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  1. Book ; Online: Analytical, Numerical and Big-Data-Based Methods in Deep Rock Mechanics

    Wang, Shaofeng / Cai, Xin / Zhou, Jian / Song, Zhengyang / Li, Xiaofeng

    2023  

    Keywords Technology: general issues ; History of engineering & technology ; complex variable method ; conformal mapping ; triangle interpolation ; stress analytical solution ; DEM numerical simulation ; laterally loaded pile ; p-y curve ; soil-pile interface ; Drucker-Prager model ; mine slope ; stability classification of rock mass ; extremum entropy ; variable weight theory ; matter-element extension ; grade variable ; polymer ; diffusion model ; crack ; expansion ratio ; grouting amount ; rockburst classification ; data-driven approach ; random forest ; beetle antennae search algorithm ; high concrete face rockfill dam ; geosynthetic-reinforced soil structures ; generalized probability density evolution method ; seismic performance ; reliability analysis ; numerical methods ; deep rock mechanics ; rock damage judgment criteria ; SPH ; blind shaft cutting blasting ; coal ; deterioration characteristics ; chemical-stress coupling factor ; damage constitutive model ; rock burst ; t-SNE ; unsupervised learning ; supervised learning ; XGBoost ; true triaxial compression test ; acoustic emission ; b value ; rock drillability ; DPM parameters ; regression analysis ; RF ; GA-SVM ; UCS prediction model ; fractured rock mass ; uranium-containing solution ; multifield coupling ; reactive transport ; rough-walled fracture ; lithology ; concrete part ; mechanical and damage behaviors ; rockburst prediction ; deep forest ; bayesian optimization ; ensemble model ; zonal disintegration ; jointed rock mass ; stress redistribution ; strength reduction ; numerical simulation ; genetic algorithm ; BP neural network ; smooth wall blasting ; parameter optimization ; deep mining ; mining disturbance ; stress evolution ; brittle-ductile transition ; backfilled stopes ; fractured aquifer ; Bingham slurry ; grout diffusion model ; slurry diffusion distance ; grouting effect ; submarine slides ; submarine pipelines ; copula function ; reliability ; slide-pipeline interaction ; strain rate ; temperature effect ; mechanical properties ; energy dissipation features ; failure modes ; fault ; water inrush ; mechanical behavior ; mining advancing direction ; mind evolutionary algorithm ; MEA-BP model ; rock mechanical parameters ; orthogonal test method ; heat-concentrated source ; optimization of heat source location ; temperature gradient ; closed-form solution ; temperature difference ; n/a
    Language English
    Size 1 electronic resource (432 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030377548
    ISBN 9783036557625 ; 3036557628
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Recent advances of tryptanthrin and its derivatives as potential anticancer agents.

    Zhou, Xiaofeng

    RSC medicinal chemistry

    2024  Volume 15, Issue 4, Page(s) 1127–1147

    Abstract: Tryptanthrin is one of the well-known natural alkaloids with a broad spectrum of biological activities and can act as anti-inflammatory, anticancer, antibacterial, antifungal, antiviral, antitubercular, and other agents. Owing to its potent anticancer ... ...

    Abstract Tryptanthrin is one of the well-known natural alkaloids with a broad spectrum of biological activities and can act as anti-inflammatory, anticancer, antibacterial, antifungal, antiviral, antitubercular, and other agents. Owing to its potent anticancer activity, tryptanthrin has been widely explored for the therapy of various cancers besides being effective against other diseases. Tryptanthrin with a pharmacological indoloquinazoline moiety can not only be modified by different functional groups to achieve various tryptanthrin derivatives, which may realize the improvement of anticancer activity, but also bind with different metal ions to obtain varied tryptanthrin metal complexes as potential anticancer agents, due to their higher anticancer activities in comparison with tryptanthrin (or its derivatives) and cisplatin. This review outlines the recent advances in the syntheses, structures, and anticancer activities of tryptanthrin derivatives and their metal complexes, trying to reveal their structure-activity relationships and to provide a helpful way for medicinal chemists in the development of new and effective tryptanthrin-based anticancer agents.
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2632-8682
    ISSN (online) 2632-8682
    DOI 10.1039/d3md00698k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Identification of important genes for human periodontal ligament cells in response to mechanical force based on WGCNA.

    Zhou, Xiaofeng

    Cellular and molecular biology (Noisy-le-Grand, France)

    2024  Volume 70, Issue 3, Page(s) 192–196

    Abstract: To identify the differentially important genes of human periodontal ligament cells (PDLC) in response to different types of force, the dataset with regard to human PDLC in response to force was retrieved from the GEO. Differentially expressed genes (DEG) ...

