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  1. Article ; Online: Prespecialist perceptions of three-dimensional heart models in anatomical education.

    Yaprak, Fulya / Ozer, Mehmet Asim / Govsa, Figen / Cinkooglu, Akin / Pinar, Yelda / Gokmen, Gokhan

    Surgical and radiologic anatomy : SRA

    2023  Volume 45, Issue 9, Page(s) 1165–1175

    Abstract: Purpose: This article aims to discuss the use of three-dimensional (3D) printed models of vascular variation cases as an educational tool for undergraduate and postgraduate anatomy students.: Methods: This advanced study involved ten anatomy ... ...

    Abstract Purpose: This article aims to discuss the use of three-dimensional (3D) printed models of vascular variation cases as an educational tool for undergraduate and postgraduate anatomy students.
    Methods: This advanced study involved ten anatomy assistants who were provided with five distinct cases of congenital cardiovascular variations, each accompanied by a computed tomography angiography (CT-A) and 1:1 solid model format. The residents were asked to generate perceptions for both formats and then compare these perceptions based on identifying the variation, defining the structural features, and evaluating relevant educational perspectives.
    Results: The vascular origin measurement values compared to the statistically evaluated real values of the related cases showed that models were 1:1 identical copies. Qualitative assessment feedback from five stations supported the usefulness of 3D models as educational tools for organ anatomy, simulation of variational structures, and overall medical education and anatomy training. Models showcasing different anatomical variations such as aortic arch with Type 2 pattern, a right-sided aortic arch with Type 2 pattern, an aberrant right subclavian artery, arteria lusoria in thorax, and a left coronary artery originating from pulmonary trunk in an Alcapa type pattern allow for better analysis due to their complex anatomies, thus optimizing the study of variation-specific anatomy. The perception level in the 3D model contained higher points in all of the nine parameters, namely identification of cardiovascular variations, defining the vessel with anomaly, aortic arch branch count and appearance order, feasibility of using it in peers and student education. 3D models received a score 9.1 points, while CT-A images were rated at 4.8 out of 10.
    Conclusion: 3D printed anatomical models of variational cardiovascular anatomy serve as essential components of anatomy training and postgraduate clinical perception by granting demonstrative feedback and a superior comprehension of the visuospatial relationship between the anatomical structures.
    MeSH term(s) Humans ; Bland White Garland Syndrome ; Educational Measurement ; Students ; Computer Simulation ; Thorax ; Models, Anatomic ; Printing, Three-Dimensional ; Imaging, Three-Dimensional/methods
    Language English
    Publishing date 2023-08-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 632839-8
    ISSN 1279-8517 ; 0930-312X ; 0930-1038
    ISSN (online) 1279-8517
    ISSN 0930-312X ; 0930-1038
    DOI 10.1007/s00276-023-03211-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Histogram Analysis of ADC Maps for Differentiating Brain Metastases From Different Histological Types of Lung Cancers.

    Bozdağ, Mustafa / Er, Ali / Çinkooğlu, Akın

    Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes

    2020  Volume 72, Issue 2, Page(s) 271–278

    Abstract: Purpose: Our study aimed to investigate the role of histogram analysis derived from apparent diffusion coefficient (ADC) maps in brain metastases (BMs) from lung cancer for differentiating histological subtype.: Methods: A total of 61 BMs (45 non- ... ...

    Abstract Purpose: Our study aimed to investigate the role of histogram analysis derived from apparent diffusion coefficient (ADC) maps in brain metastases (BMs) from lung cancer for differentiating histological subtype.
    Methods: A total of 61 BMs (45 non-small cell lung cancer [NSCLC] comprising 32 adenocarcinoma [AC], 13 squamous cell carcinoma [SCC], and 16 small-cell lung cancer [SCLC]) in 50 patients with histopathologically confirmed lung cancer were retrospectively included in this study. Pretreatment cranial diffusion-weighted imaging was performed, and the corresponding ADC maps were generated. Regions of interest were drawn on solid components of the BM on all slices of the ADC maps to obtain parameters, including ADC
    Results: ADC
    Conclusion: Apparent diffusion coefficient histogram analysis of BMs from lung cancer has significant prognostic value in differentiating histological subtypes of lung cancer.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/secondary ; Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Carcinoma, Squamous Cell/diagnostic imaging ; Diagnosis, Differential ; Diffusion Magnetic Resonance Imaging/methods ; Female ; Humans ; Lung Neoplasms/diagnostic imaging ; Male ; Middle Aged ; Retrospective Studies ; Small Cell Lung Carcinoma/diagnostic imaging
    Language English
    Publishing date 2020-06-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 418190-6
    ISSN 1488-2361 ; 0846-5371 ; 0008-2902
    ISSN (online) 1488-2361
    ISSN 0846-5371 ; 0008-2902
    DOI 10.1177/0846537120933837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The novel coronavirus pneumonia (COVID-19): a pictorial review of chest CT features.

