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  1. Article ; Online: Nature and implications of sex differences in AD pathology.

    Babapour Mofrad, Rosha / van der Flier, Wiesje M

    Nature reviews. Neurology

    2018  Volume 15, Issue 1, Page(s) 6–8

    MeSH term(s) Alzheimer Disease ; Female ; Humans ; Male ; Neuropathology ; Sex Characteristics ; tau Proteins
    Chemical Substances tau Proteins
    Language English
    Publishing date 2018-12-12
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-018-0115-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6257: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 88: Show issues

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  2. Article ; Online: Sex differences in CSF biomarkers vary by Alzheimer disease stage and

    Babapour Mofrad, Rosha / Tijms, Betty M / Scheltens, Philip / Barkhof, Frederik / van der Flier, Wiesje M / Sikkes, Sietske A M / Teunissen, Charlotte E

    Neurology

    2020  Volume 95, Issue 17, Page(s) e2378–e2388

    Abstract: Objective: To evaluate sex differences in CSF biomarkers, taking the potential modifying role of clinical disease stage and : Method: We included participants (n = 1,801) with probable Alzheimer disease (AD) dementia (n = 937), mild cognitive ... ...

    Abstract Objective: To evaluate sex differences in CSF biomarkers, taking the potential modifying role of clinical disease stage and
    Method: We included participants (n = 1,801) with probable Alzheimer disease (AD) dementia (n = 937), mild cognitive impairment (MCI; n = 437), and subjective cognitive decline (SCD; n = 427). Main outcomes were CSF β-amyloid
    Results: Three-way interactions were significant for t-Tau (
    Conclusions: Within
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Alzheimer Disease/cerebrospinal fluid ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/genetics ; Amyloid beta-Peptides/cerebrospinal fluid ; Apolipoprotein E4/genetics ; Biomarkers/cerebrospinal fluid ; Cognitive Dysfunction/cerebrospinal fluid ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/genetics ; Disease Progression ; Female ; Genotype ; Heterozygote ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Peptide Fragments/cerebrospinal fluid ; Phosphorylation ; Sex Characteristics ; tau Proteins/cerebrospinal fluid
    Chemical Substances Amyloid beta-Peptides ; Apolipoprotein E4 ; Biomarkers ; Peptide Fragments ; amyloid beta-protein (1-42) ; tau Proteins
    Language English
    Publishing date 2020-08-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000010629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.153: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 18: Show issues
    Zs.MO 374: Show issues

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  3. Article ; Online: Lumbar puncture patient video increases knowledge and reduces uncertainty: An RCT.

    Babapour Mofrad, Rosha / Fruijtier, Agnetha D / Visser, Leonie N C / Hoogland, Nina / van Dijk, Maisa / van Rossum, Frederique / Bouwman, Femke H / Smets, Ellen M A / Teunissen, Charlotte E / van der Flier, Wiesje M

    Alzheimer's & dementia (New York, N. Y.)

    2021  Volume 7, Issue 1, Page(s) e12127

    Abstract: Background: Patients often perceive a lumbar puncture (LP) as an invasive procedure. We aimed to evaluate the impact of a 3-minute educational animation-video explaining the LP procedure, on patients' knowledge, uncertainty, anxiety, and post-LP ... ...

    Abstract Background: Patients often perceive a lumbar puncture (LP) as an invasive procedure. We aimed to evaluate the impact of a 3-minute educational animation-video explaining the LP procedure, on patients' knowledge, uncertainty, anxiety, and post-LP complications.
    Methods: We included 203 newly referred memory clinic patients, who were randomly assigned to one of three conditions: (1) home viewing of the video, (2) clinic viewing of the video, or (3) control condition (care as usual). Participants completed questionnaires measuring knowledge as information recall, uncertainty, anxiety, and post-LP complications, the latter when patients underwent an LP procedure (n = 145).
    Results: Viewing the video increased information recall for both home (
    Discussion: Preparing individuals for an LP by means of an educational video can help to increase knowledge about the procedure and reduce feelings of uncertainty.
    Language English
    Publishing date 2021-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2832891-7
    ISSN 2352-8737 ; 2352-8737
    ISSN (online) 2352-8737
    ISSN 2352-8737
    DOI 10.1002/trc2.12127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Plasma amyloid-β oligomerization assay as a pre-screening test for amyloid status.

