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Article: Anti-Müllerian Hormone Concentrations for Determining Resumption of Sertoli Cell Function following Removal of a 4.7 mg Deslorelin Implant in Tomcats.

Ferré-Dolcet, Lluis / Bordogna, Matteo / Contiero, Barbara / Fontaine, Christelle / Bedin, Silvia / Romagnoli, Stefano

Animals : an open access journal from MDPI

2023 Volume 13, Issue 16

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-08-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13162552
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Article ; Online: Anti-Müllerian Hormone Concentrations for Determining Resumption of Sertoli Cell Function following Removal of a 4.7 mg Deslorelin Implant in Tomcats

Ferré-Dolcet, Lluis / Bordogna, Matteo / Contiero, Barbara / Fontaine, Christelle / Bedin, Silvia / Romagnoli, Stefano

Animals. 2023 Aug. 08, v. 13, no. 16

2023

Abstract: Background: Deslorelin implant use in cats is a medical alternative to surgical sterilization, and due to its prolonged efficacy, its use has shown growing interest in the veterinary community. In the case of breeding facilities, its removal is often ... ...

Abstract	Background: Deslorelin implant use in cats is a medical alternative to surgical sterilization, and due to its prolonged efficacy, its use has shown growing interest in the veterinary community. In the case of breeding facilities, its removal is often requested for the early restoration of testicular function. As anti-Müllerian hormones (AMH) in males is dependent of testosterone secretion, its assay may determine the restoration of testicular steroid secretion. An average of 3 weeks has been already described for tomcats’ testicular function resumption after implant removal, but information about AMH concentrations in deslorelin-treated tomcats is lacking. Methods: Fourteen tomcats were treated for temporary suppression of fertility with a 4.7 mg deslorelin implant, which was surgically removed after 3, 6 or 9 months (n = 6, 4 and 4 tomcats, respectively). A general clinical and reproductive check with a gonadorelin stimulation test for testosterone determination was performed before deslorelin implant administration. After implant removal, tomcats’ testicles were ultrasonographically checked for volume determination every 1-2 weeks with observation of the glans penis (presence or absence of spikes) and blood collection to assay both testosterone and AMH concentrations. Results: AMH concentrations increased significantly during the deslorelin treatment from 20.95 ± 4.97 ng/mL to 82.41 ± 14.59 ng/mL (p < 0.05). Following implant removal, AMH concentrations progressively decreased to pre-treatment levels, with a value of 28.42 ± 7.98 ng/mL on the third week post-removal where testosterone secretion was again detected. Conclusions: Even if a big variability of AMH concentrations exists between male individuals, resumption of tomcats’ testicular function following a deslorelin treatment can be determined by AMH assay.
Keywords	Sertoli cells ; anti-Mullerian hormone ; blood sampling ; deslorelin acetate ; gonadotropin-releasing hormone ; males ; penis ; secretion ; testosterone
Language	English
Dates of publication	2023-0808
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13162552
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Vestibular contribution to spatial encoding.

Zanchi, Silvia / Cuturi, Luigi F / Sandini, Giulio / Gori, Monica / Ferrè, Elisa R

The European journal of neuroscience

2023 Volume 58, Issue 9, Page(s) 4034–4042

Abstract: Determining the spatial relation between objects and our location in the surroundings is essential for survival. Vestibular inputs provide key information about the position and movement of our head in the three-dimensional space, contributing to spatial ...

Abstract	Determining the spatial relation between objects and our location in the surroundings is essential for survival. Vestibular inputs provide key information about the position and movement of our head in the three-dimensional space, contributing to spatial navigation. Yet, their role in encoding spatial localisation of environmental targets remains to be fully understood. We probed the accuracy and precision of healthy participants' representations of environmental space by measuring their ability to encode the spatial location of visual targets (Experiment 1). Participants were asked to detect a visual light and then walk towards it. Vestibular signalling was artificially disrupted using stochastic galvanic vestibular stimulation (sGVS) applied selectively during encoding targets' location. sGVS impaired the accuracy and precision of locating the environmental visual targets. Importantly, this effect was specific to the visual modality. The location of acoustic targets was not influenced by vestibular alterations (Experiment 2). Our findings indicate that the vestibular system plays a role in localising visual targets in the surrounding environment, suggesting a crucial functional interaction between vestibular and visual signals for the encoding of the spatial relationship between our body position and the surrounding objects.
MeSH term(s)	Humans ; Space Perception/physiology ; Vestibule, Labyrinth/physiology ; Sensation ; Movement
Language	English
Publishing date	2023-09-09
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645180-9
ISSN	1460-9568 ; 0953-816X
ISSN (online)	1460-9568
ISSN	0953-816X
DOI	10.1111/ejn.16146
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Article ; Online: Voice acoustics allow classifying autism spectrum disorder with high accuracy.

