Animals ; Graves Disease/diagnosis ; Graves Disease/epidemiology ; Graves Disease/therapy ; Graves Ophthalmopathy/diagnosis ; Graves Ophthalmopathy/epidemiology ; Graves Ophthalmopathy/therapy ; Humans ; Sex Factors
    Language English
    Publishing date 2020-12-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2020.611845
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  2. Article ; Online: Late offspring effects of antenatal thyroid screening.

    Panagiotou, Grigorios / Taylor, Peter N / Rees, D Aled / Okosieme, Onyebuchi E

    British medical bulletin

    2022  Volume 143, Issue 1, Page(s) 16–29

    Abstract: Background: Thyroid dysfunction in pregnancy is associated with adverse offspring outcomes and recent birth-cohort studies suggest that even mild degrees of thyroid dysfunction may be linked with a range of late cognitive and behavioural effects in ... ...

    Abstract Background: Thyroid dysfunction in pregnancy is associated with adverse offspring outcomes and recent birth-cohort studies suggest that even mild degrees of thyroid dysfunction may be linked with a range of late cognitive and behavioural effects in childhood and adolescence.
    Sources of data: This review summarizes recent literature of observational studies and critically appraises randomized controlled trials (RCTs) of antenatal thyroid screening and Levothyroxine intervention.
    Areas of agreement: Overt hypothyroidism and hyperthyroidism carry significant risks for unfavourable offspring outcomes and should be appropriately corrected in pregnancy.
    Areas of controversy: The significance of subclinical hypothyroidism and hypothyroxinaemia is still unclear. Meta-analyses of birth-cohort studies show associations of maternal subclinical hypothyroidism and hypothyroxinaemia with intellectual deficits, attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders, while hyperthyroidism and high-normal FT4 were linked with ADHD. RCTs have shown no benefits of screening on neurodevelopmental outcomes although Levothyroxine could have been initiated too late in pregnancy in these trials.
    Growing points: A small number of studies have shown inconsistent associations of maternal thyroid dysfunction with offspring cardiometabolic indices including blood pressure and body weight. Correction of maternal thyroid dysfunction was, however, associated with favourable long-term metabolic profiles in mothers, including lipid profiles, fat mass and body mass index. Antenatal thyroid screening may therefore present opportunities for optimizing a wider range of outcomes than envisaged.
    Areas for developing research: Future trials with early antenatal thyroid screening and intervention are necessary to clarify the impact of screening on late offspring and maternal effects.
    MeSH term(s) Female ; Humans ; Hyperthyroidism/complications ; Hyperthyroidism/diagnosis ; Hypothyroidism/complications ; Hypothyroidism/diagnosis ; Lipids ; Pregnancy ; Thyroxine
    Chemical Substances Lipids ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2022-07-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 213294-1
    ISSN 1471-8391 ; 0007-1420
    ISSN (online) 1471-8391
    ISSN 0007-1420
    DOI 10.1093/bmb/ldac018
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  3. Article: Serum Levels of Irisin and Omentin-1 in Breast Neoplasms and Their Association with Tumor Histology.

    Panagiotou, Grigorios / Triantafyllidou, Sofia / Tarlatzis, Basil C / Papakonstantinou, Eleni

    International journal of endocrinology

    2021  Volume 2021, Page(s) 6656671

    Abstract: Breast cancer is associated with obesity, possibly due to direct effects of adipokines and myokines, such as omentin-1 and irisin. In this study, we aimed to evaluate omentin-1 and irisin levels in women with benign and/or malignant breast neoplasms vs. ... ...

    Abstract Breast cancer is associated with obesity, possibly due to direct effects of adipokines and myokines, such as omentin-1 and irisin. In this study, we aimed to evaluate omentin-1 and irisin levels in women with benign and/or malignant breast neoplasms vs. healthy controls. Disease-free individuals (
    Language English
    Publishing date 2021-02-22
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2502951-4
    ISSN 1687-8345 ; 1687-8337
    ISSN (online) 1687-8345
    ISSN 1687-8337
    DOI 10.1155/2021/6656671
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  4. Article ; Online: Obesity and COVID-19: A jigsaw puzzle with still missing pieces.