    Babapour Mofrad, Rosha / Scheltens, Philip / Kim, SangYun / Kang, Sungmin / Youn, Young Chul / An, Seong Soo A / Tomassen, Jori / van Berckel, Bart N M / Visser, Pieter Jelle / van der Flier, Wiesje M / Teunissen, Charlotte E

    Alzheimer's research & therapy

    2021  Volume 13, Issue 1, Page(s) 133

    Abstract: Objective: We assessed the performance of plasma amyloid oligomerization tendency (OAβ) as a marker for abnormal amyloid status. Additionally, we examined long-term storage effects on plasma OAβ.: Methods: We included 399 subjects regardless of ... ...

    Abstract Objective: We assessed the performance of plasma amyloid oligomerization tendency (OAβ) as a marker for abnormal amyloid status. Additionally, we examined long-term storage effects on plasma OAβ.
    Methods: We included 399 subjects regardless of clinical diagnosis from the Amsterdam Dementia Cohort and European Medical Information Framework for AD project (age, 63.8 ± 6.6; 44% female). Amyloid status was determined by visual read on positron emission tomography (PET; n
    Results: MDS-OAβ was higher in individuals with abnormal amyloid, and it identified abnormal Aβ-PET with an area under the curve (AUC) of 0.74 (95% CI, 0.67-0.81), especially in samples with a storage duration < 4 years. Combining APOEe4 and age with plasma MDS-OAβ revealed an AUC of 81% for abnormal amyloid PET status (95% CI, 74-87%). Plasma MDS-OAβ correlated negatively with MMSE (r = - 0.29, p < .01) and CSF Aβ42 (r = - 0.20, p < 0.05) and positively with CSF Tau (r = 0.20, p = 0.01).
    Conclusions: Plasma MDS-OAβ combined with APOEe4 and age accurately identifies brain amyloidosis in a large Aβ-confirmed population. Using plasma MDS-OAβ as a screener reduced the costs and number of PET scans needed to screen for amyloidosis, which is relevant for clinical trials. Additionally, plasma MDS-OAβ levels appeared affected by long-term storage duration, which could be of interest for others measuring plasma Aβ biomarkers.
    MeSH term(s) Aged ; Alzheimer Disease ; Amyloid ; Amyloid beta-Peptides ; Amyloidosis ; Biomarkers ; Female ; Humans ; Male ; Middle Aged ; Peptide Fragments ; Positron-Emission Tomography ; tau Proteins
    Chemical Substances Amyloid ; Amyloid beta-Peptides ; Biomarkers ; Peptide Fragments ; tau Proteins
    Language English
    Publishing date 2021-07-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2506521-X
    ISSN 1758-9193 ; 1758-9193
    ISSN (online) 1758-9193
    ISSN 1758-9193
    DOI 10.1186/s13195-021-00873-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Lumbar puncture in patients with neurologic conditions.

    Babapour Mofrad, Rosha / Bouwman, Femke H / Slot, Rosalinde E R / Timmers, Tessa / van der Flier, Wiesje M / Scheltens, Philip / Teunissen, Charlotte E

    Alzheimer's & dementia (Amsterdam, Netherlands)

    2017  Volume 8, Page(s) 108–110

    Abstract: A lumbar puncture is performed to obtain cerebral spinal fluid. It is implemented in the clinic on a routine basis to aid the diagnosis of neurologic diseases, such as dementia. This video will show the lumbar puncture procedure as routinely performed in ...

    Abstract A lumbar puncture is performed to obtain cerebral spinal fluid. It is implemented in the clinic on a routine basis to aid the diagnosis of neurologic diseases, such as dementia. This video will show the lumbar puncture procedure as routinely performed in the VUmc Alzheimer Center.
    Language English
    Publishing date 2017-05-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2832898-X
    ISSN 2352-8729
    ISSN 2352-8729
    DOI 10.1016/j.dadm.2017.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Decision tree supports the interpretation of CSF biomarkers in Alzheimer's disease.