Briend, Frédéric / David, Céline / Silleresi, Silvia / Malvy, Joëlle / Ferré, Sandrine / Latinus, Marianne

Translational psychiatry

2023 Volume 13, Issue 1, Page(s) 250

Abstract: Early identification of children on the autism spectrum is crucial for early intervention with long-term positive effects on symptoms and skills. The need for improved objective autism detection tools is emphasized by the poor diagnostic power in current ...

Abstract	Early identification of children on the autism spectrum is crucial for early intervention with long-term positive effects on symptoms and skills. The need for improved objective autism detection tools is emphasized by the poor diagnostic power in current tools. Here, we aim to evaluate the classification performance of acoustic features of the voice in children with autism spectrum disorder (ASD) with respect to a heterogeneous control group (composed of neurotypical children, children with Developmental Language Disorder [DLD] and children with sensorineural hearing loss with Cochlear Implant [CI]). This retrospective diagnostic study was conducted at the Child Psychiatry Unit of Tours University Hospital (France). A total of 108 children, including 38 diagnosed with ASD (8.5 ± 0.25 years), 24 typically developing (TD; 8.2 ± 0.32 years) and 46 children with atypical development (DLD and CI; 7.9 ± 0.36 years) were enrolled in our studies. The acoustic properties of speech samples produced by children in the context of a nonword repetition task were measured. We used a Monte Carlo cross-validation with an ROC (Receiving Operator Characteristic) supervised k-Means clustering algorithm to develop a classification model that can differentially classify a child with an unknown disorder. We showed that voice acoustics classified autism diagnosis with an overall accuracy of 91% [CI95%, 90.40%-91.65%] against TD children, and of 85% [CI95%, 84.5%-86.6%] against an heterogenous group of non-autistic children. Accuracy reported here with multivariate analysis combined with Monte Carlo cross-validation is higher than in previous studies. Our findings demonstrate that easy-to-measure voice acoustic parameters could be used as a diagnostic aid tool, specific to ASD.
MeSH term(s)	Child ; Humans ; Autism Spectrum Disorder/complications ; Autism Spectrum Disorder/diagnosis ; Retrospective Studies ; Autistic Disorder ; Acoustics ; France
Language	English
Publishing date	2023-07-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2609311-X
ISSN	2158-3188 ; 2158-3188
ISSN (online)	2158-3188
ISSN	2158-3188
DOI	10.1038/s41398-023-02554-8
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Article ; Online: Spatial Sensory References for Vestibular Self-Motion Perception.

Zanchi, Silvia / Cuturi, Luigi F / Sandini, Giulio / Gori, Monica / Ferrè, Elisa R

Multisensory research

2023 , Page(s) 1–14

Abstract: While navigating through the surroundings, we constantly rely on inertial vestibular signals for self-motion along with visual and acoustic spatial references from the environment. However, the interaction between inertial cues and environmental spatial ... ...

Abstract	While navigating through the surroundings, we constantly rely on inertial vestibular signals for self-motion along with visual and acoustic spatial references from the environment. However, the interaction between inertial cues and environmental spatial references is not yet fully understood. Here we investigated whether vestibular self-motion sensitivity is influenced by sensory spatial references. Healthy participants were administered a Vestibular Self-Motion Detection Task in which they were asked to detect vestibular self-motion sensations induced by low-intensity Galvanic Vestibular Stimulation. Participants performed this detection task with or without an external visual or acoustic spatial reference placed directly in front of them. We computed the d prime ( d ' ) as a measure of participants' vestibular sensitivity and the criterion as an index of their response bias. Results showed that the visual spatial reference increased sensitivity to detect vestibular self-motion. Conversely, the acoustic spatial reference did not influence self-motion sensitivity. Both visual and auditory spatial references did not cause changes in response bias. Environmental visual spatial references provide relevant information to enhance our ability to perceive inertial self-motion cues, suggesting a specific interaction between visual and vestibular systems in self-motion perception.
Language	English
Publishing date	2023-12-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2708792-X
ISSN	2213-4808 ; 2213-4794
ISSN (online)	2213-4808
ISSN	2213-4794
DOI	10.1163/22134808-bja10117
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Article ; Online: International Medical Graduates in Nephrology: A Guide for Trainees and Programs.

