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  1. Article ; Online: Synthesis and functionalities of FeSn

    Muramatsu, Hisanori / Kambe, Tetsuya / Tsukamoto, Takamasa / Kuzume, Akiyoshi / Hosono, Reina / Imaoka, Takane / Yamamoto, Kimihisa

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2024  Volume 30, Issue 20, Page(s) e202400060

    Abstract: Superatoms are promising as new building block materials that can be designed by precise controlling of the constituent atoms. Stannaspherene ( ... ...

    Abstract Superatoms are promising as new building block materials that can be designed by precise controlling of the constituent atoms. Stannaspherene (Sn
    Language English
    Publishing date 2024-02-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202400060
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  2. Article ; Online: A prospective clinical trial of diathermy ablation for patients with high-grade cervical intraepithelial neoplasia from a single institution in Japan.

    Mitani, Takeji / Kukimoto, Iwao / Tsukamoto, Tetsuya / Nomura, Hiroyuki / Fujii, Takuma

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 2632

    Abstract: Approximately 500,000 women are diagnosed with cervical cancer annually, with high-grade cervical intraepithelial neoplasia (CIN) estimated to be 20 times higher. The diathermy ablation is an inexpensive minimally invasive surgeries for CIN. However, ... ...

    Abstract Approximately 500,000 women are diagnosed with cervical cancer annually, with high-grade cervical intraepithelial neoplasia (CIN) estimated to be 20 times higher. The diathermy ablation is an inexpensive minimally invasive surgeries for CIN. However, little is known about the treatment outcomes. A prospective clinical trial was therefore conducted to evaluate ablation outcomes based on detailed colposcopy findings, cytology, and biopsy results over a two-year period. We enrolled CIN2 (n = 32) and CIN3 (n = 7) patients. Eligibility criteria included: aged between 29 and 49 (median: 36, mean: 36.3), visible transformation zone with high-grade lesions not entirely occupying the cervix, and histologically diagnosed with CIN2 or CIN3. Cytology and HPV genotyping were performed, and colposcopic findings were evaluated. Colposcopy-guided diathermy ablation was conducted by a certified gynecologic oncologist. The incidence of recurrent or residual disease was 5.1% (2/39, 95% confidence interval: - 0.02 to 0.12). The prevalence of HPV infection at 12 months decreased after surgery, as 67.6% (23/34, 0.52-0.83) of patients were HPV-negative. No severe adverse events were reported, while there were five pregnancies with full-term deliveries. The promising outcome was possibly due to selection of rigorous surgical indication and skilled surgical techniques. The study highlights the importance of experienced and skilled colposcopists.TrialRegistry This study was registered in the clinical trial registration system of the University hospital Medical Information Network Clinical Trials Registry (UMIN-CTR ID: UMIN000024483). Open for the trial to the public through the website: 01/11/2016. First registration of the patient: 30/01/2017.
    MeSH term(s) Pregnancy ; Humans ; Female ; Adult ; Middle Aged ; Papillomavirus Infections ; Japan/epidemiology ; Prospective Studies ; Uterine Cervical Dysplasia/pathology ; Uterine Cervical Neoplasms/pathology ; Diathermy ; Papillomaviridae
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53197-8
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  3. Article ; Online: Possible Association Between Melanoma Arising from Congenital Naevus and Oestrogen or Progesterone Receptor Expression: Clinicopathological Analysis.

    Sumitomo, Chiho / Iwata, Yohei / Sakai, Yasuhiro / Tsukamoto, Tetsuya / Sugiura, Kazumitsu

    Acta dermato-venereologica

    2023  Volume 103, Page(s) adv00887

    MeSH term(s) Humans ; Receptors, Progesterone ; Progesterone ; Skin Neoplasms/pathology ; Melanoma/genetics ; Melanoma/pathology ; Estrogens
    Chemical Substances Receptors, Progesterone ; Progesterone (4G7DS2Q64Y) ; Estrogens
    Language English
    Publishing date 2023-03-14
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/actadv.v103.5206
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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.101: Show issues Location:
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  4. Article ; Online: Controlled Synthesis of Au

    Muramatsu, Hisanori / Kambe, Tetsuya / Tsukamoto, Takamasa / Imaoka, Takane / Yamamoto, Kimihisa

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 11

    Abstract: Superatoms are promising materials for their potential in elemental substitution and as new building blocks. Thus far, various synthesis methods of thiol-protected Au clusters including an ... ...

    Abstract Superatoms are promising materials for their potential in elemental substitution and as new building blocks. Thus far, various synthesis methods of thiol-protected Au clusters including an Au
    Language English
    Publishing date 2022-05-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27113398
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    Zs.MO 81: Show issues

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  5. Article ; Online: Autopsy case: Pathological complete response in an advanced lung cancer patient with severe immune related adverse events and COVID-19.

