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  1. Article: Perils of Technology - Laptop Induced Erythema Ab Igne (Toasted Skin Syndrome) on Abdomen.

    Mirgh, Sumeet P / Shah, Virti D / Sorabjee, Jehangir S

    Indian journal of occupational and environmental medicine

    2020  Volume 24, Issue 2, Page(s) 131–132

    Language English
    Publishing date 2020-08-19
    Publishing country India
    Document type Journal Article
    ZDB-ID 1456082-3
    ISSN 1998-3670 ; 0973-2284 ; 0019-5278
    ISSN (online) 1998-3670
    ISSN 0973-2284 ; 0019-5278
    DOI 10.4103/ijoem.IJOEM_12_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4967: Show issues Location:
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  2. Article: Lumps All Over: A Case of Chronic Tophaceous Gout (Harrison Syndrome).

    Mirgh, S P / Venkatesh, M P

    Indian journal of nephrology

    2017  Volume 27, Issue 3, Page(s) 239–240

    Language English
    Publishing date 2017-05-12
    Publishing country India
    Document type Journal Article
    ZDB-ID 2134388-3
    ISSN 1998-3662 ; 0971-4065
    ISSN (online) 1998-3662
    ISSN 0971-4065
    DOI 10.4103/0971-4065.202842
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Lumpy body & starry sky: A case of disseminated cysticercosis.

    Sorabjee, Jehangir S / Mirgh, Sumeet P

    The Indian journal of medical research

    2017  Volume 146, Issue 5, Page(s) 666–667

    MeSH term(s) Brain/diagnostic imaging ; Brain/physiopathology ; Cysticercosis/diagnosis ; Cysticercosis/diagnostic imaging ; Cysticercosis/physiopathology ; Humans ; Male ; Middle Aged ; Tomography, X-Ray Computed
    Language English
    Publishing date 2017-03-06
    Publishing country India
    Document type Case Reports ; Journal Article
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_1064_16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Primary Human Parvovirus B19 infection in an HIV patient on Antiretroviral Therapy.

    Mirgh, Sumeet P / Mishra, Vikas A / Sorabjee, Jehangir S

    The Journal of the Association of Physicians of India

    2019  Volume 66, Issue 8, Page(s) 102

    MeSH term(s) Antiretroviral Therapy, Highly Active ; Erythema Infectiosum ; HIV Infections ; Humans ; Parvoviridae Infections ; Parvovirus B19, Human
    Language English
    Publishing date 2019-07-16
    Publishing country India
    Document type Journal Article
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 313: Show issues Location:
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  5. Article: Knowing the unknown - CD8 encephalitis: A novel form of HIV-associated neurocognitive disorder.

    Mirgh, Sumeet P / Mishra, Vikas A / Harbada, Rishit K / Sorabjee, Jehangir S

    Neurology India

    2019  Volume 67, Issue 1, Page(s) 261–264

    MeSH term(s) Brain/pathology ; Brain/virology ; CD8-Positive T-Lymphocytes/virology ; Encephalitis/diagnosis ; Encephalitis/virology ; HIV/pathogenicity ; HIV Infections/virology ; Humans ; Male ; Middle Aged ; Neurocognitive Disorders/complications ; Neurocognitive Disorders/diagnosis ; Neurocognitive Disorders/virology
    Language English
    Publishing date 2019-03-12
    Publishing country India
    Document type Case Reports ; Letter
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.253630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 698: Show issues Location:
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  6. Article: A Microbial Old Friend with a New Face: A Rare Case of Pyrexia of Unknown Origin and Leukemoid Reaction.

    Mirgh, Sumeet P / Shah, Virti D / Sorabjee, Jehangir S

    Journal of global infectious diseases

    2017  Volume 9, Issue 3, Page(s) 117–119

    Abstract: We present a case of a young male, who presented to us with high-grade fever for more than four weeks, refractory seizures, multiple subcutaneous palpable lumps, and evidence of leukocytosis with predominant left shift on the peripheral smear. The ... ...

    Abstract We present a case of a young male, who presented to us with high-grade fever for more than four weeks, refractory seizures, multiple subcutaneous palpable lumps, and evidence of leukocytosis with predominant left shift on the peripheral smear. The classic "starry-sky" appearance on imaging, generalized muscular uptake on positron emission tomography-computerized tomography scan, and positive serology led to a diagnosis of disseminated cysticercosis. He responded to oral steroids. To the best of our knowledge, disseminated cysticercosis presenting as pyrexia of unknown origin and with a leukemoid reaction has never been reported in literature.
    Language English
    Publishing date 2017-07-24
    Publishing country India
    Document type Case Reports
    ZDB-ID 2545454-7
    ISSN 0974-8245 ; 0974-777X
    ISSN (online) 0974-8245
    ISSN 0974-777X
    DOI 10.4103/jgid.jgid_166_16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Low levels of CD26 on certain cellular subtypes of donor harvest is associated with better clinical outcomes post allogeneic stem cell transplantation through regulation of NF-κB pathway and pro-inflammatory cytokines.