Neyra, Javier A / Tio, Maria Clarissa / Ferrè, Silvia

Advances in chronic kidney disease

2020 Volume 27, Issue 4, Page(s) 297–304.e1

Abstract: A significant portion of the nephrology workforce has traditionally consisted of non-United States (US) citizen international medical graduates and international research trainees. Although international medical graduates are offered opportunities for ... ...

Abstract	A significant portion of the nephrology workforce has traditionally consisted of non-United States (US) citizen international medical graduates and international research trainees. Although international medical graduates are offered opportunities for training and professional growth that are beyond those available in their countries of origin, they typically encounter barriers to transition from training to practice and early-stage career development. In this article, we describe the exchange visitor and temporary worker visas granted to foreign trainees in the United States, focusing on the transition from training to nephrology practice and/or research. While we provide general recommendations on how to navigate this tedious and unpredictable process for both programs and trainees, consultation with immigration attorneys is indispensable for a successful outcome. Trainees are therefore encouraged to seek continuous support from their programs/sponsors and assistance from immigration representatives at their training institutions. We provide a positive message to emphasize that there are many pathways to arrive at the desired post-training destination.
MeSH term(s)	Biomedical Research ; Education, Medical, Graduate ; Emigration and Immigration/legislation & jurisprudence ; Fellowships and Scholarships ; Foreign Medical Graduates/education ; Humans ; Licensure ; Nephrology/education ; United States
Language	English
Publishing date	2020-08-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ISSN	1548-5609 ; 1548-5595
ISSN (online)	1548-5609
ISSN	1548-5595
DOI	10.1053/j.ackd.2020.05.003
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Zs.A 4627: Show issues

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Article: Prostatic fluid composition and semen quality in dogs with benign prostatic hyperplasia undergoing treatment with osaterone acetate

Ferré‐Dolcet, Lluis / Frigotto, Lisa / Contiero, Barbara / Bedin, Silvia / Romagnoli, Stefano

Reproduction in domestic animals. 2022 Jan., v. 57, no. 1

2022

Abstract: Benign prostatic hyperplasia (BPH) may alter prostatic fluid biochemical composition causing reduced fertility. Osaterone acetate (OA) is an androgen receptor antagonist marketed for treatment of canine BPH. Little information exists on effects of OA ... ...

Abstract	Benign prostatic hyperplasia (BPH) may alter prostatic fluid biochemical composition causing reduced fertility. Osaterone acetate (OA) is an androgen receptor antagonist marketed for treatment of canine BPH. Little information exists on effects of OA administration on biochemical composition of canine prostatic fluid and its role on fertility. The aim of this research was to study biochemical composition of prostatic fluid and its role on semen quality in dogs with BPH undergoing treatment with OA. Eight intact, 5–11‐year‐old dogs with benign prostatic hyperplasia were treated orally with OA at a dose of 0.25–0.5 mg/kg once daily for seven days. Prostatic volume, semen evaluation and a biochemical analysis of prostatic fluid were performed on the day before treatment (D0), D60, D120, D180 and D240. A significant reduction (57% and 61%) of prostatic volume was observed at D60 and D120, respectively, and a significant reduction (20%) of normal spermatozoa was observed at D60 coincident with a significant increase of sperm tail defects, which disappeared during the course of the treatment. Prostatic fluid composition did not vary during the OA treatment except for zinc (Zn²⁺) with a significant increase at D120 and D180 correlated with the return to normal sperm values. In conclusion, canine Zn²⁺ prostatic fluid concentrations decrease during development of BPH and return to normal during treatment with OA. Zn²⁺ is an important electrolyte for semen quality, suggesting that oral Zn²⁺ supplementation might be considered a treatment to improve semen quality.
Keywords	acetates ; androgen receptors ; antagonists ; chemical composition ; dogs ; electrolytes ; hyperplasia ; reproduction ; semen quality ; spermatozoa ; zinc
Language	English
Dates of publication	2022-01
Size	p. 72-79.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	1015187-4
ISSN	1439-0531 ; 0936-6768
ISSN (online)	1439-0531
ISSN	0936-6768
DOI	10.1111/rda.14030
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: New insights into the role of HNF-1β in kidney (patho)physiology.