    Abstract To identify the differentially important genes of human periodontal ligament cells (PDLC) in response to different types of force, the dataset with regard to human PDLC in response to force was retrieved from the GEO. Differentially expressed genes (DEG) analysis between mechanical force (MF) and the control group was conducted. The gene set enrichment analysis (GSEA) was applied to identify the functional enrichment in different MF groups. Weighted gene co-expression network analysis (WGCNA) of transcriptomic data was performed to identify the highly correlated genes in human PDLC in response to MF. The Lasso regression model was applied to screen the key genes. Results showed A total of 2861 DEGs were identified between the MF group and control group, including 1470 up-regulated DEGs and 1391 down-regulated DEGs. Different biological processes were enriched between the static group and the intermittent group. The Myc targets, TGF-β signaling pathway and PI3K/AKT/MTOR signaling pathway were enriched in intermittent-MF and static-MF groups. The turquoise module (including 386 hub genes) in WGCNA was highly correlated with intermittent traits and the black module (including 33 hub genes) was positively correlated with static traits. The lasso analysis result showed that the CLIC4, NPLOC4 and PRDX6 had the greatest impact on the human PDLC with mechanic stimuli with good predictive efficiency. In conclusion, we developed important genes for human PDLC in response to MF, which might be potential markers for orthodontic tooth movement.
    MeSH term(s) Humans ; Periodontal Ligament/cytology ; Periodontal Ligament/metabolism ; Gene Regulatory Networks ; Gene Expression Profiling/methods ; Stress, Mechanical ; Transcriptome/genetics ; Signal Transduction/genetics ; Gene Expression Regulation
    Language English
    Publishing date 2024-03-31
    Publishing country France
    Document type Journal Article
    ZDB-ID 1161779-2
    ISSN 1165-158X ; 0145-5680
    ISSN (online) 1165-158X
    ISSN 0145-5680
    DOI 10.14715/cmb/2024.70.3.29
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3812: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Insights of metal 8-hydroxylquinolinol complexes as the potential anticancer drugs.

    Zhou, Xiaofeng

    Journal of inorganic biochemistry

    2022  Volume 238, Page(s) 112051

    Abstract: 8-Hydroxyquinoline and its derivatives, which belong to a well-known class of quinoline based drugs with varied biological activities, have been extensively explored for the treatments of cancer, Alzheimer's disease, neurodegenerative diseases and other ... ...

    Abstract 8-Hydroxyquinoline and its derivatives, which belong to a well-known class of quinoline based drugs with varied biological activities, have been extensively explored for the treatments of cancer, Alzheimer's disease, neurodegenerative diseases and other life-threatening diseases. In virtue of the existence of bicyclic heterocyclic scaffold, their bidentate chelators can further bind to metal ions via O- and N-donors from 8-hydroxylquinolinol skeletons to yield a variety of metal 8-hydroxylquinolinol complexes appealing as the anticancer drugs with low toxicity, due to their better biological effects and higher anticancer activities than free 8-hydroxylquinolinol ligands and cis-diammine-dichloro-platinum. The present review summarizes the recent developments in the syntheses, crystal structures, and anticancer activities of metal 8-hydroxylquinolinol complexes, attempting to discover a correlation between their structures and anticancer activities, and to provide an evidence for their potential application perspectives. It means to offer the helpful and meaningful guidance for the researchers in the future syntheses of new and highly efficient anticancer metal 8-hydroxylquinolinol complexes based drugs.
    MeSH term(s) Humans ; Coordination Complexes/chemistry ; Antineoplastic Agents/chemistry ; Cisplatin/chemistry ; Neoplasms/drug therapy ; Ligands
    Chemical Substances Coordination Complexes ; Antineoplastic Agents ; Cisplatin (Q20Q21Q62J) ; Ligands
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 162843-4
    ISSN 1873-3344 ; 0162-0134
    ISSN (online) 1873-3344
    ISSN 0162-0134
    DOI 10.1016/j.jinorgbio.2022.112051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1730: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article: Economic evaluation of management strategies for complex regional pain syndrome (CRPS).

    Zhou, Xiaofeng / Zhou, Yi / Zhang, Xiaofei / Jiang, Feng

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1297927

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1297927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Inverse problem for a class of time-space fractional linear diffusion aligns

    ZHANG Xiaofeng / ZHOU Xianfeng

    Journal of Shanghai Normal University (Natural Sciences), Vol 52, Iss 3, Pp 311-

    2023  Volume 322

    Abstract: We consider a class of time-space fractional diffusion aligns with Caputo derivatives in a bounded domain. We also consider the existence, uniqueness and some important properties of the solution. Moreover, some regularity estimations will be given based ...

    Abstract We consider a class of time-space fractional diffusion aligns with Caputo derivatives in a bounded domain. We also consider the existence, uniqueness and some important properties of the solution. Moreover, some regularity estimations will be given based on different conditions.
    Keywords caputo fractional derivative ; existence ; uniqueness ; regularity ; Science (General) ; Q1-390
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Academic Journals Center of Shanghai Normal University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article: Generation of gastirc insulin-secreting organoids from human stomach sample.

    Huang, Xiaofeng / Zhou, Qiao

    Research square

    2023  

    Abstract: Stomach stem cells are accessible by biopsy and propagate robustly in culture, offering an invaluable resource for autologous cell therapies. Here we describe a detailed protocol to isolate, expand, engineer and differentiate human gastric stem cells ( ... ...