    Moriya, Ryoma / Kamihata, Naoki / Niwa, Yoshikazu / Kako, Hisashi / Takahashi, Hideaki / Kimura, Yutaro / Shigeyasu, Yoshiko / Tsukamoto, Tetsuya / Hashimoto, Naozumi / Imaizumi, Kazuyoshi

    Respiratory investigation

    2024  Volume 62, Issue 3, Page(s) 438–441

    Abstract: A 51-year-old man with advanced lung cancer underwent chemotherapy including an immune checkpoint inhibitor (ICI). Subsequently, he developed ICI-related pneumonitis and colitis, followed by a ten-month treatment course of high doses of steroids. An ... ...

    Abstract A 51-year-old man with advanced lung cancer underwent chemotherapy including an immune checkpoint inhibitor (ICI). Subsequently, he developed ICI-related pneumonitis and colitis, followed by a ten-month treatment course of high doses of steroids. An infection with the SARS-CoV-2 Omicron BA.5 variant caused lethal respiratory failure. Autopsy examination revealed no evidence of viable lung cancer cells in the evaluated organs including the lungs, suggesting that pathological complete response (pCR) could be successfully achieved by ICI treatment in advanced lung cancer patients. Recognizing steroid-resistant ICI-related adverse events as critical factors in severe COVID-19 emphasizes the need for appropriate assessment of ICI-induced pCR.
    Language English
    Publishing date 2024-03-22
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2660821-2
    ISSN 2212-5353 ; 2212-5345
    ISSN (online) 2212-5353
    ISSN 2212-5345
    DOI 10.1016/j.resinv.2024.03.002
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  6. Article ; Online: Modern cluster design based on experiment and theory.

    Tsukamoto, Takamasa / Kambe, Tetsuya / Imaoka, Takane / Yamamoto, Kimihisa

    Nature reviews. Chemistry

    2021  Volume 5, Issue 5, Page(s) 338–347

    Abstract: For decades, chemists have explored cluster compounds according to theoretical models that have proved too simplistic to accurately predict cluster properties, stabilities and functions. By incorporating molecular symmetry into existing cluster models, ... ...

    Abstract For decades, chemists have explored cluster compounds according to theoretical models that have proved too simplistic to accurately predict cluster properties, stabilities and functions. By incorporating molecular symmetry into existing cluster models, we can better study real polyatomic molecules and have new guidelines for their design. This symmetry-adapted cluster model allows us to discover substances that shatter the conventional notion of clusters. Theoretical predictors will point to the viability of new clusters, whose syntheses can be realized with parallel advances in experimental methods. This Perspective describes these modern experimental and theoretical strategies for cluster design and how they may give rise to new fields in cluster chemistry.
    Language English
    Publishing date 2021-03-24
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2397-3358
    ISSN (online) 2397-3358
    DOI 10.1038/s41570-021-00267-4
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  7. Article ; Online: Coronavirus hunted in human pneumocytes and alveolar macrophages: a case report.

    Kataoka, Michiyo / Tsukamoto, Tetsuya / Tajima, Yasuhisa / Sato, Yuko / Katano, Harutaka / Suzuki, Tadaki / Nakajima, Noriko

    Histopathology

    2022  Volume 80, Issue 7, Page(s) 1130–1134

    MeSH term(s) Alveolar Epithelial Cells ; Coronavirus ; Coronavirus Infections ; Humans ; Lung ; Macrophages, Alveolar ; Pulmonary Alveoli
    Language English
    Publishing date 2022-03-31
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.14637
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1328: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Characterization of galactosyltransferase and sialyltransferase genes mediating the elongation of the extracellular O-GlcNAc glycans.

    Tsukamoto, Yohei / Tsukamoto, Natsumi / Saiki, Wataru / Tashima, Yuko / Furukawa, Jun-Ichi / Kizuka, Yasuhiko / Narimatsu, Yoshiki / Clausen, Henrik / Takeuchi, Hideyuki / Okajima, Tetsuya

    Biochemical and biophysical research communications

    2024  Volume 703, Page(s) 149610

    Abstract: O-GlcNAc is a unique post-translational modification found in cytoplasmic, nuclear, and mitochondrial proteins. In a limited number of extracellular proteins, O-GlcNAc modifications occur through the action of EOGT, which specifically modifies subsets of ...