    Bayraktaroğlu, Selen / Çinkooğlu, Akın / Ceylan, Naim / Savaş, Recep

    Diagnostic and interventional radiology (Ankara, Turkey)

    2020  Volume 27, Issue 2, Page(s) 188–194

    Abstract: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first reported in Wuhan, China. The infection rapidly spread to more than 200 countries around the world. The clinical presentation of the ... ...

    Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first reported in Wuhan, China. The infection rapidly spread to more than 200 countries around the world. The clinical presentation of the disease may vary from mild illness to severe pneumonia such as acute respiratory distress syndrome (ARDS). The chest computed tomography (CT) has an important complementary role in diagnosis of the disease. The predominant CT findings of the disease are ground glass opacities and consolidations located in subpleural areas of lower lobes. Widespread ground-glass opacities, consolidation, air bronchograms, central involvement of lung parenchyma, mediastinal lymphadenopathy are more common in patients with the severe form of the disease. CT imaging also guides in differentiation of alternative diagnosis or in assessment of associated pulmonary embolism during the course of the disease. In this pictorial review we aim to review the CT features of COVID-19 pneumonia and mention the changes throughout the disease process.
    MeSH term(s) Adolescent ; Adult ; Aged ; COVID-19/diagnostic imaging ; Female ; Humans ; Male ; Middle Aged ; Thorax/diagnostic imaging ; Tomography, X-Ray Computed ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-08-16
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 2184145-7
    ISSN 1305-3612 ; 1305-3612
    ISSN (online) 1305-3612
    ISSN 1305-3612
    DOI 10.5152/dir.2020.20304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Diagnostic role of apparent diffusion coefficient combined with intratumoral susceptibility signals in differentiating high-grade gliomas from brain metastases.

    Bozdağ, Mustafa / Er, Ali / Çinkooğlu, Akın / Ekmekçi, Sümeyye

    The neuroradiology journal

    2020  Volume 34, Issue 3, Page(s) 169–179

    Abstract: Objective: The aim of this study was to assess whether tumoral and peritumoral apparent diffusion coefficient values and intratumoral susceptibility signals on susceptibility-weighted imaging could distinguish between high-grade gliomas and brain ... ...

    Abstract Objective: The aim of this study was to assess whether tumoral and peritumoral apparent diffusion coefficient values and intratumoral susceptibility signals on susceptibility-weighted imaging could distinguish between high-grade gliomas and brain metastases, and to investigate their associations with the Ki-67 proliferation index.
    Materials and methods: Fifty-seven patients with pathologically confirmed diagnoses of either high-grade glioma or brain metastasis were enrolled in this study (23 with high-grade gliomas and 34 with brain metastases). The minimum and mean apparent diffusion coefficients in the enhancing tumoral region (ADC
    Results: ADC
    Conclusion: The combination of tumoral apparent diffusion coefficient with intratumoral susceptibility signal grade can offer better diagnostic performances for differential diagnosis. Apparent diffusion coefficient and intratumoral susceptibility signal may reflect cellular proliferative activity in brain metastases, but not in high-grade gliomas.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/pathology ; Diagnosis, Differential ; Diffusion Magnetic Resonance Imaging/methods ; Female ; Glioma/diagnostic imaging ; Glioma/pathology ; Humans ; Male ; Middle Aged ; Neoplasm Grading ; Retrospective Studies
    Language English
    Publishing date 2020-12-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2257770-1
    ISSN 2385-1996 ; 1971-4009 ; 1120-9976
    ISSN (online) 2385-1996
    ISSN 1971-4009 ; 1120-9976
    DOI 10.1177/1971400920980164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Atypical chest CT findings of COVID-19 pneumonia: a pictorial review.

    Ceylan, Naim / Çinkooğlu, Akın / Bayraktaroğlu, Selen / Savaş, Recep

    Diagnostic and interventional radiology (Ankara, Turkey)

    2020  Volume 27, Issue 3, Page(s) 344–349

    Abstract: Coronavirus disease 2019 (COVID-19) first emerged in China and rapidly spread in the world causing a pandemic. Chest computed tomography (CT) continues to play an important role in the diagnosis and follow-up of the disease due to shortcomings of the ... ...