    Abstract Stomach stem cells are accessible by biopsy and propagate robustly in culture, offering an invaluable resource for autologous cell therapies. Here we describe a detailed protocol to isolate, expand, engineer and differentiate human gastric stem cells (hGSCs) into pancreatic islet-like organoids containing abundant gastric insulin-secreting (GINS) cells that resemble beta-cells in molecular hallmarks and function. Sequential activation of the inducing factors NGN3 and PDX1-MAFA led hGSCs onto a novel differentiation path, including endocrine progenitor and GINS precursor, before adopting beta-cell identity, at efficiencies close to 70%. GINS organoids acquired glucose-stimulated insulin secretion in 10 days post differentiation.
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.pex-2147/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: New investigational drugs to treat Sjogren's syndrome: lessons learnt from immunology.

    Zhou, Xingyu / Xu, Dong / Li, Mengtao / Zeng, Xiaofeng

    Expert opinion on investigational drugs

    2024  Volume 33, Issue 2, Page(s) 105–114

    Abstract: Introduction: Sjögren's syndrome is a heterogeneous autoimmune condition that impairs quality of life because of dryness, fatigue, pain, and systemic involvements. Current treatment largely depends on empirical evidence, with no effective therapy ... ...

    Abstract Introduction: Sjögren's syndrome is a heterogeneous autoimmune condition that impairs quality of life because of dryness, fatigue, pain, and systemic involvements. Current treatment largely depends on empirical evidence, with no effective therapy approved. Clinical trials on targeted drugs often fail to report efficacy due to common factors.
    Areas covered: This review summarizes the pathogenesis and what caused the failure of new investigational drugs in clinical trials, highlighting solutions for more effective investigations, with greater consistency between research outcomes, clinical use, and patient needs.
    Expert opinion: Unlinked pathobiology with symptoms resulted in misidentified targets and disappointing trials. Useful stratification tools are necessary for the heterogeneous SS patients. Composite endpoints or improvements in ESSDAI scores are needed, considering the high placebo response, and the unbalance between symptom burden and disease activity. Compared to classic biologics, targeted cell therapy will be a more promising field of investigation in the coming years.
    MeSH term(s) Humans ; Sjogren's Syndrome/drug therapy ; Drugs, Investigational/pharmacology ; Drugs, Investigational/therapeutic use ; Quality of Life ; Severity of Illness Index ; Pain
    Chemical Substances Drugs, Investigational
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2024.2312216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3739: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: A novel phase of superionic conductor

    Zhang, Xiaofeng / Yan, Luo / Li, Qiaoqiao / Zhang, Yongqi / Zhou, Liujiang

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 34, Page(s) 22920–22926

    Abstract: ... ...

    Abstract Na
    Language English
    Publishing date 2023-08-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp02538a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: LncRNA WWTR1-AS1 upregulates Notch3 through miR-136 to increase cancer cell stemness in cervical squamous cell carcinoma.

    Zhou, Xiaofeng / Li, Zhizun / Li, Moyu

    BMC women's health

    2024  Volume 24, Issue 1, Page(s) 104

    Abstract: Background: This Study investigated the role of WWTR1-AS1 in cervical squamous cell carcinoma (CSCC).: Results: WWTR1-AS1 expression was upregulated in CSCC tissues. WWTR1-AS1 was predicted to interact with miR-136, whereas correlation analysis ... ...

    Abstract Background: This Study investigated the role of WWTR1-AS1 in cervical squamous cell carcinoma (CSCC).
    Results: WWTR1-AS1 expression was upregulated in CSCC tissues. WWTR1-AS1 was predicted to interact with miR-136, whereas correlation analysis revealed that there was no close correlation between WWTR1-AS1 and miR-136 across CSCC samples. Moreover, WWTR1-AS1 and miR-136 did not regulate the expression of each other. In addition, overexpression of WWTR1-AS1 increased the expression levels of Notch3, which could be targeted by miR-136. Cell stemness analysis indicated that the overexpression of WWTR1-AS1 and Notch3 increased CSCC cell stemness and the capacity of CSCC cell to grow as spheroids. Overexpression of miR-136 decreased CSCC cell stemness and reversed the effects of overexpression of WWTR1-AS1 on Notch3 in CSCC cells.
    Conclusion: Therefore, WWTR1-AS1 may upregulate Notch3 through miR-136 to increase cancer cell stemness in CSCC.
    MeSH term(s) Female ; Humans ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; MicroRNAs/genetics ; RNA, Long Noncoding/genetics ; Transcriptional Coactivator with PDZ-Binding Motif Proteins ; Uterine Cervical Neoplasms/pathology ; RNA, Antisense/genetics
    Chemical Substances MicroRNAs ; MIRN136 microRNA, human ; RNA, Long Noncoding ; Transcriptional Coactivator with PDZ-Binding Motif Proteins ; WWTR1 protein, human ; RNA, Antisense ; NOTCH3 protein, human
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050444-5
    ISSN 1472-6874 ; 1472-6874
    ISSN (online) 1472-6874
    ISSN 1472-6874
    DOI 10.1186/s12905-024-02905-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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