    Kandekar, Shruti / Punatar, Sachin / Khattry, Navin / Gokarn, Anant / Jindal, Nishant / Mirgh, Sumeet / Chichra, Akanksha / Tembhare, Prashant / Rane, Pallavi / Gawde, Jitendra / Mathew, Libin / Patil, Anand / Chiplunkar, Shubhada / Kode, Jyoti

    International immunopharmacology

    2023  Volume 125, Issue Pt A, Page(s) 111054

    Abstract: ... cells showed increased risk of chronic GVHD (cGVHD, p = 0.055). Amongst the various immune cell subtypes ... decreased B cells in harvest showed significant association with aGVHD (p = 0.022) whereas increased myeloid ...

    Abstract Background: We had previously reported significant association of immunoectoenzyme CD26 expression on donor harvest with acute Graft-versus-Host-Disease (aGVHD) in allogeneic stem cell transplantation (ASCT) patients. The current study was aimed at analysing CD26 signaling pathway molecules and understanding their impact on immune reconstitution and clinical outcomes post-ASCT.
    Subjects and methodology: The study cohort included 26 transplant donors/patients who underwent reduced intensity (n = 21), myeloablative (n = 4) and non-myeloablative (n = 1) ASCT for hematological malignancies. Donors were matched related donors (n = 19) and haploidentical donors (n = 7). Surface expression of CD26, CD73 and ADA, and various immune cell subtypes were assessed by multicolour-flow cytometry. Soluble CD26 (sCD26) and cytokine levels were measured in plasma samples by ELISA and Multiplex Luminex assay, respectively. Immune cells from healthy individuals were stimulated with phytohemagglutinin (PHA) in the presence or absence of CD26 inhibitor. Effect of CD26 inhibition on NF-κB localization in PHA stimulated cells was analysed by immunofluorescence and confocal microscopy. Pro-inflammatory cytokines from the culture supernatants were detected with Cytometric bead array flow cytometry. Association of all measured markers with clinical outcomes was evaluated using appropriate statistical tests.
    Results: CD26 surface expression on PBSC donor harvest cells showed increased risk of chronic GVHD (cGVHD, p = 0.055). Amongst the various immune cell subtypes, decreased B cells in harvest showed significant association with aGVHD (p = 0.022) whereas increased myeloid dendritic cells and CD3
    Conclusion: Our study has implicated that lower CD26 expression on immune cell subtypes of the donor stem cell harvest is associated with reduced risk of GVHD and better survival. The underlying mechanism was found to be through NF-κB pathway and pro-inflammatory cytokines. Based on these observations, chemically designed or natural resources-based CD26 inhibitors can be explored further in clinical trials for improving ASCT outcomes.
    MeSH term(s) Humans ; NF-kappa B ; Dipeptidyl Peptidase 4 ; Cytokines ; Hematopoietic Stem Cell Transplantation/adverse effects ; Graft vs Host Disease ; Tissue Donors
    Chemical Substances NF-kappa B ; Dipeptidyl Peptidase 4 (EC 3.4.14.5) ; Cytokines
    Language English
    Publishing date 2023-10-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2023.111054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5408: Show issues Location:
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  8. Article ; Online: Role of Exosomes in Epithelial-Mesenchymal Transition.

    Bhattacharya, Bikramjit / Nag, Sagnik / Mukherjee, Sayantanee / Kulkarni, Mrunal / Chandane, Priti / Mandal, Debashmita / Mukerjee, Nobendu / Mirgh, Divya / Anand, Krishnan / Adhikari, Manab Deb / Gorai, Sukhamoy / Thorat, Nanasaheb

    ACS applied bio materials

    2023  Volume 7, Issue 1, Page(s) 44–58

    Abstract: Epithelial-mesenchymal transition (EMT) is a fundamental process driving cancer metastasis, transforming non-motile cells into a motile population that migrates to distant organs and forms secondary tumors. In recent years, cancer research has revealed a ...