    Abstract O-GlcNAc is a unique post-translational modification found in cytoplasmic, nuclear, and mitochondrial proteins. In a limited number of extracellular proteins, O-GlcNAc modifications occur through the action of EOGT, which specifically modifies subsets of epidermal growth factor-like (EGF) domain-containing proteins such as Notch receptors. The abnormalities due to EOGT mutations in mice and humans and the increased EOGT expression in several cancers signify the importance of EOGT pathophysiology and extracellular O-GlcNAc. Unlike intracellular O-GlcNAc monosaccharides, extracellular O-GlcNAc extends to form elongated glycan structures. However, the enzymes involved in the O-GlcNAc glycan extension have not yet been reported. In our study, we comprehensively screened potential galactosyltransferase and sialyltransferase genes related to the canonical O-GlcNAc glycan pathway and revealed the essential roles of B4GALT1 and ST3GAL4 in O-GlcNAc glycan elongation in human HEK293 cells. These findings were confirmed by sequential glycosylation of Drosophila EGF20 in vitro by EOGT, β4GalT-1, and ST3Gal-IV. Thus, the findings from our study throw light on the specific glycosyltransferases that mediate O-GlcNAc glycan elongation in human HEK293 cells.
    MeSH term(s) Humans ; Animals ; Mice ; HEK293 Cells ; Acetylglucosamine/metabolism ; Receptors, Notch/metabolism ; Galactosyltransferases/genetics ; Glycosyltransferases ; Drosophila/metabolism ; Sialyltransferases/genetics ; Polysaccharides
    Chemical Substances Acetylglucosamine (V956696549) ; Receptors, Notch ; Galactosyltransferases (EC 2.4.1.-) ; Glycosyltransferases (EC 2.4.-) ; Sialyltransferases (EC 2.4.99.-) ; Polysaccharides
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2024.149610
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Controlled Synthesis of Au 25 Superatom Using a Dendrimer Template

    Hisanori Muramatsu / Tetsuya Kambe / Takamasa Tsukamoto / Takane Imaoka / Kimihisa Yamamoto

    Molecules, Vol 27, Iss 3398, p

    2022  Volume 3398

    Abstract: Superatoms are promising materials for their potential in elemental substitution and as new building blocks. Thus far, various synthesis methods of thiol-protected Au clusters including an Au 25 superatom have been investigated. However, previously ... ...

    Abstract Superatoms are promising materials for their potential in elemental substitution and as new building blocks. Thus far, various synthesis methods of thiol-protected Au clusters including an Au 25 superatom have been investigated. However, previously reported methods were mainly depending on the thermodynamic stability of the aimed clusters. In this report, a synthesis method for thiol-protected Au clusters using a dendrimers template is proposed. In this method, the number of Au atoms was controlled by the stepwise complexation feature of a phenylazomethine dendrimer. Therefore, synthesis speed was increased compared with the case without the dendrimer template. Hybridization for the Au 25 superatoms was also achieved using the complexation control of metals.
    Keywords superatoms ; dendrimers ; gold clusters ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Automated Classification of Urinary Cells

    Atsushi Teramoto / Ayano Michiba / Yuka Kiriyama / Eiko Sakurai / Ryoichi Shiroki / Tetsuya Tsukamoto

    Applied Sciences, Vol 13, Iss 1763, p

    Using Convolutional Neural Network Pre-trained on Lung Cells

    2023  Volume 1763

    Abstract: Urine cytology, which is based on the examination of cellular images obtained from urine, is widely used for the diagnosis of bladder cancer. However, the diagnosis is sometimes difficult in highly heterogeneous carcinomas exhibiting weak cellular atypia. ...

    Abstract Urine cytology, which is based on the examination of cellular images obtained from urine, is widely used for the diagnosis of bladder cancer. However, the diagnosis is sometimes difficult in highly heterogeneous carcinomas exhibiting weak cellular atypia. In this study, we propose a new deep learning method that utilizes image information from another organ for the automated classification of urinary cells. We first extracted 3137 images from 291 lung cytology specimens obtained from lung biopsies and trained a classification process for benign and malignant cells using VGG-16, a convolutional neural network (CNN). Subsequently, 1380 images were extracted from 123 urine cytology specimens and used to fine-tune the CNN that was pre-trained with lung cells. To confirm the effectiveness of the proposed method, we introduced three different CNN training methods and compared their classification performances. The evaluation results showed that the classification accuracy of the fine-tuned CNN based on the proposed method was 98.8% regarding sensitivity and 98.2% for specificity of malignant cells, which were higher than those of the CNN trained with only lung cells or only urinary cells. The evaluation results showed that urinary cells could be automatically classified with a high accuracy rate. These results suggest the possibility of building a versatile deep-learning model using cells from different organs.
    Keywords urinary cell ; classification ; deep learning ; convolutional neural network ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 006
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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