Ferrè, Silvia / Igarashi, Peter

Pediatric nephrology (Berlin, Germany)

2018 Volume 34, Issue 8, Page(s) 1325–1335

Abstract: Hepatocyte nuclear factor-1β (HNF-1β) is an essential transcription factor that regulates the development and function of epithelia in the kidney, liver, pancreas, and genitourinary tract. Humans who carry HNF1B mutations develop heterogeneous renal ... ...

Abstract	Hepatocyte nuclear factor-1β (HNF-1β) is an essential transcription factor that regulates the development and function of epithelia in the kidney, liver, pancreas, and genitourinary tract. Humans who carry HNF1B mutations develop heterogeneous renal abnormalities, including multicystic dysplastic kidneys, glomerulocystic kidney disease, renal agenesis, renal hypoplasia, and renal interstitial fibrosis. In the embryonic kidney, HNF-1β is required for ureteric bud branching, initiation of nephrogenesis, and nephron segmentation. Ablation of mouse Hnf1b in nephron progenitors causes defective tubulogenesis, whereas later inactivation in elongating tubules leads to cyst formation due to downregulation of cystic disease genes, including Umod, Pkhd1, and Pkd2. In the adult kidney, HNF-1β controls the expression of genes required for intrarenal metabolism and solute transport by tubular epithelial cells. Tubular abnormalities observed in HNF-1β nephropathy include hyperuricemia with or without gout, hypokalemia, hypomagnesemia, and polyuria. Recent studies have identified novel post-transcriptional and post-translational regulatory mechanisms that control HNF-1β expression and activity, including the miRNA cluster miR17 ∼ 92 and the interacting proteins PCBD1 and zyxin. Further understanding of the molecular mechanisms upstream and downstream of HNF-1β may lead to the development of new therapeutic approaches in cystic kidney disease and other HNF1B-related renal diseases.
MeSH term(s)	Down-Regulation ; Gene Expression Regulation, Developmental ; Hepatocyte Nuclear Factor 1-beta/genetics ; Hepatocyte Nuclear Factor 1-beta/metabolism ; Humans ; Hydro-Lyases/metabolism ; Kidney Diseases, Cystic/blood ; Kidney Diseases, Cystic/genetics ; Kidney Diseases, Cystic/pathology ; Kidney Diseases, Cystic/urine ; Kidney Tubules/abnormalities ; Kidney Tubules/pathology ; MicroRNAs/metabolism ; Mutation ; RNA, Long Noncoding ; Receptors, Cell Surface/genetics ; TRPP Cation Channels/genetics ; Uromodulin/genetics ; Urothelium/abnormalities ; Urothelium/pathology ; Zyxin/metabolism
Chemical Substances	HNF1B protein, human ; MIR17HG, human ; MicroRNAs ; PKHD1 protein, human ; RNA, Long Noncoding ; Receptors, Cell Surface ; TRPP Cation Channels ; UMOD protein, human ; Uromodulin ; ZYX protein, human ; Zyxin ; polycystic kidney disease 2 protein ; Hepatocyte Nuclear Factor 1-beta (138674-15-4) ; Hydro-Lyases (EC 4.2.1.-) ; pterin-4a-carbinolamine dehydratase (EC 4.2.1.96)
Language	English
Publishing date	2018-07-01
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-018-3990-7
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Article ; Online: Hypoconnectivity networks in schizophrenia patients: A voxel-wise meta-analysis of Rs-fMRI.