    Abstract Coronavirus disease 2019 (COVID-19) first emerged in China and rapidly spread in the world causing a pandemic. Chest computed tomography (CT) continues to play an important role in the diagnosis and follow-up of the disease due to shortcomings of the real-time reverse transcription-polymerase chain reaction test, which is the gold standard in the diagnosis of this disease. Typical chest CT findings of COVID-19 pneumonia have been widely reported in the literature. However, atypical findings such as central involvement, peribronchovascular involvement, isolated upper lobe involvement, nodular involvement, lobar consolidation, solitary involvement, pleural and pericardial fluid, and subpleural sparing can also be seen. Knowing these atypical findings is important to avoid misdiagnosis. This review summarizes the atypical findings that can be seen in the course of the disease and may be confused with other diseases.
    MeSH term(s) COVID-19/diagnostic imaging ; Humans ; Lung/diagnostic imaging ; SARS-CoV-2 ; Tomography, X-Ray Computed/methods
    Keywords covid19
    Language English
    Publishing date 2020-10-09
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 2184145-7
    ISSN 1305-3612 ; 1305-3612
    ISSN (online) 1305-3612
    ISSN 1305-3612
    DOI 10.5152/dir.2020.20355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Lung Changes on Chest CT During 2019 Novel Coronavirus (COVID-19) Pneumonia.

    Çinkooğlu, Akın / Bayraktaroğlu, Selen / Savaş, Recep

    European journal of breast health

    2020  Volume 16, Issue 2, Page(s) 89–90

    Keywords covid19
    Language English
    Publishing date 2020-04-01
    Publishing country Turkey
    Document type Editorial
    ISSN 2587-0831
    ISSN 2587-0831
    DOI 10.5152/ejbh.2020.010420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Efficacy of chest X-ray in the diagnosis of COVID-19 pneumonia

    Akın Çinkooğlu / Selen Bayraktaroğlu / Naim Ceylan / Recep Savaş

    The Egyptian Journal of Radiology and Nuclear Medicine, Vol 52, Iss 1, Pp 1-

    comparison with computed tomography through a simplified scoring system designed for triage

    2021  Volume 9

    Abstract: Abstract Background There is no consensus on the imaging modality to be used in the diagnosis and management of Coronavirus disease 2019 (COVID-19) pneumonia. The purpose of this study was to make a comparison between computed tomography (CT) and chest X- ...

    Abstract Abstract Background There is no consensus on the imaging modality to be used in the diagnosis and management of Coronavirus disease 2019 (COVID-19) pneumonia. The purpose of this study was to make a comparison between computed tomography (CT) and chest X-ray (CXR) through a scoring system that can be beneficial to the clinicians in making the triage of patients diagnosed with COVID-19 pneumonia at their initial presentation to the hospital. Results Patients with a negative CXR (30.1%) had significantly lower computed tomography score (CTS) (p < 0.001). Among the lung zones where the only infiltration pattern was ground glass opacity (GGO) on CT images, the ratio of abnormality seen on CXRs was 21.6%. The cut-off value of X-ray score (XRS) to distinguish the patients who needed intensive care at follow-up (n = 12) was 6 (AUC = 0.933, 95% CI = 0.886–0.979, 100% sensitivity, 81% specificity). Conclusions Computed tomography is more effective in the diagnosis of COVID-19 pneumonia at the initial presentation due to the ease detection of GGOs. However, a baseline CXR taken after admission to the hospital can be valuable in predicting patients to be monitored in the intensive care units.
    Keywords Covid-19 ; Tomography ; X-rays ; Triage ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Subject code 610
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: PDL-1 Expression and Survival in Metastatic Non-small Cell Lung Cancer Patients Who Received Chemotherapy as First-Line Treatment.

    Gursoy, Pınar / Çakar, Burcu / Gunenc, Damla / Nart, Deniz / Çınkooğlu, Akın / Katgı, Nuran

    Turkish thoracic journal

    2022  Volume 23, Issue 1, Page(s) 45–51

    Abstract: Objective: To show the effect of programmed cell death protein-1ligand (PDL-1) level on survival times in patients with metastatic non-small cell lung cancer (mNSCLC) receiving chemotherapy, to determine the relationship between PDL-1 level, neutrophil- ... ...