    Michalakis, Konstantinos / Panagiotou, Grigorios / Ilias, Ioannis / Pazaitou-Panayiotou, Kalliopi

    Clinical obesity

    2020  Volume 11, Issue 1, Page(s) e12420

    Abstract: Apart from posing various mechanical and medical issues compromising general health, obesity is a major factor for respiratory tract infections, due to specific inflammation and immunological compromise. The burden of obesity on morbidity and mortality ... ...

    Abstract Apart from posing various mechanical and medical issues compromising general health, obesity is a major factor for respiratory tract infections, due to specific inflammation and immunological compromise. The burden of obesity on morbidity and mortality of SARS-CoV-2 infection/COVID-19 is considerable. Herein, we aimed to search the literature and present to the readers pathophysiologic pathways that may associate obesity and COVID-19. We present potential mechanisms, which might partly explain why patients with obesity are more prone to suffer from respiratory infections in the context of COVID-19. Better understanding of these pathways could eventually guide management strategies and therapies for COVID-19 in the future.
    MeSH term(s) COVID-19/epidemiology ; Comorbidity ; Global Health ; Humans ; Incidence ; Obesity/epidemiology ; Pandemics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-10-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2625816-X
    ISSN 1758-8111 ; 1758-8103
    ISSN (online) 1758-8111
    ISSN 1758-8103
    DOI 10.1111/cob.12420
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  5. Article ; Online: Endocrine Manifestations and New Developments in Mitochondrial Disease.

    Ng, Yi Shiau / Lim, Albert Zishen / Panagiotou, Grigorios / Turnbull, Doug M / Walker, Mark

    Endocrine reviews

    2021  Volume 43, Issue 3, Page(s) 583–609

    Abstract: Mitochondrial diseases are a group of common inherited diseases causing disruption of oxidative phosphorylation. Some patients with mitochondrial disease have endocrine manifestations, with diabetes mellitus being predominant but also include ... ...

    Abstract Mitochondrial diseases are a group of common inherited diseases causing disruption of oxidative phosphorylation. Some patients with mitochondrial disease have endocrine manifestations, with diabetes mellitus being predominant but also include hypogonadism, hypoadrenalism, and hypoparathyroidism. There have been major developments in mitochondrial disease over the past decade that have major implications for all patients. The collection of large cohorts of patients has better defined the phenotype of mitochondrial diseases and the majority of patients with endocrine abnormalities have involvement of several other systems. This means that patients with mitochondrial disease and endocrine manifestations need specialist follow-up because some of the other manifestations, such as stroke-like episodes and cardiomyopathy, are potentially life threatening. Also, the development and follow-up of large cohorts of patients means that there are clinical guidelines for the management of patients with mitochondrial disease. There is also considerable research activity to identify novel therapies for the treatment of mitochondrial disease. The revolution in genetics, with the introduction of next-generation sequencing, has made genetic testing more available and establishing a precise genetic diagnosis is important because it will affect the risk for involvement for different organ systems. Establishing a genetic diagnosis is also crucial because important reproductive options have been developed that will prevent the transmission of mitochondrial disease because of mitochondrial DNA variants to the next generation.
    MeSH term(s) Diabetes Mellitus/genetics ; Genetic Testing ; Humans ; Mitochondria ; Mitochondrial Diseases/diagnosis ; Mitochondrial Diseases/genetics ; Mitochondrial Diseases/therapy ; Phenotype
    Language English
    Publishing date 2021-09-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603096-8
    ISSN 1945-7189 ; 0163-769X
    ISSN (online) 1945-7189
    ISSN 0163-769X
    DOI 10.1210/endrev/bnab036
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    Zs.A 1562: Show issues Location:
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  6. Article ; Online: Serum Follistatin Is Increased in Thyroid Cancer and Is Associated With Adverse Tumor Characteristics in Humans.