    Abstract Epithelial-mesenchymal transition (EMT) is a fundamental process driving cancer metastasis, transforming non-motile cells into a motile population that migrates to distant organs and forms secondary tumors. In recent years, cancer research has revealed a strong connection between exosomes and the EMT. Exosomes, a subpopulation of extracellular vesicles, facilitate cellular communication and dynamically regulate various aspects of cancer metastasis, including immune cell suppression, extracellular matrix remodeling, metastasis initiation, EMT initiation, and organ-specific metastasis. Tumor-derived exosomes (TEXs) and their molecular cargo, comprising proteins, lipids, nucleic acids, and carbohydrates, are essential components that promote EMT in cancer. TEXs miRNAs play a crucial role in reprogramming the tumor microenvironment, while TEX surface integrins contribute to organ-specific metastasis. Exosome-based cancer metastasis research offers a deeper understanding about cancer and an effective theranostic platform development. Additionally, various therapeutic sources of exosomes are paving the way for innovative cancer treatment development. In this Review, we spotlight the role of exosomes in EMT and their theranostic impact, aiming to inspire cancer researchers worldwide to explore this fascinating field in more innovative ways.
    MeSH term(s) Humans ; Exosomes/genetics ; Exosomes/metabolism ; Neoplasms/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Extracellular Vesicles ; Epithelial-Mesenchymal Transition ; Tumor Microenvironment
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-12-18
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.3c00941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Relevance of vitamin D in patients undergoing HLA matched allogeneic stem cell transplant for acute leukemia.

    Jindal, Nishant / Saroha, Megha / Mirgh, Sumeet / Chichra, Akanksha / Nayak, Lingaraj / Bonda, Avinash / Gokarn, Anant / Punatar, Sachin / Bagal, Bhausaheb / Chavan, Preeti / Mathew, Libin Jacob / Kannan, Sadhana / Khattry, Navin

    Transplant immunology

    2023  Volume 81, Page(s) 101925

    Abstract: Background: In hematopoietic stem cell transplant (HSCT), vitamin D deficiency has been variably associated with increased complications, primarily graft versus host disease (GvHD), with a potential impact on survival. Results from various studies ... ...

    Abstract Background: In hematopoietic stem cell transplant (HSCT), vitamin D deficiency has been variably associated with increased complications, primarily graft versus host disease (GvHD), with a potential impact on survival. Results from various studies however, have not been consistent. This analysis was conducted to study the impact of peri-transplant vitamin D levels on transplant outcomes in patients with acute leukemia (AL) who underwent HLA matched (related/unrelated) HSCT.
    Methods: This was a single center retrospective study. Patients of AL including Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML) or Mixed Phenotypic Acute Leukemia (MPAL) who underwent fully matched or 9/10 transplants (related/unrelated) between 2008 and 2019 were included. Vitamin D deficiency was defined as serum 25-hydroxy vitamin D3 levels ≤20 ng/ml. Those with deficiency received replacement with oral vitamin D at a dose of 60,000 IU weekly for 8 weeks followed by maintenance with daily vitamin D (800 IU/day). Vitamin D levels were repeated at 4 months from start of replacement. For patients who received correction, repeat levels >20 ng/ml were considered replete. Based on vitamin D levels in the peri-transplant period (within 120 days of transplant), patients were categorised as either vitamin D replete (> 20 ng/ml) or deplete (≤ 20 ng/ml). Peri-transplant vitamin D status was correlated with transplant outcomes.
    Results: Of the 133 patients included, 31 were deplete (median vitamin D 15.0 ng/ml) and 102 were replete (median vitamin D 34 ng/ml) at time of transplant. Both groups were matched for age, diagnosis, EBMT score and disease risk index (DRI). There were no differences in time to neutrophil or platelet engraftment, CMV reactivation, acute GvHD (aGvHD) or chronic GvHD (cGvHD) between the two groups. Relapse rate, Progression Free Survival (PFS) and Overall Survival (OS) were also comparable between the 2 groups.
    Conclusion: The incidence of vitamin D deficiency was high in our patient cohort. Patients who were vitamin D deficient at the time of transplant did not have inferior outcomes, suggesting a limited role of vitamin D in influencing transplant outcomes.
    MeSH term(s) Humans ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Retrospective Studies ; Vitamin D/therapeutic use ; Leukemia, Myeloid, Acute/therapy ; Leukemia, Myeloid, Acute/etiology ; Acute Disease ; Stem Cell Transplantation ; Graft vs Host Disease ; Vitamin D Deficiency ; Transplantation Conditioning/methods
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2023-08-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1160846-8
    ISSN 1878-5492 ; 0966-3274
    ISSN (online) 1878-5492
    ISSN 0966-3274
    DOI 10.1016/j.trim.2023.101925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3784: Show issues Location:
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  10. Article: Recurrent Cytokine Storm in SARS-CoV-2 Infected Patients with Hematolymphoid Malignancy: A New Perspective

    Kamtalwar, Sujeet / Mirgh, Sumeet / More, Ashwini / Sharma, Palak / Patkar, Nikhil / Rajpal, Sweta / Chatterjee, Gaurav / Shetty, Nitin / Gokarn, Anant

    South Asian Journal of Cancer

    2023  

    Language English
    Publishing date 2023-08-11
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2719571-5
    ISSN 2278-4306 ; 2278-330X ; 2278-4306
    ISSN (online) 2278-4306
    ISSN 2278-330X ; 2278-4306
    DOI 10.1055/s-0043-1761443
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