    Abstract Objective: To show the effect of programmed cell death protein-1ligand (PDL-1) level on survival times in patients with metastatic non-small cell lung cancer (mNSCLC) receiving chemotherapy, to determine the relationship between PDL-1 level, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR).
    Material and methods: The data of 158 patients who received chemotherapy for mNSCLC were evaluated retrospectively. Clinical and demographic data, PDL-1 expression levels and follow-up periods of the patients were recorded. The patients were divided into 2 groups according to PDL-1 levels.
    Results: In all patients, progression free survival (PFS) was 5.6 months and overall survival (OS) was 18.8 months. Patients with low PDL-1 had a longer PFS than patients with high PDL-1 (p:0.038). In the gemcitabine and taxane groups, patients with low PDL-1 had a longer PFS than patients with high PDL-1 (p:0.047). There was a significant correlation between NLR and PDL-1 levels. In the groups with high PDL-1, patients with low NLR levels had higher OS than patients with high NLR level (p:0.043). Also, there was a significant difference between the OS patients with low and high PLR levels (p:0.520).
    Conclusion: In patients with mNSCLC whose PDL-1 levels and NLR levels are low, immunogenic chemotherapies such as gemcitabine and taxane can be tried as an alternative treatment.
    Language English
    Publishing date 2022-02-02
    Publishing country Turkey
    Document type Journal Article
    ISSN 2149-2530
    ISSN (online) 2149-2530
    DOI 10.5152/TurkThoracJ.2021.21151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Comparison of chest computed tomography and 3-T magnetic resonance imaging results in patients with common variable immunodeficiency.

    Bayraktaroğlu, Selen / Çinkooğlu, Akın / Tunakan Dalgıç, Ceyda / Boğatekin, Gülhan / Uysal, Funda Elmas / Ardeniz, Ömür

    Acta radiologica (Stockholm, Sweden : 1987)

    2022  Volume 64, Issue 5, Page(s) 1841–1850

    Abstract: Background: Patients with common variable immunodeficiency (CVID) have an increased incidence of pulmonary infections and require frequent follow-up computed tomography (CT) scans.: Purpose: To evaluate the diagnostic performance of 3-T magnetic ... ...

    Abstract Background: Patients with common variable immunodeficiency (CVID) have an increased incidence of pulmonary infections and require frequent follow-up computed tomography (CT) scans.
    Purpose: To evaluate the diagnostic performance of 3-T magnetic resonance imaging (MRI) in patients with CVID.
    Material and methods: In this prospective study, 3-T MRI was performed in 20 patients with CVID. The patients were imaged with CT and MRI scans on the same day. The MRI protocol included a T2-weighted HASTE sequence (TR=1400 ms, TE=95 ms, slice thickness (ST)=3 mm), T2-weighted BLADE sequence (TR=5379 ms, TE=100 ms, ST=3 mm), and 3D VIBE sequence (TR=3.9 ms, TE=1.32 ms, ST=3 mm). Mediastinal and parenchymal changes were compared. A modified Bhalla scoring system was used in the evaluation of CT and MRI scans.
    Results: A total of 17 (85%) patients had parenchymal abnormalities identified by CT or MRI. Similar findings were detected with CT and MRI in the assessment of the severity of bronchiectasis (
    Conclusion: 3-T MRI detected mediastinal and parenchymal alterations in patients with CVID and provided findings that correlated well with CT. Despite a few limitations, MRI is a well-suited radiation-free technique for patients requiring longitudinal imaging.
    MeSH term(s) Humans ; Common Variable Immunodeficiency/complications ; Common Variable Immunodeficiency/diagnostic imaging ; Common Variable Immunodeficiency/pathology ; Prospective Studies ; Tomography, X-Ray Computed/methods ; Magnetic Resonance Imaging/methods ; Lung Diseases/pathology ; Lung/pathology
    Language English
    Publishing date 2022-12-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 105-3
    ISSN 1600-0455 ; 0284-1851 ; 0349-652X
    ISSN (online) 1600-0455
    ISSN 0284-1851 ; 0349-652X
    DOI 10.1177/02841851221144249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The novel coronavirus pneumonia (COVID-19): a pictorial review of chest CT features

    Bayraktaroglu, Selen / Çinkooglu, Akin / Ceylan, Naim / Savas, Recep

    Diagn. interv. radiol

    Abstract: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first reported in Wuhan, China. The infection rapidly spread to more than 200 countries around the world. The clinical presentation of the ... ...

    Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first reported in Wuhan, China. The infection rapidly spread to more than 200 countries around the world. The clinical presentation of the disease may vary from mild illness to severe pneumonia such as acute respiratory distress syndrome (ARDS). The chest computed tomography (CT) has an important complementary role in diagnosis of the disease. The predominant CT findings of the disease are ground glass opacities and consolidations located in subpleural areas of lower lobes. Widespread ground-glass opacities, consolidation, air bronchograms, central involvement of lung parenchyma, mediastinal lymphadenopathy are more common in patients with the severe form of the disease. CT imaging also guides in differentiation of alternative diagnosis or in assessment of associated pulmonary embolism during the course of the disease. In this pictorial review we aim to review the CT features of COVID-19 pneumonia and mention the changes throughout the disease process.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #724033
    Database COVID19

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