    Panagiotou, Grigorios / Ghaly, Wael / Upadhyay, Jagriti / Pazaitou-Panayiotou, Kalliopi / Mantzoros, Christos S

    The Journal of clinical endocrinology and metabolism

    2021  Volume 106, Issue 5, Page(s) e2137–e2150

    Abstract: Context: Obesity and classical growth factors are associated with thyroid cancer (TC). However, less is known regarding novel hormones such as follistatins and activins. We hypothesized that serum follistatin but not activins would be increased in TC.!## ...

    Abstract Context: Obesity and classical growth factors are associated with thyroid cancer (TC). However, less is known regarding novel hormones such as follistatins and activins. We hypothesized that serum follistatin but not activins would be increased in TC.
    Objective: This work aimed to assess circulating levels of follistatins, activins, and growth factors in patients with a history of TC vs patients with nonmalignant thyroid diseases.
    Methods: A hospital-based, unmatched case-control study was conducted with 170 thyroidectomized patients due to well-differentiated TC and 106 thyroidectomized patients without history of malignancy. Anthropometric, biochemical, and histological parameters were recorded. Serum samples were collected in the steady state 45 days after surgery. Multivariate models were used to adjust for baseline differences of the unmatched variables. Serum levels of follistatin (FST), follistatin like-3, activin A, activin B, bioactive insulin-like growth factor-1, and stanniocalcin-2 were assayed with novel, highly specific ELISA kits.
    Results: In unmatched univariate models, TC patients had higher FST serum levels compared to cancer-free individuals, independently of histological subtype. In multivariate models adjusting for covariates, individuals in the highest tertile of FST levels were associated with an increased risk for the presence of any type of TC or specific histological subtypes, including papillary, follicular and Hürthle-cell carcinoma, and medullary TC. Higher postoperative FST concentrations were found in patients with vascular invasion and distant metastases and associated with TNM staging at diagnosis.
    Conclusion: FST serum levels are increased in TC patients and correlate with advanced tumor aggressiveness. Future longitudinal studies are needed to confirm and extend our observations.
    MeSH term(s) Adenocarcinoma, Follicular/blood ; Adenocarcinoma, Follicular/pathology ; Adenocarcinoma, Follicular/surgery ; Biomarkers, Tumor/blood ; Case-Control Studies ; Female ; Follistatin/blood ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Thyroid Cancer, Papillary/blood ; Thyroid Cancer, Papillary/pathology ; Thyroid Cancer, Papillary/surgery ; Thyroid Neoplasms/blood ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/surgery
    Chemical Substances Biomarkers, Tumor ; FST protein, human ; Follistatin
    Language English
    Publishing date 2021-02-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgab041
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  7. Article ; Online: High-Performance Luminescence Thermometer with Field-Induced Slow Magnetic Relaxation Based on a Heterometallic Cyanido-Bridged 3d-4f Complex.

    Tangoulis, Vassilis / Nastopoulos, Vassilis / Panagiotou, Nikos / Tasiopoulos, Anastasios / Itskos, Grigorios / Athanasiou, Modestos / Moreno-Pineda, Eufemio / Wernsdorfer, Wolfgang / Schulze, Michael / Malina, Ondřej

    Inorganic chemistry

    2022  Volume 61, Issue 5, Page(s) 2546–2557

    Abstract: The 1:1:1 reaction of ... ...

    Abstract The 1:1:1 reaction of DyCl
    Language English
    Publishing date 2022-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.1c03432
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  8. Article: Obesity and COVID-19: A jigsaw puzzle with still missing pieces

    Michalakis, Konstantinos / Panagiotou, Grigorios / Ilias, Ioannis / Pazaitou-Panayiotou, Kalliopi

    Clin Obes

    Abstract: Apart from posing various mechanical and medical issues compromising general health, obesity is a major factor for respiratory tract infections, due to specific inflammation and immunological compromise. The burden of obesity on morbidity and mortality ... ...