Ruiz-Torras, Silvia / Gudayol-Ferré, Esteve / Fernández-Vazquez, Oscar / Cañete-Massé, Cristina / Peró-Cebollero, Maribel / Guàrdia-Olmos, Joan

International journal of clinical and health psychology : IJCHP

2023 Volume 23, Issue 4, Page(s) 100395

Abstract: In recent years several meta-analyses regarding resting-state functional connectivity in patients with schizophrenia have been published. The authors have used different data analysis techniques: regional homogeneity, seed-based data analysis, ... ...

Abstract	In recent years several meta-analyses regarding resting-state functional connectivity in patients with schizophrenia have been published. The authors have used different data analysis techniques: regional homogeneity, seed-based data analysis, independent component analysis, and amplitude of low frequencies. Hence, we aim to perform a meta-analysis to identify connectivity networks with different activation patterns between people diagnosed with schizophrenia and healthy controls using voxel-wise analysis. Method: We collected primary studies exploring whole brain connectivity by functional magnetic resonance imaging at rest in patients with schizophrenia compared with healthy controls. We identified 25 studies included high-quality studies that included 1285 patients with schizophrenia and 1279 healthy controls. Results: The results indicate hypoactivation in the right precentral gyrus and the left superior temporal gyrus of patients with schizophrenia compared with healthy controls. Conclusions: These regions have been linked with some clinical symptoms usually present in Plea with schizophrenia, such as auditory verbal hallucinations, formal thought disorder, and the comprehension and production of gestures.
Language	English
Publishing date	2023-07-21
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2208162-8
ISSN	2174-0852 ; 1697-2600
ISSN (online)	2174-0852
ISSN	1697-2600
DOI	10.1016/j.ijchp.2023.100395
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Article ; Online: Patient Engagement and Patient Experience Data in Regulatory Review and Health Technology Assessment: A Global Landscape Review.

Bertelsen, Neil / Dewulf, Lode / Ferrè, Silvia / Vermeulen, Rebecca / Schroeder, Karlin / Gatellier, Laureline / Sargeant, Ify / Luzuriaga, Daniela / Chapman, Hayley / Brooke, Nicholas

Therapeutic innovation & regulatory science

2023 Volume 58, Issue 1, Page(s) 63–78

Abstract: Background: Working with patients through meaningful patient engagement (PE) and incorporating patient experience data (PXD) is increasingly important in medicines and medical device development. However, PE in the planning, organization, generation, ... ...

Abstract	Background: Working with patients through meaningful patient engagement (PE) and incorporating patient experience data (PXD) is increasingly important in medicines and medical device development. However, PE in the planning, organization, generation, and interpretation of PXD within regulatory and health technology assessment (HTA) decision-making processes remains challenging. We conducted a global review of the PE and PXD landscape to identify evolving resources by geography to support and highlight the potential of integration of PE and PXD in regulatory assessment and HTA. Methods: A review of literature/public information was conducted (August 2021-January 2023), led by a multistakeholder group comprising those with lived or professional experience of PE and PXD, to identify relevant regulatory and HTA initiatives and resources reviewed and categorized by geography and focus area. Results: Overall, 53 relevant initiatives/resources were identified (global, 14; North America, 11; Europe, 11; Asia, nine; UK, six; Latin America, one; Africa, one). Most focused either on PE (49%) or PXD (28%); few (11%) mentioned both PE and PXD (as largely separate activities) or demonstrated an integration of PE and PXD (11%). Conclusions: Our analysis demonstrates increasing interest in PE, PXD, and guidance on their use individually in decision-making. However, more work is needed to offer guidance on maximizing the value of patient input into decisions by combining both PE and PXD into regulatory and HTA processes; the necessity of integrating PE in the design and interpretation of PXD programs should be highlighted. A co-created framework to achieve this integration is part of a future project.
MeSH term(s)	Humans ; Patient Participation ; Europe ; Technology Assessment, Biomedical ; Biomedical Technology ; Patient Outcome Assessment
Language	English
Publishing date	2023-09-24
Publishing country	Switzerland
Document type	Review ; Journal Article
ZDB-ID	2708397-4
ISSN	2168-4804 ; 2168-4790
ISSN (online)	2168-4804
ISSN	2168-4790
DOI	10.1007/s43441-023-00573-7
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