    Babapour Mofrad, Rosha / Schoonenboom, Niki S M / Tijms, Betty M / Scheltens, Philip / Visser, Pieter Jelle / van der Flier, Wiesje M / Teunissen, Charlotte E

    Alzheimer's & dementia (Amsterdam, Netherlands)

    2018  Volume 11, Page(s) 1–9

    Abstract: Introduction: We developed and validated a clinically applicable decision tree for the use of cerebrospinal fluid biomarkers in the diagnosis of Alzheimer's disease (AD).: Methods: Subjects with probable AD (: Results: Two cerebrospinal fluid AD ... ...

    Abstract Introduction: We developed and validated a clinically applicable decision tree for the use of cerebrospinal fluid biomarkers in the diagnosis of Alzheimer's disease (AD).
    Methods: Subjects with probable AD (
    Results: Two cerebrospinal fluid AD biomarker profiles were revealed: the "classical" AD biomarker profile (amyloid β 1-42: 647-803 pg/ml; tau >374 pg/ml) and an "atypical" AD biomarker profile with strongly decreased amyloid β 1-42 (<647 pg/ml) and normal tau concentrations (<374 pg/ml). Compared to previous cutoffs, the decision tree performed better on diagnostic accuracy (86% [84-88] vs 80% [78-83]).
    Discussion: Two cerebrospinal fluid AD biomarker profiles were identified and incorporated in a readily applicable decision tree, which improved diagnostic accuracy.
    Language English
    Publishing date 2018-11-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2832898-X
    ISSN 2352-8729
    ISSN 2352-8729
    DOI 10.1016/j.dadm.2018.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Sex differences in memory clinic patients with possible vascular cognitive impairment.

    Exalto, Lieza G / Boomsma, Jooske M F / Babapour Mofrad, Rosha / Barkhof, Frederik / Groeneveld, Onno N / Heinen, Rutger / Kuijf, Hugo J / Leeuwis, Anna E / Prins, Niels D / Biessels, Geert Jan / Vd Flier, Wiesje M

    Alzheimer's & dementia (Amsterdam, Netherlands)

    2020  Volume 12, Issue 1, Page(s) e12090

    Abstract: Introduction: We aimed to establish sex differences in vascular brain damage of memory clinic patients with possible vascular cognitive impairment (VCI).: Methods: A total of 860 memory clinic patients (aged 67.7 ± 8.5; 46% female) with cognitive ... ...

    Abstract Introduction: We aimed to establish sex differences in vascular brain damage of memory clinic patients with possible vascular cognitive impairment (VCI).
    Methods: A total of 860 memory clinic patients (aged 67.7 ± 8.5; 46% female) with cognitive complaints and vascular brain damage (ie, possible VCI) from the prospective TRACE-VCI (Utrecht-Amsterdam Clinical Features and Prognosis in Vascular Cognitive Impairment) cohort study with 2-year follow-up were included. Age-adjusted female-to-male differences were calculated with general linear models, for demographic variables, vascular risk factors, clinical diagnosis, cognitive performance, and brain magnetic resonance imaging markers.
    Results: We found no difference in age nor distribution of clinical diagnoses between females and males. Females performed worse on the MMSE (Mini-Mental State Examination) and CAMCOG (Cognitive and Self-Contained Part of the Cambridge Examination for Mental Disorders of the Elderly). Females had a larger white matter hyperintensity volume, while males more often showed (lacunar) infarcts. There was no difference in microbleed prevalence. Males had smaller normalized total brain and gray matter volumes. During follow-up, occurrence of cognitive decline and institutionalization was comparable, but mortality was higher in males.
    Discussion: Our results suggest that susceptibility and underlying etiology of VCI might differ by sex. Males seem to have more large vessel brain damage compared to females that have more small vessel brain damage.
    Language English
    Publishing date 2020-08-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2832898-X
    ISSN 2352-8729
    ISSN 2352-8729
    DOI 10.1002/dad2.12090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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