    Abstract Apart from posing various mechanical and medical issues compromising general health, obesity is a major factor for respiratory tract infections, due to specific inflammation and immunological compromise. The burden of obesity on morbidity and mortality of SARS-CoV-2 infection/COVID-19 is considerable. Herein, we aimed to search the literature and present to the readers pathophysiologic pathways that may associate obesity and COVID-19. We present potential mechanisms, which might partly explain why patients with obesity are more prone to suffer from respiratory infections in the context of COVID-19. Better understanding of these pathways could eventually guide management strategies and therapies for COVID-19 in the future.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #873243
    Database COVID19

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  9. Article ; Online: Adipocytes express tissue factor and FVII and are procoagulant in a TF/FVIIa-dependent manner.

    Edén, Desirée / Panagiotou, Grigorios / Mokhtari, Dariush / Eriksson, Jan W / Åberg, Mikael / Siegbahn, Agneta

    Upsala journal of medical sciences

    2019  Volume 124, Issue 3, Page(s) 158–167

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adipocytes/drug effects ; Adipocytes/metabolism ; Blood Coagulation/physiology ; Blotting, Western ; Cells, Cultured ; Culture Media, Conditioned ; Dexamethasone/pharmacology ; Down-Regulation ; Gene Expression Regulation ; Healthy Volunteers ; Humans ; Insulin/pharmacology ; Lipolysis/genetics ; RNA, Messenger/drug effects ; RNA, Messenger/genetics ; RNA, Small Interfering/genetics ; Real-Time Polymerase Chain Reaction ; Rosiglitazone/pharmacology ; Serine Endopeptidases/genetics ; Signal Transduction ; Subcutaneous Fat/cytology ; Thromboplastin/genetics ; Transfection
    Chemical Substances Culture Media, Conditioned ; Insulin ; RNA, Messenger ; RNA, Small Interfering ; Rosiglitazone (05V02F2KDG) ; Dexamethasone (7S5I7G3JQL) ; Thromboplastin (9035-58-9) ; HABP2 protein, human (EC 3.4.21.-) ; Serine Endopeptidases (EC 3.4.21.-)
    Language English
    Publishing date 2019-08-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 183949-4
    ISSN 2000-1967 ; 0300-9734
    ISSN (online) 2000-1967
    ISSN 0300-9734
    DOI 10.1080/03009734.2019.1645248
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  10. Article ; Online: Dual Emission in a Ligand and Metal Co-Doped Lanthanide-Organic Framework: Color Tuning and Temperature Dependent Luminescence.

    Andriotou, Despoina / Diamantis, Stavros A / Zacharia, Anna / Itskos, Grigorios / Panagiotou, Nikos / Tasiopoulos, Anastasios J / Lazarides, Theodore

    Molecules (Basel, Switzerland)

    2020  Volume 25, Issue 3

    Abstract: In this study, we report the luminescence color tuning in the lanthanide metal-organic framework (LnMOF) ([La(bpdc)Cl(DMF)] ( ...

    Abstract In this study, we report the luminescence color tuning in the lanthanide metal-organic framework (LnMOF) ([La(bpdc)Cl(DMF)] (
    MeSH term(s) Algorithms ; Color ; Dimethylformamide/analogs & derivatives ; Dimethylformamide/chemistry ; Lanthanoid Series Elements/chemical synthesis ; Lanthanoid Series Elements/chemistry ; Ligands ; Luminescence ; Magnetic Resonance Spectroscopy ; Metal-Organic Frameworks/chemistry ; Metals/chemistry ; Models, Chemical ; Molecular Conformation ; Reproducibility of Results ; Temperature ; Thermogravimetry
    Chemical Substances Lanthanoid Series Elements ; Ligands ; Metal-Organic Frameworks ; Metals ; Dimethylformamide (8696NH0Y2X)
    Language English
    Publishing date 2020-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25030523
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